Synthesis of site-specific antibody-drug conjugates using unnatural amino acids
Axup, Jun Y, Bajjuri, Krishna M, Ritland, Melissa, Hutchins, Benjamin M, Kim, Chan Hyuk, Kazane, Stephanie A, Halder, Rajkumar, Forsyth, Jane S, Santidrian, Antonio F, Stafin, Karin, Lu, Yingchun, Tran, Hon, Seller, Aaron J, Biroc, Sandra L, Szydlik, Aga, Pinkstaff, Jason K, Tian, Feng, Sinha, Subhash C, Felding-Habermann, Brunhilde, Smider, Vaughn V, Schultz, Peter G
Published in Proceedings of the National Academy of Sciences - PNAS (02.10.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (02.10.2012)
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A general approach to site-specific antibody drug conjugates
Tian, Feng, Lu, Yingchun, Manibusan, Anthony, Sellers, Aaron, Tran, Hon, Sun, Ying, Phuong, Trung, Barnett, Richard, Hehli, Brad, Song, Frank, DeGuzman, Michael J., Ensari, Semsi, Pinkstaff, Jason K., Sullivan, Lorraine M., Biroc, Sandra L., Ho Cho, Schultz, Peter G., DiJoseph, John, Dougher, Maureen, Ma, Dangshe, Dushin, Russell, Leal, Mauricio, Tchistiakova, Lioudmila, Feyfant, Eric, Gerber, Hans-Peter, Sapra, Puja
Published in Proceedings of the National Academy of Sciences - PNAS (04.02.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (04.02.2014)
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GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet
CLEMMENSEN, Christoffer, CHABENNE, Joseph, PFLUGER, Paul T, PINKSTAFF, Jason, TSCHOP, Matthias H, DIMARCHI, Richard, MÜLLER, Timo D, FINAN, Brian, SULLIVAN, Lorraine, FISCHER, Katrin, KÜCHLER, Daniela, SEHRER, Laura, OGRAJSEK, Teja, HOFMANN, Susanna M, SCHRIEVER, Sonja C
Published in Diabetes (New York, N.Y.) (01.04.2014)
Published in Diabetes (New York, N.Y.) (01.04.2014)
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In vitro and in vivo evaluation of cysteine and site specific conjugated herceptin antibody-drug conjugates
Jackson, Dowdy, Atkinson, John, Guevara, Claudia I, Zhang, Chunying, Kery, Vladimir, Moon, Sung-Ju, Virata, Cyrus, Yang, Peng, Lowe, Christine, Pinkstaff, Jason, Cho, Ho, Knudsen, Nick, Manibusan, Anthony, Tian, Feng, Sun, Ying, Lu, Yingchun, Sellers, Aaron, Jia, Xiao-Chi, Joseph, Ingrid, Anand, Banmeet, Morrison, Kendall, Pereira, Daniel S, Stover, David
Published in PloS one (14.01.2014)
Published in PloS one (14.01.2014)
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FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
MU, James, PINKSTAFF, Jason, WU, Margaret, NORMAN, Thea C, RODRIGUEZ, Carlos G, KIMMEL, Bruce, METZGER, Joseph M, MANIBUSAN, Anthony, LEE, Darin, ZALLER, Dennis M, ZHANG, Bei B, DIMARCHI, Richard D, ZHIHUA LI, BERGER, Joel P, AXELROD, Douglas W, SKIDMORE, Lillian, NINA LI, MYLER, Heather, DALLAS-YANG, Qing, PUTNAM, Anna-Maria, JUN YAO, BUSSELL, Stuart
Published in Diabetes (New York, N.Y.) (01.02.2012)
Published in Diabetes (New York, N.Y.) (01.02.2012)
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Central nervous system pathology in preclinical MPS IIIB dogs reveals progressive changes in clinically relevant brain regions
Egeland, Martin T., Tarczyluk-Wells, Marta M., Asmar, Melissa M., Adintori, Evan G., Lawrence, Roger, Snella, Elizabeth M., Jens, Jackie K., Crawford, Brett E., Wait, Jill C. M., McCullagh, Emma, Pinkstaff, Jason, Cooper, Jonathan D., Ellinwood, N. Matthew
Published in Scientific reports (23.11.2020)
Published in Scientific reports (23.11.2020)
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Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21
Müller, Timo D., Sullivan, Lorraine M., Habegger, Kirk, Yi, Chun-Xia, Kabra, Dhiraj, Grant, Erin, Ottaway, Nickki, Krishna, Radha, Holland, Jenna, Hembree, Jazzminn, Perez-Tilve, Diego, Pfluger, Paul T., DeGuzman, Michael J., Siladi, Marc E., Kraynov, Vadim S., Axelrod, Douglas W., DiMarchi, Richard, Pinkstaff, Jason K., Tschöp, Matthias H.
Published in Journal of peptide science (01.06.2012)
Published in Journal of peptide science (01.06.2012)
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Safety, pharmacokinetics and CNS distribution of tralesinidase alfa administered via intracerebroventricular infusion to juvenile cynomolgus monkeys
Pinkstaff, Jason, McCullagh, Emma, Grover, Anita, Melton, Andrew C., Cherukuri, Anu, Wait, Jill CM, Nguyen, Annalisa, Butt, Mark T., Trombley, Jami L., Reed, Randall P., Adams, Eric.L., Boyd, Robert B., Chandra, Sundeep, Henshaw, Joshua, O’Neill, Charles A., Zanelli, Eric, Kovalchin, Joseph
Published in Toxicology reports (01.01.2023)
Published in Toxicology reports (01.01.2023)
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Integrin Subunit Gene Expression Is Regionally Differentiated in Adult Brain
Pinkstaff, Jason K, Detterich, Jon, Lynch, Gary, Gall, Christine
Published in The Journal of neuroscience (01.03.1999)
Published in The Journal of neuroscience (01.03.1999)
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Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B
Grover, Anita, Crippen-Harmon, Danielle, Nave, Lacey, Vincelette, Jon, Wait, Jill C. M., Melton, Andrew C., Lawrence, Roger, Brown, Jillian R., Webster, Katherine A., Yip, Bryan K., Baridon, Brian, Vitelli, Catherine, Rigney, Sara, Christianson, Terri M., Tiger, Pascale M. N., Lo, Melanie J., Holtzinger, John, Shaywitz, Adam J., Crawford, Brett E., Fitzpatrick, Paul A., LeBowitz, Jonathan H., Bullens, Sherry, Aoyagi-Scharber, Mika, Bunting, Stuart, O’Neill, Charles A., Pinkstaff, Jason, Bagri, Anil
Published in Drug delivery and translational research (01.04.2020)
Published in Drug delivery and translational research (01.04.2020)
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BS-452758-3 SUPPRESSION-REPLACEMENT GENE THERAPY FOR -MEDIATED CARDIOMYOPATHIES
Gluscevic, Martina, Kim, Changsung J., Tester, David, Christoforou, Nicolas, Bego, Mariana, Keyes, Lisa, Owens, Jane, Pinkstaff, Jason, Garmany, Ramin, Brooks, Gabriel, Ackerman, Michael J.
Published in Heart rhythm (01.05.2023)
Published in Heart rhythm (01.05.2023)
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BS-452758-1 SUPPRESSION-REPLACEMENT GENE THERAPY REVERSE REMODELS THE INTRACELLULAR CALCIUM HANDLING DISEASE PHENOTYPE OF TNNT2-MEDIATED HYPERTROPHIC CARDIOMYOPATHY
Zhou, Wei, Tester, David, Christoforou, Nicolas, Kim, Changsung J., Bego, Mariana, Keyes, Lisa, Owens, Jane, Pinkstaff, Jason, Brooks, Gabriel, Ackerman, Michael J.
Published in Heart rhythm (01.05.2023)
Published in Heart rhythm (01.05.2023)
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Journal Article
BS-452758-3 SUPPRESSION-REPLACEMENT GENE THERAPY FOR LMNA-MEDIATED CARDIOMYOPATHIES
Gluscevic, Martina, Kim, Changsung J., Tester, David, Christoforou, Nicolas, Bego, Mariana, Keyes, Lisa, Owens, Jane, Pinkstaff, Jason, Garmany, Ramin, Brooks, Gabriel, Ackerman, Michael J.
Published in Heart rhythm (01.05.2023)
Published in Heart rhythm (01.05.2023)
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Journal Article
BS-452758-1 SUPPRESSION-REPLACEMENT GENE THERAPY REVERSE REMODELS THE INTRACELLULAR CALCIUM HANDLING DISEASE PHENOTYPE OF -MEDIATED HYPERTROPHIC CARDIOMYOPATHY
Zhou, Wei, Tester, David, Christoforou, Nicolas, Kim, Changsung J., Bego, Mariana, Keyes, Lisa, Owens, Jane, Pinkstaff, Jason, Brooks, Gabriel, Ackerman, Michael J.
Published in Heart rhythm (01.05.2023)
Published in Heart rhythm (01.05.2023)
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Journal Article
Translation of nonclinical to clinical safety findings for 27 biotherapeutics
Leach, Michael W., Rana, Payal, Hu, Wenyue, Mittapalli, Rajendar K., Pinkstaff, Jason, Potter, David, Qiu, Xing Min, Ramaiah, Lila, Rohde, Cynthia, Xia, Feng, Khan, K. Nasir
Published in Toxicology and applied pharmacology (01.03.2024)
Published in Toxicology and applied pharmacology (01.03.2024)
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Pharmaceutical Industry Perspective on the Non-Clinical Evaluation of Novel Excipients: Results From an Industry Survey Conducted by the IQ Novel Excipient Working Group
Giffen, Paul S, Buckley, Lorrene A, Pinkstaff, Jason
Published in International journal of toxicology (01.12.2023)
Published in International journal of toxicology (01.12.2023)
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Journal Article
EN-482891-004 AAV9-MEDIATED KCNH2-SUPPRESSION-REPLACEMENT GENE THERAPY PROLONGS THE PATHOLOGICALLY SHORTENED QT/APD IN SHORT QT SYNDROME TYPE 1 RABBIT MODELS
Nimani, Saranda, Bains, Sahej, Alerni, Nicolo, Giammarino, Lucilla, Horváth, András, Louradour, Julien, Barbieri, Miriam, Beslac, Olgica, Egle, Manuel, Tester, David, Christoforou, Nicolas, Matas, Lluis, Lopez, Ruben, Perez-Feliz, Stefanie, Kim, Changsung J., Zhou, Wei, Ye, Dan, Jurgensen, Jacqulyn, Barry, Michael, Bego, Mariana, Keyes, Lisa, Owens, Jane, Pinkstaff, Jason, Zehender, Manfred, Brunner, Michael, Casoni, Daniela, Praz, Fabien, Haeberlin, Andreas, Brooks, Gabriel, Ackerman, Michael J., Odening, Katja E.
Published in Heart rhythm (01.05.2024)
Published in Heart rhythm (01.05.2024)
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Journal Article
KCNQ1 suppression-replacement gene therapy in transgenic rabbits with type 1 long QT syndrome
Bains, Sahej, Giammarino, Lucilla, Nimani, Saranda, Alerni, Nicolo, Tester, David J, Kim, C S John, Christoforou, Nicolas, Louradour, Julien, Horváth, András, Beslac, Olgica, Barbieri, Miriam, Matas, Lluis, Hof, Thomas S, Lopez, Ruben, Perez-Feliz, Stefanie, Parodi, Chiara, Garcia Casalta, Luisana G, Jurgensen, Jacqulyn, Barry, Michael A, Bego, Mariana, Keyes, Lisa, Owens, Jane, Pinkstaff, Jason, Koren, Gideon, Zehender, Manfred, Brunner, Michael, Casoni, Daniela, Praz, Fabien, Haeberlin, Andreas, Brooks, Gabriel, Ackerman, Michael J, Odening, Katja E
Published in European heart journal (29.09.2024)
Published in European heart journal (29.09.2024)
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