Boosting NAD+ with a small molecule that activates NAMPT
Gardell, Stephen J., Hopf, Meghan, Khan, Asima, Dispagna, Mauro, Hampton Sessions, E., Falter, Rebecca, Kapoor, Nidhi, Brooks, Jeanne, Culver, Jeffrey, Petucci, Chris, Ma, Chen-Ting, Cohen, Steven E., Tanaka, Jun, Burgos, Emmanuel S., Hirschi, Jennifer S., Smith, Steven R., Sergienko, Eduard, Pinkerton, Anthony B.
Published in Nature communications (19.07.2019)
Published in Nature communications (19.07.2019)
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Aberrant Lipid Metabolism in Anaplastic Thyroid Carcinoma Reveals Stearoyl CoA Desaturase 1 as a Novel Therapeutic Target
von Roemeling, Christina A, Marlow, Laura A, Pinkerton, Anthony B, Crist, Angela, Miller, James, Tun, Han W, Smallridge, Robert C, Copland, John A
Published in The journal of clinical endocrinology and metabolism (01.05.2015)
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Pathophysiological Role of Vascular Smooth Muscle Alkaline Phosphatase in Medial Artery Calcification
Sheen, Campbell R, Kuss, Pia, Narisawa, Sonoko, Yadav, Manisha C, Nigro, Jessica, Wang, Wei, Chhea, T Nicole, Sergienko, Eduard A, Kapoor, Kapil, Jackson, Michael R, Hoylaerts, Marc F, Pinkerton, Anthony B, O'Neill, W Charles, Millán, José Luis
Published in Journal of bone and mineral research (01.05.2015)
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Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists
Shiryaev, Sergey A., Farhy, Chen, Pinto, Antonella, Huang, Chun-Teng, Simonetti, Nicole, Ngono, Annie Elong, Dewing, Antimone, Shresta, Sujan, Pinkerton, Anthony B., Cieplak, Piotr, Strongin, Alex Y., Terskikh, Alexey V.
Published in Antiviral research (01.07.2017)
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Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11
Li, Jing, Yakushi, Tanya, Parlati, Francesco, Mackinnon, Andrew L, Perez, Christian, Ma, Yuyong, Carter, Kyle P, Colayco, Sharon, Magnuson, Gavin, Brown, Brock, Nguyen, Kevin, Vasile, Stefan, Suyama, Eigo, Smith, Layton H, Sergienko, Eduard, Pinkerton, Anthony B, Chung, Thomas D Y, Palmer, Amy E, Pass, Ian, Hess, Sonja, Cohen, Seth M, Deshaies, Raymond J
Published in Nature chemical biology (01.05.2017)
Published in Nature chemical biology (01.05.2017)
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CYCLIC SULFONAMIDE RIBONUCLEOTIDE REDUCTASE (RNR) INHIBITORS AND USES THEREOF
MEYER Stephen Todd, MAUGER Jacques, TRUONG Yen Pham Hong, ELSDON Rachelle Janette, PINKERTON Anthony B
Year of Publication 05.04.2024
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Year of Publication 05.04.2024
Patent
Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase
Ziegler, Shira G, Ferreira, Carlos R, MacFarlane, Elena Gallo, Riddle, Ryan C, Tomlinson, Ryan E, Chew, Emily Y, Martin, Ludovic, Ma, Chen-Ting, Sergienko, Eduard, Pinkerton, Anthony B, Millán, José Luis, Gahl, William A, Dietz, Harry C
Published in Science translational medicine (07.06.2017)
Published in Science translational medicine (07.06.2017)
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CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF
MEYER Stephen Todd, MAUGER Jacques, TRUONG Yen Pham Hong, ELSDON Rachelle Janette, PINKERTON Anthony B
Year of Publication 12.12.2023
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Year of Publication 12.12.2023
Patent
Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator
Akiu, Mayuko, Tsuji, Takashi, Iida, Kouki, Sogawa, Yoshitaka, Terayama, Koji, Yokoyama, Mika, Tanaka, Jun, Asano, Daigo, Honda, Tomohiro, Sakurai, Ken, Pinkerton, Anthony B., Nakamura, Tsuyoshi
Published in Chemical & pharmaceutical bulletin (01.11.2021)
Published in Chemical & pharmaceutical bulletin (01.11.2021)
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Compuestos de sulfonamida con actividad inhibidora de la TNAP
YAMAMOTO, Yuko, SOMA, Kaori, KUROSAKI, Yasunobu, IZUMI, Masanori, PINKERTON, Anthony B, MIYAZAKI, Shojiro, KISHIDA, Masamichi, INUI, Masaharu
Year of Publication 04.03.2024
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Year of Publication 04.03.2024
Patent
Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor
Pinkerton, Anthony B., Sergienko, Eduard, Bravo, Yalda, Dahl, Russell, Ma, Chen-Ting, Sun, Qing, Jackson, Michael R., Cosford, Nicholas D.P., Millán, José Luis
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
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Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators
Pinkerton, Anthony B., Sessions, E. Hampton, Hershberger, Paul, Maloney, Patrick R., Peddibhotla, Satyamaheshwar, Hopf, Meghan, Sergienko, Eduard, Ma, Chen-Ting, Smith, Layton H., Jackson, Michael R., Tanaka, Jun, Tsuji, Takashi, Akiu, Mayuko, Cohen, Steven E., Nakamura, Tsuyoshi, Gardell, Stephen J.
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
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Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia
Romanelli, Filippo, Corbo, AnthonyMarco, Salehi, Maryam, Yadav, Manisha C, Salman, Soha, Petrosian, David, Rashidbaigi, Omid J, Chait, Jesse, Kuruvilla, Jes, Plummer, Maria, Radichev, Ilian, Margulies, Kenneth B, Gerdes, A Martin, Pinkerton, Anthony B, Millán, José Luis, Savinov, Alexei Y, Savinova, Olga V
Published in PloS one (12.10.2017)
Published in PloS one (12.10.2017)
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Arylmethylamino steroids as antiparasitic agents
Krieg, Reimar, Jortzik, Esther, Goetz, Alice-Anne, Blandin, Stéphanie, Wittlin, Sergio, Elhabiri, Mourad, Rahbari, Mahsa, Nuryyeva, Selbi, Voigt, Kerstin, Dahse, Hans-Martin, Brakhage, Axel, Beckmann, Svenja, Quack, Thomas, Grevelding, Christoph G., Pinkerton, Anthony B., Schönecker, Bruno, Burrows, Jeremy, Davioud-Charvet, Elisabeth, Rahlfs, Stefan, Becker, Katja
Published in Nature communications (17.02.2017)
Published in Nature communications (17.02.2017)
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Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies
Haeussler, Kristina, Berneburg, Isabell, Jortzik, Esther, Hahn, Julia, Rahbari, Mahsa, Schulz, Norma, Preuss, Janina, Zapol'skii, Viktor A, Bode, Lars, Pinkerton, Anthony B, Kaufmann, Dieter E, Rahlfs, Stefan, Becker, Katja
Published in Malaria journal (25.01.2019)
Published in Malaria journal (25.01.2019)
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Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization
McAnally, Danielle, Siddiquee, Khandaker, Gomaa, Ahmed, Szabo, Andras, Vasile, Stefan, Maloney, Patrick R, Divlianska, Daniela B, Peddibhotla, Satyamaheshwar, Morfa, Camilo J, Hershberger, Paul, Falter, Rebecca, Williamson, Robert, Terry, David B, Farjo, Rafal, Pinkerton, Anthony B, Qi, Xiaping, Quigley, Judith, Boulton, Michael E, Grant, Maria B, Smith, Layton H
Published in PloS one (12.09.2018)
Published in PloS one (12.09.2018)
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Chronic Kidney Disease-Induced Arterial Media Calcification in Rats Prevented by Tissue Non-Specific Alkaline Phosphatase Substrate Supplementation Rather Than Inhibition of the Enzyme
Opdebeeck, Britt, Neven, Ellen, Millán, José Luis, Pinkerton, Anthony B., D’Haese, Patrick C., Verhulst, Anja
Published in Pharmaceutics (26.07.2021)
Published in Pharmaceutics (26.07.2021)
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Author Correction: Arylmethylamino steroids as antiparasitic agents
Krieg, Reimar, Jortzik, Esther, Goetz, Alice-Anne, Blandin, Stéphanie, Wittlin, Sergio, Elhabiri, Mourad, Rahbari, Mahsa, Nuryyeva, Selbi, Voigt, Kerstin, Dahse, Hans-Martin, Brakhage, Axel, Beckmann, Svenja, Quack, Thomas, Grevelding, Christoph G., Pinkerton, Anthony B., Schönecker, Bruno, Burrows, Jeremy, Davioud-Charvet, Elisabeth, Rahlfs, Stefan, Becker, Katja
Published in Nature communications (08.07.2019)
Published in Nature communications (08.07.2019)
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Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor
Maloney, Patrick R., Khan, Pasha, Hedrick, Michael, Gosalia, Palak, Milewski, Monika, Li, Linda, Roth, Gregory P., Sergienko, Eduard, Suyama, Eigo, Sugarman, Eliot, Nguyen, Kevin, Mehta, Alka, Vasile, Stefan, Su, Ying, Stonich, Derek, Nguyen, Hung, Zeng, Fu-Yue, Novo, Arianna Mangravita, Vicchiarelli, Michael, Diwan, Jena, Chung, Thomas D.Y., Smith, Layton H., Pinkerton, Anthony B.
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
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