Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents
Charrier, Jean-Damien, Durrant, Steven J, Golec, Julian M. C, Kay, David P, Knegtel, Ronald M. A, MacCormick, Somhairle, Mortimore, Michael, O'Donnell, Michael E, Pinder, Joanne L, Reaper, Philip M, Rutherford, Alistair P, Wang, Paul S. H, Young, Stephen C, Pollard, John R
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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The discovery of the potent aurora inhibitor MK-0457 (VX-680)
Bebbington, David, Binch, Hayley, Charrier, Jean-Damien, Everitt, Simon, Fraysse, Damien, Golec, Julian, Kay, David, Knegtel, Ronald, Mak, Chau, Mazzei, Francesca, Miller, Andrew, Mortimore, Michael, O’Donnell, Michael, Patel, Sanjay, Pierard, Francoise, Pinder, Joanne, Pollard, John, Ramaya, Sharn, Robinson, Daniel, Rutherford, Alistair, Studley, John, Westcott, James
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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Synthesis of the 2,3,4-trisubstituted indole fragments of nosiheptide and glycothiohexide
Bentley, DJ, Fairhurst, J, Gallagher, PT, Manteuffel, AK, Moody, CJ, Pinder, JL
Published in Organic & biomolecular chemistry (07.03.2004)
Published in Organic & biomolecular chemistry (07.03.2004)
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Synthesis of a stable pyridyl boronate and its reaction with aryl and heteroaryl halides
Durrant, Steven J., Pinder, Joanne L., Charrier, Jean-Damien, Jimenez, Juan-Miguel, Brenchley, Guy, Collier, Philip N., Kay, David, Miller, Andrew, Pierard, Francoise, Ramaya, Sharn, Sadiq, Shazia, Twin, Heather C.
Published in Heterocycles (31.12.2006)
Published in Heterocycles (31.12.2006)
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Rational Design of 5‑(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor
Knegtel, Ronald, Charrier, Jean-Damien, Durrant, Steven, Davis, Chris, O’Donnell, Michael, Storck, Pierre, MacCormick, Somhairle, Kay, David, Pinder, Joanne, Virani, Anisa, Twin, Heather, Griffiths, Matthew, Reaper, Philip, Littlewood, Peter, Young, Steve, Golec, Julian, Pollard, John
Published in Journal of medicinal chemistry (13.06.2019)
Published in Journal of medicinal chemistry (13.06.2019)
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나트륨 채널 조절제로서의 N- 테트라하이드로푸란 카르복스아미드
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Year of Publication 07.03.2024
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Year of Publication 07.03.2024
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나트륨 채널의 조절제로서의 치환된 테트라하이드로푸란
PONTILLO JOSEPH, WRAY CHRISTOPHER, THOMSON STEPHEN ANDREW, GALAN BHAIRAVI, NEUBERT TIMOTHY DONALD, ETXEBARRIA JARDI GORKA, STAMOS DEAN, HURLEY DENNIS JAMES, DURRANT STEVEN JOHN, PINDER JOANNE LOUISE, SHAW DAVID MATTHEW, BECK ELIZABETH MARY, CHUDYK EWA IWONA, CARVALHO MEIRELES LIDIO, HADIDA RUAH SARA S, KNEGTEL RONALD MARCELLUS, SKERRATT SARAH, PULLIN ROBERT, SCHMIDT YVONNE, AHMAD NADIA, VIRANI ANISA NIZARALI
Year of Publication 13.09.2022
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Year of Publication 13.09.2022
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Pyrazine derivatives useful as inhibitors of ATR kinase
DURRANT STEVEN, MORTIMORE MICHAEL, O'DONNELL MICHAEL, KAY DAVID, CHARRIER JEAN DAMIEN, YOUNG STEPHEN, REAPER PHILIP MICHAEL, PINDER JOANNE, KNEGTEL RONALD, RUTHERFORD ALISTAIR, VIRANI ANISA NIZARALI, MACCORMICK SOMHAIRLE
Year of Publication 12.07.2017
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Year of Publication 12.07.2017
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ATR 2--6--N-[5---3-]-[15-A]-3- RADIOLABELLED DERIVATIVES OF A 2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]- PYRAZOLO[15-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR THE PREPARATION OF SAID COMPOUND AND DIFFERENT SOLID FORMS THEREOF
PIERARD FRANCOISE, DAVIS CHRIS, CHARRIER JEAN DAMIEN, STUDLEY JOHN, ETXEBARRIA I JARDI GORKA, PINDER JOANNE, STORCK PIERRE HENRI, KNEGTEL RONALD, FRAYSSE DAMIEN, PANESAR MANINDER, AHMAD NADIA
Year of Publication 20.01.2017
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Year of Publication 20.01.2017
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Compounds useful as Inhibitors of ATR kinase
O'DONNELL MICHAEL, YOUNG STEPHEN, FANNING LEV T.D, CLEVELAND THOMAS, VIRANI ANISA, MACCORMICK SOMHAIRLE, BINCH HAYLEY, DURRANT STEVEN, HURLEY DENNIS, SHETH URVI, KAY DAVID, SILINA ALINA, CHARRIER JEAN DAMIEN, REAPER PHILIP MICHAEL, PINDER JOANNE, KNEGTEL RONALD, JOSHI PRAMOD
Year of Publication 08.02.2017
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Year of Publication 08.02.2017
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2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, ITS PREPARATION, DIFFERENT SOLID FORMS AND RADIOLABELLED DERIVATIVES THEREOF
SANGHVI TAPAN, DAVIS CHRISTOPHER JOHN, ETXEBARRIA I JARDI GORKA, MEDEK ALES, PANESAR MANINDER, SHAW DAVID MATTHEW, ZWICKER CARL, PIERARD FRANCOISE, CHARRIER JEAN DAMIEN, ZHANG YUEGANG, PEGG SIMON, STUDLEY JOHN, PINDER JOANNE, FRAYSSE DAMIEN, WALDO MICHAEL, ALEM NAZIHA
Year of Publication 08.08.2016
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Year of Publication 08.08.2016
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PYRAZINE DERIVATIVES USEFUL AS INHIBITORS OF ATR KINASE
DURRANT STEVEN, MORTIMORE MICHAEL, O'DONNELL MICHAEL, KAY DAVID, CHARRIER JEAN DAMIEN, YOUNG STEPHEN, REAPER PHILIP MICHAEL, PINDER JOANNE, KNEGTEL RONALD, RUTHERFORD ALISTAIR, VIRANI ANISA NIZARALI, MACCORMICK SOMHAIRLE
Year of Publication 09.01.2015
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Year of Publication 09.01.2015
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COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
SHAW DAVID, BOYALL DEAN, ETXEBARRIA I JARDI GORKA, MIDDLETON DONALD, STORCK PIERRE HENRI, TWIN HEATHER, PANESAR MANINDER, DURRANT STEVEN, ODONNELL MICHAEL, PIERARD FRANCOISE, KAY DAVID, DAVIS CHRIS, CHARRIER JEAN DAMIEN, JIMENEZ JUAN MIGUEL, STUDLEY JOHN, PINDER JOANNE, KNEGTEL RONALD, DAVIS REBECCA, FRAYSSE DAMIEN, AHMAD NADIA
Year of Publication 07.08.2015
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Year of Publication 07.08.2015
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AZAINDOLE USEFUL AS JAK AND OTHER PROTEIN KINASE INHIBITOR
EVERITT SIMON, BOYALL DEAN, BETHIEL RANDY, COME JON, LAUFFER DAVID, SALITURO FRANCESCO, ROBINSON DANIEL, HARRINGTON EDMUND, BINCH HAYLEY, FARMER LUC, MORTIMORE MICHAEL, WANG JIAN, ARONOV ALEX, PIERARD FRANCOISE, PIERCE ALBERT, GREEN JEREMY, CHARRIER JEAN-DAMIEN, COURT JOHN, PINDER JOANNE, WANG TIANSHENG, FRAYSSE DAMIEN
Year of Publication 22.06.2015
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Year of Publication 22.06.2015
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AMINOPYRAZINE COMPOUNDS USEFUL AS INHIBITORS OF TRA KINASE
O'DONNELL MICHAEL EDWARD, KAY DAVID, CHARRIER JEAN DAMIEN, DAVIS CHRISTOPHER JOHN, REAPER PHILIP MICHAEL, STORCK PIERRE HENRI, PINDER JOANNE, DURRANT STEVEN JOHN, KNEGTEL RONALD MARCELLUS ALPHONSUS, YOUNG STEPHEN CLINTON YOUNG, TWIN HEATHER CLARE, MACCORMICK SOMHAIRLE
Year of Publication 07.03.2014
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Year of Publication 07.03.2014
Patent