Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines
Parhi, Ajit K., Zhang, Yongzheng, Saionz, Kurt W., Pradhan, Padmanava, Kaul, Malvika, Trivedi, Kalkal, Pilch, Daniel S., LaVoie, Edmond J.
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
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Journal Article
Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus
Kaul, Malvika, Mark, Lilly, Parhi, Ajit K, LaVoie, Edmond J, Pilch, Daniel S
Published in Antimicrobial agents and chemotherapy (01.07.2016)
Published in Antimicrobial agents and chemotherapy (01.07.2016)
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Journal Article
Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ
Fujita, Junso, Maeda, Yoko, Mizohata, Eiichi, Inoue, Tsuyoshi, Kaul, Malvika, Parhi, Ajit K, LaVoie, Edmond J, Pilch, Daniel S, Matsumura, Hiroyoshi
Published in ACS chemical biology (21.07.2017)
Published in ACS chemical biology (21.07.2017)
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Journal Article
An FtsZ-Targeting Prodrug with Oral Antistaphylococcal Efficacy In Vivo
KAUL, Malvika, MARK, Lilly, YONGZHENG ZHANG, PARHI, Ajit K, LAVOIE, Edmond J, PILCH, Daniel S
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
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Journal Article
Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens
Ferrer-González, Edgar, Fujita, Junso, Yoshizawa, Takuya, Nelson, Julia M, Pilch, Alyssa J, Hillman, Elani, Ozawa, Mayuki, Kuroda, Natsuko, Al-Tameemi, Hassan M, Boyd, Jeffrey M, LaVoie, Edmond J, Matsumura, Hiroyoshi, Pilch, Daniel S
Published in Scientific reports (27.12.2019)
Published in Scientific reports (27.12.2019)
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Journal Article
Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723
Kaul, Malvika, Mark, Lilly, Zhang, Yongzheng, Parhi, Ajit K., LaVoie, Edmond J., Pilch, Daniel S.
Published in Biochemical pharmacology (15.12.2013)
Published in Biochemical pharmacology (15.12.2013)
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Journal Article
A FtsZ Inhibitor That Can Utilize Siderophore-Ferric Iron Uptake Transporter Systems for Activity against Gram-Negative Bacterial Pathogens
Bryan, Eric J, Qiao, Qi, Wang, Yuxuan, Roberge, Jacques Y, LaVoie, Edmond J, Pilch, Daniel S
Published in Antibiotics (Basel) (22.02.2024)
Published in Antibiotics (Basel) (22.02.2024)
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Journal Article
Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives
Parhi, Ajit, Lu, Songfeng, Kelley, Cody, Kaul, Malvika, Pilch, Daniel S., LaVoie, Edmond J.
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
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Journal Article
TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens
Bryan, Eric J, Sagong, Hye Yeon, Parhi, Ajit K, Grier, Mark C, Roberge, Jacques Y, LaVoie, Edmond J, Pilch, Daniel S
Published in Antibiotics (Basel) (20.05.2022)
Published in Antibiotics (Basel) (20.05.2022)
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Journal Article
Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes
Kelley, Cody, Lu, Songfeng, Parhi, Ajit, Kaul, Malvika, Pilch, Daniel S., LaVoie, Edmond J.
Published in European journal of medicinal chemistry (01.02.2013)
Published in European journal of medicinal chemistry (01.02.2013)
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Journal Article
Enterococcal and streptococcal resistance to PC190723 and related compounds: Molecular insights from a FtsZ mutational analysis
Kaul, Malvika, Zhang, Yongzheng, Parhi, Ajit K., LaVoie, Edmond J., Tuske, Steve, Arnold, Eddy, Kerrigan, John E., Pilch, Daniel S.
Published in Biochimie (01.10.2013)
Published in Biochimie (01.10.2013)
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Journal Article
Fluorescence-Based Approach for Detecting and Characterizing Antibiotic-Induced Conformational Changes in Ribosomal RNA: Comparing Aminoglycoside Binding to Prokaryotic and Eukaryotic Ribosomal RNA Sequences
Kaul, Malvika, Barbieri, Christopher M, Pilch, Daniel S
Published in Journal of the American Chemical Society (24.03.2004)
Published in Journal of the American Chemical Society (24.03.2004)
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Journal Article
Macrocyclic biphenyl tetraoxazoles: Synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity
Blankson, Gifty A., Pilch, Daniel S., Liu, Angela A., Liu, Leroy F., Rice, Joseph E., LaVoie, Edmond J.
Published in Bioorganic & medicinal chemistry (01.08.2013)
Published in Bioorganic & medicinal chemistry (01.08.2013)
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Journal Article
A G-quadruplex Stabilizer Induces M-phase Cell Cycle Arrest
Tsai, Yuan-Chin, Qi, Haiyan, Lin, Chao-Po, Lin, Ren-Kuo, Kerrigan, John E., Rzuczek, Suzanne G., LaVoie, Edmond J., Rice, Joseph E., Pilch, Daniel S., Lyu, Yi Lisa, Liu, Leroy F.
Published in The Journal of biological chemistry (21.08.2009)
Published in The Journal of biological chemistry (21.08.2009)
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Journal Article
Defining the Basis for the Specificity of Aminoglycoside-rRNA Recognition: A Comparative Study of Drug Binding to the A Sites of Escherichia coli and Human rRNA
Kaul, Malvika, Barbieri, Christopher M., Pilch, Daniel S.
Published in Journal of molecular biology (11.02.2005)
Published in Journal of molecular biology (11.02.2005)
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Journal Article
Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity
Satyanarayana, Mavurapu, Kim, Young-Ah, Rzuczek, Suzanne G., Pilch, Daniel S., Liu, Angela A., Liu, Leroy F., Rice, Joseph E., LaVoie, Edmond J.
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Journal Article
Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites
Kondo, Jiro, Hainrichson, Mariana, Nudelman, Igor, Shallom-Shezifi, Dalia, Barbieri, Christopher M, Pilch, Daniel S, Westhof, Eric, Baasov, Timor
Published in Chembiochem : a European journal of chemical biology (24.09.2007)
Published in Chembiochem : a European journal of chemical biology (24.09.2007)
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