Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex
Uzquiano, Ana, Kedaigle, Amanda J, Pigoni, Martina, Paulsen, Bruna, Adiconis, Xian, Kim, Kwanho, Faits, Tyler, Nagaraja, Surya, Antón-Bolaños, Noelia, Gerhardinger, Chiara, Tucewicz, Ashley, Murray, Evan, Jin, Xin, Buenrostro, Jason, Chen, Fei, Velasco, Silvia, Regev, Aviv, Levin, Joshua Z, Arlotta, Paola
Published in Cell (29.09.2022)
Published in Cell (29.09.2022)
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Journal Article
Lack of Sez6 Family Proteins Impairs Motor Functions, Short-Term Memory, and Cognitive Flexibility and Alters Dendritic Spine Properties
Nash, Amelia, Aumann, Timothy D, Pigoni, Martina, Lichtenthaler, Stefan F, Takeshima, Hiroshi, Munro, Kathryn M, Gunnersen, Jenny M
Published in Cerebral cortex (New York, N.Y. 1991) (14.04.2020)
Published in Cerebral cortex (New York, N.Y. 1991) (14.04.2020)
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Journal Article
The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation
Brummer, Tobias, Pigoni, Martina, Rossello, Armando, Wang, Huanhuan, Noy, Peter J, Tomlinson, Michael G, Blobel, Carl P, Lichtenthaler, Stefan F
Published in The FASEB journal (01.07.2018)
Published in The FASEB journal (01.07.2018)
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Journal Article
Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3
Pigoni, Martina, Hsia, Hung‐En, Hartmann, Jana, Rudan Njavro, Jasenka, Shmueli, Merav D, Müller, Stephan A, Güner, Gökhan, Tüshaus, Johanna, Kuhn, Peer‐Hendrik, Kumar, Rohit, Gao, Pan, Tran, Mai Ly, Ramazanov, Bulat, Blank, Birgit, Hipgrave Ederveen, Agnes L, Von Blume, Julia, Mulle, Christophe, Gunnersen, Jenny M, Wuhrer, Manfred, Rammes, Gerhard, Busche, Marc Aurel, Koeglsperger, Thomas, Lichtenthaler, Stefan F
Published in The EMBO journal (03.08.2020)
Published in The EMBO journal (03.08.2020)
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Journal Article
The β-Secretase Substrate Seizure 6–Like Protein (SEZ6L) Controls Motor Functions in Mice
Ong-Pålsson, Emma, Njavro, Jasenka Rudan, Wilson, Yvette, Pigoni, Martina, Schmidt, Andree, Müller, Stephan A., Meyer, Michael, Hartmann, Jana, Busche, Marc Aurel, Gunnersen, Jenny M., Munro, Kathryn M., Lichtenthaler, Stefan F.
Published in Molecular neurobiology (01.02.2022)
Published in Molecular neurobiology (01.02.2022)
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Journal Article
Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a “TRAP” to increase levels of TIMP-3 in the tissue
Scilabra, Simone D., Yamamoto, Kazuhiro, Pigoni, Martina, Sakamoto, Kazuma, Müller, Stephan A., Papadopoulou, Alkmini, Lichtenthaler, Stefan F., Troeberg, Linda, Nagase, Hideaki, Kadomatsu, Kenji
Published in Matrix biology (01.05.2017)
Published in Matrix biology (01.05.2017)
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Journal Article
BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains
Causevic, Mirsada, Dominko, Kristina, Malnar, Martina, Vidatic, Lea, Cermak, Stjepko, Pigoni, Martina, Kuhn, Peer-Hendrik, Colombo, Alessio, Havas, Daniel, Flunkert, Stefanie, McDonald, Jessica, Gunnersen, Jenny M, Hutter-Paier, Birgit, Tahirovic, Sabina, Windisch, Manfred, Krainc, Dimitri, Lichtenthaler, Stefan F, Hecimovic, Silva
Published in PloS one (06.07.2018)
Published in PloS one (06.07.2018)
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Journal Article
Autism genes converge on asynchronous development of shared neuron classes
Paulsen, Bruna, Velasco, Silvia, Kedaigle, Amanda J., Pigoni, Martina, Quadrato, Giorgia, Deo, Anthony J., Adiconis, Xian, Uzquiano, Ana, Sartore, Rafaela, Yang, Sung Min, Simmons, Sean K., Symvoulidis, Panagiotis, Kim, Kwanho, Tsafou, Kalliopi, Podury, Archana, Abbate, Catherine, Tucewicz, Ashley, Smith, Samantha N., Albanese, Alexandre, Barrett, Lindy, Sanjana, Neville E., Shi, Xi, Chung, Kwanghun, Lage, Kasper, Boyden, Edward S., Regev, Aviv, Levin, Joshua Z., Arlotta, Paola
Published in Nature (London) (10.02.2022)
Published in Nature (London) (10.02.2022)
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Journal Article
Tau deletion reduces plaque‐associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease
Peters, Finn, Salihoglu, Hazal, Pratsch, Katrin, Herzog, Etienne, Pigoni, Martina, Sgobio, Carmelo, Lichtenthaler, Stefan F, Neumann, Ulf, Herms, Jochen
Published in The EMBO journal (02.12.2019)
Published in The EMBO journal (02.12.2019)
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Journal Article
Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity
Pigoni, Martina, Uzquiano, Ana, Paulsen, Bruna, Kedaigle, Amanda J, Yang, Sung Min, Symvoulidis, Panagiotis, Adiconis, Xian, Velasco, Silvia, Sartore, Rafaela, Kim, Kwanho, Tucewicz, Ashley, Tropp, Sarah Yoshimi, Tsafou, Kalliopi, Jin, Xin, Barrett, Lindy, Chen, Fei, Boyden, Edward S, Regev, Aviv, Levin, Joshua Z, Arlotta, Paola
Published in Human molecular genetics (05.09.2023)
Published in Human molecular genetics (05.09.2023)
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Journal Article
The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling
Schmidt, Andree, Hrupka, Brian, van Bebber, Frauke, Sunil Kumar, Sanjay, Feng, Xiao, Tschirner, Sarah K, Aßfalg, Marlene, Müller, Stephan A, Hilger, Laura Sophie, Hofmann, Laura I, Pigoni, Martina, Jocher, Georg, Voytyuk, Iryna, Self, Emily L, Ito, Mana, Hyakkoku, Kana, Yoshimura, Akimasa, Horiguchi, Naotaka, Feederle, Regina, De Strooper, Bart, Schulte-Merker, Stefan, Lammert, Eckhard, Moechars, Dieder, Schmid, Bettina, Lichtenthaler, Stefan F
Published in The Journal of clinical investigation (15.08.2024)
Published in The Journal of clinical investigation (15.08.2024)
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Journal Article
Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons
Pigoni, Martina, Wanngren, Johanna, Kuhn, Peer-Hendrik, Munro, Kathryn M, Gunnersen, Jenny M, Takeshima, Hiroshi, Feederle, Regina, Voytyuk, Iryna, De Strooper, Bart, Levasseur, Mikail D, Hrupka, Brian J, Müller, Stephan A, Lichtenthaler, Stefan F
Published in Molecular neurodegeneration (05.10.2016)
Published in Molecular neurodegeneration (05.10.2016)
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Journal Article
Tau deletion reduces plaque‐associated BACE 1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease
Peters, Finn, Salihoglu, Hazal, Pratsch, Katrin, Herzog, Etienne, Pigoni, Martina, Sgobio, Carmelo, Lichtenthaler, Stefan F, Neumann, Ulf, Herms, Jochen
Published in The EMBO journal (02.12.2019)
Published in The EMBO journal (02.12.2019)
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Journal Article
Minibrains: What's in a Name? The Reality of Organoids
Lopes, Melissa, Kohman, Richie E, Lunshof, Jeantine E, Paulsen, Bruna, Pigoni, Martina, White, Sasha, Aach, John, Hyun, Insoo
Published in American scientist (01.07.2021)
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Published in American scientist (01.07.2021)
Journal Article
Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor
Scilabra, Simone D., Pigoni, Martina, Pravatá, Veronica, Schätzl, Tobias, Müller, Stephan A., Troeberg, Linda, Lichtenthaler, Stefan F.
Published in Scientific reports (02.10.2018)
Published in Scientific reports (02.10.2018)
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Journal Article
How collaboration between bioethicists and neuroscientists can advance research
Hyun, Insoo, Scharf-Deering, J. C., Sullivan, Sarah, Aach, John Dennis, Arlotta, Paola, Baum, Matthew L., Church, George M., Goldenberg, Aaron, Greely, Henry T., Khoshakhlagh, Parastoo, Kohman, Richie E., Lopes, Melissa, Lowenthal, Caroline, Lu, Aric, Ng, Alex H. M., Pasca, Sergiu P., Paulsen, Bruna, Pigoni, Martina, Scott, Christopher T., Silbersweig, David A., Skylar-Scott, Mark A., Truog, Robert D., Lunshof, Jeantine E.
Published in Nature neuroscience (01.11.2022)
Published in Nature neuroscience (01.11.2022)
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Journal Article
Minibrains: What's in a Name?
Lopes, Melissa, Kohman, Richie, Lunshof, Jeantine, Paulsen, Bruna, Pigoni, Martina, White, Alexandra, Aach, John, Hyun, Insoo
Published in American scientist (01.07.2021)
Published in American scientist (01.07.2021)
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Journal Article
USE OF BRAIN ORGANOIDS AND SINGLE CELL GENOMICS TO UNDERSTAND AND TREAT NEURODEVELOPMENTAL AND NEUROPSYCHIATRIC DISORDERS
Pigoni, Martina, Da Silveira Paulsen, Bruna, Kedaigle, Amanda J, Levin, Joshua Z, Arlotta, Paola, Regev, Aviv, Velasco, Silvia
Year of Publication 04.01.2024
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Year of Publication 04.01.2024
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