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Docking Study Yields Four Novel Inhibitors of the Protooncogene Pim-1 Kinase
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Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3‑Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS)
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A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors
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Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole
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Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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2-Aminopyrazolo[1,5- a]pyrimidines as potent and selective inhibitors of JAK2
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Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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Year of Publication 23.08.2018
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ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE
LIAO YUSHENG, PIERCE ALBERT C, CAO JINGRONG, DAVID MESSERSMITH, ANNE-LAURE GRILLOT, HARDWIN O'DOWD, UPUL K BANDARAGE, WANG JIAN, PHILIP N COLLIER, ARONOV ALEX, ARNAUD LE TIRAN, SUGANTHINI NANTHAKUMAR, ROBERT J DAVIES, ELAINE KRUEGER, RONALD GERY JR, COME JON H, JAMES A HENDERSON
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Year of Publication 29.06.2017
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Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases
Farmer, Luc J, Ledeboer, Mark W, Hoock, Thomas, Arnost, Michael J, Bethiel, Randy S, Bennani, Youssef L, Black, James J, Brummel, Christopher L, Chakilam, Ananthsrinivas, Dorsch, Warren A, Fan, Bin, Cochran, John E, Halas, Summer, Harrington, Edmund M, Hogan, James K, Howe, David, Huang, Hui, Jacobs, Dylan H, Laitinen, Leena M, Liao, Shengkai, Mahajan, Sudipta, Marone, Valerie, Martinez-Botella, Gabriel, McCarthy, Pamela, Messersmith, David, Namchuk, Mark, Oh, Luke, Penney, Marina S, Pierce, Albert C, Raybuck, Scott A, Rugg, Arthur, Salituro, Francesco G, Saxena, Kumkum, Shannon, Dean, Shlyakter, Dina, Swenson, Lora, Tian, Shi-Kai, Town, Christopher, Wang, Jian, Wang, Tiansheng, Wannamaker, M. Woods, Winquist, Raymond J, Zuccola, Harmon J
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE
LIAO YUSHENG, PIERCE ALBERT C, CAO JINGRONG, DAVID MESSERSMITH, ANNE-LAURE GRILLOT, HARDWIN O'DOWD, UPUL K BANDARAGE, WANG JIAN, PHILIP N COLLIER, ARONOV ALEX, ARNAUD LE TIRAN, SUGANTHINI NANTHAKUMAR, ROBERT J DAVIES, ELAINE KRUEGER, RONALD GERY JR, COME JON H, JAMES A HENDERSON
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Year of Publication 04.06.2015
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ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE
LIAO YUSHENG, HENDERSON JAMES A, PIERCE ALBERT C, BANDARAGE UPUL K, CAO JINGRONG, COLLIER PHILIP N, DAVIES ROBERT J, WANG JIAN, ARONOV ALEX, NANTHAKUMAR SUGANTHINI, GREY RONALD, KRUEGER ELAINE, O'DOWD HARDWIN, COME JON H, GRILLOT ANNE LAURE, MESSERSMITH DAVID, TIRAN AMAUD LE
Year of Publication 03.09.2012
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Year of Publication 03.09.2012
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Diaminotriazoles useful as inhibitors of protein kinases
PIERCE ALBERT C, ARNOST MICHAEL, SALITURO FRANCESCO G, LEDEBOER MARK, NANTHAKUMAR SUGANTHI, GALULLO VINCENT, LEDFORD BRIAN, JAYARAJ ANDREW, DAVIES ROBERT J, FORSTER CORNELIA J, BINCH HAYLEY, XU JINWANG, WANG JIAN, GREY RONALD, HENKEL GREG, TIAN SHI KAI, MESSERSMITH DAVID
Year of Publication 10.02.2006
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Year of Publication 10.02.2006
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Corrigendum to “A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors” [Bioorg. Med. Chem. Lett. 20 (2010) 153]
Wang, Tiansheng, Ledeboer, Mark W., Duffy, John P., Salituro, Francesco G., Pierce, Albert C., Zuccola, Harmon J., Block, Eric, Shlyakter, Dina, Hogan, James K., Bennani, Youssef L.
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors T.W. would like to dedicate this Letter to his PhD mentor, Professor Zhengming Li of Nankai University, Tianjin, China, in honor of his more than 50 years of teaching and research in organic chemistry
Wang, Tiansheng, Ledeboer, Mark W, Duffy, John P, Pierce, Albert C, Zuccola, Harmon J, Block, Eric, Shlyakter, Dina, Hogan, James K, Bennani, Youssef L
Published in Bioorganic & medicinal chemistry letters (01.01.2010)
Published in Bioorganic & medicinal chemistry letters (01.01.2010)
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