Loading…
Loading…
Site-Specific Scissors Based on Myeloperoxidase for Phosphorothioate DNA
Hu, Zhian, Yang, Jinlei, Xu, Fujian, Sun, Gongwei, Pan, Xingyu, Xia, Mengchan, Zhang, Sichun, Zhang, Xinrong
Published in Journal of the American Chemical Society (11.08.2021)
Published in Journal of the American Chemical Society (11.08.2021)
Get full text
Journal Article
Loading…
Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides
Østergaard, Michael E, De Hoyos, Cheryl L, Wan, W Brad, Shen, Wen, Low, Audrey, Berdeja, Andres, Vasquez, Guillermo, Murray, Susan, Migawa, Michael T, Liang, Xue-hai, Swayze, Eric E, Crooke, Stanley T, Seth, Punit P
Published in Nucleic acids research (28.02.2020)
Published in Nucleic acids research (28.02.2020)
Get full text
Journal Article
Loading…
Comparison of safety and immunogenicity of two doses of investigational hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide and three doses of a licensed hepatitis B vaccine in healthy adults 18–55 years of age
Halperin, Scott A., Ward, Brian, Cooper, Curtis, Predy, Gerald, Diaz-Mitoma, Francisco, Dionne, Marc, Embree, Joanne, McGeer, Allison, Zickler, Paul, Moltz, Karl-Heinz, Martz, René, Meyer, Ingo, McNeil, Shelly, Langley, Joanne M., Martins, Eduardo, Heyward, William L., Martin, J. Tyler
Published in Vaccine (28.03.2012)
Published in Vaccine (28.03.2012)
Get full text
Journal Article
Loading…
Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences
Wadley, Taylor, Moon, Sun Hee, DeMott, Michael S., Wanchai, Visanu, Huang, En, Dedon, Peter C., Boysen, Gunnar, Nookaew, Intawat
Published in Frontiers in microbiology (21.04.2022)
Published in Frontiers in microbiology (21.04.2022)
Get full text
Journal Article
Loading…
A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant
Halperin, Scott A, Van Nest, Gary, Smith, Bruce, Abtahi, Simin, Whiley, Heather, Eiden, Joseph J
Published in Vaccine (02.06.2003)
Published in Vaccine (02.06.2003)
Get full text
Journal Article
Loading…
Pharmacokinetics of an anti-human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (GEM 91) in HIV-infected subjects
Zhang, R, Yan, J, Shahinian, H K, Shahinian, H, Amin, G, Lu, Z, Liu, T, Saag, M S, Jiang, Z, Temsamani, J, Martin, R R
Published in Clinical pharmacology and therapeutics (01.07.1995)
Published in Clinical pharmacology and therapeutics (01.07.1995)
Get more information
Journal Article
Loading…
TPI ASM8 reduces eosinophil progenitors in sputum after allergen challenge
Imaoka, H., Campbell, H., Babirad, I., Watson, R. M., Mistry, M., Sehmi, R., Gauvreau, G. M.
Published in Clinical and experimental allergy (01.12.2011)
Published in Clinical and experimental allergy (01.12.2011)
Get full text
Journal Article
Loading…
Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia
Narayanan, PadmaKumar, Curtis, Brian R, Shen, Lijiang, Schneider, Eugene, Tami, Joseph A, Paz, Suzanne, Burel, Sebastien A, Tai, Li-Jung, Machemer, Todd, Kwoh, T Jesse, Xia, Shuting, Shattil, Sanford J, Witztum, Joseph L, Engelhardt, Jeffery A, Henry, Scott P, Monia, Brett P, Hughes, Steven G
Published in Nucleic acid therapeutics (01.04.2020)
Published in Nucleic acid therapeutics (01.04.2020)
Get more information
Journal Article
Loading…
Control of cyclic oligoadenylate synthesis in a type III CRISPR system
Rouillon, Christophe, Athukoralage, Januka S, Graham, Shirley, Grüschow, Sabine, White, Malcolm F
Published in eLife (02.07.2018)
Published in eLife (02.07.2018)
Get full text
Journal Article
Loading…
Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects
Séréni, D, Tubiana, R, Lascoux, C, Katlama, C, Taulera, O, Bourque, A, Cohen, A, Dvorchik, B, Martin, R R, Tournerie, C, Gouyette, A, Schechter, P J
Published in Journal of clinical pharmacology (01.01.1999)
Published in Journal of clinical pharmacology (01.01.1999)
Get more information
Journal Article
Loading…
A Randomized, Double-Masked, Placebo-Controlled Study of Alicaforsen, an Antisense Inhibitor of Intercellular Adhesion Molecule 1, for the Treatment of Subjects With Active Crohn’s Disease
Yacyshyn, Bruce, Chey, William Y., Wedel, Mark K., Yu, Rosie Z., Paul, David, Chuang, Emil
Published in Clinical gastroenterology and hepatology (01.02.2007)
Published in Clinical gastroenterology and hepatology (01.02.2007)
Get full text
Journal Article
Loading…
Dose–response effects of TPI ASM8 in asthmatics after allergen
Gauvreau, G. M., Pageau, R., Séguin, R., Carballo, D., Gauthier, J., D’Anjou, H., Campbell, H., Watson, R., Mistry, M., Parry‐Billings, M., Killian, K., Renzi, P. M.
Published in Allergy (Copenhagen) (01.09.2011)
Published in Allergy (Copenhagen) (01.09.2011)
Get full text
Journal Article
Loading…
Anti-HIV Activities of Intramolecular G4 and Non-G4 Oligonucleotides
Prokofjeva, Maria, Tsvetkov, Vladimir, Basmanov, Dmitry, Varizhuk, Anna, Lagarkova, Maria, Smirnov, Igor, Prusakov, Kirill, Klinov, Dmitry, Prassolov, Vladimir, Pozmogova, Galina, Mikhailov, Sergey N.
Published in Nucleic acid therapeutics (01.02.2017)
Published in Nucleic acid therapeutics (01.02.2017)
Get full text
Journal Article
Loading…
Oral Delivery of Antisense Oligonucleotides in Man
Tillman, Lloyd G., Geary, Richard S., Hardee, Gregory E.
Published in Journal of pharmaceutical sciences (01.01.2008)
Published in Journal of pharmaceutical sciences (01.01.2008)
Get full text
Journal Article
Loading…
Biochemical, crystallographic and biophysical characterization of histidine triad nucleotide-binding protein 2 with different ligands including a non-hydrolyzable analog of Ap4A
Dolot, Rafał, Krakowiak, Agnieszka, Kaczmarek, Renata, Włodarczyk, Artur, Pichlak, Marta, Nawrot, Barbara
Published in Biochimica et biophysica acta. General subjects (01.11.2021)
Published in Biochimica et biophysica acta. General subjects (01.11.2021)
Get full text
Journal Article
Loading…
Antisense Therapy against CCR3 and the Common Beta Chain Attenuates Allergen-induced Eosinophilic Responses
Gauvreau, Gail M, Boulet, Louis Philippe, Cockcroft, Donald W, Baatjes, Adrian, Cote, Johanne, Deschesnes, Francine, Davis, Beth, Strinich, Tara, Howie, Karen, Duong, MyLinh, Watson, Richard M, Renzi, Paolo M, O'Byrne, Paul M
Published in American journal of respiratory and critical care medicine (01.05.2008)
Published in American journal of respiratory and critical care medicine (01.05.2008)
Get full text
Journal Article
Loading…
A Phase II dose ranging, double‐blind, placebo‐controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left‐sided ulcerative colitis
VAN DEVENTER, S. J. H., WEDEL, M. K., BAKER, B. F., XIA, S., CHUANG, E., MINER, P. B.
Published in Alimentary pharmacology & therapeutics (15.05.2006)
Published in Alimentary pharmacology & therapeutics (15.05.2006)
Get full text
Journal Article
Loading…
Loading…
Inflammatory Non-CpG Antisense Oligonucleotides Are Signaling Through TLR9 in Human Burkitt Lymphoma B Bjab Cells
Pollak, Adam J, Cauntay, Patrick, Machemer, Todd, Paz, Suzanne, Damle, Sagar, Henry, Scott P, Burel, Sebastien A
Published in Nucleic acid therapeutics (01.12.2022)
Published in Nucleic acid therapeutics (01.12.2022)
Get more information
Journal Article