Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds
Cruz-Migoni, Abimael, Canning, Peter, Quevedo, Camilo E., Bataille, Carole J. R., Bery, Nicolas, Miller, Ami, Russell, Angela J., Phillips, Simon E. V., Carr, Stephen B., Rabbitts, Terence H.
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2019)
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Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy
Bonthron, David T, Uppal, Sandeep, Diggle, Christine P, Carr, Ian M, Fishwick, Colin W G, Ahmed, Mushtaq, Ibrahim, Gamal H, Helliwell, Philip S, Latos-Biele ska, Anna, Phillips, Simon E V, Markham, Alexander F, Bennett, Christopher P
Published in Nature genetics (01.06.2008)
Published in Nature genetics (01.06.2008)
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Journal Article
Van der Waals Interactions Dominate Ligand−Protein Association in a Protein Binding Site Occluded from Solvent Water
Barratt, Elizabeth, Bingham, Richard J, Warner, Daniel J, Laughton, Charles A, Phillips, Simon E. V, Homans, Steve W
Published in Journal of the American Chemical Society (24.08.2005)
Published in Journal of the American Chemical Society (24.08.2005)
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Journal Article
Reaction Mechanism of N‑Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis
Daniels, Adam D, Campeotto, Ivan, van der Kamp, Marc W, Bolt, Amanda H, Trinh, Chi H, Phillips, Simon E. V, Pearson, Arwen R, Nelson, Adam, Mulholland, Adrian J, Berry, Alan
Published in ACS chemical biology (18.04.2014)
Published in ACS chemical biology (18.04.2014)
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Journal Article
Packaging signals in single-stranded RNA viruses: nature’s alternative to a purely electrostatic assembly mechanism
Stockley, Peter G., Twarock, Reidun, Bakker, Saskia E., Barker, Amy M., Borodavka, Alexander, Dykeman, Eric, Ford, Robert J., Pearson, Arwen R., Phillips, Simon E. V., Ranson, Neil A., Tuma, Roman
Published in Journal of biological physics (01.03.2013)
Published in Journal of biological physics (01.03.2013)
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Journal Article
Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment
Quevedo, Camilo E., Cruz-Migoni, Abimael, Bery, Nicolas, Miller, Ami, Tanaka, Tomoyuki, Petch, Donna, Bataille, Carole J. R., Lee, Lydia Y. W., Fallon, Phillip S., Tulmin, Hanna, Ehebauer, Matthias T., Fernandez-Fuentes, Narcis, Russell, Angela J., Carr, Stephen B., Phillips, Simon E. V., Rabbitts, Terence H.
Published in Nature communications (09.08.2018)
Published in Nature communications (09.08.2018)
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Journal Article
Purification, characterization, and identification of a novel bifunctional catalase-phenol oxidase from Scytalidium thermophilum
Sutay Kocabas, Didem, Bakir, Ufuk, Phillips, Simon E. V, McPherson, Michael J, Ogel, Zumrut B
Published in Applied microbiology and biotechnology (01.06.2008)
Published in Applied microbiology and biotechnology (01.06.2008)
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Journal Article
The structural basis of Holliday junction resolution by T7 endonuclease I
HADDEN, Jonathan M, DECLAIS, Anne-Cécile, CARR, Stephen B, LILLEY, David M. J, PHILLIPS, Simon E. V
Published in Nature (04.10.2007)
Published in Nature (04.10.2007)
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Journal Article
Exploring the Roles of the Metal Ions in Escherichia coli Copper Amine Oxidase
Smith, Mark A, Pirrat, Pascale, Pearson, Arwen R, Kurtis, Christian R. P, Trinh, Chi H, Gaule, Thembaninkosi G, Knowles, Peter F, Phillips, Simon E. V, McPherson, Michael J
Published in Biochemistry (Easton) (16.02.2010)
Published in Biochemistry (Easton) (16.02.2010)
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Journal Article
Structure, recombinant expression and mutagenesis studies of the catalase with oxidase activity from Scytalidium thermophilum
Yuzugullu, Yonca, Trinh, Chi H., Smith, Mark A., Pearson, Arwen R., Phillips, Simon E. V., Sutay Kocabas, Didem, Bakir, Ufuk, Ogel, Zumrut B., McPherson, Michael J.
Published in Acta crystallographica. Section D, Biological crystallography. (01.03.2013)
Published in Acta crystallographica. Section D, Biological crystallography. (01.03.2013)
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Journal Article
Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging
Ptchelkine, Denis, Gillum, Ashley, Mochizuki, Tomohiro, Lucas-Staat, Soizick, Liu, Ying, Krupovic, Mart, Phillips, Simon E. V., Prangishvili, David, Huiskonen, Juha T.
Published in Nature communications (10.11.2017)
Published in Nature communications (10.11.2017)
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Journal Article
Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein
Bingham, Richard J., Findlay, John B. C., Hsieh, Shih-Yang, Kalverda, Arnout P., Kjellberg, Alexandra, Perazzolo, Chiara, Phillips, Simon E. V., Seshadri, Kothandaraman, Trinh, Chi H., Turnbull, W. Bruce, Bodenhausen, Geoffrey, Homans, Steve W.
Published in Journal of the American Chemical Society (18.02.2004)
Published in Journal of the American Chemical Society (18.02.2004)
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Journal Article
Revealing the density of encoded functions in a viral RNA
Patel, Nikesh, Dykeman, Eric C., Coutts, Robert H. A., Lomonossoff, George P., Rowlands, David J., Phillips, Simon E. V., Ranson, Neil, Twarock, Reidun, Tuma, Roman, Stockley, Peter G.
Published in Proceedings of the National Academy of Sciences - PNAS (17.02.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (17.02.2015)
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Journal Article
Importance of the Active Site “Canopy” Residues in an O2‑Tolerant [NiFe]-Hydrogenase
Brooke, Emily J, Evans, Rhiannon M, Islam, Shams T. A, Roberts, Gerri M, Wehlin, Sara A. M, Carr, Stephen B, Phillips, Simon E. V, Armstrong, Fraser A
Published in Biochemistry (Easton) (10.01.2017)
Published in Biochemistry (Easton) (10.01.2017)
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Journal Article
Structures of replication initiation proteins from staphylococcal antibiotic resistance plasmids reveal protein asymmetry and flexibility are necessary for replication
Carr, Stephen B, Phillips, Simon E V, Thomas, Christopher D
Published in Nucleic acids research (18.03.2016)
Published in Nucleic acids research (18.03.2016)
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Journal Article
2-Aminotetralones: Novel inhibitors of MurA and MurZ
Dunsmore, Colin J., Miller, Keith, Blake, Katy L., Patching, Simon G., Henderson, Peter J.F., Garnett, James A., Stubbings, William J., Phillips, Simon E.V., Palestrant, Deborah J., Angeles, Joseph De Los, Leeds, Jennifer A., Chopra, Ian, Fishwick, Colin W.G.
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Journal Article
Role of the Interactions between the Active Site Base and the Substrate Schiff Base in Amine Oxidase Catalysis. Evidence from Structural and Spectroscopic Studies of the 2-Hydrazinopyridine Adduct of Escherichia coli Amine Oxidase
Mure, Minae, Brown, Doreen E, Saysell, Colin, Rogers, Melanie S, Wilmot, Carrie M, Kurtis, Christian R, McPherson, Michael J, Phillips, Simon E. V, Knowles, Peter F, Dooley, David M
Published in Biochemistry (Easton) (08.02.2005)
Published in Biochemistry (Easton) (08.02.2005)
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Journal Article
The Stacking Tryptophan of Galactose Oxidase: A Second-Coordination Sphere Residue that Has Profound Effects on Tyrosyl Radical Behavior and Enzyme Catalysis
Rogers, Melanie S, Tyler, Ejan M, Akyumani, Nana, Kurtis, Christian R, Spooner, R. Kate, Deacon, Sarah E, Tamber, Sarita, Firbank, Susan J, Mahmoud, Khaled, Knowles, Peter F, Phillips, Simon E. V, McPherson, Michael J, Dooley, David M
Published in Biochemistry (Easton) (17.04.2007)
Published in Biochemistry (Easton) (17.04.2007)
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