Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GATSBY): an international randomised, open-label, adaptive, phase 2/3 study
Thuss-Patience, Peter C, MD, Shah, Manish A, MD, Ohtsu, Atsushi, MD, Van Cutsem, Eric, Prof, Ajani, Jaffer A, Prof, Castro, Hugo, MD, Mansoor, Wasat, PhD, Chung, Hyun Cheol, Prof, Bodoky, Gyorgy, Prof, Shitara, Kohei, MD, Phillips, Gail D Lewis, MS, van der Horst, Tina, MSc, Harle-Yge, Marie-Laurence, MSc, Althaus, Betsy L, PharmD, Kang, Yoon-Koo, Prof
Published in The lancet oncology (01.05.2017)
Published in The lancet oncology (01.05.2017)
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Relationship between Tumor Biomarkers and Efficacy in EMILIA, a Phase III Study of Trastuzumab Emtansine in HER2-Positive Metastatic Breast Cancer
Baselga, José, Lewis Phillips, Gail D, Verma, Sunil, Ro, Jungsil, Huober, Jens, Guardino, Alice E, Samant, Meghna K, Olsen, Steve, de Haas, Sanne L, Pegram, Mark D
Published in Clinical cancer research (01.08.2016)
Published in Clinical cancer research (01.08.2016)
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Mechanisms of Acquired Resistance to Trastuzumab Emtansine in Breast Cancer Cells
Li, Guangmin, Guo, Jun, Shen, Ben-Quan, Yadav, Daniela Bumbaca, Sliwkowski, Mark X, Crocker, Lisa M, Lacap, Jennifer A, Phillips, Gail D Lewis
Published in Molecular cancer therapeutics (01.07.2018)
Published in Molecular cancer therapeutics (01.07.2018)
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Journal Article
A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies
Schaefer, Gabriele, Haber, Lauric, Crocker, Lisa M., Shia, Steven, Shao, Lily, Dowbenko, Donald, Totpal, Klara, Wong, Anne, Lee, Chingwei V., Stawicki, Scott, Clark, Robyn, Fields, Carter, Lewis Phillips, Gail D., Prell, Rodney A., Danilenko, Dimitry M., Franke, Yvonne, Stephan, Jean-Philippe, Hwang, Jiyoung, Wu, Yan, Bostrom, Jenny, Sliwkowski, Mark X., Fuh, Germaine, Eigenbrot, Charles
Published in Cancer cell (18.10.2011)
Published in Cancer cell (18.10.2011)
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Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941
Junttila, Teemu T., Akita, Robert W., Parsons, Kathryn, Fields, Carter, Lewis Phillips, Gail D., Friedman, Lori S., Sampath, Deepak, Sliwkowski, Mark X.
Published in Cancer cell (05.05.2009)
Published in Cancer cell (05.05.2009)
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Journal Article
Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (T-DM1)
Uppal, Hirdesh, Doudement, Estelle, Mahapatra, Kaushiki, Darbonne, Walter C, Bumbaca, Daniela, Shen, Ben-Quan, Du, Xiaoyan, Saad, Ola, Bowles, Kristin, Olsen, Steve, Lewis Phillips, Gail D, Hartley, Dylan, Sliwkowski, Mark X, Girish, Sandhya, Dambach, Donna, Ramakrishnan, Vanitha
Published in Clinical cancer research (01.01.2015)
Published in Clinical cancer research (01.01.2015)
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Journal Article
Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
Lewis Phillips, Gail D, Li, Guangmin, Dugger, Debra L, Crocker, Lisa M, Parsons, Kathryn L, Mai, Elaine, Blättler, Walter A, Lambert, John M, Chari, Ravi V J, Lutz, Robert J, Wong, Wai Lee T, Jacobson, Frederic S, Koeppen, Hartmut, Schwall, Ralph H, Kenkare-Mitra, Sara R, Spencer, Susan D, Sliwkowski, Mark X
Published in Cancer research (Chicago, Ill.) (15.11.2008)
Published in Cancer research (Chicago, Ill.) (15.11.2008)
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The effect of different linkers on target cell catabolism and pharmacokinetics/pharmacodynamics of trastuzumab maytansinoid conjugates
Erickson, Hans K, Lewis Phillips, Gail D, Leipold, Douglas D, Provenzano, Carmela A, Mai, Elaine, Johnson, Holly A, Gunter, Bert, Audette, Charlene A, Gupta, Manish, Pinkas, Jan, Tibbitts, Jay
Published in Molecular cancer therapeutics (01.05.2012)
Published in Molecular cancer therapeutics (01.05.2012)
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Journal Article
Dual Targeting of HER2-Positive Cancer with Trastuzumab Emtansine and Pertuzumab: Critical Role for Neuregulin Blockade in Antitumor Response to Combination Therapy
LEWIS PHILLIPS, Gail D, FIELDS, Carter T, DIERAS, Veronique, CRIVELLARI, Diana, LIANG FANG, GUARDINO, Ellie, OLSEN, Steven R, CROCKER, Lisa M, SLIWKOWSKI, Mark X, GUANGMIN LI, DOWBENKO, Donald, SCHAEFER, Gabriele, MILLER, Kathy, ANDRE, Fabrice, BURRIS, Howard A, ALBAIN, Kathy S, HARBECK, Nadia
Published in Clinical cancer research (15.01.2014)
Published in Clinical cancer research (15.01.2014)
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Trastuzumab uptake and its relation to efficacy in an animal model of HER2-positive breast cancer brain metastasis
Lewis Phillips, Gail D., Nishimura, Merry C., Lacap, Jennifer Arca, Kharbanda, Samir, Mai, Elaine, Tien, Janet, Malesky, Kimberly, Williams, Simon P., Marik, Jan, Phillips, Heidi S.
Published in Breast cancer research and treatment (01.08.2017)
Published in Breast cancer research and treatment (01.08.2017)
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Journal Article
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy
Song, Kyung W, Edgar, Kyle A, Hanan, Emily J, Hafner, Marc, Oeh, Jason, Merchant, Mark, Sampath, Deepak, Nannini, Michelle A, Hong, Rebecca, Phu, Lilian, Forrest, William F, Stawiski, Eric, Schmidt, Stephen, Endres, Nicholas, Guan, Jane, Wallin, Jeffrey J, Cheong, Jonathan, Plise, Emile G, Lewis Phillips, Gail D, Salphati, Laurent, Heffron, Timothy P, Olivero, Alan G, Malek, Shiva, Staben, Steven T, Kirkpatrick, Donald S, Dey, Anwesha, Friedman, Lori S
Published in Cancer discovery (01.01.2022)
Published in Cancer discovery (01.01.2022)
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Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein– and Peptide–Payload Conjugates: Application to THIOMAB Antibody–Drug Conjugates
Sadowsky, Jack D, Pillow, Thomas H, Chen, Jinhua, Fan, Fang, He, Changrong, Wang, Yanli, Yan, Gang, Yao, Hui, Xu, Zijin, Martin, Shanique, Zhang, Donglu, Chu, Phillip, dela Cruz-Chuh, Josefa, O’Donohue, Aimee, Li, Guangmin, Del Rosario, Geoffrey, He, Jintang, Liu, Luna, Ng, Carl, Su, Dian, Lewis Phillips, Gail D, Kozak, Katherine R, Yu, Shang-Fan, Xu, Keyang, Leipold, Douglas, Wai, John
Published in Bioconjugate chemistry (16.08.2017)
Published in Bioconjugate chemistry (16.08.2017)
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Journal Article
Activity of trastuzumab emtansine (T-DM1) in 3D cell culture
Boyer, Jean Zheng, Phillips, Gail D. Lewis, Nitta, Hiro, Garsha, Karl, Admire, Brittany, Kraft, Robert, Dennis, Eslie, Vela, Elizabeth, Towne, Penny
Published in Breast cancer research and treatment (01.07.2021)
Published in Breast cancer research and treatment (01.07.2021)
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Journal Article
Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer
JUNUTULA, Jagath R, FLAGELLA, Kelly M, MAI, Elaine, LEWIS PHILLIPS, Gail D, HIRARAGI, Hajime, FUJI, Reina N, TIBBITTS, Jay, VANDLEN, Richard, SPENCER, Susan D, SCHELLER, Richard H, POLAKIS, Paul, SLIWKOWSKI, Mark X, GRAHAM, Richard A, PARSONS, Kathryn L, HA, Edward, RAAB, Helga, BHAKTA, Sunil, NGUYEN, Trung, DUGGER, Debra L, GUANGMIN LI
Published in Clinical cancer research (01.10.2010)
Published in Clinical cancer research (01.10.2010)
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Immolation of p‑Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody–Drug Conjugates with Phenol-Containing Payloads
Zhang, Donglu, Le, Hoa, Cruz-Chuh, Josefa dela, Bobba, Sudheer, Guo, Jun, Staben, Leanna, Zhang, Chenghong, Ma, Yong, Kozak, Katherine R, Lewis Phillips, Gail D, Vollmar, Breanna S, Sadowsky, Jack D, Vandlen, Richard, Wei, BinQing, Su, Dian, Fan, Peter, Dragovich, Peter S, Khojasteh, S. Cyrus, Hop, Cornelis E. C. A, Pillow, Thomas H
Published in Bioconjugate chemistry (21.02.2018)
Published in Bioconjugate chemistry (21.02.2018)
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Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody–Drug Conjugates
Staben, Leanna R, Chen, Jinhua, Cruz-Chuh, Josefa dela, del Rosario, Geoff, Go, Mary Ann, Guo, Jun, Khojasteh, S. Cyrus, Kozak, Katherine R, Li, Guangmin, Ng, Carl, Lewis Phillips, Gail D, Pillow, Thomas H, Rowntree, Rebecca K, Wai, John, Wei, BinQing, Xu, Keyang, Xu, Zijin, Yu, Shang-Fan, Zhang, Donglu, Dragovich, Peter S
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Journal Article
Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering
Pillow, Thomas H, Tien, Janet, Parsons-Reponte, Kathryn L, Bhakta, Sunil, Li, Hao, Staben, Leanna R, Li, Guangmin, Chuh, Josefa, Fourie-O’Donohue, Aimee, Darwish, Martine, Yip, Victor, Liu, Luna, Leipold, Douglas D, Su, Dian, Wu, Elmer, Spencer, Susan D, Shen, Ben-Quan, Xu, Keyang, Kozak, Katherine R, Raab, Helga, Vandlen, Richard, Lewis Phillips, Gail D, Scheller, Richard H, Polakis, Paul, Sliwkowski, Mark X, Flygare, John A, Junutula, Jagath R
Published in Journal of medicinal chemistry (09.10.2014)
Published in Journal of medicinal chemistry (09.10.2014)
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Pyrrolobenzodiazepine Dimer Antibody–Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers
Gregson, Stephen J., Masterson, Luke A., Wei, Binqing, Pillow, Thomas H., Spencer, Susan D., Kang, Gyoung-Dong, Yu, Shang-Fan, Raab, Helga, Lau, Jeffrey, Li, Guangmin, Lewis Phillips, Gail D., Gunzner-Toste, Janet, Safina, Brian S., Ohri, Rachana, Darwish, Martine, Kozak, Katherine R., dela Cruz-Chuh, Josefa, Polson, Andrew, Flygare, John A., Howard, Philip W.
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Journal Article
Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates
Staben, Leanna R., Koenig, Stefan G., Lehar, Sophie M., Vandlen, Richard, Zhang, Donglu, Chuh, Josefa, Yu, Shang-Fan, Ng, Carl, Guo, Jun, Liu, Yanzhou, Fourie-O'Donohue, Aimee, Go, MaryAnn, Linghu, Xin, Segraves, Nathaniel L., Wang, Tao, Chen, Jinhua, Wei, BinQing, Phillips, Gail D. Lewis, Xu, Keyang, Kozak, Katherine R., Mariathasan, Sanjeev, Flygare, John A., Pillow, Thomas H.
Published in Nature chemistry (01.12.2016)
Published in Nature chemistry (01.12.2016)
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Molecular predictors of response to a humanized anti–insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer
Zha, Jiping, O'Brien, Carol, Savage, Heidi, Huw, Ling-Yuh, Zhong, Fiona, Berry, Leanne, Lewis Phillips, Gail D, Luis, Elizabeth, Cavet, Guy, Hu, Xiaolan, Amler, Lukas C, Lackner, Mark R
Published in Molecular cancer therapeutics (01.08.2009)
Published in Molecular cancer therapeutics (01.08.2009)
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