Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death
Woodley, Keith, Dillingh, Laura S., Giotopoulos, George, Madrigal, Pedro, Rattigan, Kevin M., Philippe, Céline, Dembitz, Vilma, Magee, Aoife M. S., Asby, Ryan, van de Lagemaat, Louie N., Mapperley, Christopher, James, Sophie C., Prehn, Jochen H. M., Tzelepis, Konstantinos, Rouault-Pierre, Kevin, Vassiliou, George S., Kranc, Kamil R., Helgason, G. Vignir, Huntly, Brian J. P., Gallipoli, Paolo
Published in Nature communications (14.04.2023)
Published in Nature communications (14.04.2023)
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Journal Article
ER Stress and Unfolded Protein Response in Leukemia: Friend, Foe, or Both?
Féral, Kelly, Jaud, Manon, Philippe, Céline, Di Bella, Doriana, Pyronnet, Stéphane, Rouault-Pierre, Kevin, Mazzolini, Laurent, Touriol, Christian
Published in Biomolecules (Basel, Switzerland) (30.01.2021)
Published in Biomolecules (Basel, Switzerland) (30.01.2021)
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Journal Article
Translational Regulations in Response to Endoplasmic Reticulum Stress in Cancers
Jaud, Manon, Philippe, Céline, Di Bella, Doriana, Tang, Weiwei, Pyronnet, Stéphane, Laurell, Henrik, Mazzolini, Laurent, Rouault-Pierre, Kevin, Touriol, Christian
Published in Cells (Basel, Switzerland) (26.02.2020)
Published in Cells (Basel, Switzerland) (26.02.2020)
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Journal Article
The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes
Berastegui, Nerea, Ainciburu, Marina, Romero, Juan P., Garcia-Olloqui, Paula, Alfonso-Pierola, Ana, Philippe, Céline, Vilas-Zornoza, Amaia, San Martin-Uriz, Patxi, Ruiz-Hernández, Raquel, Abarrategi, Ander, Ordoñez, Raquel, Alignani, Diego, Sarvide, Sarai, Castro-Labrador, Laura, Lamo-Espinosa, José M., San-Julian, Mikel, Jimenez, Tamara, López-Cadenas, Félix, Muntion, Sandra, Sanchez-Guijo, Fermin, Molero, Antonieta, Montoro, Maria Julia, Tazón, Bárbara, Serrano, Guillermo, Diaz-Mazkiaran, Aintzane, Hernaez, Mikel, Huerga, Sofía, Bewicke-Copley, Findlay, Rio-Machin, Ana, Maurano, Matthew T., Díez-Campelo, María, Valcarcel, David, Rouault-Pierre, Kevin, Lara-Astiaso, David, Ezponda, Teresa, Prosper, Felipe
Published in Nature communications (09.12.2022)
Published in Nature communications (09.12.2022)
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Journal Article
The PERK Branch of the Unfolded Protein Response Promotes DLL4 Expression by Activating an Alternative Translation Mechanism
Jaud, Manon, Philippe, Céline, Van Den Berghe, Loic, Ségura, Christèle, Mazzolini, Laurent, Pyronnet, Stéphane, Laurell, Henrik, Touriol, Christian
Published in Cancers (25.01.2019)
Published in Cancers (25.01.2019)
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Journal Article
Pivotal role of the endoplasmic reticulum stress-related XBP1s/miR-22/SIRT1 axis in acute myeloid leukemia apoptosis and response to chemotherapy
Philippe, Céline, Jaud, Manon, Féral, Kelly, Gay, Alexandre, Van Den Berghe, Loïc, Farce, Manon, Bousquet, Marina, Pyronnet, Stéphane, Mazzolini, Laurent, Rouault-Pierre, Kevin, Touriol, Christian
Published in Leukemia (01.08.2024)
Published in Leukemia (01.08.2024)
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Journal Article
Germline ERCC excision repair 6 like 2 (ERCC6L2) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment
Armes, Hannah, Bewicke‐Copley, Findlay, Rio‐Machin, Ana, Di Bella, Doriana, Philippe, Céline, Wozniak, Anna, Tummala, Hemanth, Wang, Jun, Ezponda, Teresa, Prosper, Felipe, Dokal, Inderjeet, Vulliamy, Tom, Kilpivaara, Outi, Wartiovaara‐Kautto, Ulla, Fitzgibbon, Jude, Rouault‐Pierre, Kevin
Published in British journal of haematology (01.12.2022)
Published in British journal of haematology (01.12.2022)
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Journal Article
Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1 -mutated myelodysplasia
Mian, Syed A, Philippe, Céline, Maniati, Eleni, Protopapa, Pantelitsa, Bergot, Tiffany, Piganeau, Marion, Nemkov, Travis, Di Bella, Doriana, Morales, Valle, Finch, Andrew J, D'Alessandro, Angelo, Bianchi, Katiuscia, Wang, Jun, Gallipoli, Paolo, Kordasti, Shahram, Kubasch, Anne Sophie, Cross, Michael, Platzbecker, Uwe, Wiseman, Daniel H, Bonnet, Dominique, Bernard, Delphine G, Gribben, John G, Rouault-Pierre, Kevin
Published in Science translational medicine (01.03.2023)
Published in Science translational medicine (01.03.2023)
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Journal Article
Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation
Dembitz, Vilma, Lawson, Hannah, Burt, Richard, Natani, Sirisha, Philippe, Céline, James, Sophie C., Atkinson, Samantha, Durko, Jozef, Wang, Lydia M., Campos, Joana, Magee, Aoife M. S., Woodley, Keith, Austin, Michael J., Rio-Machin, Ana, Casado, Pedro, Bewicke-Copley, Findlay, Rodriguez Blanco, Giovanny, Pereira-Martins, Diego, Oudejans, Lieve, Boet, Emeline, von Kriegsheim, Alex, Schwaller, Juerg, Finch, Andrew J., Patel, Bela, Sarry, Jean-Emmanuel, Tamburini, Jerome, Schuringa, Jan Jacob, Hazlehurst, Lori, Copland III, John A., Yuneva, Mariia, Peck, Barrie, Cutillas, Pedro, Fitzgibbon, Jude, Rouault-Pierre, Kevin, Kranc, Kamil, Gallipoli, Paolo
Published in Leukemia (01.11.2024)
Published in Leukemia (01.11.2024)
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Journal Article
PERK mediates the IRES-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress
Philippe, Céline, Dubrac, Alexandre, Quelen, Cathy, Desquesnes, Aurore, Van Den Berghe, Loic, Ségura, Christèle, Filleron, Thomas, Pyronnet, Stéphane, Prats, Hervé, Brousset, Pierre, Touriol, Christian
Published in Science signaling (03.05.2016)
Published in Science signaling (03.05.2016)
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Journal Article
Hypoxia and ER stress promote Staufen1 expression through an alternative translation mechanism
Bonnet-Magnaval, Florence, Philippe, Céline, Van Den Berghe, Loïc, Prats, Hervé, Touriol, Christian, Lacazette, Eric
Published in Biochemical and biophysical research communications (14.10.2016)
Published in Biochemical and biophysical research communications (14.10.2016)
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Journal Article
Key contribution of eIF4H-mediated translational control in tumor promotion
Vaysse, Charlotte, Philippe, Céline, Martineau, Yvan, Quelen, Cathy, Hieblot, Corinne, Renaud, Claire, Nicaise, Yvan, Desquesnes, Aurore, Pannese, Maria, Filleron, Thomas, Escourrou, Ghislaine, Lawson, Malcolm, Rintoul, Robert C, Delisle, Marie Bernadette, Pyronnet, Stéphane, Brousset, Pierre, Prats, Hervé, Touriol, Christian
Published in Oncotarget (24.11.2015)
Published in Oncotarget (24.11.2015)
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Journal Article
The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts
Choi, In Young, Ling, Jonathan P., Zhang, Jian, Helmenstine, Eric, Walter, Wencke, Tsakiroglou, Panagiotis, Bergman, Riley E., Philippe, Céline, Manley, James L., Rouault-Pierre, Kevin, Li, Bing, Wiseman, Daniel H., Batta, Kiran, Ouseph, Madhu, Bernard, Elsa, Dubner, Benjamin, Li, Xiao, Haferlach, Torsten, Koget, Anna, Fazal, Salman, Jain, Tania, Gocke, Christopher D., DeZern, Amy E., Dalton, William Brian
Published in Blood advances (13.08.2024)
Published in Blood advances (13.08.2024)
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Journal Article
Periurbanisation and natural hazards
Astrade, Laurent, Lutoff, Céline, Nedjai, Rachid, Philippe, Céline, Loison, Delphine, Bottollier-Depois, Sandrine
Published in Revue de géographie alpine (01.06.2007)
Published in Revue de géographie alpine (01.06.2007)
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Journal Article
Improving Outcome in Infantile Autism with Folate Receptor Autoimmunity and Nutritional Derangements: A Self-Controlled Trial
Quadros, Edward V., Jadot, Annick, Philippe, Céline, Thomas, Aurore, Vrancken, Géraldine, DiDuca, Marco, Sequeira, Jeffrey M., Ramaekers, Vincent Th, Peters, Marie
Published in Autism Research and Treatment (2019)
Published in Autism Research and Treatment (2019)
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Journal Article
Vitamin B5 and Succinyl-CoA Improve Ineffective Erythropoiesis in SF3B1 Mutated Myelodysplasia
Mian, Syed, Philippe, Celine, Maniati, Eleni, Bergot, Tiffany, Piganeau, Marion, Di Bella, Doriana, Morales, Valle, Finch, Andrew, Bianchi, Katiuscia, Wang, Jun, Gallipoli, Paolo, Platzbecker, Uwe, Wiseman, Daniel H, Bonnet, Dominique, Bernard, Delphine, Gribben, John, Rouault-Pierre, Kevin
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia
Woodley, Keith, Dillingh, Laura S, Giotopoulos, George, Madrigal, Pedro, Tzelepis, Konstantinos, Philippe, Celine, Rattigan, Kevin, Asby, Ryan, Dembitz, Vilma, Magee, Aoife S.M., Helgason, Gudmundur, Rouault-Pierre, Kevin, Vassiliou, George S., Huntly, Brian J.P, Gallipoli, Paolo
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia
Dembitz, Vilma, Lawson, Hannah, Philippe, Celine, Burt, Richard J., James, Sophie, Magee, Aoife S.M., Woodley, Keith, Durko, Jozef, Campos, Joana, Austin, Michael James, Rio-Machin, Ana, Casado Izquierdo, Pedro, Bewicke-Copley, Findlay, Rodriguez Blanco, Giovanny, Patel, Bela, Hazlehurst, Lori, Peck, Barrie, Finch, Andrew, Cutillas, Pedro, Fitzgibbon, Jude, Yuneva, Mariia, Rouault-Pierre, Kevin, Copland, John, Kranc, Kamil, Gallipoli, Paolo
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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