FGF-2 Regulates Cell Proliferation, Migration, and Angiogenesis through an NDY1/KDM2B-miR-101-EZH2 Pathway
Kottakis, Filippos, Polytarchou, Christos, Foltopoulou, Parthena, Sanidas, Ioannis, Kampranis, Sotirios C., Tsichlis, Philip N.
Published in Molecular cell (22.07.2011)
Published in Molecular cell (22.07.2011)
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Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells
Iliopoulos, Dimitrios, Lindahl-Allen, Marianne, Polytarchou, Christos, Hirsch, Heather A., Tsichlis, Philip N., Struhl, Kevin
Published in Molecular cell (10.09.2010)
Published in Molecular cell (10.09.2010)
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Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization
Arranz, Alicia, Doxaki, Christina, Vergadi, Eleni, Martinez de la Torre, Yeny, Vaporidi, Katerina, Lagoudaki, Eleni D, Ieronymaki, Eleftheria, Androulidaki, Ariadne, Venihaki, Maria, Margioris, Andrew N, Stathopoulos, Efstathios N, Tsichlis, Philip N, Tsatsanis, Christos
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
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The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs
Androulidaki, Ariadne, Iliopoulos, Dimitrios, Arranz, Alicia, Doxaki, Christina, Schworer, Steffen, Zacharioudaki, Vassiliki, Margioris, Andrew N., Tsichlis, Philip N., Tsatsanis, Christos
Published in Immunity (Cambridge, Mass.) (21.08.2009)
Published in Immunity (Cambridge, Mass.) (21.08.2009)
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Journal Article
Phosphoproteomics Screen Reveals Akt Isoform-Specific Signals Linking RNA Processing to Lung Cancer
Sanidas, Ioannis, Polytarchou, Christos, Hatziapostolou, Maria, Ezell, Scott A., Kottakis, Filippos, Hu, Lan, Guo, Ailan, Xie, Jianxin, Comb, Michael J., Iliopoulos, Dimitrios, Tsichlis, Philip N.
Published in Molecular cell (20.02.2014)
Published in Molecular cell (20.02.2014)
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Journal Article
Akt isoforms in the immune system
Guerau-de-Arellano, Mireia, Piedra-Quintero, Zayda L, Tsichlis, Philip N
Published in Frontiers in immunology (23.08.2022)
Published in Frontiers in immunology (23.08.2022)
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Journal Article
Energy Depletion Inhibits Phosphatidylinositol 3-Kinase/Akt Signaling and Induces Apoptosis via AMP-activated Protein Kinase-dependent Phosphorylation of IRS-1 at Ser-794
Tzatsos, Alexandros, Tsichlis, Philip N.
Published in The Journal of biological chemistry (22.06.2007)
Published in The Journal of biological chemistry (22.06.2007)
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Journal Article
MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells
Iliopoulos, Dimitrios, Polytarchou, Christos, Hatziapostolou, Maria, Kottakis, Filippos, Maroulakou, Ioanna G, Struhl, Kevin, Tsichlis, Philip N
Published in Science signaling (13.10.2009)
Published in Science signaling (13.10.2009)
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Journal Article
Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation
POLYTARCHOU, Christos, ILIOPOULOS, Dimitrios, HATZIAPOSTOLOU, Maria, KOTTAKIS, Filippos, MAROULAKOU, Ioanna, STRUHL, Kevin, TSICHLIS, Philip N
Published in Cancer research (Chicago, Ill.) (01.07.2011)
Published in Cancer research (Chicago, Ill.) (01.07.2011)
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Journal Article
PHENSIM: Phenotype Simulator
Alaimo, Salvatore, Rapicavoli, Rosaria Valentina, Marceca, Gioacchino P, La Ferlita, Alessandro, Serebrennikova, Oksana B, Tsichlis, Philip N, Mishra, Bud, Pulvirenti, Alfredo, Ferro, Alfredo
Published in PLoS computational biology (24.06.2021)
Published in PLoS computational biology (24.06.2021)
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RNAdetector: a free user-friendly stand-alone and cloud-based system for RNA-Seq data analysis
La Ferlita, Alessandro, Alaimo, Salvatore, Di Bella, Sebastiano, Martorana, Emanuele, Laliotis, Georgios I, Bertoni, Francesco, Cascione, Luciano, Tsichlis, Philip N, Ferro, Alfredo, Bosotti, Roberta, Pulvirenti, Alfredo
Published in BMC bioinformatics (03.06.2021)
Published in BMC bioinformatics (03.06.2021)
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NDY1/KDM2B Functions as a Master Regulator of Polycomb Complexes and Controls Self-Renewal of Breast Cancer Stem Cells
KOTTAKIS, Filippos, FOLTOPOULOU, Parthena, MCNIEL, Elizabeth, KUPERWASSER, Charlotte, TSICHLIS, Philip N, SANIDAS, Ioannis, KELLER, Patricia, WRONSKI, Ania, DAKE, Benjamin T, EZELL, Scott A, ZHU SHEN, NABER, Stephen P, HINDS, Philip W
Published in Cancer research (Chicago, Ill.) (15.07.2014)
Published in Cancer research (Chicago, Ill.) (15.07.2014)
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Journal Article
Stat5 Regulates the Phosphatidylinositol 3-Kinase/Akt1 Pathway during Mammary Gland Development and Tumorigenesis
Schmidt, Jeffrey W., Wehde, Barbara L., Sakamoto, Kazuhito, Triplett, Aleata A., Anderson, Steven M., Tsichlis, Philip N., Leone, Gustavo, Wagner, Kay-Uwe
Published in Molecular and cellular biology (01.04.2014)
Published in Molecular and cellular biology (01.04.2014)
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Journal Article
AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing
Laliotis, Georgios I, Chavdoula, Evangelia, Paraskevopoulou, Maria D, Kaba, Abdul, La Ferlita, Alessandro, Singh, Satishkumar, Anastas, Vollter, Nair, 2nd, Keith A, Orlacchio, Arturo, Taraslia, Vasiliki, Vlachos, Ioannis, Capece, Marina, Hatzigeorgiou, Artemis, Palmieri, Dario, Tsatsanis, Christos, Alaimo, Salvatore, Sehgal, Lalit, Carbone, David P, Coppola, Vincenzo, Tsichlis, Philip N
Published in Nature communications (30.07.2021)
Published in Nature communications (30.07.2021)
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Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47phox
Polytarchou, Christos, Hatziapostolou, Maria, Yau, Tung On, Christodoulou, Niki, Hinds, Philip W., Kottakis, Filippos, Sanidas, Ioannis, Tsichlis, Philip N.
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2020)
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The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells
Zacharopoulou, Nefeli, Tsapara, Anna, Kallergi, Galatea, Schmid, Evi, Alkahtani, Saad, Alarifi, Saud, Tsichlis, Philip N., Kampranis, Sotirios C., Stournaras, Christos
Published in Cellular physiology and biochemistry (01.01.2018)
Published in Cellular physiology and biochemistry (01.01.2018)
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Journal Article
Retraction Note: AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing
Laliotis, Georgios I., Chavdoula, Evangelia, Paraskevopoulou, Maria D., Kaba, Abdul, La Ferlita, Alessandro, Singh, Satishkumar, Anastas, Vollter, Nair, Keith A., Orlacchio, Arturo, Taraslia, Vasiliki, Vlachos, Ioannis, Capece, Marina, Hatzigeorgiou, Artemis, Palmieri, Dario, Tsatsanis, Christos, Alaimo, Salvatore, Sehgal, Lalit, Carbone, David P., Coppola, Vincenzo, Tsichlis, Philip N.
Published in Nature communications (28.06.2022)
Published in Nature communications (28.06.2022)
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Genetic ablation of interacting with Spt6 (Iws1) causes early embryonic lethality
Orlacchio, Arturo, Stark, Aaron E, Foray, Claudia, Amari, Foued, Sheetz, Tyler, Reese, Erika, Tessari, Anna, La Perle, Krista, Palmieri, Dario, Tsichlis, Philip N, Coppola, Vincenzo
Published in PloS one (12.09.2018)
Published in PloS one (12.09.2018)
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Journal Article
protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY
Ezell, Scott A, Polytarchou, Christos, Hatziapostolou, Maria, Guo, Ailan, Sanidas, Ioannis, Bihani, Teeru, Comb, Michael J, Sourvinos, George, Tsichlis, Philip N
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2012)
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