The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
Franke, Thomas F, Yang, Sung-Il, Chan, Tung O, Datta, Ketaki, Kazlauskas, Andrius, Morrison, Deborah K, Kaplan, David R, Tsichlis, Philip N
Published in Cell (02.06.1995)
Published in Cell (02.06.1995)
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Small cell lung cancer: Subtypes and therapeutic implications
Wang, Walter Z., Shulman, Alyssa, Amann, Joseph M., Carbone, David P., Tsichlis, Philip N.
Published in Seminars in cancer biology (01.11.2022)
Published in Seminars in cancer biology (01.11.2022)
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Tumor Progression Locus-2 Is a Critical Regulator of Pancreatic and Lung Inflammation during Acute Pancreatitis
Van Acker, Gijs J.D., Perides, George, Weiss, Eric R., Das, Santasabuj, Tsichlis, Philip N., Steer, Michael L.
Published in The Journal of biological chemistry (27.07.2007)
Published in The Journal of biological chemistry (27.07.2007)
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Journal Article
A Transcriptional Signature and Common Gene Networks Link Cancer with Lipid Metabolism and Diverse Human Diseases
Hirsch, Heather A., Iliopoulos, Dimitrios, Joshi, Amita, Zhang, Yong, Jaeger, Savina A., Bulyk, Martha, Tsichlis, Philip N., Shirley Liu, X., Struhl, Kevin
Published in Cancer cell (13.04.2010)
Published in Cancer cell (13.04.2010)
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Journal Article
Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase
Chang, Hwai Wen, Aoki, Masahiro, Fruman, David, Auger, Kurt R., Bellacosa, Alfonso, Tsichlis, Philip N., Cantley, Lewis C., Roberts, Thomas M., Vogt, Peter K.
Published in Science (American Association for the Advancement of Science) (20.06.1997)
Published in Science (American Association for the Advancement of Science) (20.06.1997)
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Journal Article
Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation
Serebrennikova, Oksana B, Tsatsanis, Christos, Mao, Changchuin, Gounaris, Elias, Ren, Wenying, Siracusa, Linda D, Eliopoulos, Aristides G, Khazaie, Khashayarsha, Tsichlis, Philip N
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.2012)
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Journal Article
Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity
Webb, Lindsay M, Sengupta, Shouvonik, Edell, Claudia, Piedra-Quintero, Zayda L, Amici, Stephanie A, Miranda, Janiret Narvaez, Bevins, Makenzie, Kennemer, Austin, Laliotis, Georgios, Tsichlis, Philip N, Guerau-de-Arellano, Mireia
Published in The Journal of clinical investigation (01.04.2020)
Published in The Journal of clinical investigation (01.04.2020)
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Journal Article
Proline hydroxylation linked to Akt activation
Voulgarelis, Michael, Tsichlis, Philip N.
Published in Science (American Association for the Advancement of Science) (26.08.2016)
Published in Science (American Association for the Advancement of Science) (26.08.2016)
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Toll-like receptor 2-dependent extracellular signal-regulated kinase signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells
Richardson, Edward T, Shukla, Supriya, Sweet, David R, Wearsch, Pamela A, Tsichlis, Philip N, Boom, W Henry, Harding, Clifford V
Published in Infection and immunity (01.06.2015)
Published in Infection and immunity (01.06.2015)
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Journal Article
Expression signature of human endogenous retroviruses in chronic lymphocytic leukemia
Ferlita, Alessandro La, Nigita, Giovanni, Tsyba, Liudmyla, Palamarchuk, Alexey, Alaimo, Salvatore, Pulvirenti, Alfredo, Balatti, Veronica, Rassenti, Laura, Tsichlis, Philip N, Kipps, Thomas, Pekarsky, Yuri, Croce, Carlo M
Published in Proceedings of the National Academy of Sciences - PNAS (31.10.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (31.10.2023)
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Journal Article
MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice
Polytarchou, Christos, Hommes, Daniel W, Palumbo, Tiziana, Hatziapostolou, Maria, Koutsioumpa, Marina, Koukos, Georgios, van der Meulen-de Jong, Andrea E, Oikonomopoulos, Angelos, van Deen, Welmoed K, Vorvis, Christina, Serebrennikova, Oksana B, Birli, Eleni, Choi, Jennifer, Chang, Lin, Anton, Peter A, Tsichlis, Philip N, Pothoulakis, Charalabos, Verspaget, Hein W, Iliopoulos, Dimitrios
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2015)
Published in Gastroenterology (New York, N.Y. 1943) (01.10.2015)
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Journal Article
Tumor Induction by an Lck-MyrAkt Transgene is Delayed by Mechanisms Controlling the Size of the Thymus
Malstrom, Scott, Tili, Esmerina, Kappes, Dietmar, Ceci, Jeffrey D., Tsichlis, Philip N.
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2001)
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Journal Article
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/Neu and MMTV-polyoma middle T transgenic mice
MAROULAKOU, Ioanna G, OEMLER, William, NABER, Stephen P, TSICHLIS, Philip N
Published in Cancer research (Chicago, Ill.) (2007)
Published in Cancer research (Chicago, Ill.) (2007)
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Journal Article
Oncogenic transformation induced by membrane-targeted Akt2 and Akt3
MENDE, Ines, MALSTROM, Scott, TSICHLIS, Philip N, VOGT, Peter K, AOKI, Masahiro
Published in Oncogene (19.07.2001)
Published in Oncogene (19.07.2001)
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Journal Article
The epigenetic factor KDM2B regulates cell adhesion, small rho GTPases, actin cytoskeleton and migration in prostate cancer cells
Zacharopoulou, Nefeli, Tsapara, Anna, Kallergi, Galatea, Schmid, Evi, Tsichlis, Philip N., Kampranis, Sotirios C., Stournaras, Christos
Published in Biochimica et biophysica acta. Molecular cell research (01.04.2018)
Published in Biochimica et biophysica acta. Molecular cell research (01.04.2018)
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Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4
Chavdoula, Evangelia, Anastas, Vollter, La Ferlita, Alessandro, Aldana, Julian, Carota, Giuseppe, Spampinato, Mariarita, Soysal, Burak, Cosentini, Ilaria, Parashar, Sameer, Sircar, Anuvrat, Nigita, Giovanni, Sehgal, Lalit, Freitas, Michael A, Tsichlis, Philip N
Published in Metabolism, clinical and experimental (01.01.2024)
Published in Metabolism, clinical and experimental (01.01.2024)
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Journal Article
Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47 phox
Polytarchou, Christos, Hatziapostolou, Maria, Yau, Tung On, Christodoulou, Niki, Hinds, Philip W, Kottakis, Filippos, Sanidas, Ioannis, Tsichlis, Philip N
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2020)
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