Quantitation of Lysosomal Trapping of Basic Lipophilic Compounds Using In Vitro Assays and In Silico Predictions Based on the Determination of the Full pH Profile of the Endo-/Lysosomal System in Rat Hepatocytes
Schmitt, Maximilian V, Lienau, Philip, Fricker, Gert, Reichel, Andreas
Published in Drug metabolism and disposition (01.01.2019)
Published in Drug metabolism and disposition (01.01.2019)
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Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer
Lücking, Ulrich, Scholz, Arne, Lienau, Philip, Siemeister, Gerhard, Kosemund, Dirk, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Denner, Karsten, Bömer, Ulf, Schäfer, Martina, Eis, Knut, Valencia, Ray, Ince, Stuart, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl, Klebl, Bert, Choidas, Axel, Nussbaumer, Peter, Baumann, Matthias, Schultz‐Fademrecht, Carsten, Rühter, Gerd, Eickhoff, Jan, Brands, Michael
Published in ChemMedChem (08.11.2017)
Published in ChemMedChem (08.11.2017)
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Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases
Hoffmann, Jens, Fichtner, Iduna, Lemm, Margit, Lienau, Philip, Hess-Stumpp, Holger, Rotgeri, Andrea, Hofmann, Birte, Klar, Ulrich
Published in Neuro-oncology (Charlottesville, Va.) (01.04.2009)
Published in Neuro-oncology (Charlottesville, Va.) (01.04.2009)
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Systematic Analysis of the Whole-Body Tissue Distribution and Fatty Acid Compositions of Membrane Lipids in CD1 and NMRI Mice and Wistar Rats
Liu, Xiaohui, Reichel, Andreas, Yang, Tao, Wang, Yusong, Wang, Xueying, Jiao, Yupei, Ruan, Huabin, Schmitt, Maximilian V., Xu, Lina, Lienau, Philip
Published in International journal of analytical chemistry (30.11.2020)
Published in International journal of analytical chemistry (30.11.2020)
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A probabilistic approach to classifying metabolic stability
Schwaighofer, Anton, Schroeter, Timon, Mika, Sebastian, Hansen, Katja, Ter Laak, Antonius, Lienau, Philip, Reichel, Andreas, Heinrich, Nikolaus, Müller, Klaus-Robert
Published in Journal of chemical information and modeling (01.04.2008)
Published in Journal of chemical information and modeling (01.04.2008)
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Exploration of Novel Chemical Space: Synthesis and in vitro Evaluation of N‐Functionalized Tertiary Sulfonimidamides
Izzo, Flavia, Schäfer, Martina, Lienau, Philip, Ganzer, Ursula, Stockman, Robert, Lücking, Ulrich
Published in Chemistry : a European journal (02.07.2018)
Published in Chemistry : a European journal (02.07.2018)
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The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models
Wengner, Antje M, Siemeister, Gerhard, Lücking, Ulrich, Lefranc, Julien, Wortmann, Lars, Lienau, Philip, Bader, Benjamin, Bömer, Ulf, Moosmayer, Dieter, Eberspächer, Uwe, Golfier, Sven, Schatz, Christoph A, Baumgart, Simon J, Haendler, Bernard, Lejeune, Pascale, Schlicker, Andreas, von Nussbaum, Franz, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik
Published in Molecular cancer therapeutics (01.01.2020)
Published in Molecular cancer therapeutics (01.01.2020)
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Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat
Schmitt, Maximilian V, Reichel, Andreas, Liu, Xiaohui, Fricker, Gert, Lienau, Philip
Published in Drug metabolism and disposition (01.01.2021)
Published in Drug metabolism and disposition (01.01.2021)
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Increasing Complexity: A Practical Synthetic Approach to Three‐Dimensional, Cyclic Sulfoximines and First Insights into Their in Vitro Properties
Boulard, Emilie, Zibulski, Vivien, Oertel, Luisa, Lienau, Philip, Schäfer, Martina, Ganzer, Ursula, Lücking, Ulrich
Published in Chemistry : a European journal (01.04.2020)
Published in Chemistry : a European journal (01.04.2020)
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BAY 1000394, a novel cyclin-dependent kinase inhibitor, with potent antitumor activity in mono- and in combination treatment upon oral application
Siemeister, Gerhard, Lücking, Ulrich, Wengner, Antje M, Lienau, Philip, Steinke, Wolfram, Schatz, Christoph, Mumberg, Dominik, Ziegelbauer, Karl
Published in Molecular cancer therapeutics (01.10.2012)
Published in Molecular cancer therapeutics (01.10.2012)
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Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer
Lücking, Ulrich, Kosemund, Dirk, Böhnke, Niels, Lienau, Philip, Siemeister, Gerhard, Denner, Karsten, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Bömer, Ulf, Schäfer, Martina, Ince, Stuart, Mumberg, Dominik, Scholz, Arne, Izumi, Raquel, Hwang, Stuart, von Nussbaum, Franz
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma
Narita, Tomoko, Ishida, Takashi, Ito, Asahi, Masaki, Ayako, Kinoshita, Shiori, Suzuki, Susumu, Takino, Hisashi, Yoshida, Takashi, Ri, Masaki, Kusumoto, Shigeru, Komatsu, Hirokazu, Imada, Kazunori, Tanaka, Yuetsu, Takaori-Kondo, Akifumi, Inagaki, Hiroshi, Scholz, Arne, Lienau, Philip, Kuroda, Taruho, Ueda, Ryuzo, Iida, Shinsuke
Published in Blood (31.08.2017)
Published in Blood (31.08.2017)
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Quantitative molecular tissue atlas of Bis(monoacylglycero)phosphate and phosphatidylglycerol membrane lipids in rodent organs generated by methylation assisted high resolution mass spectrometry
Wang, Xueying, Schmitt, Maximilian V., Xu, Lina, Jiao, Yupei, Guo, Lvjun, Lienau, Philip, Reichel, Andreas, Liu, Xiaohui
Published in Analytica chimica acta (25.11.2019)
Published in Analytica chimica acta (25.11.2019)
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Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models
Lücking, Ulrich, Wortmann, Lars, Wengner, Antje M, Lefranc, Julien, Lienau, Philip, Briem, Hans, Siemeister, Gerhard, Bömer, Ulf, Denner, Karsten, Schäfer, Martina, Koppitz, Marcus, Eis, Knut, Bartels, Florian, Bader, Benjamin, Bone, Wilhelm, Moosmayer, Dieter, Holton, Simon J, Eberspächer, Uwe, Grudzinska-Goebel, Joanna, Schatz, Christoph, Deeg, Gesa, Mumberg, Dominik, von Nussbaum, Franz
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics
Hillisch, Alexander, Gericke, Kersten M, Allerheiligen, Swen, Roehrig, Susanne, Schaefer, Martina, Tersteegen, Adrian, Schulz, Simone, Lienau, Philip, Gnoth, Mark, Puetter, Vera, Hillig, Roman C, Heitmeier, Stefan
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity
Wengner, Antje M, Siemeister, Gerhard, Koppitz, Marcus, Schulze, Volker, Kosemund, Dirk, Klar, Ulrich, Stoeckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Raschke, Marian, Frisk, Anna-Lena, von Ahsen, Oliver, Michels, Martin, Kreft, Bertolt, von Nussbaum, Franz, Brands, Michael, Mumberg, Dominik, Ziegelbauer, Karl
Published in Molecular cancer therapeutics (01.04.2016)
Published in Molecular cancer therapeutics (01.04.2016)
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The Lab Oddity Prevails: Discovery of Pan-CDK Inhibitor (R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the Treatment of Cancer
Lücking, Ulrich, Jautelat, Rolf, Krüger, Martin, Brumby, Thomas, Lienau, Philip, Schäfer, Martina, Briem, Hans, Schulze, Julia, Hillisch, Alexander, Reichel, Andreas, Wengner, Antje Margret, Siemeister, Gerhard
Published in ChemMedChem (01.07.2013)
Published in ChemMedChem (01.07.2013)
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Discovery and Characterization of BAY-184: A New Potent and Selective Acylsulfonamide-Benzofuran In Vivo -Active KAT6AB Inhibitor
Ter Laak, Antonius, Hillig, Roman C, Ferrara, Steven J, Korr, Daniel, Barak, Naomi, Lienau, Philip, Herbert, Simon, Fernández-Montalván, Amaury Ernesto, Neuhaus, Roland, Gorjánácz, Mátyás, Puetter, Vera, Badock, Volker, Bone, Wilhelm, Strathdee, Craig, Siegel, Franziska, Schatz, Christoph, Nowak-Reppel, Katrin, Doehr, Olaf, Gradl, Stefan, Hartung, Ingo V, Meyerson, Matthew, Bouché, Léa
Published in Journal of medicinal chemistry (25.10.2024)
Published in Journal of medicinal chemistry (25.10.2024)
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