Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences
Mendoza, Juan L., Schmidt, André, Li, Qin, Nuvaga, Emmanuel, Barrett, Tyler, Bridges, Robert J., Feranchak, Andrew P., Brautigam, Chad A., Thomas, Philip J.
Published in Cell (20.01.2012)
Published in Cell (20.01.2012)
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Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene
Sosnay, Patrick R, Siklosi, Karen R, Van Goor, Fredrick, Kaniecki, Kyle, Yu, Haihui, Sharma, Neeraj, Ramalho, Anabela S, Amaral, Margarida D, Dorfman, Ruslan, Zielenski, Julian, Masica, David L, Karchin, Rachel, Millen, Linda, Thomas, Philip J, Patrinos, George P, Corey, Mary, Lewis, Michelle H, Rommens, Johanna M, Castellani, Carlo, Penland, Christopher M, Cutting, Garry R
Published in Nature genetics (01.10.2013)
Published in Nature genetics (01.10.2013)
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Isogenic cell models of cystic fibrosis-causing variants in natively expressing pulmonary epithelial cells
Valley, Hillary C., Bukis, Katherine M., Bell, Alisa, Cheng, Yi, Wong, Eric, Jordan, Nikole J., Allaire, Normand E., Sivachenko, Andrey, Liang, Feng, Bihler, Hermann, Thomas, Philip J., Mahiou, Jerome, Mense, Martin
Published in Journal of cystic fibrosis (01.07.2019)
Published in Journal of cystic fibrosis (01.07.2019)
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Direct Binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric Coupling between the Binding Site and the NBD1:CL4 Interface
Hudson, Rhea P, Dawson, Jennifer E, Chong, P Andrew, Yang, Zhengrong, Millen, Linda, Thomas, Philip J, Brouillette, Christie G, Forman-Kay, Julie D
Published in Molecular pharmacology (01.08.2017)
Published in Molecular pharmacology (01.08.2017)
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Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions
Bozoky, Zoltan, Krzeminski, Mickael, Muhandiram, Ranjith, Birtley, James R, Al-Zahrani, Ateeq, Thomas, Philip J, Frizzell, Raymond A, d, Robert C, man-Kay, Julie D
Published in Proceedings of the National Academy of Sciences - PNAS (19.11.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (19.11.2013)
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Inefficient SRP Interaction with a Nascent Chain Triggers a mRNA Quality Control Pathway
Karamyshev, Andrey L., Patrick, Anna E., Karamysheva, Zemfira N., Griesemer, Dustin S., Hudson, Henry, Tjon-Kon-Sang, Sandra, Nilsson, IngMarie, Otto, Hendrik, Liu, Qinghua, Rospert, Sabine, von Heijne, Gunnar, Johnson, Arthur E., Thomas, Philip J.
Published in Cell (16.01.2014)
Published in Cell (16.01.2014)
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Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding
Huerta, Carlos, Jiang, Xin, Trevino, Isaac, Bender, Christopher F., Ferguson, Deborah A., Probst, Brandon, Swinger, Kerren K., Stoll, Vincent S., Thomas, Philip J., Dulubova, Irina, Visnick, Melean, Wigley, W. Christian
Published in Biochimica et biophysica acta (01.11.2016)
Published in Biochimica et biophysica acta (01.11.2016)
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Journal Article
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis
Balch, William E, Hutt, Darren M, Herman, David, Rodrigues, Ana P C, Noel, Sabrina, Pilewski, Joseph M, Matteson, Jeanne, Hoch, Ben, Kellner, Wendy, Kelly, Jeffery W, Schmidt, Andre, Thomas, Philip J, Matsumura, Yoshihiro, Skach, William R, Gentzsch, Martina, Riordan, John R, Sorscher, Eric J, Okiyoneda, Tsukasa, Yates, John R, Lukacs, Gergely L, Frizzell, Raymond A, Manning, Gerard, Gottesfeld, Joel M
Published in Nature chemical biology (01.01.2010)
Published in Nature chemical biology (01.01.2010)
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IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway
Yang, Dongki, Li, Qin, So, Insuk, Huang, Chou-Long, Ando, Hideaki, Mizutani, Akihiro, Seki, George, Mikoshiba, Katsuhiko, Thomas, Philip J, Muallem, Shmuel
Published in The Journal of clinical investigation (01.03.2011)
Published in The Journal of clinical investigation (01.03.2011)
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Journal Article
Gating of CFTR by the STAS domain of SLC26 transporters
Muallem, Shmuel, Ko, Shigeru B.H, Zeng, Weizhong, Dorwart, Michael R, Luo, Xiang, Kim, Kil Hwan, Millen, Linda, Goto, Hidemi, Naruse, Satoru, Soyombo, Abigail, Thomas, Philip J
Published in Nature cell biology (01.04.2004)
Published in Nature cell biology (01.04.2004)
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Endoproteolytic Activity of the Proteasome
Liu, Chang-Wei, Corboy, Michael J., DeMartino, George N., Thomas, Philip J.
Published in Science (American Association for the Advancement of Science) (17.01.2003)
Published in Science (American Association for the Advancement of Science) (17.01.2003)
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ATP Binding and ATP Hydrolysis Play Distinct Roles in the Function of 26S Proteasome
Liu, Chang-Wei, Li, Xiaohua, Thompson, David, Wooding, Kerry, Chang, Tsui-ling, Tang, Zhanyun, Yu, Hongtao, Thomas, Philip J., DeMartino, George N.
Published in Molecular cell (06.10.2006)
Published in Molecular cell (06.10.2006)
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Journal Article
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3− secretion: relevance to cystic fibrosis
Wang, Youxue, Soyombo, Abigail A, Shcheynikov, Nikolay, Zeng, Weizhong, Dorwart, Michael, Marino, Christopher R, Thomas, Philip J, Muallem, Shmuel
Published in The EMBO journal (01.11.2006)
Published in The EMBO journal (01.11.2006)
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Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6
Shcheynikov, Nikolay, Wang, Youxue, Park, Meeyoung, Ko, Shigeru B H, Dorwart, Michael, Naruse, Satoru, Thomas, Philip J, Muallem, Shmuel
Published in The Journal of general physiology (01.05.2006)
Published in The Journal of general physiology (01.05.2006)
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Journal Article
Cooperative, ATP-dependent Association of the Nucleotide Binding Cassettes during the Catalytic Cycle of ATP-binding Cassette Transporters
Moody, Jonathan E, Millen, Linda, Binns, Derk, Hunt, John F, Thomas, Philip J
Published in The Journal of biological chemistry (14.06.2002)
Published in The Journal of biological chemistry (14.06.2002)
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Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening
Kalid, Ori, Mense, Martin, Fischman, Sharon, Shitrit, Alina, Bihler, Hermann, Ben-Zeev, Efrat, Schutz, Nili, Pedemonte, Nicoletta, Thomas, Philip J., Bridges, Robert J., Wetmore, Diana R., Marantz, Yael, Senderowitz, Hanoch
Published in Journal of computer-aided molecular design (01.12.2010)
Published in Journal of computer-aided molecular design (01.12.2010)
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Journal Article
Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator
Lewis, Hal A, Buchanan, Sean G, Burley, Stephen K, Conners, Kris, Dickey, Mark, Dorwart, Michael, Fowler, Richard, Gao, Xia, Guggino, William B, Hendrickson, Wayne A, Hunt, John F, Kearins, Margaret C, Lorimer, Don, Maloney, Peter C, Post, Kai W, Rajashankar, Kanagalaghatta R, Rutter, Marc E, Sauder, J Michael, Shriver, Stephanie, Thibodeau, Patrick H, Thomas, Philip J, Zhang, Marie, Zhao, Xun, Emtage, Spencer
Published in The EMBO journal (28.01.2004)
Published in The EMBO journal (28.01.2004)
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