ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses
Jossé, Rozenn, Martin, Scott E, Guha, Rajarshi, Ormanoglu, Pinar, Pfister, Thomas D, Reaper, Philip M, Barnes, Christopher S, Jones, Julie, Charlton, Peter, Pollard, John R, Morris, Joel, Doroshow, James H, Pommier, Yves
Published in Cancer research (Chicago, Ill.) (01.12.2014)
Published in Cancer research (Chicago, Ill.) (01.12.2014)
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Journal Article
Enhancing Mn(II)-Binding and Manganese Peroxidase Activity in a Designed Cytochrome c Peroxidase through Fine-Tuning Secondary-Sphere Interactions
Hosseinzadeh, Parisa, Mirts, Evan N, Pfister, Thomas D, Gao, Yi-Gui, Mayne, Christopher, Robinson, Howard, Tajkhorshid, Emad, Lu, Yi
Published in Biochemistry (Easton) (15.03.2016)
Published in Biochemistry (Easton) (15.03.2016)
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Journal Article
Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity
Pfister, Thomas D, Reinhold, William C, Agama, Keli, Gupta, Shalu, Khin, Sonny A, Kinders, Robert J, Parchment, Ralph E, Tomaszewski, Joseph E, Doroshow, James H, Pommier, Yves
Published in Molecular cancer therapeutics (01.07.2009)
Published in Molecular cancer therapeutics (01.07.2009)
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Journal Article
Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells
Navas, Tony, Pfister, Thomas D, Colantonio, Simona, Aziz, Amina, Dieckman, Lynda, Saul, Richard G, Kaczmarczyk, Jan, Borgel, Suzanne, Alcoser, Sergio Y, Hollingshead, Melinda G, Lee, Young H, Bottaro, Donald P, Hiltke, Tara, Whiteley, Gordon, Takebe, Naoko, Kinders, Robert J, Parchment, Ralph E, Tomaszewski, Joseph E, Doroshow, James H
Published in PloS one (21.06.2018)
Published in PloS one (21.06.2018)
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Journal Article
Identifying the Elusive Sites of Tyrosyl Radicals in Cytochrome c Peroxidase: Implications for Oxidation of Substrates Bound at a Site Remote from the Heme
Miner, Kyle D, Pfister, Thomas D, Hosseinzadeh, Parisa, Karaduman, Nadime, Donald, Lynda J, Loewen, Peter C, Lu, Yi, Ivancich, Anabella
Published in Biochemistry (Easton) (17.06.2014)
Published in Biochemistry (Easton) (17.06.2014)
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Journal Article
A Site-Selective Dual Anchoring Strategy for Artificial Metalloprotein Design
Carey, James R, Ma, Steven K, Pfister, Thomas D, Garner, Dewain K, Kim, Hyeon K, Abramite, Joseph A, Wang, Zhilin, Guo, Zijian, Lu, Yi
Published in Journal of the American Chemical Society (08.09.2004)
Published in Journal of the American Chemical Society (08.09.2004)
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Journal Article
The Root Causes of Pharmacodynamic Assay Failure
Ferry-Galow, Katherine V., PhD, Makhlouf, Hala R., MD, PhD, Wilsker, Deborah F., PhD, Lawrence, Scott M, Pfister, Thomas D., PhD, Marrero, Allison M., PhD, Bigelow, Kristina M, Yutzy, William H, Ji, Jiuping J., PhD, Butcher, Donna O, Gouker, Brad A, Kummar, Shivaani, MD, Chen, Alice P., MD, Kinders, Robert J., PhD, Parchment, Ralph E., PhD, Doroshow, James H., MD
Published in Seminars in oncology (01.08.2016)
Published in Seminars in oncology (01.08.2016)
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Journal Article
Neutral Thiol as a Proximal Ligand to Ferrous Heme Iron: Implications for Heme Proteins That Lose Cysteine Thiolate Ligation on Reduction
Perera, Roshan, Sono, Masanori, Sigman, Jeffrey A., Pfister, Thomas D., Lu, Yi, Dawson, John H.
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.2003)
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Journal Article
Development and validation of an immunoassay for quantification of topoisomerase I in solid tumor tissues
Pfister, Thomas D, Hollingshead, Melinda, Kinders, Robert J, Zhang, Yiping, Evrard, Yvonne A, Ji, Jiuping, Khin, Sonny A, Borgel, Suzanne, Stotler, Howard, Carter, John, Divelbiss, Raymond, Kummar, Shivaani, Pommier, Yves, Parchment, Ralph E, Tomaszewski, Joseph E, Doroshow, James H
Published in PloS one (28.12.2012)
Published in PloS one (28.12.2012)
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Journal Article
Safety, immunologic and clinical activity of Durvalumab in combination with Olaparib or Cediranib in advanced leiomyosarcoma: Results of the DAPPER clinical trial
Salawu, Abdulazeez, Wang, Ben X, Han, Ming, Geady, Caryn, Heirali, Alya, Berman, Hal K, Pfister, Thomas D, Hernando-Calvo, Alberto, Al-Ezzi, Esmail Mutahar, Stayner, Lee-Anne, Gupta, Abha A, Ayodele, Olubukola, Lam, Bernard, Hansen, Aaron R, Spreafico, Anna, Bedard, Philippe L, Butler, Marcus O, Avery, Lisa, Coburn, Bryan, Haibe-Kains, Benjamin, Siu, Lillian L, Abdul Razak, Albiruni R
Published in Clinical cancer research (13.10.2023)
Published in Clinical cancer research (13.10.2023)
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Journal Article
119 Uncovering spatial biology of mouse tumor immune microenvironment using imaging mass cytometry
Raza, Qanber, Lim, Liang, Pfister, Thomas D, Loh, Christina
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Pharmacodynamic Response of the MET/HGF Receptor to Small-Molecule Tyrosine Kinase Inhibitors Examined with Validated, Fit-for-Clinic Immunoassays
Srivastava, Apurva K, Hollingshead, Melinda G, Weiner, Jennifer, Navas, Tony, Evrard, Yvonne A, Khin, Sonny A, Ji, Jiuping Jay, Zhang, Yiping, Borgel, Suzanne, Pfister, Thomas D, Kinders, Robert J, Bottaro, Donald P, Linehan, W Marston, Tomaszewski, Joseph E, Doroshow, James H, Parchment, Ralph E
Published in Clinical cancer research (15.07.2016)
Published in Clinical cancer research (15.07.2016)
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Journal Article
Monitoring Drug-Induced γH2AX as a Pharmacodynamic Biomarker in Individual Circulating Tumor Cells
Wang, Lihua H., Pfister, Thomas D., Parchment, Ralph E., Kummar, Shivaani, Rubinstein, Larry, Evrard, Yvonne A., Gutierrez, Martin E., Murgo, Anthony J., Tomaszewski, Joseph E., Doroshow, James H., Kinders, Robert J.
Published in Clinical cancer research (01.02.2010)
Published in Clinical cancer research (01.02.2010)
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Journal Article
Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors
Kummar, Shivaani, Chen, Alice, Gutierrez, Martin, Pfister, Thomas D., Wang, Lihua, Redon, Christophe, Bonner, William M., Yutzy, William, Zhang, Yiping, Kinders, Robert J., Ji, Jiuping, Allen, Deborah, Covey, Joseph M., Eiseman, Julie L., Holleran, Julianne L., Beumer, Jan H., Rubinstein, Larry, Collins, Jerry, Tomaszewski, Joseph, Parchment, Ralph, Pommier, Yves, Doroshow, James H.
Published in Cancer chemotherapy and pharmacology (01.07.2016)
Published in Cancer chemotherapy and pharmacology (01.07.2016)
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Journal Article
Exon Array Analyses across the NCI-60 Reveal Potential Regulation of TOP1 by Transcription Pausing at Guanosine Quartets in the First Intron
REINHOLD, William C, MERGNY, Jean-Louis, HONGFANG LIU, RYAN, Michael, PFISTER, Thomas D, KINDERS, Robert, PARCHMENT, Ralph, DOROSHOW, James, WEINSTEIN, John N, POMMIER, Yves
Published in Cancer research (Chicago, Ill.) (15.03.2010)
Published in Cancer research (Chicago, Ill.) (15.03.2010)
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Journal Article
Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations
Jensen, Niels Frank, Agama, Keli, Roy, Amit, Smith, David Hersi, Pfister, Thomas D, Rømer, Maria Unni, Zhang, Hong-Liang, Doroshow, James H, Knudsen, Birgitta R, Stenvang, Jan, Brünner, Nils, Pommier, Yves
Published in Journal of experimental & clinical cancer research (31.03.2016)
Published in Journal of experimental & clinical cancer research (31.03.2016)
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Journal Article
Abstract 5544: Development of recombinant transcription factor proteins and antibodies for application in clinical immunoassays
Pfister, Thomas D., Dieckman, Lynda J., Kinders, Robert J., Book, Anne, Colantonio, Simona, Mutreja, Karun, Lawrence, Scott M., Aziz, Amina, Hiltke, Tara, Whiteley, Gordon, Parchment, Ralph E., Tomaszewski, Joseph E., Weinberg, Robert A., Doroshow, James H.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
Monooxygenation of an aromatic ring by F43W/H64D/V68I myoglobin mutant and hydrogen peroxide. Myoglobin mutants as a model for P450 hydroxylation chemistry
Pfister, Thomas D, Ohki, Takahiro, Ueno, Takafumi, Hara, Isao, Adachi, Seiji, Makino, Yumiko, Ueyama, Norikazu, Lu, Yi, Watanabe, Yoshihito
Published in The Journal of biological chemistry (01.04.2005)
Published in The Journal of biological chemistry (01.04.2005)
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