Therapeutic Agents Based on DNA Sequence Specific Binding
Pett, Luke, Hartley, John A, Kiakos, Konstantinos
Published in Current topics in medicinal chemistry (01.05.2015)
Published in Current topics in medicinal chemistry (01.05.2015)
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Journal Article
The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds
Mpima, Sheila, Ohnmacht, Stephan A., Barletta, Maria, Husby, Jarmila, Pett, Luke C., Gunaratnam, Mekala, Hilton, Stephen T., Neidle, Stephen
Published in Bioorganic & medicinal chemistry (15.10.2013)
Published in Bioorganic & medicinal chemistry (15.10.2013)
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Journal Article
Effects of N-terminus modified Hx-amides on DNA binding affinity, sequence specificity, cellular uptake, and gene expression
Kiakos, Konstantinos, Satam, Vijay, Patil, Pravin C., Sweers, Jeffrey, Bowerman, Michael, Tzou, Sam, Olsen, Kevin, Lee, Megan, Schaschl, Helmut, Keppler, Bernhard K., Hochhauser, Daniel, Lee, Moses, Hartley, John A., Pett, Luke
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
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Journal Article
Nuclear Localization and Gene Expression Modulation by a Fluorescent Sequence-Selective p-Anisyl-benzimidazolecarboxamido Imidazole-Pyrrole Polyamide
Kiakos, Konstantinos, Pett, Luke, Satam, Vijay, Patil, Pravin, Hochhauser, Daniel, Lee, Moses, Hartley, John A.
Published in Chemistry & biology (23.07.2015)
Published in Chemistry & biology (23.07.2015)
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Abstract 3755: Genome-wide transcriptome analysis reveals the distinct gene expression profiles and specific biological effects of fluorescent polyamides, HxIP and azaHxPI
Pett, Luke, Satam, Vijay, Patil, Pravin, Lee, Moses, Hartley, John A., Kiakos, Konstantinos
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
DNA-binding properties of new fluorescent AzaHx-amides: Methoxy-pyridyl-aza-benzimidazole-pyrrole-imidazole/pyrrole
Liu, Beibei, Pett, Luke, Kiakos, Konstantinos, Patil, Pravin, Satam, Vijay, Hartley, John A., Lee, Moses, Wilson, W.David
Published in Chembiochem : a European journal of chemical biology (15.08.2018)
Published in Chembiochem : a European journal of chemical biology (15.08.2018)
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Journal Article
DNA‐Binding Properties of New Fluorescent AzaHx Amides: Methoxypyridylazabenzimidazolepyrroleimidazole/pyrrole
Liu, Beibei, Pett, Luke, Kiakos, Konstantinos, Patil, Pravin C., Satam, Vijay, Hartley, John A., Lee, Moses, Wilson, W. David
Published in Chembiochem : a European journal of chemical biology (17.09.2018)
Published in Chembiochem : a European journal of chemical biology (17.09.2018)
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Journal Article
Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide
Pett, Luke, Kiakos, Konstantinos, Satam, Vijay, Patil, Pravin, Laughlin-Toth, Sarah, Gregory, Matthew, Bowerman, Michael, Olson, Kevin, Savagian, Mia, Lee, Megan, Lee, Moses, Wilson, W. David, Hochhauser, Daniel, Hartley, John A.
Published in Biochimica et biophysica acta (01.05.2017)
Published in Biochimica et biophysica acta (01.05.2017)
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SPIKE-1: A Randomised Phase II/III trial in a community setting, assessing use of camostat in reducing the clinical progression of COVID-19 by blocking SARS-CoV-2 Spike protein-initiated membrane fusion
Halford, Sarah, Wan, Susan, Dragoni, Ilaria, Silvester, Julie, Nazarov, Bobojon, Anthony, Daniel, Anthony, Suzie, Ladds, Emma, Norrie, John, Dhaliwal, Kevin
Published in Current controlled trials in cardiovascular medicine (19.08.2021)
Published in Current controlled trials in cardiovascular medicine (19.08.2021)
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Journal Article
AzaHx, a novel fluorescent, DNA minor groove and G.C recognition element: Synthesis and DNA binding properties of a p-anisyl-4-aza-benzimidazole-pyrrole-imidazole (azaHx-PI) polyamide
Satam, Vijay, Babu, Balaji, Patil, Pravin, Brien, Kimberly A., Olson, Kevin, Savagian, Mia, Lee, Megan, Mepham, Andrew, Jobe, Laura Beth, Bingham, John P., Pett, Luke, Wang, Shuo, Ferrara, Maddi, Bruce, Chrystal D., Wilson, W. David, Lee, Moses, Hartley, John A., Kiakos, Konstantinos
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
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Journal Article
AzaHx, a novel fluorescent, DNA minor groove and G·C recognition element: Synthesis and DNA binding properties of a p-anisyl-4-aza-benzimidazole-pyrrole-imidazole (azaHx-PI) polyamide
Satam, Vijay, Babu, Balaji, Patil, Pravin, Brien, Kimberly A., Olson, Kevin, Savagian, Mia, Lee, Megan, Mepham, Andrew, Jobe, Laura Beth, Bingham, John P., Pett, Luke, Wang, Shuo, Ferrara, Maddi, Bruce, Chrystal D., Wilson, W. David, Lee, Moses, Hartley, John A., Kiakos, Konstantinos
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
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Journal Article