Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice
Yuan, Taolin, Kumar, Surinder, Skinner, Mary E., Victor-Joseph, Ryan, Abuaita, Majd, Keijer, Jaap, Zhang, Jessica, Kunkel, Thaddeus J., Liu, Yanghan, Petrunak, Elyse M., Saunders, Thomas L., Lieberman, Andrew P., Stuckey, Jeanne A., Neamati, Nouri, Al-Murshedi, Fathiya, Alfadhel, Majid, Spelbrink, Johannes N., Rodenburg, Richard, de Boer, Vincent C.J., Lombard, David B.
Published in iScience (21.06.2024)
Published in iScience (21.06.2024)
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Structures of Human Steroidogenic Cytochrome P450 17A1 with Substrates
Petrunak, Elyse M., DeVore, Natasha M., Porubsky, Patrick R., Scott, Emily E.
Published in The Journal of biological chemistry (21.11.2014)
Published in The Journal of biological chemistry (21.11.2014)
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Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site
Petrunak, Elyse M., Bart, Aaron G., Peng, Hwei-Ming, Auchus, Richard J., Scott, Emily E.
Published in The Journal of biological chemistry (01.03.2023)
Published in The Journal of biological chemistry (01.03.2023)
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Structure-Based Design of N‑(5-Phenylthiazol-2-yl)acrylamides as Novel and Potent Glutathione S‑Transferase Omega 1 Inhibitors
Dai, Weiyang, Samanta, Soma, Xue, Ding, Petrunak, Elyse M, Stuckey, Jeanne A, Han, Yanyan, Sun, Duxin, Wu, Yong, Neamati, Nouri
Published in Journal of medicinal chemistry (28.03.2019)
Published in Journal of medicinal chemistry (28.03.2019)
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Structural insights into the function of steroidogenic cytochrome P450 17A1
Yadav, Rahul, Petrunak, Elyse M., Estrada, D. Fernando, Scott, Emily E.
Published in Molecular and cellular endocrinology (05.02.2017)
Published in Molecular and cellular endocrinology (05.02.2017)
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Design, Synthesis, and Biological Evaluation of 4‑Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase
Madak, Joseph T, Cuthbertson, Christine R, Miyata, Yoshinari, Tamura, Shuzo, Petrunak, Elyse M, Stuckey, Jeanne A, Han, Yanyan, He, Miao, Sun, Duxin, Showalter, Hollis D, Neamati, Nouri
Published in Journal of medicinal chemistry (28.06.2018)
Published in Journal of medicinal chemistry (28.06.2018)
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Journal Article
Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors
Bonomo, Silvia, Hansen, Cecilie H., Petrunak, Elyse M., Scott, Emily E., Styrishave, Bjarne, Jørgensen, Flemming Steen, Olsen, Lars
Published in Scientific reports (12.07.2016)
Published in Scientific reports (12.07.2016)
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An engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling
Kim, Sun Kyung, Barron, Lindsey, Hinck, Cynthia S., Petrunak, Elyse M., Cano, Kristin E., Thangirala, Avinash, Iskra, Brian, Brothers, Molly, Vonberg, Machell, Leal, Belinda, Richter, Blair, Kodali, Ravindra, Taylor, Alexander B., Du, Shoucheng, Barnes, Christopher O., Sulea, Traian, Calero, Guillermo, Hart, P. John, Hart, Matthew J., Demeler, Borries, Hinck, Andrew P.
Published in The Journal of biological chemistry (28.04.2017)
Published in The Journal of biological chemistry (28.04.2017)
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Journal Article
Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase
Madak, Joseph T., Cuthbertson, Christine R., Miyata, Yoshinari, Tamura, Shuzo, Petrunak, Elyse M., Stuckey, Jeanne A., Han, Yanyan, He, Miao, Sun, Duxin, Showalter, Hollis D., Neamati, Nouri
Published in Journal of medicinal chemistry (04.05.2017)
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Published in Journal of medicinal chemistry (04.05.2017)
Journal Article
SIRT5 variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology
Yuan, Taolin, Kumar, Surinder, Skinner, Mary, Victor-Joseph, Ryan, Abuaita, Majd, Keijer, Jaap, Zhang, Jessica, Kunkel, Thaddeus J, Liu, Yanghan, Petrunak, Elyse M, Saunders, Thomas L, Lieberman, Andrew P, Stuckey, Jeanne A, Neamati, Nouri, Al-Murshedi, Fathiya, Alfadhel, Majid, Spelbrink, Johannes N, Rodenburg, Richard, de Boer, Vincent C J, Lombard, David B
Published in bioRxiv : the preprint server for biology (08.12.2023)
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Published in bioRxiv : the preprint server for biology (08.12.2023)
Journal Article
SIRT5 variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology
Yuan, Taolin, Kumar, Surinder, Skinner, Mary E, Victor-Joseph, Ryan, Abuaita, Majd, Keijer, Jaap, Zhang, Jessica, Kunkel, Thaddeus, Liu, Yanghan, Petrunak, Elyse, Saunders, Thomas, Lieberman, Andrew P, Stuckey, Jeanne A, Nouri Neamati, Almurshedi, Fathiya, Alfadhel, Majid, Spelbrink, Johannes N, Rodenburg, Richard, De Boer, Vincent Cj, Lombard, David B
Published in bioRxiv (08.12.2023)
Published in bioRxiv (08.12.2023)
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