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Kirichok, Alexander A., Shton, Irina O., Pishel, Irina M., Zozulya, Sergey A., Borysko, Petro O., Kubyshkin, Vladimir, Zaporozhets, Olha A., Tolmachev, Andrei A., Mykhailiuk, Pavel K.
Published in Chemistry : a European journal (11.04.2018)
Published in Chemistry : a European journal (11.04.2018)
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Hydroaminoalkyl Functionalization of Pyrimidin-2(1H)-ones by Visible Light Organophotocatalysis: A Radical Approach to Biginelli-Type Dihydropyrimidines
Lukianov, Oleh, Tkachuk, Viktor, Shishkina, Svitlana, Lachmann, Leonid, Vadzyuk, Olga, Borysko, Petro, Kovalskyy, Dmytro, Gillaizeau, Isabelle, Sukach, Volodymyr
Published in Advanced synthesis & catalysis (24.10.2023)
Published in Advanced synthesis & catalysis (24.10.2023)
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Effect of gem‐Difluorination on the Key Physicochemical Properties Relevant to Medicinal Chemistry: The Case of Functionalized Cycloalkanes
Holovach, Sergey, Melnykov, Kostiantyn P., Skreminskiy, Artem, Herasymchuk, Maksym, Tavlui, Olha, Aloshyn, Danylo, Borysko, Petro, Rozhenko, Alexander B., Ryabukhin, Sergey V., Volochnyuk, Dmitriy M., Grygorenko, Oleksandr O.
Published in Chemistry : a European journal (01.04.2022)
Published in Chemistry : a European journal (01.04.2022)
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Photochemical In-Flow Synthesis of 2,4-Methanopyrrolidines: Pyrrolidine Analogues with Improved Water Solubility and Reduced Lipophilicity
Levterov, Vadym V, Michurin, Oleg, Borysko, Petro O, Zozulya, Sergey, Sadkova, Iryna V, Tolmachev, Andrey A, Mykhailiuk, Pavel K
Published in Journal of organic chemistry (07.12.2018)
Published in Journal of organic chemistry (07.12.2018)
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Photochemical Synthesis of 2‑Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline
Druzhenko, Tetiana, Skalenko, Yevhen, Samoilenko, Maryna, Denisenko, Aleksandr, Zozulya, Sergey, Borysko, Petro O, Sokolenko, Maria I, Tarasov, Alexandr, Mykhailiuk, Pavel K
Published in Journal of organic chemistry (02.02.2018)
Published in Journal of organic chemistry (02.02.2018)
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2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring
Levterov, Vadym V, Panasiuk, Yaroslav, Sahun, Kateryna, Stashkevych, Oleksandr, Badlo, Valentyn, Shablykin, Oleh, Sadkova, Iryna, Bortnichuk, Lina, Klymenko-Ulianov, Oleksii, Holota, Yuliia, Lachmann, Leonid, Borysko, Petro, Horbatok, Kateryna, Bodenchuk, Iryna, Bas, Yuliia, Dudenko, Dmytro, Mykhailiuk, Pavel K
Published in Nature communications (02.10.2023)
Published in Nature communications (02.10.2023)
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Difluoromethyl Nitrile Oxide (CF2HCNO): A Neglected Chemical Reagent
Khutorianskyi, Andrii, Chalyk, Bohdan, Borysko, Petro, Kondratiuk, Anna, Mykhailiuk, Pavel K.
Published in European journal of organic chemistry (25.07.2017)
Published in European journal of organic chemistry (25.07.2017)
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Discovery of Novel N-Acylhydrazone Derivatives as Potent Inhibitors of Sirtuin-1
Lipson, Victoria V., Yaremenko, Fedyr G., Vakula, Volodymyr M., Kovalenko, Svitlana V., Kyrychenko, Alexander V., Desenko, Sergiy M., Borysko, Petro О., Zozulya, Sergiy O.
Published in SynOpen (2017) (01.04.2024)
Published in SynOpen (2017) (01.04.2024)
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SAR by Space: Enriching Hit Sets from the Chemical Space
Klingler, Franca-Maria, Gastreich, Marcus, Grygorenko, Oleksandr O, Savych, Olena, Borysko, Petro, Griniukova, Anastasia, Gubina, Kateryna E, Lemmen, Christian, Moroz, Yurii S
Published in Molecules (Basel, Switzerland) (26.08.2019)
Published in Molecules (Basel, Switzerland) (26.08.2019)
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Oxa-spirocycles: synthesis, properties and applications
Fominova, Kateryna, Diachuk, Taras, Granat, Dmitry, Savchuk, Taras, Vilchynskyi, Vladyslav, Svitlychnyi, Oleksiy, Meliantsev, Vladyslav, Kovalchuk, Igor, Litskan, Eduard, Levterov, Vadym V, Badlo, Valentyn R, Vaskevych, Ruslan I, Vaskevych, Alla I, Bolbut, Andrii V, Semeno, Volodymyr V, Iminov, Rustam, Shvydenko, Kostiantyn, Kuznetsova, Anastasiia S, Dmytriv, Yurii V, Vysochyn, Daniil, Ripenko, Vasyl, Tolmachev, Andrei A, Pavlova, Olexandra, Kuznietsova, Halyna, Pishel, Iryna, Borysko, Petro, Mykhailiuk, Pavel K
Published in Chemical science (Cambridge) (01.09.2021)
Published in Chemical science (Cambridge) (01.09.2021)
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In Vitro Evaluation of In Silico Screening Approaches in Search for Selective ACE2 Binding Chemical Probes
Rayevsky, Alexey V, Poturai, Andrii S, Kravets, Iryna O, Pashenko, Alexander E, Borisova, Tatiana A, Tolstanova, Ganna M, Volochnyuk, Dmitriy M, Borysko, Petro O, Vadzyuk, Olga B, Alieksieieva, Diana O, Zabolotna, Yuliana, Klimchuk, Olga, Horvath, Dragos, Marcou, Gilles, Ryabukhin, Sergey V, Varnek, Alexandre
Published in Molecules (Basel, Switzerland) (24.08.2022)
Published in Molecules (Basel, Switzerland) (24.08.2022)
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Synthesis of methotrexate-betulonic acid hybrids and evaluation of their effect on artificial and Caco-2 cell membranes
Semenenko, Olexander M., Lipson, Victoria V., Sadchenko, Alina O., Vashchenko, Olga V., Kasian, Natalia A., Sviechnikova, Liliia, Lisetski, Longin M., Babak, Mykola L., Vakula, Volodymyr M., Borysov, Oleksandr, Holota, Yuliia, Zozulya, Sergey O., Borysko, Petro O., Mazepa, Olexander
Published in Steroids (01.01.2024)
Published in Steroids (01.01.2024)
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Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry
Krasavin, Mikhail, Kalinin, Stanislav, Zozulya, Sergey, Gryniukova, Anastasiia, Borysko, Petro, Angeli, Andrea, Supuran, Claudiu T.
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
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Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement
Krasavin, Mikhail, Kalinin, Stanislav, Zozulya, Sergey, Griniukova, Anastasia, Borysko, Petro, Angeli, Andrea, Supuran, Claudiu T.
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
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A prospective compound screening contest identified broader inhibitors for Sirtuin 1
Chiba, Shuntaro, Ohue, Masahito, Gryniukova, Anastasiia, Borysko, Petro, Zozulya, Sergey, Yasuo, Nobuaki, Yoshino, Ryunosuke, Ikeda, Kazuyoshi, Shin, Woong-Hee, Kihara, Daisuke, Iwadate, Mitsuo, Umeyama, Hideaki, Ichikawa, Takaaki, Teramoto, Reiji, Hsin, Kun-Yi, Gupta, Vipul, Kitano, Hiroaki, Sakamoto, Mika, Higuchi, Akiko, Miura, Nobuaki, Yura, Kei, Mochizuki, Masahiro, Ramakrishnan, Chandrasekaran, Thangakani, A Mary, Velmurugan, D, Gromiha, M Michael, Nakane, Itsuo, Uchida, Nanako, Hakariya, Hayase, Tan, Modong, Nakamura, Hironori K, Suzuki, Shogo D, Ito, Tomoki, Kawatani, Masahiro, Kudoh, Kentaroh, Takashina, Sakurako, Yamamoto, Kazuki Z, Moriwaki, Yoshitaka, Oda, Keita, Kobayashi, Daisuke, Okuno, Tatsuya, Minami, Shintaro, Chikenji, George, Prathipati, Philip, Nagao, Chioko, Mohsen, Attayeb, Ito, Mari, Mizuguchi, Kenji, Honma, Teruki, Ishida, Takashi, Hirokawa, Takatsugu, Akiyama, Yutaka, Sekijima, Masakazu
Published in Scientific reports (20.12.2019)
Published in Scientific reports (20.12.2019)
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An iterative compound screening contest method for identifying target protein inhibitors using the tyrosine-protein kinase Yes
Chiba, Shuntaro, Ishida, Takashi, Ikeda, Kazuyoshi, Mochizuki, Masahiro, Teramoto, Reiji, Taguchi, Y-H, Iwadate, Mitsuo, Umeyama, Hideaki, Ramakrishnan, Chandrasekaran, Thangakani, A Mary, Velmurugan, D, Gromiha, M Michael, Okuno, Tatsuya, Kato, Koya, Minami, Shintaro, Chikenji, George, Suzuki, Shogo D, Yanagisawa, Keisuke, Shin, Woong-Hee, Kihara, Daisuke, Yamamoto, Kazuki Z, Moriwaki, Yoshitaka, Yasuo, Nobuaki, Yoshino, Ryunosuke, Zozulya, Sergey, Borysko, Petro, Stavniichuk, Roman, Honma, Teruki, Hirokawa, Takatsugu, Akiyama, Yutaka, Sekijima, Masakazu
Published in Scientific reports (20.09.2017)
Published in Scientific reports (20.09.2017)
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The iterative application of a large chemical space in the drug discovery process
Savych, Olena V., Gryniukova, Anastasia V., Alieksieieva, Diana O., Dziuba, Igor M., Borysko, Petro O., Dudenko, Dmytro V., Brovarets, Volodymyr S., Moroz, Yurii S.
Published in Z͡h︡urnal orhanichnoï ta farmat͡s︡evtychnoï khimiï (23.12.2021)
Published in Z͡h︡urnal orhanichnoï ta farmat͡s︡evtychnoï khimiï (23.12.2021)
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2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring
Denisenko, Aleksandr, Garbuz, Pavel, Voloshchuk, Nataliya M. M., Holota, Yuliia, Al-Maali, Galeb, Borysko, Petro, Mykhailiuk, Pavel K. K.
Published in Nature chemistry (01.08.2023)
Published in Nature chemistry (01.08.2023)
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Acidity of saturated (hetero)cyclic α-fluoro carboxylic acids and lipophilicity of their amide derivatives
Pidvyshennyi, Oleksii, Melnykov, Kostiantyn P., Liashuk, Oleksandr, Lesyk, Dmytro, Holota, Yuliia, Borysko, Petro, Grygorenko, Oleksandr O.
Published in Journal of fluorine chemistry (01.08.2024)
Published in Journal of fluorine chemistry (01.08.2024)
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Magnet for the Needle in Haystack: “Crystal Structure First” Fragment Hits Unlock Active Chemical Matter Using Targeted Exploration of Vast Chemical Spaces
Müller, Janis, Klein, Raphael, Tarkhanova, Olga, Gryniukova, Anastasiia, Borysko, Petro, Merkl, Stefan, Ruf, Moritz, Neumann, Alexander, Gastreich, Marcus, Moroz, Yurii S., Klebe, Gerhard, Glinca, Serghei
Published in Journal of medicinal chemistry (08.12.2022)
Published in Journal of medicinal chemistry (08.12.2022)
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