From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9
Petrilli, Whitney L., Adam, Gregory C., Erdmann, Roman S., Abeywickrema, Pravien, Agnani, Vijayalakshmi, Ai, Xi, Baysarowich, Jen, Byrne, Noel, Caldwell, John P., Chang, Wonsuk, DiNunzio, Edward, Feng, Zhe, Ford, Rachael, Ha, Sookhee, Huang, Yongcheng, Hubbard, Brian, Johnston, Jennifer M., Kavana, Michael, Lisnock, Jean-Marie, Liang, Rui, Lu, Jun, Lu, Zhijian, Meng, Juncai, Orth, Peter, Palyha, Oksana, Parthasarathy, Gopal, Salowe, Scott P., Sharma, Sujata, Shipman, Jennifer, Soisson, Stephen M., Strack, Alison M., Youm, Hyewon, Zhao, Kake, Zink, Deborah L., Zokian, Hratch, Addona, George H., Akinsanya, Karen, Tata, James R., Xiong, Yusheng, Imbriglio, Jason E.
Published in Cell chemical biology (16.01.2020)
Published in Cell chemical biology (16.01.2020)
Get full text
Journal Article
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9
Petrilli, Whitney L, Adam, Gregory C, Erdmann, Roman S, Abeywickrema, Pravien, Agnani, Vijayalakshmi, Ai, Xi, Baysarowich, Jen, Byrne, Noel, Caldwell, John P, Chang, Wonsuk, DiNunzio, Edward, Feng, Zhe, Ford, Rachael, Ha, Sookhee, Huang, Yongcheng, Hubbard, Brian, Johnston, Jennifer M, Kavana, Michael, Lisnock, Jean-Marie, Liang, Rui, Lu, Jun, Lu, Zhijian, Meng, Juncai, Orth, Peter, Palyha, Oksana, Parthasarathy, Gopal, Salowe, Scott P, Sharma, Sujata, Shipman, Jennifer, Soisson, Stephen M, Strack, AlisonM, Youm, Hyewon, Zhao, Kake, Zink, Deborah L, Zokian, Hratch, Addona, George H, Akinsanya, Karen, Tata, James R, Xiong, Yusheng, Imbriglio, Jason E
Published in Cell chemical biology (18.02.2021)
Published in Cell chemical biology (18.02.2021)
Get full text
Journal Article
Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension
Petrilli, Whitney L, Hoyt, Scott B, London, Clare, McMasters, Daniel, Verras, Andreas, Struthers, Mary, Cully, Doris, Wisniewski, Thomas, Ren, Ning, Bopp, Charlene, Sok, Andrea, Chen, Qing, Li, Ying, Tung, Elaine, Tang, Wei, Salituro, Gino, Knemeyer, Ian, Karanam, Bindhu, Clemas, Joseph, Zhou, Gaochao, Gibson, Jack, Shipley, Carrie Ann, MacNeil, Douglas J, Duffy, Ruth, Tata, James R, Ujjainwalla, Feroze, Ali, Amjad, Xiong, Yusheng
Published in ACS medicinal chemistry letters (12.01.2017)
Published in ACS medicinal chemistry letters (12.01.2017)
Get full text
Journal Article
헬리오스의 피페리디닐 소분자 분해 및 사용 방법들
ZHANG TINGHU, LIU HU, BEAR BRIAN, PETRILLI WHITNEY, JONES LYN, CHE JIANWEI
Year of Publication 21.06.2023
Get full text
Year of Publication 21.06.2023
Patent
Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys
Hoyt, Scott B, Petrilli, Whitney, London, Clare, Liang, Gui-Bai, Tata, Jim, Hu, Qingzhong, Yin, Lina, van Koppen, Chris J, Hartmann, Rolf W, Struthers, Mary, Wisniewski, Tom, Ren, Ning, Bopp, Charlene, Sok, Andrea, Cai, Tian-Quan, Stribling, Sloan, Pai, Lee-Yuh, Ma, Xiuying, Metzger, Joe, Verras, Andreas, McMasters, Daniel, Chen, Qing, Tung, Elaine, Tang, Wei, Salituro, Gino, Buist, Nicole, Clemas, Joe, Zhou, Gaochao, Gibson, Jack, Maxwell, Carrie Ann, Lassman, Mike, McLaughlin, Theresa, Castro-Perez, Jose, Szeto, Daphne, Forrest, Gail, Hajdu, Richard, Rosenbach, Mark, Xiong, Yusheng
Published in ACS medicinal chemistry letters (13.08.2015)
Published in ACS medicinal chemistry letters (13.08.2015)
Get full text
Journal Article
PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE
Liu, Hu, Petrilli, Whitney, Zhang, Tinghu, Che, Jianwei, Jones, Lyn, Bear, Brian
Year of Publication 01.02.2024
Get full text
Year of Publication 01.02.2024
Patent
PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE
JONES, Lyn, CHE, Jianwei, LIU, Hu, ZHANG, Tinghu, PETRILLI, Whitney, BEAR, Brian
Year of Publication 23.08.2023
Get full text
Year of Publication 23.08.2023
Patent
Piperidinyl small molecule degraders of helios and methods of use
JONES, Lyn, CHE, Jianwei, LIU, Hu, ZHANG, Tinghu, PETRILLI, Whitney, BEAR, Brian
Year of Publication 30.03.2023
Get full text
Year of Publication 30.03.2023
Patent
PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE
JONES, Lyn, CHE, Jianwei, LIU, Hu, ZHANG, Tinghu, PETRILLI, Whitney, BEAR, Brian
Year of Publication 21.04.2022
Get full text
Year of Publication 21.04.2022
Patent
PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE
PETRILLI, WHITNEY, LIU, HU, CHE, JIANWEI, BEAR, BRIAN, JONES, LYN, ZHANG, TINGHU
Year of Publication 21.04.2022
Get full text
Year of Publication 21.04.2022
Patent
SUBSTITUTED 1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE MOLECULES AS PCSK9 ALLOSTERIC BINDERS
LU, Zhijian, XIONG, Yusheng, PETRILLI, Whitney Lane, LIANG, Rui, HOYT, Scott, B, YOUM, Hyewon, TAYLOR, Jerry Andrew, FENG, Zhe, CHANG, Wonsuk, IMBRIGLIO, Jason Eugene
Year of Publication 08.03.2023
Get full text
Year of Publication 08.03.2023
Patent
Substituted 1-methyl-1,2,3,4-tetrahydroisoquinoline molecules as PCSK9 allosteric binders
Imbriglio, Jason Eugene, Lu, Zhijian, Taylor, Jerry Andrew, Chang, Wonsuk, Petrilli, Whitney Lane, Hoyt, Scott B, Feng, Zhe, Liang, Rui, Xiong, Yusheng, Youm, Hyewon
Year of Publication 18.05.2021
Get full text
Year of Publication 18.05.2021
Patent
SUBSTITUTED 1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE MOLECULES AS PCSK9 ALLOSTERIC BINDERS
Imbriglio, Jason Eugene, Lu, Zhijian, Taylor, Jerry Andrew, Chang, Wonsuk, Petrilli, Whitney Lane, Hoyt, Scott B, Feng, Zhe, Liang, Rui, Xiong, Yusheng, Youm, Hyewon
Year of Publication 26.11.2020
Get full text
Year of Publication 26.11.2020
Patent
DEGRADADORES DE MOLÉCULAS PEQUEÑAS DE PIPERIDINILO DE HELIOS Y PROCEDIMIENTOS DE USO
TINGHU ZHANG, LYN JONES, BRIAN BEAR, HU LIU, JIANWEI CHE, WHITNEY PETRILLI
Year of Publication 29.09.2023
Get full text
Year of Publication 29.09.2023
Patent
DEGRADADORES DE MOLECULAS PEQUENAS DE PIPERIDINILO DE HELIOS Y PROCEDIMIENTOS DE USO
JONES, Lyn, CHE, Jianwei, LIU, Hu, ZHANG, Tinghu, PETRILLI, Whitney, BEAR, Brian
Year of Publication 15.08.2023
Get full text
Year of Publication 15.08.2023
Patent