Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease
Vezzoli, Elena, Caron, Ilaria, Talpo, Francesca, Besusso, Dario, Conforti, Paola, Battaglia, Elisa, Sogne, Elisa, Falqui, Andrea, Petricca, Lara, Verani, Margherita, Martufi, Paola, Caricasole, Andrea, Bresciani, Alberto, Cecchetti, Ottavia, Rivetti di Val Cervo, Pia, Sancini, Giulio, Riess, Olaf, Nguyen, Hoa, Seipold, Lisa, Saftig, Paul, Biella, Gerardo, Cattaneo, Elena, Zuccato, Chiara
Published in The Journal of clinical investigation (01.06.2019)
Published in The Journal of clinical investigation (01.06.2019)
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TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
Hegde, Ramanath Narayana, Chiki, Anass, Petricca, Lara, Martufi, Paola, Arbez, Nicolas, Mouchiroud, Laurent, Auwerx, Johan, Landles, Christian, Bates, Gillian P, Singh‐Bains, Malvindar K, Dragunow, Mike, Curtis, Maurice A, Faull, Richard LM, Ross, Christopher A, Caricasole, Andrea, Lashuel, Hilal A
Published in The EMBO journal (01.09.2020)
Published in The EMBO journal (01.09.2020)
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Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes
Valenza, Marta, Leoni, Valerio, Karasinska, Joanna M, Petricca, Lara, Fan, Jianjia, Carroll, Jeffrey, Pouladi, Mahmoud A, Fossale, Elisa, Nguyen, Huu Phuc, Riess, Olaf, MacDonald, Marcy, Wellington, Cheryl, DiDonato, Stefano, Hayden, Michael, Cattaneo, Elena
Published in The Journal of neuroscience (11.08.2010)
Published in The Journal of neuroscience (11.08.2010)
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Striatal infusion of cholesterol promotes dose‐dependent behavioral benefits and exerts disease‐modifying effects in Huntington's disease mice
Birolini, Giulia, Valenza, Marta, Di Paolo, Eleonora, Vezzoli, Elena, Talpo, Francesca, Maniezzi, Claudia, Caccia, Claudio, Leoni, Valerio, Taroni, Franco, Bocchi, Vittoria D, Conforti, Paola, Sogne, Elisa, Petricca, Lara, Cariulo, Cristina, Verani, Margherita, Caricasole, Andrea, Falqui, Andrea, Biella, Gerardo, Cattaneo, Elena
Published in EMBO molecular medicine (07.10.2020)
Published in EMBO molecular medicine (07.10.2020)
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Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay
Cariulo, Cristina, Martufi, Paola, Verani, Margherita, Azzollini, Lucia, Bruni, Giordana, Weiss, Andreas, Deguire, Sean M, Lashuel, Hilal A, Scaricamazza, Eugenia, Sancesario, Giulia Maria, Schirinzi, Tommaso, Mercuri, Nicola Biagio, Sancesario, Giuseppe, Caricasole, Andrea, Petricca, Lara
Published in Frontiers in neuroscience (22.08.2019)
Published in Frontiers in neuroscience (22.08.2019)
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Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy
Fodale, Valentina, Kegulian, Natalie C, Verani, Margherita, Cariulo, Cristina, Azzollini, Lucia, Petricca, Lara, Daldin, Manuel, Boggio, Roberto, Padova, Alessandro, Kuhn, Rainer, Pacifici, Robert, Macdonald, Douglas, Schoenfeld, Ryan C, Park, Hyunsun, Isas, J Mario, Langen, Ralf, Weiss, Andreas, Caricasole, Andrea
Published in PloS one (02.12.2014)
Published in PloS one (02.12.2014)
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Recombinant Adeno Associated Viral (AAV) vector type 9 delivery of Ex1-Q138-mutant huntingtin in the rat striatum as a short-time model for in vivo studies in drug discovery
Ceccarelli, Ilaria, Fiengo, Pasquale, Remelli, Rosaria, Miragliotta, Vincenzo, Rossini, Lara, Biotti, Irene, Cappelli, Alessandra, Petricca, Lara, La Rosa, Salvatore, Caricasole, Andrea, Pollio, Giuseppe, Scali, Carla
Published in Neurobiology of disease (01.02.2016)
Published in Neurobiology of disease (01.02.2016)
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Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
Cariulo, Cristina, Azzollini, Lucia, Verani, Margherita, Martufi, Paola, Boggio, Roberto, Chiki, Anass, Deguire, Sean M., Cherubini, Marta, Gines, Silvia, Marsh, J. Lawrence, Conforti, Paola, Cattaneo, Elena, Santimone, Iolanda, Squitieri, Ferdinando, Lashuel, Hilal A., Petricca, Lara, Caricasole, Andrea
Published in Proceedings of the National Academy of Sciences - PNAS (12.12.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (12.12.2017)
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A user's guide for α‐synuclein biomarker studies in biological fluids: Perianalytical considerations
Mollenhauer, Brit, Batrla, Richard, El‐Agnaf, Omar, Galasko, Douglas R., Lashuel, Hilal A., Merchant, Kalpana M., Shaw, Lesley M., Selkoe, Dennis J., Umek, Robert, Vanderstichele, Hugo, Zetterberg, Henrik, Zhang, Jing, Caspell‐Garcia, Chelsea, Coffey, Chris, Hutten, Samantha J., Frasier, Mark, Taylor, Peggy
Published in Movement disorders (01.08.2017)
Published in Movement disorders (01.08.2017)
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IKBKB reduces huntingtin aggregation by phosphorylating serine 13 via a non-canonical IKK pathway
Cariulo, Cristina, Martufi, Paola, Verani, Margherita, Toledo-Sherman, Leticia, Lee, Ramee, Dominguez, Celia, Petricca, Lara, Caricasole, Andrea
Published in Life science alliance (01.10.2023)
Published in Life science alliance (01.10.2023)
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Journal Article
Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13
Cariulo, Cristina, Verani, Margherita, Martufi, Paola, Ingenito, Raffaele, Finotto, Marco, Deguire, Sean M., Lavery, Daniel J., Toledo-Sherman, Leticia, Lee, Ramee, Doherty, Elizabeth M., Vogt, Thomas F., Dominguez, Celia, Lashuel, Hilal A., Petricca, Lara, Caricasole, Andrea
Published in Biochemical and biophysical research communications (15.01.2020)
Published in Biochemical and biophysical research communications (15.01.2020)
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Comparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms
Petricca, Lara, Chiki, Nour, Hanna-El-Daher, Layane, Aeschbach, Lorène, Burai, Ritwik, Stoops, Erik, Fares, Mohamed-Bilal, Lashuel, Hilal A
Published in Journal of Parkinson's disease (01.01.2022)
Published in Journal of Parkinson's disease (01.01.2022)
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Journal Article
Conformational modulation mediated by polyglutamine expansion in CAG repeat expansion disease-associated proteins
Verani, Margherita, Bustamante, Maria, Martufi, Paola, Daldin, Manuel, Cariulo, Cristina, Azzollini, Lucia, Fodale, Valentina, Puglisi, Francesca, Weiss, Andreas, Macdonald, Douglas, Petricca, Lara, Caricasole, Andrea
Published in Biochemical and biophysical research communications (16.09.2016)
Published in Biochemical and biophysical research communications (16.09.2016)
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Journal Article
Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ
Bustamante, Maria Blaire, Ansaloni, Annalisa, Pedersen, Jeppe Falsig, Azzollini, Lucia, Cariulo, Cristina, Wang, Zhe-Ming, Petricca, Lara, Verani, Margherita, Puglisi, Francesca, Park, Hyunsun, Lashuel, Hilal, Caricasole, Andrea
Published in Biochemical and biophysical research communications (07.08.2015)
Published in Biochemical and biophysical research communications (07.08.2015)
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Journal Article
Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells
Massai, Luisa, Petricca, Lara, Magnoni, Letizia, Rovetini, Luca, Haider, Salman, Andre, Ralph, Tabrizi, Sarah J, Süssmuth, Sigurd D, Landwehrmeyer, Bernhard G, Caricasole, Andrea, Pollio, Giuseppe, Bernocco, Simonetta
Published in BMC biochemistry (25.11.2013)
Published in BMC biochemistry (25.11.2013)
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Journal Article
Comparative analysis of total alpha-synuclein (αSYN) immunoassays reveals that they do not capture the diversity of modified αSYN proteoforms
Petricca, Lara, Nour Chiki, Hanna-El-Daher, Layane, Aeschbach, Lorene, Burai, Ritwik, Stoops, Erik, Mohamed-Bilal, Fares, Lashuel, Hilal
Published in bioRxiv (14.03.2022)
Published in bioRxiv (14.03.2022)
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Paper
Dose-dependent and disease-modifying effects of striatal infusion of cholesterol in Huntington's disease
Birolini, Giulia, Valenza, Marta, Dipaolo, Eleonora, Vezzoli, Elena, Talpo, Francesca, Maniezzi, Claudia, Caccia, Claudio, Leoni, Valerio, Bocchi, Vittoria D, Conforti, Paola, Sogne, Elisa, Petricca, Lara, Cariulo, Cristina, Verani, Margherita, Caricasole, Andrea, Falqui, Andrea, Biella, Gerardo, Cattaneo, Elena
Published in bioRxiv (15.05.2020)
Published in bioRxiv (15.05.2020)
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TBK1 regulates autophagic clearance of soluble mutant huntingtin and inhibits aggregation/toxicity in different models of Huntington's disease
Hegde, Ramanath Narayana, Chiki, Anass, Petricca, Lara, Martufi, Paola, Arbez, Nicolas, Mouchiroud, Laurent, Auwerx, Johan, Landles, Christian, Bates, Gillian P, Singh-Bains, Malvindar K, Curtis, Maurice A, Faull, Richard L M, Ross, Christopher A, Caricasole, Andrea, Lashuel, Hilal A
Published in bioRxiv (10.12.2019)
Published in bioRxiv (10.12.2019)
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