Synthesis, radiolabeling with fluorine-18 and preliminary in vivo evaluation of a heparan sulphate mimetic as potent angiogenesis and heparanase inhibitor for cancer applications
Kuhnast, B., El Hadri, A., Boisgard, R., Hinnen, F., Richard, S., Caravano, A., Nancy-Portebois, V., Petitou, M., Tavitian, B., Dolle, F.
Published in Organic & biomolecular chemistry (01.01.2016)
Published in Organic & biomolecular chemistry (01.01.2016)
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Reversible biotinylated oligosaccharides: a new approach for a better management of anticoagulant therapy
SAVI, P., HERAULT, J. P., DUCHAUSSOY, P., MILLET, L., SCHAEFFER, P., PETITOU, M., BONO, F., HERBERT, J. M.
Published in Journal of thrombosis and haemostasis (01.10.2008)
Published in Journal of thrombosis and haemostasis (01.10.2008)
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First in man study of EP217609, a new long-acting, neutralisable parenteral antithrombotic with a dual mechanism of action
Gueret, Pierre, Combe, S., Krezel, C., Fuseau, E., van Giersbergen, P. L. M., Petitou, M., Neuhart, E.
Published in European journal of clinical pharmacology (01.09.2016)
Published in European journal of clinical pharmacology (01.09.2016)
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Neutralization of EP217609, a new dual-action FIIa/FXa anticoagulant, by its specific antidote avidin: a phase I study
Gueret, P., Combe, S., Krezel, C., Fuseau, E., van Giersbergen, P. L. M., Petitou, M., Neuhart, E.
Published in European journal of clinical pharmacology (2017)
Published in European journal of clinical pharmacology (2017)
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EP42675, a synthetic parenteral dual‐action anticoagulant: pharmacokinetics, pharmacodynamics, and absence of interactions with antiplatelet drugs
Gueret, P., Krezel, C., Fuseau, E., Giersbergen, P. L. M., Petitou, M., Neuhart, E.
Published in Journal of thrombosis and haemostasis (01.01.2014)
Published in Journal of thrombosis and haemostasis (01.01.2014)
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Biochemical and Pharmacological Properties of SANORG 34006, a Potent and Long-Acting Synthetic Pentasaccharide
Herbert, J.M., Hérault, J.P., Bernat, A., van Amsterdam, R.G.M., Lormeau, J.C., Petitou, M., van Boeckel, C., Hoffmann, P., Meuleman, D.G.
Published in Blood (01.06.1998)
Published in Blood (01.06.1998)
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Conformation of heparin pentasaccharide bound to antithrombin III
Hricovíni, M, Guerrini, M, Bisio, A, Torri, G, Petitou, M, Casu, B
Published in Biochemical journal (15.10.2001)
Published in Biochemical journal (15.10.2001)
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Reversible biotinylated oligosaccharides: a new approach for a better management of anticoagulant therapy
SAVI, P., HERAULT, J.P., DUCHAUSSOY, P., MILLET, L., SCHAEFFER, P., PETITOU, M., BONO, F., HERBERT, J.M.
Published in Journal of thrombosis and haemostasis (01.10.2008)
Published in Journal of thrombosis and haemostasis (01.10.2008)
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SR123781A, a synthetic heparin mimetic
Herbert, J M, Hérault, J P, Bernat, A, Savi, P, Schaeffer, P, Driguez, P A, Duchaussoy, P, Petitou, M
Published in Thrombosis and haemostasis (01.05.2001)
Published in Thrombosis and haemostasis (01.05.2001)
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Conformational flexibility: a new concept for explaining binding and biological properties of iduronic acid-containing glycosaminoglycans
Casu, B., Petitou, M., Provasoli, M., Sinaÿ, P.
Published in Trends in Biochemical Sciences (01.06.1988)
Published in Trends in Biochemical Sciences (01.06.1988)
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Book Review
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Pharmacokinetics of new synthetic heparin mimetics
Hérault, J P, Bernat, A, Roye, F, Michaux, C, Schaeffer, P, Bono, F, Petitou, M, Herbert, J M
Published in Thrombosis and haemostasis (01.06.2002)
Published in Thrombosis and haemostasis (01.06.2002)
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The structure of synthetic oligosaccharides in relation to factor IXa inhibition
Hérault, J P, Gaich, C, Bono, F, Driguez, P A, Duchaussoy, P, Petitou, M, Herbert, J M
Published in Thrombosis and haemostasis (01.09.2002)
Published in Thrombosis and haemostasis (01.09.2002)
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Journal Article
Experimental Proof for the Structure of a Thrombin-Inhibiting Heparin Molecule
Petitou, Maurice, Imberty, Anne, Duchaussoy, Philippe, Driguez, Pierre-Alexandre, Ceccato, Marie-Line, Gourvenec, Françoise, Sizun, Philippe, Hérault, Jean-Pascal, Pérez, Serge, Herbert, Jean-Marc
Published in Chemistry : a European journal (16.02.2001)
Published in Chemistry : a European journal (16.02.2001)
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Comparative effects of two synthetic oligosaccharides on platelet activation induced by plasma from HIT patients
Savi, P., Pflieger, A‐M., Hérault, J‐P., Michaux, C., Duchaussoy, P., Petitou, M., Herbert, J‐M.
Published in Journal of thrombosis and haemostasis (01.09.2003)
Published in Journal of thrombosis and haemostasis (01.09.2003)
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Biochemical and Pharmacological Properties of SANORG 32701: Comparison With the `Synthetic Pentasaccharide' (SR 90107/ORG 31540) and Standard Heparin
Herbert, J.M, Herault, J.P, Bernat, A, van Amsterdam, R.G.M, Vogel, G.M.T, Lormeau, J.C, Petitou, M, Meuleman, D.G
Published in Circulation research (01.09.1996)
Published in Circulation research (01.09.1996)
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Glycosaminoglycans enhance megakaryocytopoiesis by modifying the activities of hematopoietic growth regulators
Han, Z. C., Bellucci, S., Shen, Z. X., Maffrand, J. P., Pascal, M., Petitou, M., Lormeau, J., Caen, J. P.
Published in Journal of cellular physiology (01.07.1996)
Published in Journal of cellular physiology (01.07.1996)
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A Synthetic Antithrombin III Binding Pentasaccharide Is Now a Drug! What Comes Next?
Petitou, Maurice, van Boeckel, Constant A. A.
Published in Angewandte Chemie International Edition (14.06.2004)
Published in Angewandte Chemie International Edition (14.06.2004)
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Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity
Choay, J., Petitou, M., Lormeau, J.C., Sinaÿ, P., Casu, B., Gatti, G.
Published in Biochemical and biophysical research communications (31.10.1983)
Published in Biochemical and biophysical research communications (31.10.1983)
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Inhibition of leucocyte elastase by heparin and its derivatives
Redini, F, Tixier, J M, Petitou, M, Choay, J, Robert, L, Hornebeck, W
Published in Biochemical journal (01.06.1988)
Published in Biochemical journal (01.06.1988)
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