Aβ profiles generated by Alzheimer's disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset
Petit, Dieter, Fernández, Sara Gutiérrez, Zoltowska, Katarzyna Marta, Enzlein, Thomas, Ryan, Natalie S, O'Connor, Antoinette, Szaruga, Maria, Hill, Elizabeth, Vandenberghe, Rik, Fox, Nick C, Chávez-Gutiérrez, Lucía
Published in Molecular psychiatry (01.06.2022)
Published in Molecular psychiatry (01.06.2022)
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Journal Article
Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ‐secretase modulators
Petit, Dieter, Hitzenberger, Manuel, Lismont, Sam, Zoltowska, Katarzyna Marta, Ryan, Natalie S, Mercken, Marc, Bischoff, François, Zacharias, Martin, Chávez‐Gutiérrez, Lucía
Published in The EMBO journal (17.06.2019)
Published in The EMBO journal (17.06.2019)
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Journal Article
APP substrate ectodomain defines amyloid‐β peptide length by restraining γ‐secretase processivity and facilitating product release
Koch, Matthias, Enzlein, Thomas, Chen, Shu‐Yu, Petit, Dieter, Lismont, Sam, Zacharias, Martin, Hopf, Carsten, Chávez‐Gutiérrez, Lucía
Published in The EMBO journal (01.12.2023)
Published in The EMBO journal (01.12.2023)
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Journal Article
Enzyme–substrate interface targeting by imidazole‐based γ‐secretase modulators activates γ‐secretase and stabilizes its interaction with APP
Petit, Dieter, Hitzenberger, Manuel, Koch, Matthias, Lismont, Sam, Zoltowska, Katarzyna Marta, Enzlein, Thomas, Hopf, Carsten, Zacharias, Martin, Chávez‐Gutiérrez, Lucía
Published in The EMBO journal (02.11.2022)
Published in The EMBO journal (02.11.2022)
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Journal Article
O3‐01‐04: MECHANISM SECURING ‘γ‐SECRETASE‐APP/Aβ’ COMPLEXES AND REGULATING Aβ LENGTH
Petit, Dieter, Szaruga, Maria, Lismont, Sam, Hitzenberger, Manuel, Zoltowska, Katarzyna Marta, Zacharias, Martin, Gutiérrez, Lucía Chávez
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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