Introduction of a Fluorine Atom at C3 of 3-Deazauridine Shifts Its Antimetabolic Activity from Inhibition of CTP Synthetase to Inhibition of Orotidylate Decarboxylase, an Early Event in the de Novo Pyrimidine Nucleotide Biosynthesis Pathway
Balzarini, Jan, Gago, Federico, Kulik, Wim, van Kuilenburg, André B.P., Karlsson, Anna, Peterson, Matt A., Robins, Morris J.
Published in The Journal of biological chemistry (31.08.2012)
Published in The Journal of biological chemistry (31.08.2012)
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Synthesis and biological evaluation of novel pyrazolo[1,5-a]pyrimidines: Discovery of a selective inhibitor of JAK1 JH2 pseudokinase and VPS34
Singleton, Justin D., Dass, Reuben, Neubert, Nathaniel R., Smith, Rachel M., Webber, Zak, Hansen, Marc D.H., Peterson, Matt A.
Published in Bioorganic & medicinal chemistry letters (15.01.2020)
Published in Bioorganic & medicinal chemistry letters (15.01.2020)
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Discovery of a nanomolar inhibitor of lung adenocarcinoma in vitro
Shelton, Jadd R., Balzarini, Jan, Peterson, Matt A.
Published in Bioorganic & medicinal chemistry letters (01.11.2014)
Published in Bioorganic & medicinal chemistry letters (01.11.2014)
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Synthesis and SAR of 2′,3′-bis-O-substituted N6, 5′-bis-ureidoadenosine derivatives: Implications for prodrug delivery and mechanism of action
Shelton, Jadd R., Cutler, Christopher E., Browning, Megan S., Balzarini, Jan, Peterson, Matt A.
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
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Synthesis and SAR of 2',3'-bis-O-substituted N(6), 5'-bis-ureidoadenosine derivatives: implications for prodrug delivery and mechanism of action
Shelton, Jadd R, Cutler, Christopher E, Browning, Megan S, Balzarini, Jan, Peterson, Matt A
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
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Synthesis, SAR, and preliminary mechanistic evaluation of novel antiproliferative N6,5′-bis-ureido- and 5′-carbamoyl-N6-ureidoadenosine derivatives
Shelton, Jadd R., Cutler, Christopher E., Oliveira, Marcelio, Balzarini, Jan, Peterson, Matt A.
Published in Bioorganic & medicinal chemistry (15.01.2012)
Published in Bioorganic & medicinal chemistry (15.01.2012)
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Synthesis and Biological Evaluation of 6-(Alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one Base and Nucleoside Derivatives
Robins, Morris J, Miranda, Karl, Rajwanshi, Vivek K, Peterson, Matt A, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik, Balzarini, Jan
Published in Journal of medicinal chemistry (12.01.2006)
Published in Journal of medicinal chemistry (12.01.2006)
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Synthesis and Biological Evaluation of 3,3-Difluoropyridine-2,4(1H,3H)-dione and 3-Deaza-3-fluorouracil Base and Nucleoside Derivatives
Robins, Morris J, Yang, Hong, Miranda, Karl, Peterson, Matt A, Clercq, Erik De, Balzarini, Jan
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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Synthesis and Antiviral Evaluation of 6-(Alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one Nucleosides and Analogues with Ethynyl, Ethenyl, and Ethyl Spacers at C6 of the Furopyrimidine Core
Robins, Morris J, Nowak, Ireneusz, Rajwanshi, Vivek K, Miranda, Karl, Cannon, John F, Peterson, Matt A, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik, Balzarini, Jan
Published in Journal of medicinal chemistry (09.08.2007)
Published in Journal of medicinal chemistry (09.08.2007)
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Bergman cycloaromatization of imidazole-fused enediynes: the remarkable effect of N-aryl substitution
Zhao, Zhengrong, Peng, Yunshan, Dalley, N.Kent, Cannon, John F, Peterson, Matt A
Published in Tetrahedron letters (26.04.2004)
Published in Tetrahedron letters (26.04.2004)
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An efficient synthesis of C-6 aminated 3-bromoimidazo[1,2-b]pyridazines
Iorkula, Terungwa H., Tolman, Bryce A., Burt, Scott R., Peterson, Matt A.
Published in Synthetic communications (17.01.2024)
Published in Synthetic communications (17.01.2024)
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