Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes
Sims, Emily K, Bahnson, Henry T, Nyalwidhe, Julius, Haataja, Leena, Davis, Asa K, Speake, Cate, DiMeglio, Linda A, Blum, Janice, Morris, Margaret A, Mirmira, Raghavendra G, Nadler, Jerry, Mastracci, Teresa L, Marcovina, Santica, Qian, Wei-Jun, Yi, Lian, Swensen, Adam C, Yip-Schneider, Michele, Schmidt, C Max, Considine, Robert V, Arvan, Peter, Greenbaum, Carla J, Evans-Molina, Carmella
Published in Diabetes care (01.02.2019)
Published in Diabetes care (01.02.2019)
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Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion
Cunningham, Corey N, He, Kaiyu, Arunagiri, Anoop, Paton, Adrienne W, Paton, James C, Arvan, Peter, Tsai, Billy
Published in Diabetes (New York, N.Y.) (01.03.2017)
Published in Diabetes (New York, N.Y.) (01.03.2017)
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Evolution of insulin at the edge of foldability and its medical implications
Rege, Nischay K., Liu, Ming, Yang, Yanwu, Dhayalan, Balamurugan, Wickramasinghe, Nalinda P., Chen, Yen-Shan, Rahimi, Leili, Guo, Huan, Haataja, Leena, Sun, Jinhong, Ismail-Beigi, Faramarz, Phillips, Nelson B., Arvan, Peter, Weiss, Michael A.
Published in Proceedings of the National Academy of Sciences - PNAS (24.11.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (24.11.2020)
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Integration of ER protein quality control mechanisms defines [beta] cell function and ER architecture
Shrestha, Neha, Torres, Mauricio, Zhang, Jason, Lu, You, Haataja, Leena, Reinert, Rachel B, Knupp, Jeffrey, Chen, Yu-Jie, Parlakgul, Gunes, Arruda, Ana Paula, Tsai, Billy, Arvan, Peter, Qi, Ling
Published in The Journal of clinical investigation (01.01.2023)
Published in The Journal of clinical investigation (01.01.2023)
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Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway
A Avelar, Rita, Gupta, Riya, Carvette, Grace, da Veiga Leprevost, Felipe, Jasti, Medhasri, Colina, Jose, Teitel, Jessica, Nesvizhskii, Alexey I, O'Connor, Caitlin M, Hatzoglou, Maria, Shenolikar, Shirish, Arvan, Peter, Narla, Goutham, DiFeo, Analisa
Published in Cell death and differentiation (30.09.2024)
Published in Cell death and differentiation (30.09.2024)
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SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells
Iida, Hitoshi, Kono, Tatsuyoshi, Lee, Chih-Chun, Krishnan, Preethi, Arvin, Matthew C., Weaver, Staci A., Jarvela, Timothy S., Branco, Renato C. S., McLaughlin, Madeline R., Bone, Robert N., Tong, Xin, Arvan, Peter, Lindberg, Iris, Evans-Molina, Carmella
Published in Diabetologia (01.11.2023)
Published in Diabetologia (01.11.2023)
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Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets
Tran, Duc T, Pottekat, Anita, Lee, Kouta, Raghunathan, Megha, Loguercio, Salvatore, Mir, Saiful A, Paton, Adrienne W, Paton, James C, Arvan, Peter, Kaufman, Randal J, Itkin-Ansari, Pamela
Published in The journal of clinical endocrinology and metabolism (01.11.2022)
Published in The journal of clinical endocrinology and metabolism (01.11.2022)
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The cholinesterase-like domain of thyroglobulin functions as an intramolecular chaperone
Lee, Jaemin, Di Jeso, Bruno, Arvan, Peter
Published in The Journal of clinical investigation (01.08.2008)
Published in The Journal of clinical investigation (01.08.2008)
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Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis
Arunagiri, Anoop, Alam, Maroof, Haataja, Leena, Draz, Hassan, Alasad, Bashiyer, Samy, Praveen, Sadique, Nadeed, Tong, Yue, Cai, Ying, Shakeri, Hadis, Fantuzzi, Federica, Ibrahim, Hazem, Jang, Insook, Sidarala, Vaibhav, Soleimanpour, Scott A., Satin, Leslie S., Otonkoski, Timo, Cnop, Miriam, Itkin‐Ansari, Pamela, Kaufman, Randal J., Liu, Ming, Arvan, Peter
Published in Protein science (01.04.2024)
Published in Protein science (01.04.2024)
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1461-P: Quantifying Proinsulin Misfolding in the Endoplasmic Reticulum
ARUNAGIRI, ANOOP, ALAM, MD MAROOF, HAATAJA, LEENA, SAMY, PRAVEEN J., SOLEIMANPOUR, SCOTT, SATIN, LESLIE S., ITKIN-ANSARI, PAMELA, LIU, MING, ARVAN, PETER
Published in Diabetes (New York, N.Y.) (01.06.2022)
Published in Diabetes (New York, N.Y.) (01.06.2022)
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200-OR: IER3IP1 Is Critical for Maintaining Glucose Homeostasis through Regulating the Endoplasmic Reticulum Function and Survival of ß-Cells
YANG, JING, ZHEN, JINYANG, FENG, WENLI, FAN, ZHENQIAN, HUANG, YUMENG, SHU, HUA, LI, XIN, QIAO, JINGTING, FAN, YUXIN, SUN, JINHONG, LI, NA, LIU, TENGLI, WANG, SHUSEN, ZHANG, XIAONA, ARVAN, PETER, LIU, MING
Published in Diabetes (New York, N.Y.) (01.06.2022)
Published in Diabetes (New York, N.Y.) (01.06.2022)
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Role of Proinsulin Self-Association in Mutant INS Gene-Induced Diabetes of Youth
Sun, Jinhong, Xiong, Yi, Li, Xin, Haataja, Leena, Chen, Wei, Mir, Saiful A, Lv, Li, Madley, Rachel, Larkin, Dennis, Anjum, Arfah, Dhayalan, Balamurugan, Rege, Nischay, Wickramasinghe, Nalinda P, Weiss, Michael A, Itkin-Ansari, Pamela, Kaufman, Randal J, Ostrov, David A, Arvan, Peter, Liu, Ming
Published in Diabetes (New York, N.Y.) (01.05.2020)
Published in Diabetes (New York, N.Y.) (01.05.2020)
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The G209R mutant mouse as a model for human PCSK1 polyendocrinopathy
Shakya, Manita, Gahlot, Surbhi, Martin, Nicolle K, Arunagiri, Anoop, Martin, Martin G, Arvan, Peter, Low, Malcolm J, Lindberg, Iris
Published in Endocrinology (Philadelphia) (01.05.2022)
Published in Endocrinology (Philadelphia) (01.05.2022)
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Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity
Yang, Mei-Ling, Connolly, Sean E, Gee, Renelle J, Lam, TuKiet T, Kanyo, Jean, Peng, Jian, Guyer, Perrin, Syed, Farooq, Tse, Hubert M, Clarke, Steven G, Clarke, Catherine F, James, Eddie A, Speake, Cate, Evans-Molina, Carmella, Arvan, Peter, Herold, Kevan C, Wen, Li, Mamula, Mark J
Published in Diabetes (New York, N.Y.) (01.09.2022)
Published in Diabetes (New York, N.Y.) (01.09.2022)
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2166-P: Sel1L-Hrd1 ERAD Is a Key Regulator of Beta-Cell Function and Identity
SHRESTHA, NEHA, LI, XIN, JI, YEWEI, REINERT, RACHEL B., ARVAN, PETER, QI, LING
Published in Diabetes (New York, N.Y.) (01.06.2019)
Published in Diabetes (New York, N.Y.) (01.06.2019)
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Biological behaviors of mutant proinsulin contribute to the phenotypic spectrum of diabetes associated with insulin gene mutations
Wang, Heting, Saint-Martin, Cécile, Xu, Jialu, Ding, Li, Wang, Ruodan, Feng, Wenli, Liu, Ming, Shu, Hua, Fan, Zhenqian, Haataja, Leena, Arvan, Peter, Bellanné-Chantelot, Christine, Cui, Jingqiu, Huang, Yumeng
Published in Molecular and cellular endocrinology (01.12.2020)
Published in Molecular and cellular endocrinology (01.12.2020)
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Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells
Taneera, Jalal, Prasad, Rashmi B., Dhaiban, Sarah, Mohammed, Abdul Khader, Haataja, Leena, Arvan, Peter, Hamad, Mawieh, Groop, Leif, Wollheim, Claes B.
Published in Molecular and cellular endocrinology (05.09.2018)
Published in Molecular and cellular endocrinology (05.09.2018)
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Abnormalities in proinsulin processing in islets from individuals with longstanding T1D
Sims, Emily K., Syed, Farooq, Nyalwidhe, Julius, Bahnson, Henry T., Haataja, Leena, Speake, Cate, Morris, Margaret A., Balamurugan, Appakalai N., Mirmira, Raghavendra G., Nadler, Jerry, Mastracci, Teresa L., Arvan, Peter, Greenbaum, Carla J., Evans-Molina, Carmella
Published in Translational research : the journal of laboratory and clinical medicine (01.11.2019)
Published in Translational research : the journal of laboratory and clinical medicine (01.11.2019)
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