Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG
Iyer, Sangeetha, Sam, Feba S, DiPrimio, Nina, Preston, Graeme, Verheijen, Jan, Murthy, Kausalya, Parton, Zachary, Tsang, Hillary, Lao, Jessica, Morava, Eva, Perlstein, Ethan O
Published in Disease models & mechanisms (11.11.2019)
Published in Disease models & mechanisms (11.11.2019)
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Journal Article
N-glycoproteomic and proteomic alterations in SRD5A3-deficient fibroblasts
Garapati, Kishore, Ranatunga, Wasantha, Joshi, Neha, Budhraja, Rohit, Sabu, Saniha, Kantautas, Kristin A, Preston, Graeme, Perlstein, Ethan O, Kozicz, Tamas, Morava, Eva, Pandey, Akhilesh
Published in Glycobiology (Oxford) (30.09.2024)
Published in Glycobiology (Oxford) (30.09.2024)
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Journal Article
Sorbitol Is a Severity Biomarker for PMM2‐CDG with Therapeutic Implications
Ligezka, Anna N., Radenkovic, Silvia, Saraswat, Mayank, Garapati, Kishore, Ranatunga, Wasantha, Krzysciak, Wirginia, Yanaihara, Hitoshi, Preston, Graeme, Brucker, William, McGovern, Renee M., Reid, Joel M., Cassiman, David, Muthusamy, Karthik, Johnsen, Christin, Mercimek‐Andrews, Saadet, Larson, Austin, Lam, Christina, Edmondson, Andrew C., Ghesquière, Bart, Witters, Peter, Raymond, Kimiyo, Oglesbee, Devin, Pandey, Akhilesh, Perlstein, Ethan O., Kozicz, Tamas, Morava, Eva
Published in Annals of neurology (01.12.2021)
Published in Annals of neurology (01.12.2021)
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Journal Article
Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit
Vaughen, John P, Theisen, Emma, Rivas-Serna, Irma Magaly, Berger, Andrew B, Kalakuntla, Prateek, Anreiter, Ina, Mazurak, Vera C, Rodriguez, Tamy Portillo, Mast, Joshua D, Hartl, Tom, Perlstein, Ethan O, Reimer, Richard J, Clandinin, M Thomas, Clandinin, Thomas R
Published in Neuron (Cambridge, Mass.) (05.10.2022)
Published in Neuron (Cambridge, Mass.) (05.10.2022)
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Journal Article
Accumulation of an antidepressant in vesiculogenic membranes of yeast cells triggers autophagy
Chen, Jingqiu, Korostyshevsky, Daniel, Lee, Sean, Perlstein, Ethan O
Published in PloS one (18.04.2012)
Published in PloS one (18.04.2012)
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Journal Article
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
Schreiber, Stuart L, Rubinsztein, David C, Sarkar, Sovan, Perlstein, Ethan O, Imarisio, Sara, Pineau, Sandra, Cordenier, Axelle, Maglathlin, Rebecca L, Webster, John A, Lewis, Timothy A, O'Kane, Cahir J
Published in Nature chemical biology (01.06.2007)
Published in Nature chemical biology (01.06.2007)
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Journal Article
Systematic Review: Drug Repositioning for Congenital Disorders of Glycosylation (CDG)
Brasil, Sandra, Allocca, Mariateresa, Magrinho, Salvador C M, Santos, Inês, Raposo, Madalena, Francisco, Rita, Pascoal, Carlota, Martins, Tiago, Videira, Paula A, Pereira, Florbela, Andreotti, Giuseppina, Jaeken, Jaak, Kantautas, Kristin A, Perlstein, Ethan O, Ferreira, Vanessa Dos Reis
Published in International journal of molecular sciences (05.08.2022)
Published in International journal of molecular sciences (05.08.2022)
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Journal Article
Drug screens of NGLY1 deficiency in worm and fly models reveal catecholamine, NRF2 and anti-inflammatory-pathway activation as potential clinical approaches
Iyer, Sangeetha, Mast, Joshua D, Tsang, Hillary, Rodriguez, Tamy P, DiPrimio, Nina, Prangley, Madeleine, Sam, Feba S, Parton, Zachary, Perlstein, Ethan O
Published in Disease models & mechanisms (2019)
Published in Disease models & mechanisms (2019)
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Journal Article
The antidepressant sertraline targets intracellular vesiculogenic membranes in yeast
Rainey, Meredith M, Korostyshevsky, Daniel, Lee, Sean, Perlstein, Ethan O
Published in Genetics (Austin) (01.08.2010)
Published in Genetics (Austin) (01.08.2010)
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Journal Article
Small Molecule Enhancers of Rapamycin-Induced TOR Inhibition Promote Autophagy, Reduce Toxicity in Huntington's Disease Models and Enhance Killing of Mycobacteria by Macrophages
Floto, R. Andres, Sarkar, Sovan, Perlstein, Ethan O., Kampmann, Beate, Schreiber, Stuart L., Rubinsztein, David C.
Published in Autophagy (01.11.2007)
Published in Autophagy (01.11.2007)
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Journal Article
GEX1A, a Polyketide from Streptomyces chromofuscus, Corrects the Cellular Defects Associated with Niemann-Pick Type C1 in Human Fibroblasts
Granatosky, Eve A, DiPrimio, Nina, Pickering, Jarred R. E, Stevens, D. Cole, Perlstein, Ethan O, Taylor, Richard E
Published in Journal of natural products (Washington, D.C.) (28.09.2018)
Published in Journal of natural products (Washington, D.C.) (28.09.2018)
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Journal Article
Genetic basis of individual differences in the response to small-molecule drugs in yeast
Schreiber, Stuart L, Kruglyak, Leonid, Perlstein, Ethan O, Ruderfer, Douglas M, Roberts, David C
Published in Nature genetics (01.04.2007)
Published in Nature genetics (01.04.2007)
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Journal Article
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
Sarkar, Sovan, Perlstein, Ethan O, Imarisio, Sara, Pineau, Sandra, Cordenier, Axelle, Maglathlin, Rebecca L, Webster, John A, Lewis, Timothy A, O'Kane, Cahir J, Schreiber, Stuart L, Rubinsztein, David C
Published in Nature chemical biology (07.05.2007)
Published in Nature chemical biology (07.05.2007)
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