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C. elegans in high-throughput drug discovery
O'Reilly, Linda P., Luke, Cliff J., Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Published in Advanced drug delivery reviews (01.04.2014)
Published in Advanced drug delivery reviews (01.04.2014)
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Autophagy-Enhancing Drug Promotes Degradation of Mutant α₁-Antitrypsin Z and Reduces Hepatic Fibrosis
Hidvegi, Tunda, Ewing, Michael, Hale, Pamela, Dippold, Christine, Beckett, Caroline, Kemp, Carolyn, Maurice, Nicholas, Mukherjee, Amitava, Goldbach, Christina, Watkins, Simon, Michalopoulos, George, Perlmutter, David H
Published in Science (American Association for the Advancement of Science) (09.07.2010)
Published in Science (American Association for the Advancement of Science) (09.07.2010)
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Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy
Oh, Young Mi, Lee, Seong Won, Kim, Woo Kyung, Chen, Shawei, Church, Victoria A., Cates, Kitra, Li, Tiandao, Zhang, Bo, Dolle, Roland E., Dahiya, Sonika, Pak, Stephen C., Silverman, Gary A., Perlmutter, David H., Yoo, Andrew S.
Published in Nature neuroscience (01.11.2022)
Published in Nature neuroscience (01.11.2022)
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Assessing civility at an academic health science center: Implications for employee satisfaction and well-being
Campbell, Lisa A., LaFreniere, Jenna R., Almekdash, Mhd Hasan, Perlmutter, David D., Song, Huaxin, Kelly, Patricia J., Keesari, Rohali, Shannon, Kay Leigh
Published in PloS one (26.02.2021)
Published in PloS one (26.02.2021)
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Functions of autophagy in normal and diseased liver
Czaja, Mark J., Ding, Wen-Xing, Donohue, Terrence M., Friedman, Scott L., Kim, Jae-Sung, Komatsu, Masaaki, Lemasters, John J., Lemoine, Antoinette, Lin, Jiandie D., Ou, Jing-hsiung James, Perlmutter, David H., Randall, Glenn, Ray, Ratna B., Tsung, Allan, Yin, Xiao-Ming
Published in Autophagy (01.08.2013)
Published in Autophagy (01.08.2013)
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Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z
Gosai, Sager J., Kwak, Joon Hyeok, Luke, Cliff J., Long, Olivia S., King, Dale E., Kovatch, Kevin J., Johnston, Paul A., Shun, Tong Ying, Lazo, John S., Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Published in PloS one (12.11.2010)
Published in PloS one (12.11.2010)
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GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration
Winkler, Ethan A, Nishida, Yoichiro, Sagare, Abhay P, Rege, Sanket V, Bell, Robert D, Perlmutter, David, Sengillo, Jesse D, Hillman, Sara, Kong, Pan, Nelson, Amy R, Sullivan, John S, Zhao, Zhen, Meiselman, Herbert J, Wenby, Rosalinda B, Soto, Jamie, Abel, E Dale, Makshanoff, Jacob, Zuniga, Edward, De Vivo, Darryl C, Zlokovic, Berislav V
Published in Nature neuroscience (01.04.2015)
Published in Nature neuroscience (01.04.2015)
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An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z
Wang, Yan, Cobanoglu, Murat C., Li, Jie, Hidvegi, Tunda, Hale, Pamela, Ewing, Michael, Chu, Andrew S., Gong, Zhenwei, Muzumdar, Radhika, Pak, Stephen C., Silverman, Gary A., Bahar, Ivet, Perlmutter, David H.
Published in PloS one (01.01.2019)
Published in PloS one (01.01.2019)
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NFκB mitigates the pathological effects of misfolded α1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms
Mukherjee, Amitava, Hidvegi, Tunda, Araya, Patrick, Ewing, Michael, Stolz, Donna B., Perlmutter, David H.
Published in Cell death and differentiation (01.03.2019)
Published in Cell death and differentiation (01.03.2019)
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Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance
Singh, Itender, Sagare, Abhay P., Coma, Mireia, Perlmutter, David, Gelein, Robert, Bell, Robert D., Deane, Richard J., Zhong, Elaine, Parisi, Margaret, Ciszewski, Joseph, Kasper, R. Tristan, Deane, Rashid
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (03.09.2013)
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Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis
Shi, Qingya, Pei, Fen, Silverman, Gary A., Pak, Stephen C., Perlmutter, David H., Liu, Bing, Bahar, Ivet
Published in International journal of molecular sciences (19.04.2020)
Published in International journal of molecular sciences (19.04.2020)
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Induced pluripotent stem cells model personalized variations in liver disease resulting from α1‐antitrypsin deficiency
Tafaleng, Edgar N., Chakraborty, Souvik, Han, Bing, Hale, Pamela, Wu, Wanquan, Soto‐Gutierrez, Alejandro, Feghali‐Bostwick, Carol A., Wilson, Andrew A., Kotton, Darrell N., Nagaya, Masaki, Strom, Stephen C., Roy‐Chowdhury, Jayanta, Stolz, Donna B., Perlmutter, David H., Fox, Ira J.
Published in Hepatology (Baltimore, Md.) (01.07.2015)
Published in Hepatology (Baltimore, Md.) (01.07.2015)
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Is severe progressive liver disease caused by alpha‐1‐antitrypsin deficiency more common in children or adults?
Chu, Andrew S., Chopra, Kapil B., Perlmutter, David H.
Published in Liver transplantation (01.07.2016)
Published in Liver transplantation (01.07.2016)
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Quantitative assessment of cell fate decision between autophagy and apoptosis
Liu, Bing, Oltvai, Zoltán N., Bayır, Hülya, Silverman, Gary A., Pak, Stephen C., Perlmutter, David H., Bahar, Ivet
Published in Scientific reports (14.12.2017)
Published in Scientific reports (14.12.2017)
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Variants in autophagy genes MTMR12 and FAM134A are putative modifiers of the hepatic phenotype in α1-antitrypsin deficiency
Tafaleng, Edgar N., Li, Jie, Wang, Yan, Hidvegi, Tunda, Soto-Gutierrez, Alex, Locke, Adam E., Nicholas, Thomas J., Wang, Yung-Chun, Pak, Stephen, Cho, Michael H., Silverman, Edwin K., Silverman, Gary A., Jin, Sheng Chih, Fox, Ira J., Perlmutter, David H.
Published in Hepatology (Baltimore, Md.) (01.10.2024)
Published in Hepatology (Baltimore, Md.) (01.10.2024)
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Fluphenazine Reduces Proteotoxicity in C. elegans and Mammalian Models of Alpha-1-Antitrypsin Deficiency
Li, Jie, Pak, Stephen C., O’Reilly, Linda P., Benson, Joshua A., Wang, Yan, Hidvegi, Tunda, Hale, Pamela, Dippold, Christine, Ewing, Michael, Silverman, Gary A., Perlmutter, David H.
Published in PloS one (31.01.2014)
Published in PloS one (31.01.2014)
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