Therapeutically relevant engraftment of a CRISPR-Cas9-edited HSC-enriched population with HbF reactivation in nonhuman primates
Humbert, Olivier, Radtke, Stefan, Samuelson, Clare, Carrillo, Ray R, Perez, Anai M, Reddy, Sowmya S, Lux, Christopher, Pattabhi, Sowmya, Schefter, Lauren E, Negre, Olivier, Lee, Ciaran M, Bao, Gang, Adair, Jennifer E, Peterson, Christopher W, Rawlings, David J, Scharenberg, Andrew M, Kiem, Hans-Peter
Published in Science translational medicine (31.07.2019)
Published in Science translational medicine (31.07.2019)
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Efficient polymer nanoparticle-mediated delivery of gene editing reagents into human hematopoietic stem and progenitor cells
El-Kharrag, Rkia, Berckmueller, Kurt E., Madhu, Ravishankar, Cui, Margaret, Campoy, Gabriela, Mack, Heather M., Wolf, Carl B., Perez, Anai M., Humbert, Olivier, Kiem, Hans-Peter, Radtke, Stefan
Published in Molecular therapy (01.06.2022)
Published in Molecular therapy (01.06.2022)
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Journal Article
Stochastic fate decisions of HSCs after transplantation: early contribution, symmetric expansion, and pool formation
Radtke, Stefan, Enstrom, Mark, Pande, Dnyanada, Duke, Elizabeth R., Cardozo-Ojeda, E. Fabian, Madhu, Ravishankar, Owen, Staci, Kanestrom, Greta, Cui, Margaret, Perez, Anai M., Schiffer, Joshua T., Kiem, Hans-Peter
Published in Blood (06.07.2023)
Published in Blood (06.07.2023)
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Journal Article
Purification of Human CD34+CD90+ HSCs Reduces Target Cell Population and Improves Lentiviral Transduction for Gene Therapy
Radtke, Stefan, Pande, Dnyanada, Cui, Margaret, Perez, Anai M., Chan, Yan-Yi, Enstrom, Mark, Schmuck, Stefanie, Berger, Andrew, Eunson, Tom, Adair, Jennifer E., Kiem, Hans-Peter
Published in Molecular therapy. Methods & clinical development (11.09.2020)
Published in Molecular therapy. Methods & clinical development (11.09.2020)
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Journal Article
Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering
Michels, Kathryn R, Sheih, Alyssa, Hernandez, Susana A, Brandes, Alissa H, Parrilla, Don, Irwin, Blythe, Perez, Anai M, Ting, Hung-An, Nicolai, Christopher J, Gervascio, Timothy, Shin, Seungjin, Pankau, Mark D, Muhonen, Mason, Freeman, Jessica, Gould, Sarah, Getto, Rich, Larson, Ryan P, Ryu, Byoung Y, Scharenberg, Andrew M, Sullivan, Alessandra M, Green, Shon
Published in Journal for immunotherapy of cancer (01.03.2023)
Published in Journal for immunotherapy of cancer (01.03.2023)
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Journal Article
Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
Radtke, Stefan, Perez, Anai M, Venkataraman, Rasika, Reddy, Sowmya, Haworth, Kevin G, Humbert, Olivier, Kiem, Hans-Peter, Peterson, Christopher W
Published in Journal of visualized experiments (15.02.2019)
Published in Journal of visualized experiments (15.02.2019)
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Isolation of a Highly Purified HSC-enriched CD34+CD90+CD45RA− Cell Subset for Allogeneic Transplantation in the Nonhuman Primate Large-animal Model
Radtke, Stefan, Colonna, Lucrezia, Perez, Anai M., Hoffman, Michelle, Kean, Leslie S., Kiem, Hans-Peter
Published in Transplantation direct (01.08.2020)
Published in Transplantation direct (01.08.2020)
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438 In vivo Engineered CAR-T cells for oncology using a surface-engineered lentivirus platform: nonclinical safety and biodistribution
Brandes, Alissa, Koo, Soo Min, Parilla, Don, Hernandez, Susana, Nicolai, Christopher, Sheih, Alyssa, Ting, Anna, Michels, Kathryn, Gervascio, Tim, Coelho, Nanda, Perez, Anai, Freeman, Jessica, Muhonen, Mason, Gould, Sarah, Sullivan, Alessandra M, Teoh, Jeff, Getto, Rich, Ryu, Byoung, Scharenberg, Andrew, Larson, Ryan
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
HSCs Engraft in a Stochastic Pattern and Form Clonal Pools after Transplantation
Radtke, Stefan, Enstrom, Mark, Pande, Dnyanada, Madhu, Ravishankar, Owen, Staci, Kanestrom, Greta, Cui, Margaret, Perez, Anai M, Kiem, Hans-Peter
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Efficient Nanoparticle-Mediated Delivery of Gene Editing Reagents into Human Hematopoietic Stem and Progenitor Cells
El Kharrag, Rkia, Berckmueller, Kurt, Cui, Margaret, Madhu, Ravishankar, Perez, Anai M, Humbert, Olivier, Kiem, Hans-Peter, Radtke, Stefan
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Vivovec™ Surface-Engineered Lentiviral Particles Mediate In Vivo CAR T Generation with Potent and Highly Durable Activity in Non-Human Primates and Tumor-Bearing Humanized Mice
Parker, Maura, Ulrich-Lewis, Justin, Tang, Weiliang, Nicolai, Chris, Michels, Kathryn, Hernandez, Susana, Parrilla, Don, Cooper, Sara, Perez, Anai, McDonnell, Mollie, Hamilton, Greyson, Wu, Chang-Chih, Shin, Seungjin, Scharenberg, Andrew M., Larson, Ryan P., Beitz, Laurie, Ryu, Byoung Y.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Fully Closed, Large-Scale, and Clinical Grade Cell Sorting of Hematopoietic Stem Cell (HSC)-Enriched CD90+ Cells for Transplantation and Gene Therapy
Radtke, Stefan, Cui, Margaret, Perez, Anai M, Chan, Yan-Yi, Schmuck, Stefanie, Berger, Andrew J, Eunson, Thomas, Kiem, Hans-Peter
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Parkinson's disease and diabetes mellitus: common mechanisms and treatment repurposing
Labandeira, Carmen, Fraga-Bau, Arturo, Arias Ron, David, Alvarez-Rodriguez, Elena, Vicente-Alba, Pablo, Lago-Garma, Javier, Rodriguez-Perez, Ana
Published in Neural regeneration research (01.08.2022)
Published in Neural regeneration research (01.08.2022)
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Journal Article
Persistence of CRISPR/Cas9-Edited Hematopoietic Stem and Progenitor Cells and Reactivation of Fetal Hemoglobin in Nonhuman Primates
Humbert, Olivier, Radtke, Stefan, Carillo, Ray R, Perez, Anai M, Reddy, Sowmya Somashekar, Schefter, Lauren E, Lux, Christopher, Pattabhi, Sowmya, Negre, Olivier, Lee, Ciaran M, Adair, Jennifer, Peterson, Christopher, Bao, Gang, Rawlings, David J., Scharenberg, Andrew M., Kiem, Hans-Peter
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
TWO-DIMENSIONAL SIMULATION OF NON-NEWTONIAN FLOW
PÉREZ, ANDRÉS V, REYNA HUANCARA, CUTIRE, FLOR, Perez, Nataly, PEREZ, ANAI
Published in WIT Transactions on the Built Environment (07.12.2020)
Published in WIT Transactions on the Built Environment (07.12.2020)
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