Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor
Perera, Timothy P S, Jovcheva, Eleonora, Mevellec, Laurence, Vialard, Jorge, De Lange, Desiree, Verhulst, Tinne, Paulussen, Caroline, Van De Ven, Kelly, King, Peter, Freyne, Eddy, Rees, David C, Squires, Matthew, Saxty, Gordon, Page, Martin, Murray, Christopher W, Gilissen, Ron, Ward, George, Thompson, Neil T, Newell, David R, Cheng, Na, Xie, Liang, Yang, Jennifer, Platero, Suso J, Karkera, Jayaprakash D, Moy, Christopher, Angibaud, Patrick, Laquerre, Sylvie, Lorenzi, Matthew V
Published in Molecular cancer therapeutics (01.06.2017)
Published in Molecular cancer therapeutics (01.06.2017)
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Journal Article
Quantification and clinical validation of the selective MET kinase inhibitor DO-2 and its metabolites DO-5 and M3 in human plasma
Sikkema, Barend J., Mathijssen, Ron H.J., Robbrecht, Debbie G.J., Perera, Timothy P.S., Koolen, Stijn L.W., de Bruijn, Peter
Published in Journal of pharmaceutical and biomedical analysis (15.03.2024)
Published in Journal of pharmaceutical and biomedical analysis (15.03.2024)
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Journal Article
Induction of MET by Ionizing Radiation and Its Role in Radioresistance and Invasive Growth of Cancer
DE BACCO, Francesca, LURAGHI, Paolo, MEDICO, Enzo, REATO, Gigliola, GIROLAMI, Flavia, PERERA, Timothy, GABRIELE, Pietro, COMOGLIO, Paolo M, BOCCACCIO, Carla
Published in JNCI : Journal of the National Cancer Institute (20.04.2011)
Published in JNCI : Journal of the National Cancer Institute (20.04.2011)
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Journal Article
Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
Bardelli, Alberto, Corso, Simona, Bertotti, Andrea, Hobor, Sebastijan, Valtorta, Emanuele, Siravegna, Giulia, Sartore-Bianchi, Andrea, Scala, Elisa, Cassingena, Andrea, Zecchin, Davide, Apicella, Maria, Migliardi, Giorgia, Galimi, Francesco, Lauricella, Calogero, Zanon, Carlo, Perera, Timothy, Veronese, Silvio, Corti, Giorgio, Amatu, Alessio, Gambacorta, Marcello, Diaz, Jr, Luis A, Sausen, Mark, Velculescu, Victor E, Comoglio, Paolo, Trusolino, Livio, Di Nicolantonio, Federica, Giordano, Silvia, Siena, Salvatore
Published in Cancer discovery (01.06.2013)
Published in Cancer discovery (01.06.2013)
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Journal Article
MET Signaling in Colon Cancer Stem-like Cells Blunts the Therapeutic Response to EGFR Inhibitors
LURAGHI, Paolo, REATO, Gigliola, PERERA, Timothy, BERTOTTI, Andrea, TRUSOLINO, Livio, COMOGLIO, Paolo M, BOCCACCIO, Carla, CIPRIANO, Elia, SASSI, Francesco, ORZAN, Francesca, BIGATTO, Viola, DE BACCO, Francesca, MENIETTI, Elena, MAY HAN, RIDEOUT, William M
Published in Cancer research (Chicago, Ill.) (15.03.2014)
Published in Cancer research (Chicago, Ill.) (15.03.2014)
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Journal Article
Microenvironment-derived HGF overcomes genetically determined sensitivity to anti-MET drugs
Pennacchietti, Selma, Cazzanti, Manuela, Bertotti, Andrea, Rideout, 3rd, William M, Han, May, Gyuris, Jeno, Perera, Timothy, Comoglio, Paolo M, Trusolino, Livio, Michieli, Paolo
Published in Cancer research (Chicago, Ill.) (15.11.2014)
Published in Cancer research (Chicago, Ill.) (15.11.2014)
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Journal Article
Cancer Cells Haploinsufficient for ATM Are Sensitized to PARP Inhibitors by MET Inhibition
D'Ambrosio, Concetta, Erriquez, Jessica, Capellero, Sonia, Cignetto, Simona, Alvaro, Maria, Ciamporcero, Eric, Di Renzo, Maria Flavia, Perera, Timothy, Valabrega, Giorgio, Olivero, Martina
Published in International journal of molecular sciences (21.05.2022)
Published in International journal of molecular sciences (21.05.2022)
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Journal Article
One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancer
Steenbrugge, Jonas, Bellemans, Julie, Vander Elst, Niels, Demeyere, Kristel, De Vliegher, Josephine, Perera, Timothy, De Wever, Olivier, Van Den Broeck, Wim, De Spiegelaere, Ward, Sanders, Niek N., Meyer, Evelyne
Published in Oncoimmunology (31.12.2022)
Published in Oncoimmunology (31.12.2022)
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Journal Article
Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations
GALIMI, Francesco, TORTI, Davide, PARALUPPI, Gianluca, GONELLA, Federica, MAIONE, Francesca, PISACANE, Alberto, DAVID, Ezio, TORCHIO, Bruno, RISIO, Mauro, SALIZZONI, Mauro, CAPUSSOTTI, Lorenzo, PERERA, Timothy, SASSI, Francesco, MEDICO, Enzo, DI RENZO, Maria Flavia, COMOGLIO, Paolo M, TRUSOLINO, Livio, BERTOTTI, Andrea, ISELLA, Claudio, CORA, Davide, GASTALDI, Stefania, RIBERO, Dario, MURATORE, Andrea, MASSUCCO, Paolo, SIATIS, Dimitrios
Published in Clinical cancer research (15.05.2011)
Published in Clinical cancer research (15.05.2011)
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Journal Article
MET exon 14 skipping mutation is a hepatocyte growth factor (HGF)-dependent oncogenic driver in vitro and in humanised HGF knock-in mice
Fernandes, Marie, Hoggard, Brynna, Jamme, Philippe, Paget, Sonia, Truong, Marie-José, Grégoire, Valérie, Vinchent, Audrey, Descarpentries, Clotilde, Morabito, Angela, Stanislovas, Justas, Farage, Enoir, Meneboo, Jean-Pascal, Sebda, Shéhérazade, Bouchekioua-Bouzaghou, Katia, Nollet, Marie, Humez, Sarah, Perera, Timothy, Fromme, Paul, Grumolato, Luca, Figeac, Martin, Copin, Marie-Christine, Tulasne, David, Cortot, Alexis B, Kermorgant, Stéphanie, Kherrouche, Zoulika
Published in Molecular oncology (01.11.2023)
Published in Molecular oncology (01.11.2023)
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Journal Article
phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation
Vivanco, Igor, Rohle, Daniel, Versele, Matthias, Iwanami, Akio, Kuga, Daisuke, Oldrini, Barbara, Tanaka, Kazuhiro, Dang, Julie, Kubek, Sara, Palaskas, Nicolaos, Hsueh, Teli, Evans, Michael, Mulholland, David, Wolle, Daniel, Rajasekaran, Sigrid, Rajasekaran, Ayyappan, Liau, Linda M, Cloughesy, Timothy F, Dikic, Ivan, Brennan, Cameron, Wu, Hong, Mischel, Paul S, Perera, Timothy, Mellinghoff, Ingo K
Published in Proceedings of the National Academy of Sciences - PNAS (06.04.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (06.04.2010)
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Journal Article
OMO-1 reduces progression and enhances cisplatin efficacy in a 4T1-based non-c-MET addicted intraductal mouse model for triple-negative breast cancer
Steenbrugge, Jonas, Vander Elst, Niels, Demeyere, Kristel, De Wever, Olivier, Sanders, Niek N, Van Den Broeck, Wim, Ciamporcero, Eric, Perera, Timothy, Meyer, Evelyne
Published in NPJ breast cancer (17.03.2021)
Published in NPJ breast cancer (17.03.2021)
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Journal Article
Abstract LB-329: Identification of alternative mechanisms of resistance to FGFR inhibitor treatment in FGFR1-amplified large cell compared to FGFR1-amplified small cell lung cancer models
Jovcheva, Eleonora, Ogata, Souichi, Ven, Kelly Van De, Paulussen, Caroline, Weyer, Inez Van de, Wolf, Hans D., Ceulemans, Hugo, McClue, Steve, Vialard, Jorge, Perera, Timothy
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
C-met inhibition blocks bone metastasis development induced by renal cancer stem cells
D’Amico, Lucia, Belisario, Dimas, Migliardi, Giorgia, Grange, Cristina, Bussolati, Benedetta, D’Amelio, Patrizia, Perera, Timothy, Dalmasso, Ettore, Carbonare, Luca Dalle, Godio, Laura, Comoglio, Paolo, Trusolino, Livio, Ferracini, Riccardo, Roato, Ilaria
Published in Oncotarget (19.07.2016)
Published in Oncotarget (19.07.2016)
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Journal Article
A Nuclear SH3 Domain-binding Protein That Colocalizes with mRNA Splicing Factors and Intermediate Filament-containing Perinuclear Networks
Craggs, Graham, Finan, Peter M., Lawson, Durward, Wingfield, Jonathan, Perera, Timothy, Gadher, Smita, Totty, Nicholas F., Kellie, Stuart
Published in The Journal of biological chemistry (10.08.2001)
Published in The Journal of biological chemistry (10.08.2001)
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Journal Article
Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours
Martin, Valentina, Chiriaco, Cristina, Modica, Chiara, Acquadro, Anna, Cortese, Marco, Galimi, Francesco, Perera, Timothy, Gammaitoni, Loretta, Aglietta, Massimo, Comoglio, Paolo M, Vigna, Elisa, Sangiolo, Dario
Published in British journal of cancer (01.03.2019)
Published in British journal of cancer (01.03.2019)
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Journal Article
A Phase I Trial of the Dual MET Kinase/OCT-2 Inhibitor OMO-1 in Metastatic Solid Malignancies Including MET Exon 14 Mutated Lung Cancer
Pruis, Melinda A, Krebs, Matthew G, Plummer, Ruth, De Vos, Filip, Angevin, Eric, Prenen, Hans, Forster, Martin D, Clack, Glen, Van der Aa, Annegret, Tjwa, Marc, Jansen, Ellen, Perera, Timothy, Lolkema, Martijn P
Published in The oncologist (Dayton, Ohio) (11.12.2023)
Published in The oncologist (Dayton, Ohio) (11.12.2023)
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Journal Article
Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases
Reynolds, C. Hugh, Garwood, Claire J., Wray, Selina, Price, Caroline, Kellie, Stuart, Perera, Timothy, Zvelebil, Marketa, Yang, Alice, Sheppard, Paul W., Varndell, Ian M., Hanger, Diane P., Anderton, Brian H.
Published in The Journal of biological chemistry (27.06.2008)
Published in The Journal of biological chemistry (27.06.2008)
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Journal Article
Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody
Pupo, Emanuela, Ducano, Nadia, Lupo, Barbara, Vigna, Elisa, Avanzato, Daniele, Perera, Timothy, Trusolino, Livio, Lanzetti, Letizia, Comoglio, Paolo M
Published in Cancer research (Chicago, Ill.) (01.09.2016)
Published in Cancer research (Chicago, Ill.) (01.09.2016)
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