RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention
Donnelly, Christopher J., Zhang, Ping-Wu, Pham, Jacqueline T., Haeusler, Aaron R., Mistry, Nipun A., Vidensky, Svetlana, Daley, Elizabeth L., Poth, Erin M., Hoover, Benjamin, Fines, Daniel M., Maragakis, Nicholas, Tienari, Pentti J., Petrucelli, Leonard, Traynor, Bryan J., Wang, Jiou, Rigo, Frank, Bennett, C. Frank, Blackshaw, Seth, Sattler, Rita, Rothstein, Jeffrey D.
Published in Neuron (Cambridge, Mass.) (16.10.2013)
Published in Neuron (Cambridge, Mass.) (16.10.2013)
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A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
Pasanen, Petra, Myllykangas, Liisa, Siitonen, Maija, Raunio, Anna, Kaakkola, Seppo, Lyytinen, Jukka, Tienari, Pentti J, Pöyhönen, Minna, Paetau, Anders
Published in Neurobiology of aging (01.09.2014)
Published in Neurobiology of aging (01.09.2014)
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Lewy-related pathology exhibits two anatomically and genetically distinct progression patterns: a population-based study of Finns aged 85
Raunio, Anna, Kaivola, Karri, Tuimala, Jarno, Kero, Mia, Oinas, Minna, Polvikoski, Tuomo, Paetau, Anders, Tienari, Pentti J., Myllykangas, Liisa
Published in Acta neuropathologica (01.11.2019)
Published in Acta neuropathologica (01.11.2019)
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Journal Article
Age-related penetrance of the C9orf72 repeat expansion
Murphy, Natalie A, Arthur, Karissa C, Tienari, Pentti J, Houlden, Henry, Chiò, Adriano, Traynor, Bryan J
Published in Scientific reports (18.05.2017)
Published in Scientific reports (18.05.2017)
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Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study
Laaksovirta, Hannu, MD, Peuralinna, Terhi, MSc, Schymick, Jennifer C, PhD, Scholz, Sonja W, MD, Lai, Shaoi-Lin, MD, Myllykangas, Liisa, MD, Sulkava, Raimo, MD, Jansson, Lilja, Hernandez, Dena G, MSc, Gibbs, J Raphael, BS, Nalls, Michael A, PhD, Heckerman, David, MD, Tienari, Pentti J, MD, Traynor, Bryan J, Dr
Published in Lancet neurology (01.10.2010)
Published in Lancet neurology (01.10.2010)
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Vascular and Alzheimer Disease in Dementia
Strandberg, Timo E., Tienari, Pentti J., Kivimäki, Mika
Published in Annals of neurology (01.05.2020)
Published in Annals of neurology (01.05.2020)
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A novel class of somatic mutations in blood detected preferentially in CD8 + cells
Valori, Miko, Jansson, Lilja, Kiviharju, Anna, Ellonen, Pekka, Rajala, Hanna, Awad, Shady Adnan, Mustjoki, Satu, Tienari, Pentti J
Published in Clinical immunology (Orlando, Fla.) (01.02.2017)
Published in Clinical immunology (Orlando, Fla.) (01.02.2017)
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Fibrinolysis associated proteins and lipopolysaccharide bioactivity in plasma and cerebrospinal fluid in multiple sclerosis
Lehikoinen, Joonas, Strandin, Tomas, Parantainen, Jukka, Nurmi, Katariina, Eklund, Kari K., Rivera, Francisco J., Vaheri, Antti, Tienari, Pentti J.
Published in Journal of neuroimmunology (15.10.2024)
Published in Journal of neuroimmunology (15.10.2024)
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Job-related exhaustion risk variant in UST is associated with dementia and DNA methylation
Sulkava, Sonja, Haukka, Jari, Kaivola, Karri, Doagu, Fatma, Lahtinen, Alexandra, Kantojärvi, Katri, Pärn, Kalle, Palta, Priit, Myllykangas, Liisa, Sulkava, Raimo, Laatikainen, Tiina, Tienari, Pentti J, Paunio, Tiina
Published in Scientific reports (13.06.2024)
Published in Scientific reports (13.06.2024)
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APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical study
Kurki, Samu N, Kantonen, Jonas, Kaivola, Karri, Hokkanen, Laura, Mäyränpää, Mikko I, Puttonen, Henri, Martola, Juha, Pöyhönen, Minna, Kero, Mia, Tuimala, Jarno, Carpén, Olli, Kantele, Anu, Vapalahti, Olli, Tiainen, Marjaana, Tienari, Pentti J, Kaila, Kai, Hästbacka, Johanna, Myllykangas, Liisa
Published in Acta neuropathologica communications (23.12.2021)
Published in Acta neuropathologica communications (23.12.2021)
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Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data
Madsen, I. E. H., Nyberg, S. T., Magnusson Hanson, L. L., Ferrie, J. E., Ahola, K., Alfredsson, L., Batty, G. D., Bjorner, J. B., Borritz, M., Burr, H., Chastang, J.-F., de Graaf, R., Dragano, N., Hamer, M., Jokela, M., Knutsson, A., Koskenvuo, M., Koskinen, A., Leineweber, C., Niedhammer, I., Nielsen, M. L., Nordin, M., Oksanen, T., Pejtersen, J. H., Pentti, J., Plaisier, I., Salo, P., Singh-Manoux, A., Suominen, S., ten Have, M., Theorell, T., Toppinen-Tanner, S., Vahtera, J., Väänänen, A., Westerholm, P. J. M., Westerlund, H., Fransson, E. I., Heikkilä, K., Virtanen, M., Rugulies, R., Kivimäki, M.
Published in Psychological medicine (01.06.2017)
Published in Psychological medicine (01.06.2017)
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Association of Healthy Lifestyle With Years Lived Without Major Chronic Diseases
Nyberg, Solja T, Singh-Manoux, Archana, Pentti, Jaana, Madsen, Ida E H, Sabia, Severine, Alfredsson, Lars, Bjorner, Jakob B, Borritz, Marianne, Burr, Hermann, Goldberg, Marcel, Heikkilä, Katriina, Jokela, Markus, Knutsson, Anders, Lallukka, Tea, Lindbohm, Joni V, Nielsen, Martin L, Nordin, Maria, Oksanen, Tuula, Pejtersen, Jan H, Rahkonen, Ossi, Rugulies, Reiner, Shipley, Martin J, Sipilä, Pyry N, Stenholm, Sari, Suominen, Sakari, Vahtera, Jussi, Virtanen, Marianna, Westerlund, Hugo, Zins, Marie, Hamer, Mark, Batty, G David, Kivimäki, Mika
Published in JAMA internal medicine (01.05.2020)
Published in JAMA internal medicine (01.05.2020)
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The Phenotype of the C9ORF72 Expansion Carriers According to Revised Criteria for bvFTD
Solje, Eino, Aaltokallio, Heidi, Koivumaa-Honkanen, Heli, Suhonen, Noora M, Moilanen, Virpi, Kiviharju, Anna, Traynor, Bryan, Tienari, Pentti J, Hartikainen, Päivi, Remes, Anne M
Published in PloS one (06.07.2015)
Published in PloS one (06.07.2015)
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Hemophagocytic lymphohistiocytosis in 2 patients with multiple sclerosis treated with alemtuzumab
Saarela, Mika, Senthil, Keerthi, Jones, Joanne, Tienari, Pentti J, Soilu-Hänninen, Merja, Airas, Laura, Coles, Alasdair, Saarinen, Jukka T
Published in Neurology (01.05.2018)
Published in Neurology (01.05.2018)
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Genome-wide analysis of the heritability of amyotrophic lateral sclerosis
Keller, Margaux F, Ferrucci, Luigi, Singleton, Andrew B, Tienari, Pentti J, Laaksovirta, Hannu, Restagno, Gabriella, Chiò, Adriano, Traynor, Bryan J, Nalls, Michael A
Published in JAMA neurology (01.09.2014)
Published in JAMA neurology (01.09.2014)
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Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals
Jaago, Mariliis, Rähni, Annika, Pupina, Nadežda, Pihlak, Arno, Sadam, Helle, Tuvikene, Jürgen, Avarlaid, Annela, Planken, Anu, Planken, Margus, Haring, Liina, Vasar, Eero, Baćević, Miljana, Lambert, France, Kalso, Eija, Pussinen, Pirkko, Tienari, Pentti J, Vaheri, Antti, Lindholm, Dan, Timmusk, Tõnis, Ghaemmaghami, Amir M, Palm, Kaia
Published in Scientific reports (07.10.2022)
Published in Scientific reports (07.10.2022)
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The shared ancestry between the C9orf72 hexanucleotide repeat expansion and intermediate-length alleles using haplotype sharing trees and HAPTK
Rautila, Osma S., Kaivola, Karri, Rautila, Harri, Hokkanen, Laura, Launes, Jyrki, Strandberg, Timo E., Laaksovirta, Hannu, Palmio, Johanna, Tienari, Pentti J.
Published in American journal of human genetics (01.02.2024)
Published in American journal of human genetics (01.02.2024)
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