Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
Kurumbail, Ravi G, Stevens, Anna M, Gierse, James K, McDonald, Joseph J, Stegeman, Roderick A, Pak, Jina Y, Gildehaus, Daniel, iyashiro, Julie M, Penning, Thomas D, Seibert, Karen, Isakson, Peter C, Stallings, William C
Published in Nature (London) (26.12.1996)
Published in Nature (London) (26.12.1996)
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Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer
Zhu, Gui-Dong, Gong, Jianchun, Gandhi, Viraj B., Liu, Xuesong, Shi, Yan, Johnson, Eric F., Donawho, Cherrie K., Ellis, Paul A, Bouska, Jennifer J., Osterling, Donald J., Olson, Amanda M., Park, Chang, Luo, Yan, Shoemaker, Alexander, Giranda, Vincent L., Penning, Thomas D.
Published in Bioorganic & medicinal chemistry (01.08.2012)
Published in Bioorganic & medicinal chemistry (01.08.2012)
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Synthesis of potent leukotriene A(4) hydrolase inhibitors. identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid
Penning, TD, Russell, MA, Chen, BB, Chen, HY, Liang, CD, Mahoney, MW, Malecha, JW, Miyashiro, JM, Yu, SS, Askonas, LJ, Gierse, JK, Harding, EI, Highkin, MK, Kachur, JF, Kim, SH, Villani-Price, D, Pyla, EY, Ghoreishi-Haack, NS, Smith, WG
Published in Journal of medicinal chemistry (01.08.2002)
Published in Journal of medicinal chemistry (01.08.2002)
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Structure-activity relationship studies on 1-[2-(4-phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase
Penning, TD, Chandrakumar, NS, Chen, BB, Chen, HY, Desai, BN, Djuric, SW, Docter, SH, Gasiecki, AF, Haack, RA, Miyashiro, JM, Russell, MA, Yu, SS, Corley, DG, Durley, RC, Kilpatrick, BF, Parnas, BL, Askonas, LJ, Gierse, JK, Harding, EI, Highkin, MK, Kachur, JF, Kim, SH, Krivi, GG, Villani-Price, D, Pyla, EY, Smith, WG, Ghoreishi-Haack, NS
Published in Journal of medicinal chemistry (24.02.2000)
Published in Journal of medicinal chemistry (24.02.2000)
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Synthesis of cinnamic acids and related isosteres as potent and selective alpha v beta 3 receptor antagonists
Penning, Thomas D, Russell, Mark A, Chen, Barbara B, Chen, Helen Y, Desai, Bipin N, Docter, Stephen H, Edwards, David J, Gesicki, Glen J, Liang, Chi-Dean, Malecha, James W, Yu, Stella S, Engleman, V Wayne, Freeman, Sandra K, Hanneke, Melanie L, Shannon, Kristen E, Westlin, Marisa M, Nickols, G Allen
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
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Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase
Penning, Thomas D, Chandrakumar, Nizal S, Desai, Bipin N, Djuric, Stevan W, Gasiecki, Alan F, Liang, Chi-Dean, Miyashiro, Julie M, Russell, Mark A, Askonas, Leslie J, Gierse, James K, Harding, Elizabeth I, Highkin, Maureen K, Kachur, James F, Kim, Suzanne H, Villani-Price, Doreen, Pyla, E Yvonne, Ghoreishi-Haack, Nayereh S, Smith, Walter G
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
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Triply convergent synthesis of (-)-prostaglandin E2 methyl ester
Johnson, Carl R, Penning, Thomas D
Published in Journal of the American Chemical Society (01.07.1988)
Published in Journal of the American Chemical Society (01.07.1988)
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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
Kurumbail, Ravi G, Stevens, Anna M, Gierse, James K, McDonald, Joseph J, Stegeman, Roderick A, Pak, Jina Y, Gildehaus, Daniel, Miyashiro, Julie M, Penning, Thomas D, Seibert, Karen, Isakson, Peter C, Stallings, William C
Published in Nature (London) (06.02.1997)
Published in Nature (London) (06.02.1997)
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3,4-diarylthiophenes are selective COX-2 inhibitors
Bertenshaw, Stephen R., Talley, John J., Rogier, D.J., Graneto, Matthew J., Rogers, Roland S., Kramer, Steven W., Penning, Thomas D., Koboldt, Carol M., Veenhuizen, Amy W., Zhang, Yan, Perkins, William E.
Published in Bioorganic & medicinal chemistry letters (07.12.1995)
Published in Bioorganic & medicinal chemistry letters (07.12.1995)
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IMPROVED PROCEDURE FOR THE REDUCTION OF N-ACYLOXAZOLIDINONES
PENNING, TD, DJURIC, SW, HAACK, RA, KALISH, VJ, MIYASHIRO, JM, ROWELL, BW, YU, SS
Published in Synthetic communications (01.01.1990)
Published in Synthetic communications (01.01.1990)
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3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2
Penning, Thomas D., Kramer, Steven W., Lee, Len F., Collins, Paul W., Koboldt, Carol M., Seibert, Karen, Veenhuizen, Amy W., Zhang, Yan Y., Isakson, Peter C.
Published in Bioorganic & medicinal chemistry letters (19.08.1997)
Published in Bioorganic & medicinal chemistry letters (19.08.1997)
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Triply convergent synthesis of (-)-prostaglandin E2
Johnson, Carl R, Penning, Thomas D
Published in Journal of the American Chemical Society (01.09.1986)
Published in Journal of the American Chemical Society (01.09.1986)
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SECOND-GENERATION LEUKOTRIENE-B-4 RECEPTOR ANTAGONISTS RELATED TO SC-41930 - HETEROCYCLIC REPLACEMENT OF THE METHYL KETONE PHARMACOPHORE
PENNING, TD, DJURIC, SW, MIYASHIRO, JM, YU, S, SNYDER, JP, SPANGLER, D, ANGLIN, CP, FRETLAND, DJ, KACHUR, JF, KEITH, RH, TSAI, BS, VILLANIPRICE, D, WALSH, RE, WIDOMSKI, DL
Published in Journal of medicinal chemistry (17.03.1995)
Published in Journal of medicinal chemistry (17.03.1995)
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Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib)
Penning, T D, Talley, J J, Bertenshaw, S R, Carter, J S, Collins, P W, Docter, S, Graneto, M J, Lee, L F, Malecha, J W, Miyashiro, J M, Rogers, R S, Rogier, D J, Yu, S S, AndersonGD, Burton, E G, Cogburn, J N, Gregory, S A, Koboldt, C M, Perkins, W E, Seibert, K, Veenhuizen, A W, Zhang, Y Y, Isakson, P C
Published in Journal of medicinal chemistry (25.04.1997)
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Published in Journal of medicinal chemistry (25.04.1997)
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Synthesis and pharmacological activity of rationally designed inhibitors of the leukotriene A4 hydrolase enzyme
Djuric, Stevan W., Huff, Renee M., Penning, Thomas D., Clare, Michael, Swenton, Lydia, Kachur, James F., Villani-Price, Doreen, Krivi, Gwen G., Pyla, E.Yvonne, Warren, Thomas G.
Published in Bioorganic & medicinal chemistry letters (01.11.1992)
Published in Bioorganic & medicinal chemistry letters (01.11.1992)
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Applications of enzymes in the synthesis of bioactive polyols
Johnson, C. R., Adams, J. P., Bis, S. J., De Jong, R. L., Golebiowski, Adam, Medich, J. R., Penning, T. D., Senanayake, C. H., Steensma, D. H., Van Zandt, M. C.
Published in Pure and applied chemistry (01.01.1992)
Published in Pure and applied chemistry (01.01.1992)
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Conference Proceeding
Leukotriene B4-induced granulocyte trafficking in guinea pig dermis. Effect of second-generation leukotriene B4 receptor antagonists, SC-50605 and SC-51146
Fretland, D J, Widomski, D L, Anglin, C P, Penning, T D, Yu, S, Djuric, S W
Published in Inflammation (01.06.1993)
Published in Inflammation (01.06.1993)
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12(R)-Hydroxyeicosatetraenoic acid is a neutrophil chemoattractant in the cavine, lapine, murine and canine dermis
Fretland, D.J., Widomski, D.L., Zemaitis, J.M., Tsai, B.S., Djuric, S.W., Penning, T.D., Miyashiro, J.M., Bauer, R.F.
Published in Prostaglandins, leukotrienes and essential fatty acids (01.08.1989)
Published in Prostaglandins, leukotrienes and essential fatty acids (01.08.1989)
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