Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors
Yap, Timothy A, O'Carrigan, Brent, Penney, Marina S, Lim, Joline S, Brown, Jessica S, de Miguel Luken, Maria J, Tunariu, Nina, Perez-Lopez, Raquel, Rodrigues, Daniel Nava, Riisnaes, Ruth, Figueiredo, Ines, Carreira, Suzanne, Hare, Brian, McDermott, Katherine, Khalique, Saira, Williamson, Chris T, Natrajan, Rachael, Pettitt, Stephen J, Lord, Christopher J, Banerji, Udai, Pollard, John, Lopez, Juanita, de Bono, Johann S
Published in Journal of clinical oncology (20.09.2020)
Published in Journal of clinical oncology (20.09.2020)
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Journal Article
Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases
Farmer, Luc J, Ledeboer, Mark W, Hoock, Thomas, Arnost, Michael J, Bethiel, Randy S, Bennani, Youssef L, Black, James J, Brummel, Christopher L, Chakilam, Ananthsrinivas, Dorsch, Warren A, Fan, Bin, Cochran, John E, Halas, Summer, Harrington, Edmund M, Hogan, James K, Howe, David, Huang, Hui, Jacobs, Dylan H, Laitinen, Leena M, Liao, Shengkai, Mahajan, Sudipta, Marone, Valerie, Martinez-Botella, Gabriel, McCarthy, Pamela, Messersmith, David, Namchuk, Mark, Oh, Luke, Penney, Marina S, Pierce, Albert C, Raybuck, Scott A, Rugg, Arthur, Salituro, Francesco G, Saxena, Kumkum, Shannon, Dean, Shlyakter, Dina, Swenson, Lora, Tian, Shi-Kai, Town, Christopher, Wang, Jian, Wang, Tiansheng, Wannamaker, M. Woods, Winquist, Raymond J, Zuccola, Harmon J
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Journal Article
Intrahepatic and Peripheral CXCL10 Expression in Hepatitis C Virus-Infected Patients Treated With Telaprevir, Pegylated Interferon, and Ribavirin
Zeremski, Marija, Dimova, Rositsa B., Benjamin, Samantha, Penney, Marina S., Botfield, Martyn C., Talal, Andrew H.
Published in The Journal of infectious diseases (01.06.2015)
Published in The Journal of infectious diseases (01.06.2015)
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Journal Article
Telaprevir‐based treatment effects on hepatitis C virus in liver and blood
Talal, Andrew H., Dimova, Rositsa B., Zhang, Eileen Z., Jiang, Min, Penney, Marina S., Sullivan, James C., Botfield, Martyn C., Chakilam, Ananthsrinivas, Sawant, Rishikesh, Cervini, Christine M., Zeremski, Marija, Jacobson, Ira M., Kwong, Ann D.
Published in Hepatology (Baltimore, Md.) (01.12.2014)
Published in Hepatology (Baltimore, Md.) (01.12.2014)
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Journal Article
PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1
Simeone-Penney, Marina C, Severgnini, Mariano, Rozo, Lilliana, Takahashi, Satoe, Cochran, Brent H, Simon, Amy R
Published in American journal of physiology. Lung cellular and molecular physiology (01.04.2008)
Published in American journal of physiology. Lung cellular and molecular physiology (01.04.2008)
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Journal Article
Telaprevir‐based treatment effects on hepatitis C virus in liver and blood
Talal, Andrew H., Dimova, Rositsa B., Zhang, Eileen Z., Jiang, Min, Penney, Marina S., Sullivan, James C., Botfield, Martyn C., Chakilam, Ananthsrinivas, Sawant, Rishikesh, Cervini, Christine M., Zeremski, Marija, Jacobson, Ira M., Kwong, Ann D.
Published in Hepatology (Baltimore, Md.) (01.12.2014)
Published in Hepatology (Baltimore, Md.) (01.12.2014)
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Journal Article
Abstract 3711: Pre-clinical combinations of ATR and PARP inhibitors: Defining target patient populations and dose schedule
Pollard, John, Reaper, Phil, Peek, Adele, Hughes, Stuart, Djeha, Hakim, Cummings, Steven, Larbi, Karen, Penney, Marina, Sullivan, Jim, Takemoto, Darin, DeFranco, Chris
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 3716: Potent radiation enhancement with VX-984, a selective DNA-PKcs inhibitor for the treatment of NSCLC
Boucher, Diane, Hoover, Russell, Wang, Yuxin, Gu, Yong, Newsome, David, Ford, Pamella, Moody, Cameron, Damagnez, Veronique, Arimoto, Reiko, Hillier, Shawn, Wood, Mark, Markland, William, Eustace, Brenda, Cottrell, Kevin, Penney, Marina, Furey, Brinley, Tanner, Kirk, Maxwell, John, Charifson, Paul
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract CT012: Phase 1 trial of first-in-class ATR inhibitor VX-970 in combination with cisplatin (Cis) in patients (pts) with advanced solid tumors (NCT02157792)
Shapiro, Geoffrey, Wesolowski, Robert, Middleton, Mark, Devoe, Craig, Constantinidou, Anastasia, Papadatos-Pastos, Dionysis, Fricano, Marjorie, Zhang, Yanqiong, Karan, Sharon, Pollard, John, Penney, Marina, Asmal, Mohammed, Renshaw, F. Gary, Fields, Scott Z., Yap, Timothy A.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Phase I trial of first-in-class ATR inhibitor VX-970 in combination with gemcitabine (Gem) in advanced solid tumors (NCT02157792)
Plummer, Elizabeth R., Dean, Emma Jane, Evans, T.R. Jeffry, Greystoke, Alastair, Herbschleb, Karin, Ranson, Malcolm, Brown, Jennifer, Zhang, Yanqiong, Karan, Sharon, Pollard, John, Penney, Marina S., Asmal, Mohammed, Fields, Scott Z., Middleton, Mark R.
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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Journal Article
ATR 억제제를 사용한 암 치료 방법
PENNEY MARINA, TAKEMOTO DARIN, SULLIVAN JAMES, REAPER PHILIP MICHAEL, GEHO DAVID, POLLARD JOHN ROBERT
Year of Publication 10.09.2020
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Year of Publication 10.09.2020
Patent
Abstract 3717: Defining optimal dose schedules for ATR inhibitors in combination with DNA damaging drugs: Informing clinical studies of VX-970, the first-in-class ATR inhibitor
Pollard, John, Reaper, Phil, Peek, Adele, Hughes, Stuart, Gladwell, Scott, Jones, Julie, Chiu, Peter, Wood, Mark, Tolman, Crystal, Johnson, Mac, Littlewood, Peter, Penney, Marina, McDermott, Katherine, Hare, Brian, Fields, Scott Z., Asmal, Mohammed, O’Carrigan, Brent, Yap, Timothy A.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Phase I trial of a first-in-class ATR inhibitor VX-970 as monotherapy (mono) or in combination (combo) with carboplatin (CP) incorporating pharmacodynamics (PD) studies
O'Carrigan, Brent, de Miguel Luken, Maria Jose, Papadatos-Pastos, Dionysios, Brown, Jessica, Tunariu, Nina, Perez Lopez, Raquel, Ganegoda, Mahesha, Riisnaes, Ruth, Figueiredo, Ines, Carreira, Suzanne, Hare, Brian, Yang, Fang, McDermott, Katherine, Penney, Marina S., Pollard, John, Lopez, Juanita Suzanne, Banerji, Udai, De Bono, Johann S., Fields, Scott Z., Yap, Timothy Anthony
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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Journal Article
Abstract 1644: VX-970, the first-in-class inhibitor of the DNA damage repair enzyme ATR
Pollard, John, Reaper, Philip, Jones, Julie, Barnes, Christopher, Gladwell, Scott, Hughes, Stuart, Peak, Adele, Djeha, Hakim, Hall, Amy, Newsome, David, Wang, Yuxin, Boucher, Diane, Eustace, Brenda, Gu, Yong, Hare, Brian, Johnson, Mac, Milton, Sean, Murphy, Cheryl, Takemoto, Darin, Tolman, Crystal, Wood, Mark, Furey, Brinley, Penney, Marina, Li, Howard, Defranco, Christopher, Asmal, Mohammed, Fields, Scott
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract PR14: Phase I trial of first-in-class ataxia telangiectasia-mutated and Rad3-related (ATR) inhibitor VX-970 as monotherapy (mono) or in combination with carboplatin (CP) in advanced cancer patients (pts) with preliminary evidence of target modulation and antitumor activity
Yap, Timothy A., Luken, Maria J. de Miguel, O'Carrigan, Brent, Roda, Desam, Papadatos-Pastos, Dionysis, Lorente, David, Tunariu, Nina, Lopez, Raquel Perez, Gayle, Sasha, Riisnaes, Ruth, Figueiredo, Ines, Miranda, Susana, Carreira, Suzanne, Yang, Fang, Karan, Sharon, Penney, Marina, Pollard, John, Molife, L. Rhoda, Banerji, Udai, Asmal, Mohammed, Fields, Scott Z., Bono, Johann S. de
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
DNA-손상제 및 DNA-PK 저해제의 조합을 사용한 암 치료 방법
BOUCHER DIANE M, HARE BRIAN, MARKLAND WILLIAM, HILLIER SHAWN M, NEWSOME DAVID A, TSAI WANJUNG, PENNEY MARINA S
Year of Publication 05.06.2019
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Year of Publication 05.06.2019
Patent
항증식 화합물 및 이의 용도
HOOVER RUSSELL R, TANG QING, BOYD MICHAEL, DORSCH WARREN, WAAL NATHAN D, TAKEMOTO DARIN, CHANDUPATLA KISHAN, LI PAN, DENG HONGBO, DONG HUIJUN, PENNEY MARINA, LAUFFER DAVID J, YU HENRY, BEMIS GUY, JOHNSON MAC ARTHUR JR, RONKIN STEVEN, WANG TIANSHENG, CLARK MICHAEL, KUKAMI SHASHANK, COLLIER PHILIP
Year of Publication 13.01.2021
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Year of Publication 13.01.2021
Patent