Effects of exenatide and open-label SGLT2 inhibitor treatment, given in parallel or sequentially, on mortality and cardiovascular and renal outcomes in type 2 diabetes: insights from the EXSCEL trial
Clegg, Lindsay E, Penland, Robert C, Bachina, Srinivas, Boulton, David W, Thuresson, Marcus, Heerspink, Hiddo J L, Gustavson, Stephanie, Sjöström, C David, Ruggles, James A, Hernandez, Adrian F, Buse, John B, Mentz, Robert J, Holman, Rury R
Published in Cardiovascular diabetology (22.10.2019)
Published in Cardiovascular diabetology (22.10.2019)
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Predicted Cardiac Hemodynamic Consequences of the Renal Actions of SGLT2i in the DAPA-HF Study Population: A Mathematical Modeling Analysis
Yu, Hongtao, Tang, Weifeng, Greasley, Peter J, Penland, Robert C, Boulton, David W, Hallow, K Melissa
Published in Journal of clinical pharmacology (01.05.2021)
Published in Journal of clinical pharmacology (01.05.2021)
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Reduction of Cardiovascular Risk and Improved Estimated Glomerular Filtration Rate by SGLT2 Inhibitors, Including Dapagliflozin, Is Consistent Across the Class: An Analysis of the Placebo Arm of EXSCEL
Clegg, Lindsay E, Heerspink, Hiddo J L, Penland, Robert C, Tang, Weifeng, Boulton, David W, Bachina, Srinivas, Fox, Robert D, Fenici, Peter, Thuresson, Marcus, Mentz, Robert J, Hernandez, Adrian F, Holman, Rury R
Published in Diabetes care (01.02.2019)
Published in Diabetes care (01.02.2019)
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Potassium homeostasis and therapeutic intervention with sodium zirconium cyclosilicate: A model‐informed drug development case study
Clegg, Lindsay E., Chu, Lulu, Nagard, Mats, Boulton, David W., Penland, Robert C.
Published in CPT: pharmacometrics and systems pharmacology (01.02.2024)
Published in CPT: pharmacometrics and systems pharmacology (01.02.2024)
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Effect of once‐weekly exenatide on estimated glomerular filtration rate slope depends on baseline renal risk: A post hoc analysis of the EXSCEL trial
van der Aart‐van der Beek, Annemarie B., Clegg, Lindsay E., Penland, Robert C., Boulton, David W., Sjöström, C. David, Mentz, Robert J., Holman, Rury R., Heerspink, Hiddo J. L.
Published in Diabetes, obesity & metabolism (01.12.2020)
Published in Diabetes, obesity & metabolism (01.12.2020)
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A mechanistic modeling platform of SGLT2 inhibition: Implications for type 1 diabetes
Sokolov, Victor, Yakovleva, Tatiana, Stolbov, Leonid, Penland, Robert C., Boulton, David, Parkinson, Joanna, Tang, Weifeng
Published in CPT: pharmacometrics and systems pharmacology (01.06.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.06.2023)
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Differentiating the Sodium‐Glucose Cotransporter 1 Inhibition Capacity of Canagliflozin vs. Dapagliflozin and Empagliflozin Using Quantitative Systems Pharmacology Modeling
Sokolov, Victor, Yakovleva, Tatiana, Chu, Lulu, Tang, Weifeng, Greasley, Peter J., Johansson, Susanne, Peskov, Kirill, Helmlinger, Gabriel, Boulton, David W., Penland, Robert C.
Published in CPT: pharmacometrics and systems pharmacology (01.04.2020)
Published in CPT: pharmacometrics and systems pharmacology (01.04.2020)
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Quantitative Systems Pharmacology: An Exemplar Model‐Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development
Helmlinger, Gabriel, Sokolov, Victor, Peskov, Kirill, Hallow, Karen M., Kosinsky, Yuri, Voronova, Veronika, Chu, Lulu, Yakovleva, Tatiana, Azarov, Ivan, Kaschek, Daniel, Dolgun, Artem, Schmidt, Henning, Boulton, David W., Penland, Robert C.
Published in CPT: pharmacometrics and systems pharmacology (01.06.2019)
Published in CPT: pharmacometrics and systems pharmacology (01.06.2019)
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Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation
Erdemli, Gül, Kim, Albert M, Ju, Haisong, Springer, Clayton, Penland, Robert C, Hoffmann, Peter K
Published in Frontiers in pharmacology (01.01.2012)
Published in Frontiers in pharmacology (01.01.2012)
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Dapagliflozin pharmacokinetics is similar between patients with heart failure with reduced ejection fraction and patients with type 2 diabetes mellitus
Melin, Johanna, Parkinson, Joanna, Hamrén, Bengt, Penland, Robert C., Boulton, David W., Tang, Weifeng
Published in British journal of clinical pharmacology (01.02.2024)
Published in British journal of clinical pharmacology (01.02.2024)
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A model‐based approach to investigating the relationship between glucose‐insulin dynamics and dapagliflozin treatment effect in patients with type 2 diabetes
Shah, Millie, Stolbov, Leonid, Yakovleva, Tatiana, Tang, Weifeng, Sokolov, Victor, Penland, Robert C., Boulton, David, Parkinson, Joanna
Published in Diabetes, obesity & metabolism (01.04.2021)
Published in Diabetes, obesity & metabolism (01.04.2021)
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Novel Orally Swallowable IntelliCap® Device to Quantify Regional Drug Absorption in Human GI Tract Using Diltiazem as Model Drug
Becker, Dieter, Zhang, Jin, Heimbach, Tycho, Penland, Robert C., Wanke, Christoph, Shimizu, Jeff, Kulmatycki, Kenneth
Published in AAPS PharmSciTech (01.12.2014)
Published in AAPS PharmSciTech (01.12.2014)
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Comparison of the urinary glucose excretion contributions of SGLT2 and SGLT1: A quantitative systems pharmacology analysis in healthy individuals and patients with type 2 diabetes treated with SGLT2 inhibitors
Yakovleva, Tatiana, Sokolov, Victor, Chu, Lulu, Tang, Weifeng, Greasley, Peter J., Peilot Sjögren, Helena, Johansson, Susanne, Peskov, Kirill, Helmlinger, Gabriel, Boulton, David W., Penland, Robert C.
Published in Diabetes, obesity & metabolism (01.12.2019)
Published in Diabetes, obesity & metabolism (01.12.2019)
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Predicted Cardiac Functional Responses to Renal Actions of SGLT2i in the DAPACARD Trial Population: A Mathematical Modeling Analysis
Yu, Hongtao, Basu, Sanchita, Tang, Weifeng, Penland, Robert C, Greasley, Peter J, Oscarsson, Jan, Boulton, David W, Hallow, K Melissa
Published in Journal of clinical pharmacology (01.04.2022)
Published in Journal of clinical pharmacology (01.04.2022)
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Cardiovascular and renal safety of metformin in patients with diabetes and moderate or severe chronic kidney disease: Observations from the EXSCEL and SAVOR‐TIMI 53 cardiovascular outcomes trials
Clegg, Lindsay E., Jing, Yankang, Penland, Robert C., Boulton, David W., Hernandez, Adrian F., Holman, Rury R., Vora, Jiten
Published in Diabetes, obesity & metabolism (01.05.2021)
Published in Diabetes, obesity & metabolism (01.05.2021)
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Renal Effects of Dapagliflozin in People with and without Diabetes with Moderate or Severe Renal Dysfunction: Prospective Modeling of an Ongoing Clinical Trial
Hallow, K Melissa, Boulton, David W, Penland, Robert C, Helmlinger, Gabriel, Nieves, Emily H, van Raalte, Daniël H, Heerspink, Hiddo L, Greasley, Peter J
Published in The Journal of pharmacology and experimental therapeutics (01.10.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2020)
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