Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia
Khera, Amit V., MD, Won, Hong-Hee, PhD, Peloso, Gina M., PhD, Lawson, Kim S., MS, Bartz, Traci M., MS, Deng, Xuan, MSc, van Leeuwen, Elisabeth M, Natarajan, Pradeep, MD, MMSc, Emdin, Connor A., HBSc, Bick, Alexander G., PhD, Morrison, Alanna C., PhD, Brody, Jennifer A., BA, Gupta, Namrata, PhD, Nomura, Akihiro, MD, Kessler, Thorsten, MD, Duga, Stefano, PhD, Bis, Joshua C., PhD, van Duijn, Cornelia M., PhD, Cupples, L. Adrienne, PhD, Psaty, Bruce, MD, PhD, Rader, Daniel J., MD, Danesh, John, DPhil, Schunkert, Heribert, MD, McPherson, Ruth, MD, Farrall, Martin, MD, Watkins, Hugh, MD, PhD, Lander, Eric, PhD, Wilson, James G., MD, Correa, Adolfo, MD, PhD, Boerwinkle, Eric, PhD, Merlini, Piera Angelica, MD, Ardissino, Diego, MD, Saleheen, Danish, MBBS, PhD, Gabriel, Stacey, PhD, Kathiresan, Sekar, MD
Published in Journal of the American College of Cardiology (07.06.2016)
Published in Journal of the American College of Cardiology (07.06.2016)
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Journal Article
Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19
Huffman, Jennifer E., Butler-Laporte, Guillaume, Khan, Atlas, Pairo-Castineira, Erola, Drivas, Theodore G., Peloso, Gina M., Nakanishi, Tomoko, Ganna, Andrea, Verma, Anurag, Baillie, J. Kenneth, Kiryluk, Krzysztof, Richards, J. Brent, Zeberg, Hugo
Published in Nature genetics (01.02.2022)
Published in Nature genetics (01.02.2022)
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Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents
Khetarpal, Sumeet A., Schjoldager, Katrine T., Christoffersen, Christina, Raghavan, Avanthi, Edmondson, Andrew C., Reutter, Heiko M., Ahmed, Bouhouche, Ouazzani, Reda, Peloso, Gina M., Vitali, Cecilia, Zhao, Wei, Somasundara, Amritha Varshini Hanasoge, Millar, John S., Park, YoSon, Fernando, Gayani, Livanov, Valentin, Choi, Seungbum, Noé, Eric, Patel, Pritesh, Ho, Siew Peng, Kirchgessner, Todd G., Wandall, Hans H., Hansen, Lars, Bennett, Eric P., Vakhrushev, Sergey Y., Saleheen, Danish, Kathiresan, Sekar, Brown, Christopher D., Abou Jamra, Rami, LeGuern, Eric, Clausen, Henrik, Rader, Daniel J.
Published in Cell metabolism (09.08.2016)
Published in Cell metabolism (09.08.2016)
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Recurring exon deletions in the HP (haptoglobin) gene contribute to lower blood cholesterol levels
Boettger, Linda M, Salem, Rany M, Handsaker, Robert E, Peloso, Gina M, Kathiresan, Sekar, Hirschhorn, Joel N, McCarroll, Steven A
Published in Nature genetics (01.04.2016)
Published in Nature genetics (01.04.2016)
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Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy
DeForest, Natalie, Wang, Yuqi, Zhu, Zhiyi, Dron, Jacqueline S., Koesterer, Ryan, Natarajan, Pradeep, Flannick, Jason, Amariuta, Tiffany, Peloso, Gina M., Majithia, Amit R.
Published in Nature communications (14.09.2024)
Published in Nature communications (14.09.2024)
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A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels
Khetarpal, Sumeet A, Zeng, Xuemei, Millar, John S, Vitali, Cecilia, Somasundara, Amritha Varshini Hanasoge, Zanoni, Paolo, Landro, James A, Barucci, Nicole, Zavadoski, William J, Sun, Zhiyuan, de Haard, Hans, Toth, Ildikó V, Peloso, Gina M, Natarajan, Pradeep, Cuchel, Marina, Lund-Katz, Sissel, Phillips, Michael C, Tall, Alan R, Kathiresan, Sekar, DaSilva-Jardine, Paul, Yates, Nathan A, Rader, Daniel J
Published in Nature medicine (01.09.2017)
Published in Nature medicine (01.09.2017)
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Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium
Grove, Megan L, Yu, Bing, Cochran, Barbara J, Haritunians, Talin, Bis, Joshua C, Taylor, Kent D, Hansen, Mark, Borecki, Ingrid B, Cupples, L Adrienne, Fornage, Myriam, Gudnason, Vilmundur, Harris, Tamara B, Kathiresan, Sekar, Kraaij, Robert, Launer, Lenore J, Levy, Daniel, Liu, Yongmei, Mosley, Thomas, Peloso, Gina M, Psaty, Bruce M, Rich, Stephen S, Rivadeneira, Fernando, Siscovick, David S, Smith, Albert V, Uitterlinden, Andre, van Duijn, Cornelia M, Wilson, James G, O'Donnell, Christopher J, Rotter, Jerome I, Boerwinkle, Eric
Published in PloS one (12.07.2013)
Published in PloS one (12.07.2013)
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Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk
Yu, Zhi, Fidler, Trevor P, Ruan, Yunfeng, Vlasschaert, Caitlyn, Nakao, Tetsushi, Uddin, Md Mesbah, Mack, Taralynn, Niroula, Abhishek, Heimlich, J Brett, Zekavat, Seyedeh M, Gibson, Christopher J, Griffin, Gabriel K, Wang, Yuxuan, Peloso, Gina M, Heard-Costa, Nancy, Levy, Daniel, Vasan, Ramachandran S, Aguet, François, Ardlie, Kristin G, Taylor, Kent D, Rich, Stephen S, Rotter, Jerome I, Libby, Peter, Jaiswal, Siddhartha, Ebert, Benjamin L, Bick, Alexander G, Tall, Alan R, Natarajan, Pradeep
Published in The Journal of clinical investigation (15.09.2023)
Published in The Journal of clinical investigation (15.09.2023)
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Journal Article
Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program
Small, Aeron M, Peloso, Gina M, Linefsky, Jason, Aragam, Jayashri, Galloway, Ashley, Tanukonda, Vidisha, Wang, Lu-Chen, Yu, Zhi, Sunitha Selvaraj, Margaret, Farber-Eger, Eric H, Baker, Michael T, Setia-Verma, Shefali, Lee, Simon S K, Preuss, Michael, Ritchie, Marylyn D, Damrauer, Scott M, Rader, Daniel J, Wells, Quinn S, Loos, Ruth, Lubitz, Steven A, Thanassoulis, George, Cho, Kelly, Wilson, Peter W F, Natarajan, Pradeep, O'Donnell, Christopher J
Published in Circulation (New York, N.Y.) (21.03.2023)
Published in Circulation (New York, N.Y.) (21.03.2023)
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Genome-wide discovery for diabetes-dependent triglycerides-associated loci
Selvaraj, Margaret Sunitha, Paruchuri, Kaavya, Haidermota, Sara, Bernardo, Rachel, Rich, Stephen S, Peloso, Gina M, Natarajan, Pradeep
Published in PloS one (21.10.2022)
Published in PloS one (21.10.2022)
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Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure
Rasooly, Danielle, Peloso, Gina M., Pereira, Alexandre C., Dashti, Hesam, Giambartolomei, Claudia, Wheeler, Eleanor, Aung, Nay, Ferolito, Brian R., Pietzner, Maik, Farber-Eger, Eric H., Wells, Quinn Stanton, Kosik, Nicole M., Gaziano, Liam, Posner, Daniel C., Bento, A. Patrícia, Hui, Qin, Liu, Chang, Aragam, Krishna, Wang, Zeyuan, Charest, Brian, Huffman, Jennifer E., Wilson, Peter W. F., Phillips, Lawrence S., Whittaker, John, Munroe, Patricia B., Petersen, Steffen E., Cho, Kelly, Leach, Andrew R., Magariños, María Paula, Gaziano, John Michael, Langenberg, Claudia, Sun, Yan V., Joseph, Jacob, Casas, Juan P.
Published in Nature communications (10.07.2023)
Published in Nature communications (10.07.2023)
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Beverage Consumption and Longitudinal Changes in Lipoprotein Concentrations and Incident Dyslipidemia in US Adults: The Framingham Heart Study
Haslam, Danielle E, Peloso, Gina M, Herman, Mark A, Dupuis, Josée, Lichtenstein, Alice H, Smith, Caren E, McKeown, Nicola M
Published in Journal of the American Heart Association (03.03.2020)
Published in Journal of the American Heart Association (03.03.2020)
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Lipid levels and risk of acute pancreatitis using bidirectional Mendelian randomization
Wang, Biqi, Dron, Jacqueline S., Wang, Yuxuan, Choi, Seung Hoan, Huffman, Jennifer E., Cho, Kelly, Wilson, Peter W. F., Natarajan, Pradeep, Peloso, Gina M.
Published in Scientific reports (15.03.2024)
Published in Scientific reports (15.03.2024)
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Aggregate penetrance of genomic variants for actionable disorders in European and African Americans
Natarajan, Pradeep, Gold, Nina B, Bick, Alexander G, McLaughlin, Heather, Kraft, Peter, Rehm, Heidi L, Peloso, Gina M, Wilson, James G, Correa, Adolfo, Seidman, Jonathan G, Seidman, Christine E, Kathiresan, Sekar, Green, Robert C
Published in Science translational medicine (09.11.2016)
Published in Science translational medicine (09.11.2016)
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Whole genome DNA and RNA sequencing of whole blood elucidates the genetic architecture of gene expression underlying a wide range of diseases
Liu, Chunyu, Joehanes, Roby, Ma, Jiantao, Wang, Yuxuan, Sun, Xianbang, Keshawarz, Amena, Sooda, Meera, Huan, Tianxiao, Hwang, Shih-Jen, Bui, Helena, Tejada, Brandon, Munson, Peter J., Demirkale, Cumhur Y., Heard-Costa, Nancy L., Pitsillides, Achilleas N., Peloso, Gina M., Feolo, Michael, Sharopova, Nataliya, Vasan, Ramachandran S., Levy, Daniel
Published in Scientific reports (23.11.2022)
Published in Scientific reports (23.11.2022)
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Journal Article
Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study
Keshawarz, Amena, Bui, Helena, Joehanes, Roby, Ma, Jiantao, Liu, Chunyu, Huan, Tianxiao, Hwang, Shih-Jen, Tejada, Brandon, Sooda, Meera, Courchesne, Paul, Munson, Peter J., Demirkale, Cumhur Y., Yao, Chen, Heard-Costa, Nancy L., Pitsillides, Achilleas N., Lin, Honghuang, Liu, Ching-Ti, Wang, Yuxuan, Peloso, Gina M., Lundin, Jessica, Haessler, Jeffrey, Du, Zhaohui, Cho, Michael, Hersh, Craig P., Castaldi, Peter, Raffield, Laura M., Wen, Jia, Li, Yun, Reiner, Alexander P., Feolo, Mike, Sharopova, Nataliya, Vasan, Ramachandran S., DeMeo, Dawn L., Carson, April P., Kooperberg, Charles, Levy, Daniel
Published in Scientific reports (10.08.2023)
Published in Scientific reports (10.08.2023)
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A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
Kathiresan, Sekar, Manning, Alisa K, Demissie, Serkalem, D'Agostino, Ralph B, Surti, Aarti, Guiducci, Candace, Gianniny, Lauren, Burtt, Nöel P, Melander, Olle, Orho-Melander, Marju, Arnett, Donna K, Peloso, Gina M, Ordovas, Jose M, Cupples, L Adrienne
Published in BMC medical genetics (19.09.2007)
Published in BMC medical genetics (19.09.2007)
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Genome-wide and phenome-wide analysis of ideal cardiovascular health in the VA Million Veteran Program
Huang, Rose D L, Nguyen, Xuan-Mai T, Peloso, Gina M, Trinder, Mark, Posner, Daniel C, Aragam, Krishna G, Ho, Yuk-Lam, Lynch, Julie A, Damrauer, Scott M, Chang, Kyong-Mi, Tsao, Philip S, Natarajan, Pradeep, Assimes, Themistocles, Gaziano, J Michael, Djousse, Luc, Cho, Kelly, Wilson, Peter W F, Huffman, Jennifer E, O'Donnell, Christopher J
Published in PloS one (25.05.2022)
Published in PloS one (25.05.2022)
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Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction
Thormaehlen, Aenne S, Schuberth, Christian, Won, Hong-Hee, Blattmann, Peter, Joggerst-Thomalla, Brigitte, Theiss, Susanne, Asselta, Rosanna, Duga, Stefano, Merlini, Pier Angelica, Ardissino, Diego, Lander, Eric S, Gabriel, Stacey, Rader, Daniel J, Peloso, Gina M, Pepperkok, Rainer, Kathiresan, Sekar, Runz, Heiko
Published in PLoS genetics (01.02.2015)
Published in PLoS genetics (01.02.2015)
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