Search Results - "Pei, Zhonghua" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors

Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors

by Parr, Brendan T, Pastor, Richard, Sellers, Benjamin D, Pei, Zhonghua, Jaipuri, Firoz A, Castanedo, Georgette M, Gazzard, Lewis, Kumar, Sanjeev, Li, Xiaokai, Liu, Wen, Mendonca, Rohan, Pavana, Roheeth K, Potturi, Hima, Shao, Cheng, Velvadapu, Venkata, Waldo, Jesse P, Wu, Guosheng, Yuen, Po-wai, Zhang, Zuhui, Zhang, Yamin, Harris, Seth F, Oh, Angela J, DiPasquale, Antonio, Dement, Kevin, La, Hank, Goon, Leanne, Gustafson, Amy, VanderPorten, Erica C, Mautino, Mario R, Liu, Yichin
Published in ACS medicinal chemistry letters (09.04.2020)

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Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

by Szczepankiewicz, Bruce G, Liu, Gang, Hajduk, Philip J, Abad-Zapatero, Cele, Pei, Zhonghua, Xin, Zhili, Lubben, Thomas H, Trevillyan, James M, Stashko, Michael A, Ballaron, Stephen J, Liang, Heng, Huang, Flora, Hutchins, Charles W, Fesik, Stephen W, Jirousek, Michael R
Published in Journal of the American Chemical Society (09.04.2003)

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Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors

Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors

by Pei, Zhonghua, Li, Xiaofeng, von Geldern, Thomas W, Longenecker, Kenton, Pireh, Daisy, Stewart, Kent D, Backes, Bradley J, Lai, Chunqiu, Lubben, Thomas H, Ballaron, Stephen J, Beno, David W. A, Kempf-Grote, Anita J, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (19.04.2007)

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Fragment Screening and Assembly: A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor

Fragment Screening and Assembly: A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor

by Liu, Gang, Xin, Zhili, Pei, Zhonghua, Hajduk, Philip J, Abad-Zapatero, Cele, Hutchins, Charles W, Zhao, Hongyu, Lubben, Thomas H, Ballaron, Stephen J, Haasch, Deanna L, Kaszubska, Wiweka, Rondinone, Cristina M, Trevillyan, James M, Jirousek, Michael R
Published in Journal of medicinal chemistry (25.09.2003)

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Discovery of Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 1. Identification of an Additional Binding Pocket Based on an Anilino Diaryl Sulfide Lead

Discovery of Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 1. Identification of an Additional Binding Pocket Based on an Anilino Diaryl Sulfide Lead

by Liu, Gang, Link, J. T, Pei, Zhonghua, Reilly, Edward B, Leitza, Sandra, Nguyen, Bach, Marsh, Kennan C, Okasinski, Gregory F, von Geldern, Thomas W, Ormes, Mark, Fowler, Kerry, Gallatin, Mike
Published in Journal of medicinal chemistry (19.10.2000)

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Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands

Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands

by Liu, Gang, Xin, Zhili, Liang, Heng, Abad-Zapatero, Cele, Hajduk, Philip J, Janowick, David A, Szczepankiewicz, Bruce G, Pei, Zhonghua, Hutchins, Charles W, Ballaron, Stephen J, Stashko, Michael A, Lubben, Thomas H, Berg, Cathy E, Rondinone, Cristina M, Trevillyan, James M, Jirousek, Michael R
Published in Journal of medicinal chemistry (31.07.2003)

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Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

by Pei, Zhonghua, Li, Xiaofeng, Longenecker, Kenton, von Geldern, Thomas W, Wiedeman, Paul E, Lubben, Thomas H, Zinker, Bradley A, Stewart, Kent, Ballaron, Stephen J, Stashko, Michael A, Mika, Amanda K, Beno, David W. A, Long, Michelle, Wells, Heidi, Kempf-Grote, Anita J, Madar, David J, McDermott, Todd S, Bhagavatula, Lakshmi, Fickes, Michael G, Pireh, Daisy, Solomon, Larry R, Lake, Marc R, Edalji, Rohinton, Fry, Elizabeth H, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (15.06.2006)

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Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

by Zhao, Hongyu, Liu, Gang, Xin, Zhili, Serby, Michael D., Pei, Zhonghua, Szczepankiewicz, Bruce G., Hajduk, Philip J., Abad-Zapatero, Cele, Hutchins, Charles W., Lubben, Thomas H., Ballaron, Stephen J., Haasch, Deanna L., Kaszubska, Wiweka, Rondinone, Cristina M., Trevillyan, James M., Jirousek, Michael R.
Published in Bioorganic & medicinal chemistry letters (15.11.2004)

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Discovery of 2-[4-{{2-(2S,5R)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279): A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes

Discovery of 2-[4-{{2-(2S,5R)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279): A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes

by Madar, David J, Kopecka, Hana, Pireh, Daisy, Yong, Hong, Pei, Zhonghua, Li, Xiaofeng, Wiedeman, Paul E, Djuric, Stevan W, Von Geldern, Thomas W, Fickes, Michael G, Bhagavatula, Lakshmi, McDermott, Todd, Wittenberger, Steven, Richards, Steven J, Longenecker, Kenton L, Stewart, Kent D, Lubben, Thomas H, Ballaron, Stephen J, Stashko, Michael A, Long, Michelle A, Wells, Heidi, Zinker, Bradley A, Mika, Amanda K, Beno, David W. A, Kempf-Grote, Anita J, Polakowski, James, Segreti, Jason, Reinhart, Glenn A, Fryer, Ryan M, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (19.10.2006)

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Inhibition of Protein Tyrosine Phosphatase 1B as a Potential Treatment of Diabetes and Obesity

Inhibition of Protein Tyrosine Phosphatase 1B as a Potential Treatment of Diabetes and Obesity

by Pei, Zhonghua, Liu, Gang, Lubben, Thomas H, Szczepankiewicz, Bruce G
Published in Current pharmaceutical design (01.01.2004)

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Discovery of ((4R,5S)-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Discovery of ((4R,5S)-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

by Pei, Zhonghua, Li, Xiaofeng, von Geldern, Thomas W, Madar, David J, Longenecker, Kenton, Yong, Hong, Lubben, Thomas H, Stewart, Kent D, Zinker, Bradley A, Backes, Bradley J, Judd, Andrew S, Mulhern, Mathew, Ballaron, Stephen J, Stashko, Michael A, Mika, Amanda K, Beno, David W. A, Reinhart, Glenn A, Fryer, Ryan M, Preusser, Lee C, Kempf-Grote, Anita J, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (02.11.2006)

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Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors

Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors

by Longenecker, Kenton L, Stewart, Kent D, Madar, David J, Jakob, Clarissa G, Fry, Elizabeth H, Wilk, Sherwin, Lin, Chun W, Ballaron, Stephen J, Stashko, Michael A, Lubben, Thomas H, Yong, Hong, Pireh, Daisy, Pei, Zhonghua, Basha, Fatima, Wiedeman, Paul E, von Geldern, Thomas W, Trevillyan, James M, Stoll, Vincent S
Published in Biochemistry (Easton) (20.06.2006)

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Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit

Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit

by Backes, Bradley J., Longenecker, Kenton, Hamilton, Gregory L., Stewart, Kent, Lai, Chunqiu, Kopecka, Hana, von Geldern, Thomas W., Madar, David J., Pei, Zhonghua, Lubben, Thomas H., Zinker, Bradley A., Tian, Zhenping, Ballaron, Stephen J., Stashko, Michael A., Mika, Amanda K., Beno, David W.A., Kempf-Grote, Anita J., Black-Schaefer, Candace, Sham, Hing L., Trevillyan, James M.
Published in Bioorganic & medicinal chemistry letters (01.04.2007)

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Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

by Liu, Gang, Szczepankiewicz, Bruce G, Pei, Zhonghua, Janowick, David A, Xin, Zhili, Hajduk, Philip J, Abad-Zapatero, Cele, Liang, Heng, Hutchins, Charles W, Fesik, Stephen W, Ballaron, Steve J, Stashko, Mike A, Lubben, Tom, Mika, Amanda K, Zinker, Bradley A, Trevillyan, James M, Jirousek, Michael R
Published in Journal of medicinal chemistry (22.05.2003)

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Identification of a monoacid-Based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B

Identification of a monoacid-Based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B

by Xin, Zhili, Liu, Gang, Abad-Zapatero, Cele, Pei, Zhonghua, Szczepankiewicz, Bruce G., Li, Xiaofeng, Zhang, Tianyuan, Hutchins, Charles W., Hajduk, Philip J., Ballaron, Stephen J., Stashko, Michael A., Lubben, Thomas H., Trevillyan, James M., Jirousek, Michael R.
Published in Bioorganic & medicinal chemistry letters (17.11.2003)

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Potent, selective inhibitors of protein tyrosine phosphatase 1B

Potent, selective inhibitors of protein tyrosine phosphatase 1B

by Xin, Zhili, Oost, Thorsten K, Abad-Zapatero, Cele, Hajduk, Philip J, Pei, Zhonghua, Szczepankiewicz, Bruce G, Hutchins, Charles W, Ballaron, Steve J, Stashko, Mike A, Lubben, Tom, Trevillyan, James M, Jirousek, Mike R, Liu, Gang
Published in Bioorganic & medicinal chemistry letters (02.06.2003)

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Comparison of microparticle manipulating characteristics of canonical vortex beam and power-exponent-phase vortex beam

Comparison of microparticle manipulating characteristics of canonical vortex beam and power-exponent-phase vortex beam

by Pei, Zhonghua, Huang, Sujuan, Chen, Yi, Yan, Cheng
Published in Journal of modern optics (23.02.2021)

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Discovery of Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 4. Structure−Activity Relationship of Substituents on the Benzene Ring of the Cinnamide

Discovery of Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 4. Structure−Activity Relationship of Substituents on the Benzene Ring of the Cinnamide

by Winn, Martin, Reilly, Edward B, Liu, Gang, Huth, Jeffrey R, Jae, Hwan-Soo, Freeman, Jennifer, Pei, Zhonghua, Xin, Zhili, Lynch, John, Kester, Jeff, von Geldern, Thomas W, Leitza, Sandra, DeVries, Peter, Dickinson, Robert, Mussatto, Donna, Okasinski, Gregory F
Published in Journal of medicinal chemistry (06.12.2001)

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Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors

Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors

by Pei, Zhonghua, Li, Xiaofeng, Liu, Gang, Abad-Zapatero, Cele, Lubben, Tom, Zhang, Tianyuan, Ballaron, Stephen J., Hutchins, Charles W., Trevillyan, James M., Jirousek, Michael R.
Published in Bioorganic & medicinal chemistry letters (06.10.2003)

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Attainment of syn-selectivity for boron-mediated asymmetric aldol reactions of carboxylic esters

Attainment of syn-selectivity for boron-mediated asymmetric aldol reactions of carboxylic esters

by Liu, Ji-Feng, Abiko, Atsushi, Pei, Zhonghua, Buske, Dana C, Masamune, Satoru
Published in Tetrahedron letters (02.04.1998)

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