The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism
Hudson, Brian D, Shimpukade, Bharat, Mackenzie, Amanda E, Butcher, Adrian J, Pediani, John D, Christiansen, Elisabeth, Heathcote, Helen, Tobin, Andrew B, Ulven, Trond, Milligan, Graeme
Published in Molecular pharmacology (01.11.2013)
Published in Molecular pharmacology (01.11.2013)
Get full text
Journal Article
Orexin-1 Receptor-Cannabinoid CB1 Receptor Heterodimerization Results in Both Ligand-dependent and -independent Coordinated Alterations of Receptor Localization and Function
Ellis, James, Pediani, John D., Canals, Meritxell, Milasta, Sandra, Milligan, Graeme
Published in The Journal of biological chemistry (15.12.2006)
Published in The Journal of biological chemistry (15.12.2006)
Get full text
Journal Article
A Molecular Basis for Selective Antagonist Destabilization of Dopamine D3 Receptor Quaternary Organization
Marsango, Sara, Caltabiano, Gianluigi, Jiménez-Rosés, Mireia, Millan, Mark J., Pediani, John D., Ward, Richard J., Milligan, Graeme
Published in Scientific reports (18.05.2017)
Published in Scientific reports (18.05.2017)
Get full text
Journal Article
A general method to quantify ligand-driven oligomerization from fluorescence-based images
Stoneman, Michael R., Biener, Gabriel, Ward, Richard J., Pediani, John D., Badu, Dammar, Eis, Annie, Popa, Ionel, Milligan, Graeme, Raicu, Valerică
Published in Nature methods (01.06.2019)
Published in Nature methods (01.06.2019)
Get full text
Journal Article
Regulation of Oligomeric Organization of the Serotonin 5-Hydroxytryptamine 2C (5-HT2C) Receptor Observed by Spatial Intensity Distribution Analysis
Ward, Richard J., Pediani, John D., Godin, Antoine G., Milligan, Graeme
Published in The Journal of biological chemistry (15.05.2015)
Published in The Journal of biological chemistry (15.05.2015)
Get full text
Journal Article
Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t
Ward, Richard J., Pediani, John D., Marsango, Sara, Jolly, Richard, Stoneman, Michael R., Biener, Gabriel, Handel, Tracy M., Raicu, Valerică, Milligan, Graeme
Published in The Journal of biological chemistry (01.01.2021)
Published in The Journal of biological chemistry (01.01.2021)
Get full text
Journal Article
The M 1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes
Marsango, Sara, Jenkins, Laura, Pediani, John D, Bradley, Sophie J, Ward, Richard J, Hesse, Sarah, Biener, Gabriel, Stoneman, Michael R, Tobin, Andrew B, Raicu, Valerica, Milligan, Graeme
Published in Proceedings of the National Academy of Sciences - PNAS (14.06.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (14.06.2022)
Get full text
Journal Article
The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes
Marsango, Sara, Jenkins, Laura, Pediani, John D, Bradley, Sophie J, Ward, Richard J, Hesse, Sarah, Biener, Gabriel, Stoneman, Michael R, Tobin, Andrew B, Raicu, Valerica, Milligan, Graeme
Published in Proceedings of the National Academy of Sciences - PNAS (14.06.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (14.06.2022)
Get full text
Journal Article
Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL)
Alvarez-Curto, Elisa, Prihandoko, Rudi, Tautermann, Christofer S, Zwier, Jurriaan M, Pediani, John D, Lohse, Martin J, Hoffmann, Carsten, Tobin, Andrew B, Milligan, Graeme
Published in Molecular pharmacology (01.12.2011)
Published in Molecular pharmacology (01.12.2011)
Get full text
Journal Article
Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes
Shaw, Andy, Jeromson, Stewart, Watterson, Kenneth R, Pediani, John D, Gallagher, Iain J, Whalley, Tim, Dreczkowski, Gillian, Brooks, Naomi, Galloway, Stuart D, Hamilton, D Lee
Published in American Journal of Physiology: Cell Physiology (01.06.2017)
Published in American Journal of Physiology: Cell Physiology (01.06.2017)
Get full text
Journal Article
Novel Role for Proteinase-activated Receptor 2 (PAR2) in Membrane Trafficking of Proteinase-activated Receptor 4 (PAR4)
Cunningham, Margaret R., McIntosh, Kathryn A., Pediani, John D., Robben, Joris, Cooke, Alexandra E., Nilsson, Mary, Gould, Gwyn W., Mundell, Stuart, Milligan, Graeme, Plevin, Robin
Published in The Journal of biological chemistry (11.05.2012)
Published in The Journal of biological chemistry (11.05.2012)
Get full text
Journal Article
Intramolecular Fluorescence Resonance Energy Transfer (FRET) Sensors of the Orexin OX1 and OX2 Receptors Identify Slow Kinetics of Agonist Activation
Xu, Tian-Rui, Ward, Richard J., Pediani, John D., Milligan, Graeme
Published in The Journal of biological chemistry (27.04.2012)
Published in The Journal of biological chemistry (27.04.2012)
Get full text
Journal Article