The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline
Chini, Claudia, Hogan, Kelly A., Warner, Gina M., Tarragó, Mariana G., Peclat, Thais R., Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo
Published in Biochemical and biophysical research communications (28.05.2019)
Published in Biochemical and biophysical research communications (28.05.2019)
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Heavy-chain antibody targeting of CD38 NAD+ hydrolase ectoenzyme to prevent fibrosis in multiple organs
Shi, Bo, Amin, Asif, Dalvi, Pranjali, Wang, Wenxia, Lukacs, Nicholas, Kai, Li, Cheresh, Paul, Peclat, Thais R., Chini, Claudia C., Chini, Eduardo N., van Schooten, Wim, Varga, John
Published in Scientific reports (12.12.2023)
Published in Scientific reports (12.12.2023)
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Journal Article
CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging
Peclat, Thais R., Thompson, Katie L., Warner, Gina M., Chini, Claudia C.S., Tarragó, Mariana G., Mazdeh, Delaram Z., Zhang, Chunlian, Zavala‐Solorio, Jose, Kolumam, Ganesh, Liang Wong, Yao, Cohen, Robert L., Chini, Eduardo N.
Published in Aging cell (01.04.2022)
Published in Aging cell (01.04.2022)
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Journal Article
Dihydronicotinamide Riboside Is a Potent NAD + Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages
Chini, Claudia C S, Peclat, Thais R, Gomez, Lilian S, Zeidler, Julianna D, Warner, Gina M, Kashyap, Sonu, Mazdeh, Delaram Z, Hayat, Faisal, Migaud, Marie E, Paulus, Aneel, Chanan-Khan, Asher A, Chini, Eduardo N
Published in Frontiers in immunology (25.02.2022)
Published in Frontiers in immunology (25.02.2022)
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Journal Article
Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)
Zeidler, Julianna D., Chini, Claudia C.S., Kanamori, Karina S., Kashyap, Sonu, Espindola-Netto, Jair M., Thompson, Katie, Warner, Gina, Cabral, Fernanda S., Peclat, Thais R., Gomez, Lilian Sales, Lopez, Sierra A., Wandersee, Miles K., Schoon, Renee A., Reid, Kimberly, Menzies, Keir, Beckedorff, Felipe, Reid, Joel M., Brachs, Sebastian, Meyer, Ralph G., Meyer-Ficca, Mirella L., Chini, Eduardo Nunes
Published in iScience (18.11.2022)
Published in iScience (18.11.2022)
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The CD38 glycohydrolase and the NAD sink: implications for pathological conditions
Zeidler, Julianna D, Hogan, Kelly A, Agorrody, Guillermo, Peclat, Thais R, Kashyap, Sonu, Kanamori, Karina S, Gomez, Lilian Sales, Mazdeh, Delaram Z, Warner, Gina M, Thompson, Katie L, Chini, Claudia C S, Chini, Eduardo Nunes
Published in American Journal of Physiology: Cell Physiology (01.03.2022)
Published in American Journal of Physiology: Cell Physiology (01.03.2022)
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Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity
Peclat, Thais R, Agorrody, Guillermo, Colman, Laura, Kashyap, Sonu, Zeidler, Julianna D, Chini, Claudia C S, Warner, Gina M, Thompson, Katie L, Dalvi, Pranjali, Beckedorff, Felipe, Ebtehaj, Sanam, Herrmann, Joerg, van Schooten, Wim, Chini, Eduardo Nunes
Published in Cardiovascular research (14.03.2024)
Published in Cardiovascular research (14.03.2024)
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Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine-induced ventricular arrhythmias
Agorrody, Guillermo, Peclat, Thais R., Peluso, Gonzalo, Gonano, Luis A., Santos, Leonardo, van Schooten, Wim, Chini, Claudia C.S., Escande, Carlos, Chini, Eduardo N., Contreras, Paola
Published in Journal of molecular and cellular cardiology (01.05.2022)
Published in Journal of molecular and cellular cardiology (01.05.2022)
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Journal Article
Critical Role of Astrocyte NAD + Glycohydrolase in Myelin Injury and Regeneration
Langley, Monica R, Choi, Chan-Il, Peclat, Thais R, Guo, Yong, Simon, Whitney L, Yoon, Hyesook, Kleppe, Laurel, Lucchinetti, Claudia F, Chini, Claudia C S, Chini, Eduardo N, Scarisbrick, Isobel A
Published in The Journal of neuroscience (13.10.2021)
Published in The Journal of neuroscience (13.10.2021)
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Journal Article
FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue
Zhang, Yingyi, Hao, Jielu, Tarrago, Mariana G., Warner, Gina M., Giorgadze, Nino, Wei, Qing, Huang, Yan, He, Kai, Chen, Chuan, Peclat, Thais R., White, Thomas A., Ling, Kun, Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo N., Hu, Jinghua
Published in Cell reports (Cambridge) (03.08.2021)
Published in Cell reports (Cambridge) (03.08.2021)
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Journal Article
Remimazolam in Cardiac Anesthesia: Analysis of Recent Data
Ripoll, Juan G., Orjuela, Rayssa Becerra, Kanaparthi, Anuradha, Diaz Soto, Juan C., ElSaban, Mariam A., Peclat, Thais R., Wieruszewski, Patrick M., Abcejo, Arnoley S., Chang, Marvin G., Bittner, Edward A., Ramakrishna, Harish
Published in Journal of cardiothoracic and vascular anesthesia (22.08.2024)
Published in Journal of cardiothoracic and vascular anesthesia (22.08.2024)
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The additional prognostic value of myocardial perfusion SPECT in patients with known coronary artery disease with high exercise capacity
Peclat, Thais R., de Souza, Ana Carolina do A.H., Souza, Victor F., Nakamoto, Aline M.K., Neves, Felipe M., Silva, Izabella C.R., Lima, Ronaldo S.L.
Published in Journal of nuclear cardiology (01.10.2021)
Published in Journal of nuclear cardiology (01.10.2021)
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Prognostic value of a faster, low-radiation myocardial perfusion SPECT protocol in a CZT camera
Lima, Ronaldo S. L., Peclat, Thaís R., Souza, Ana Carolina A. H., Nakamoto, Aline M. K., Neves, Felipe M., Souza, Victor F., Glerian, Letícia B., De Lorenzo, Andrea
Published in The International Journal of Cardiovascular Imaging (01.12.2017)
Published in The International Journal of Cardiovascular Imaging (01.12.2017)
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Journal Article
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD + and NMN levels
Chini, Claudia C S, Peclat, Thais R, Warner, Gina M, Kashyap, Sonu, Espindola-Netto, Jair Machado, de Oliveira, Guilherme C, Gomez, Lilian S, Hogan, Kelly A, Tarragó, Mariana G, Puranik, Amrutesh S, Agorrody, Guillermo, Thompson, Katie L, Dang, Kevin, Clarke, Starlynn, Childs, Bennett G, Kanamori, Karina S, Witte, Micaela A, Vidal, Paola, Kirkland, Anna L, De Cecco, Marco, Chellappa, Karthikeyani, McReynolds, Melanie R, Jankowski, Connor, Tchkonia, Tamara, Kirkland, James L, Sedivy, John M, van Deursen, Jan M, Baker, Darren J, van Schooten, Wim, Rabinowitz, Joshua D, Baur, Joseph A, Chini, Eduardo N
Published in Nature metabolism (01.11.2020)
Published in Nature metabolism (01.11.2020)
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A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis
Cal, Karina, Leyva, Alejandro, Rodríguez-Duarte, Jorge, Ruiz, Santiago, Santos, Leonardo, Colella, Lucía, Ingold, Mariana, Vilaseca, Cecilia, Galliussi, German, Ziegler, Lucía, Peclat, Thais R, Bresque, Mariana, Handy, Rachel M, King, Rachel, Dos Reis, Larissa Menezes, Espasandin, Camila, Breining, Peter, Dapueto, Rosina, Lopez, Andrés, Thompson, Katie L, Agorrody, Guillermo, DeVallance, Evan, Meadows, Ethan, Lewis, Sara E, Barbosa, Gabriele Catarine Santana, de Souza, Leonardo Osbourne Lai, Chichierchio, Marina Santos, Valez, Valeria, Aicardo, Adrián, Contreras, Paola, Vendelbo, Mikkel H, Jakobsen, Steen, Kamaid, Andrés, Porcal, Williams, Calliari, Aldo, Verdes, José Manuel, Du, Jianhai, Wang, Yekai, Hollander, John M, White, Thomas A, Radi, Rafael, Moyna, Guillermo, Quijano, Celia, O'Doherty, Robert, Moraes-Vieira, Pedro, Holloway, Graham P, Leonardi, Roberta, Mori, Marcelo A, Camacho-Pereira, Juliana, Kelley, Eric E, Duran, Rosario, Lopez, Gloria V, Batthyány, Carlos, Chini, Eduardo N, Escande, Carlos
Published in Research square (12.07.2023)
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Published in Research square (12.07.2023)
Journal Article
Critical role for astrocyte NAD+ glycohydrolase in myelin injury and regeneration
Langley, Monica R, Chan-Il, Choi, Peclat, Thais R, Guo, Yong, Whitney, Simon, Yoon, Hyesook, Kleppe, Laurel, Lucchinetti, Claudia F, Claudia Cs Chini, Chini, Eduardo N, Scarisbrick, Isobel A
Published in bioRxiv (16.12.2020)
Published in bioRxiv (16.12.2020)
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