Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor
Maira, Sauveur-Michel, Pecchi, Sabina, Huang, Alan, Burger, Matthew, Knapp, Mark, Sterker, Dario, Schnell, Christian, Guthy, Daniel, Nagel, Tobi, Wiesmann, Marion, Brachmann, Saskia, Fritsch, Christine, Dorsch, Marion, Chène, Patrick, Shoemaker, Kevin, De Pover, Alain, Menezes, Daniel, Martiny-Baron, Georg, Fabbro, Doriano, Wilson, Christopher J, Schlegel, Robert, Hofmann, Francesco, García-Echeverría, Carlos, Sellers, William R, Voliva, Charles F
Published in Molecular cancer therapeutics (01.02.2012)
Published in Molecular cancer therapeutics (01.02.2012)
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Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer
Burger, Matthew T, Pecchi, Sabina, Wagman, Allan, Ni, Zhi-Jie, Knapp, Mark, Hendrickson, Thomas, Atallah, Gordana, Pfister, Keith, Zhang, Yanchen, Bartulis, Sarah, Frazier, Kelly, Ng, Simon, Smith, Aaron, Verhagen, Joelle, Haznedar, Joshua, Huh, Kay, Iwanowicz, Ed, Xin, Xiaohua, Menezes, Daniel, Merritt, Hanne, Lee, Isabelle, Wiesmann, Marion, Kaufman, Susan, Crawford, Kenneth, Chin, Michael, Bussiere, Dirksen, Shoemaker, Kevin, Zaror, Isabel, Maira, Sauveur-Michel, Voliva, Charles F
Published in ACS medicinal chemistry letters (13.10.2011)
Published in ACS medicinal chemistry letters (13.10.2011)
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Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor
Karpov, Alexei S, Amiri, Payman, Bellamacina, Cornelia, Bellance, Marie-Helene, Breitenstein, Werner, Daniel, Dylan, Denay, Regis, Fabbro, Doriano, Fernandez, Cesar, Galuba, Inga, Guerro-Lagasse, Stephanie, Gutmann, Sascha, Hinh, Linda, Jahnke, Wolfgang, Klopp, Julia, Lai, Albert, Lindvall, Mika K, Ma, Sylvia, Möbitz, Henrik, Pecchi, Sabina, Rummel, Gabriele, Shoemaker, Kevin, Trappe, Joerg, Voliva, Charles, Cowan-Jacob, Sandra W, Marzinzik, Andreas L
Published in ACS medicinal chemistry letters (09.07.2015)
Published in ACS medicinal chemistry letters (09.07.2015)
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Synthesis and in Vitro and in Vivo Evaluation of Phosphoinositide-3-kinase Inhibitors
Burger, Matthew T, Knapp, Mark, Wagman, Allan, Ni, Zhi-Jie, Hendrickson, Thomas, Atallah, Gordana, Zhang, Yanchen, Frazier, Kelly, Verhagen, Joelle, Pfister, Keith, Ng, Simon, Smith, Aaron, Bartulis, Sarah, Merrit, Hanne, Weismann, Marion, Xin, Xiaohua, Haznedar, Joshua, Voliva, Charles F, Iwanowicz, Ed, Pecchi, Sabina
Published in ACS medicinal chemistry letters (13.01.2011)
Published in ACS medicinal chemistry letters (13.01.2011)
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A New Bromo Trienyne: Synthesis of all-E, Conjugated Tetra-, Penta-, and Hexaenes Common to Oxo Polyene Macrolide Antibiotics
Lipshutz, Bruce H, Ullman, Brett, Lindsley, Craig, Pecchi, Sabina, Buzard, D. J, Dickson, David
Published in Journal of organic chemistry (04.09.1998)
Published in Journal of organic chemistry (04.09.1998)
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Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors
Renhowe, Paul A, Pecchi, Sabina, Shafer, Cynthia M, Machajewski, Timothy D, Jazan, Elisa M, Taylor, Clarke, Antonios-McCrea, William, McBride, Christopher M, Frazier, Kelly, Wiesmann, Marion, Lapointe, Gena R, Feucht, Paul H, Warne, Robert L, Heise, Carla C, Menezes, Daniel, Aardalen, Kimberly, Ye, Helen, He, Molly, Le, Vincent, Vora, Jayesh, Jansen, Johanna M, Wernette-Hammond, Mary Ellen, Harris, Alex L
Published in Journal of medicinal chemistry (22.01.2009)
Published in Journal of medicinal chemistry (22.01.2009)
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Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model
Han, Wooseok, Menezes, Daniel L., Xu, Yongjin, Knapp, Mark S., Elling, Robert, Burger, Matthew T., Ni, Zhi-Jie, Smith, Aaron, Lan, Jiong, Williams, Teresa E., Verhagen, Joelle, Huh, Kay, Merritt, Hanne, Chan, John, Kaufman, Susan, Voliva, Charles F., Pecchi, Sabina
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
Published in Bioorganic & medicinal chemistry letters (01.02.2016)
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Heteroatom-Assisted Isomerization of Oxiranes to Allylic Alcohols Promoted by Bases
Mordini, Alessandro, Pecchi, Sabina, Capozzi, Giuseppe, Capperucci, Antonella, Degl'Innocenti, Alessandro, Reginato, Gianna, Ricci, Alfredo
Published in Journal of organic chemistry (01.08.1994)
Published in Journal of organic chemistry (01.08.1994)
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Identification and structure–activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors
Pecchi, Sabina, Renhowe, Paul A., Taylor, Clarke, Kaufman, Susan, Merritt, Hanne, Wiesmann, Marion, Shoemaker, Kevin R., Knapp, Mark S., Ornelas, Elizabeth, Hendrickson, Thomas F., Fantl, Wendy, Voliva, Charles F.
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Journal Article
Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K
Pecchi, Sabina, Ni, Zhi-Jie, Han, Wooseok, Smith, Aaron, Lan, Jiong, Burger, Matthew, Merritt, Hanne, Wiesmann, Marion, Chan, John, Kaufman, Susan, Knapp, Mark S., Janssen, Johanna, Huh, Kay, Voliva, Charles F.
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors
Ni, Zhi-Jie, Barsanti, Paul, Brammeier, Nathan, Diebes, Anthony, Poon, Daniel J., Ng, Simon, Pecchi, Sabina, Pfister, Keith, Renhowe, Paul A., Ramurthy, Savithri, Wagman, Allan S., Bussiere, Dirksen E., Le, Vincent, Zhou, Yasheen, Jansen, Johanna M., Ma, Sylvia, Gesner, Thomas G.
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
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Abstract 4498: Biological characterization of NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials
Voliva, charles F., Pecchi, Sabina, Burger, Matthew, Nagel, Tobi, Schnell, Christian, Fritsch, christine, Brachmann, saskia, Menezes, Daniel, Knapp, Mark, Shoemaker, Kevin, Wiesmann, Marion, Huh, kay, Zaror, Isabel, Dorsch, Marion, Sellers, William R., Garcia-Echeverria, Carlos, Maira, Michel
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Abstract 4497: NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials, shows significant antitumor activity in xenograft and primary tumor models
Maira, Michel, Menezes, Daniel, Pecchi, Sabina, Shoemaker, Kevin, Burger, Matthew, Schnell, christian, Fritsch, christine, Brachmann, Saskia, Nagel, Tobi, Sellers, William R., Garcia-Echeverria, Carlos, Wiesmann, Marion, Voliva, charles F.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS
HAN WOOSEOK, MIN ZHONGCHENG, ZHANG QIONG, LEE PATRICK, LINDVALL MIKA, POON DANIEL, HUANG ZILIN, JIANG QUN, PAN YUE, ZHOU JIANGUANG, BAGDANOFF JEFFREY T, JIN JEFF XIANMING, KOU XIANG, RAUNIYAR VIVEK, DING YU, ZHU SHEJIN, PFISTER KEITH BRUCE, WANG XIAOJING MICHAEL, PECCHI SABINA
Year of Publication 05.07.2016
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Year of Publication 05.07.2016
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COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
JIN JEFF (XIANMING), TELLEW JOHN, ZHANG QIONG, POON DANIEL, COSTALES ABRAN Q, PECCHI SABINA, HUANG SHENLIN, LIU ZUOSHENG
Year of Publication 21.08.2012
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Year of Publication 21.08.2012
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Design and structure–activity relationship of heterocyclic analogs of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones as inhibitors of receptor tyrosine kinases
Frazier, Kelly, Jazan, Elisa, McBride, Christopher M., Pecchi, Sabina, Renhowe, Paul A., Shafer, Cynthia M., Taylor, Clarke, Bussiere, Dirksen, He, Molly Min, Jansen, Johanna M., Lapointe, Gena, Ma, Sylvia, Vora, Jayesh, Wiesmann, Marion
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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LHMDS mediated tandem acylation–cyclization of 2-aminobenzenecarbonitriles with 2-benzymidazol-2-yl acetates: a short and efficient route to the synthesis of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones
Antonios-McCrea, William R., Frazier, Kelly A., Jazan, Elisa M., Machajewski, Timothy D., McBride, Christopher M., Pecchi, Sabina, Renhowe, Paul A., Shafer, Cynthia M., Taylor, Clarke
Published in Tetrahedron letters (30.01.2006)
Published in Tetrahedron letters (30.01.2006)
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AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS
ZHU, SHEJIN, JIN, JEFF XIANMING, ZHANG, QIONG, PECCHI, SABINA, MIN, ZHONGCHENG, DING, YU, WANG, XIAOJING MICHAEL, HAN, WOOSEOK, POON, DANIEL, PFISTER, KEITH BRUCE, HUANG, ZILIN, LINDVALL, MIKA, KOU, XIANG, PAN, YUE, JIANG, QUN, BAGDANOFF, JEFFREY T, RAUNIYAR, VIVEK, ZHOU, JIANGUANG, LEE, PATRICK
Year of Publication 19.09.2023
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Year of Publication 19.09.2023
Patent