Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
Liu, David S., Duong, Cuong P., Haupt, Sue, Montgomery, Karen G., House, Colin M., Azar, Walid J., Pearson, Helen B., Fisher, Oliver M., Read, Matthew, Guerra, Glen R., Haupt, Ygal, Cullinane, Carleen, Wiman, Klas G., Abrahmsen, Lars, Phillips, Wayne A., Clemons, Nicholas J.
Published in Nature communications (28.03.2017)
Published in Nature communications (28.03.2017)
Get full text
Journal Article
Cancer-Associated Fibroblast Heterogeneity, Activation and Function: Implications for Prostate Cancer
Owen, Jasmine S, Clayton, Aled, Pearson, Helen B
Published in Biomolecules (Basel, Switzerland) (29.12.2022)
Published in Biomolecules (Basel, Switzerland) (29.12.2022)
Get full text
Journal Article
The PTEN Conundrum: How to Target PTEN-Deficient Prostate Cancer
Turnham, Daniel J, Bullock, Nicholas, Dass, Manisha S, Staffurth, John N, Pearson, Helen B
Published in Cells (Basel, Switzerland) (22.10.2020)
Published in Cells (Basel, Switzerland) (22.10.2020)
Get full text
Journal Article
SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia
Pearson, Helen B, Perez-Mancera, Pedro A, Dow, Lukas E, Ryan, Andrew, Tennstedt, Pierre, Bogani, Debora, Elsum, Imogen, Greenfield, Andy, Tuveson, David A, Simon, Ronald, Humbert, Patrick O
Published in The Journal of clinical investigation (01.11.2011)
Published in The Journal of clinical investigation (01.11.2011)
Get full text
Journal Article
The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer
Rebello, Richard J, Kusnadi, Eric, Cameron, Donald P, Pearson, Helen B, Lesmana, Analia, Devlin, Jennifer R, Drygin, Denis, Clark, Ashlee K, Porter, Laura, Pedersen, John, Sandhu, Shahneen, Risbridger, Gail P, Pearson, Richard B, Hannan, Ross D, Furic, Luc
Published in Clinical cancer research (15.11.2016)
Published in Clinical cancer research (15.11.2016)
Get full text
Journal Article
Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer
Johnstone, Cameron N, Smith, Yvonne E, Cao, Yuan, Burrows, Allan D, Cross, Ryan S N, Ling, Xiawei, Redvers, Richard P, Doherty, Judy P, Eckhardt, Bedrich L, Natoli, Anthony L, Restall, Christina M, Lucas, Erin, Pearson, Helen B, Deb, Siddhartha, Britt, Kara L, Rizzitelli, Alexandra, Li, Jason, Harmey, Judith H, Pouliot, Normand, Anderson, Robin L
Published in Disease models & mechanisms (01.03.2015)
Published in Disease models & mechanisms (01.03.2015)
Get full text
Journal Article
Increasing Intracellular Bioavailable Copper Selectively Targets Prostate Cancer Cells
Cater, Michael A, Pearson, Helen B, Wolyniec, Kamil, Klaver, Paul, Bilandzic, Maree, Paterson, Brett M, Bush, Ashley I, Humbert, Patrick O, La Fontaine, Sharon, Donnelly, Paul S, Haupt, Ygal
Published in ACS chemical biology (19.07.2013)
Published in ACS chemical biology (19.07.2013)
Get full text
Journal Article
Exploring the Wnt Pathway as a Therapeutic Target for Prostate Cancer
Koushyar, Sarah, Meniel, Valerie S, Phesse, Toby J, Pearson, Helen B
Published in Biomolecules (Basel, Switzerland) (15.02.2022)
Published in Biomolecules (Basel, Switzerland) (15.02.2022)
Get full text
Journal Article
Keratin 76 is required for tight junction function and maintenance of the skin barrier
DiTommaso, Tia, Cottle, Denny L, Pearson, Helen B, Schlüter, Holger, Kaur, Pritinder, Humbert, Patrick O, Smyth, Ian M
Published in PLoS genetics (01.10.2014)
Published in PLoS genetics (01.10.2014)
Get full text
Journal Article
Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution
Denoyer, Delphine, Pearson, Helen B, Clatworthy, Sharnel A S, Smith, Zoe M, Francis, Paul S, Llanos, Roxana M, Volitakis, Irene, Phillips, Wayne A, Meggyesy, Peter M, Masaldan, Shashank, Cater, Michael A
Published in Oncotarget (14.06.2016)
Published in Oncotarget (14.06.2016)
Get full text
Journal Article
Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland
Godde, Nathan J, Sheridan, Julie M, Smith, Lorey K, Pearson, Helen B, Britt, Kara L, Galea, Ryan C, Yates, Laura L, Visvader, Jane E, Humbert, Patrick O
Published in PLoS genetics (01.05.2014)
Published in PLoS genetics (01.05.2014)
Get full text
Journal Article
Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
Shorning, Boris Y, Zabkiewicz, Joanna, McCarthy, Afshan, Pearson, Helen B, Winton, Douglas J, Sansom, Owen J, Ashworth, Alan, Clarke, Alan R
Published in PloS one (19.09.2019)
Published in PloS one (19.09.2019)
Get full text
Journal Article
Targeting a STING agonist to perivascular macrophages in prostate tumors delays resistance to androgen deprivation therapy
Al-janabi, Haider, Moyes, Katy, Allen, Richard, Fisher, Matthew, Crespo, Mateus, Gurel, Bora, Rescigno, Pasquale, de Bono, Johann, Nunns, Harry, Bailey, Christopher, Junker-Jensen, Anna, Muthana, Munitta, Phillips, Wayne A, Pearson, Helen B, Taplin, Mary-Ellen, Brown, Janet E, Lewis, Claire E
Published in Journal for immunotherapy of cancer (25.07.2024)
Published in Journal for immunotherapy of cancer (25.07.2024)
Get full text
Journal Article
A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation
Wölwer, Christina B, Pase, Luke B, Pearson, Helen B, Gödde, Nathan J, Lackovic, Kurt, Huang, David C S, Russell, Sarah M, Humbert, Patrick O
Published in PloS one (16.11.2015)
Published in PloS one (16.11.2015)
Get full text
Journal Article
Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine
Shorning, Boris Y, Zabkiewicz, Joanna, McCarthy, Afshan, Pearson, Helen B, Winton, Douglas J, Sansom, Owen J, Ashworth, Alan, Clarke, Alan R
Published in PloS one (23.01.2009)
Published in PloS one (23.01.2009)
Get full text
Journal Article
Development and Characterisation of a New Patient-Derived Xenograft Model of AR-Negative Metastatic Castration-Resistant Prostate Cancer
Turnham, Daniel J, Mullen, Manisha S, Bullock, Nicholas P, Gilroy, Kathryn L, Richards, Anna E, Patel, Radhika, Quintela, Marcos, Meniel, Valerie S, Seaton, Gillian, Kynaston, Howard, Clarkson, Richard W E, Phesse, Toby J, Nelson, Peter S, Haffner, Michael C, Staffurth, John N, Pearson, Helen B
Published in Cells (Basel, Switzerland) (12.04.2024)
Published in Cells (Basel, Switzerland) (12.04.2024)
Get full text
Journal Article
Lkb1 Deficiency Causes Prostate Neoplasia in the Mouse
PEARSON, Helen B, MCCARTHY, Afshan, COFFINS, Christopher M. P, ASHWORTH, Alan, CLARKE, Alan R
Published in Cancer research (Chicago, Ill.) (01.04.2008)
Published in Cancer research (Chicago, Ill.) (01.04.2008)
Get full text
Journal Article
Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations
Flanagan, Dustin J, Barker, Nick, Costanzo, Natasha S Di, Mason, Elizabeth A, Gurney, Austin, Meniel, Valerie S, Koushyar, Sarah, Austin, Chloe R, Ernst, Matthias, Pearson, Helen B, Boussioutas, Alex, Clevers, Hans, Phesse, Toby J, Vincan, Elizabeth
Published in Cancer research (Chicago, Ill.) (01.03.2019)
Published in Cancer research (Chicago, Ill.) (01.03.2019)
Get full text
Journal Article
Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth
Pearson, Helen B, Li, Jason, Meniel, Valerie S, Fennell, Christina M, Waring, Paul, Montgomery, Karen G, Rebello, Richard J, Macpherson, Arthi A, Koushyar, Sarah, Furic, Luc, Cullinane, Carleen, Clarkson, Richard W, Smalley, Matthew J, Simpson, Kaylene J, Phesse, Toby J, Shepherd, Peter R, Humbert, Patrick O, Sansom, Owen J, Phillips, Wayne A
Published in Cancer discovery (01.06.2018)
Published in Cancer discovery (01.06.2018)
Get full text
Journal Article