Structure-specific amyloid precipitation in biofluids
Rodrigues, M., Bhattacharjee, P., Brinkmalm, A., Do, D. T., Pearson, C. M., De, S., Ponjavic, A., Varela, J. A., Kulenkampff, K., Baudrexel, I., Emin, D., Ruggeri, F. S., Lee, J. E., Carr, A. R., Knowles, T. P. J., Zetterberg, H., Snaddon, T. N., Gandhi, S., Lee, S. F., Klenerman, D.
Published in Nature chemistry (01.09.2022)
Published in Nature chemistry (01.09.2022)
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Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding
Martyn, Gabriella E., Wienert, Beeke, Yang, Lu, Shah, Manan, Norton, Laura J., Burdach, Jon, Kurita, Ryo, Nakamura, Yukio, Pearson, Richard C. M., Funnell, Alister P. W., Quinlan, Kate G. R., Crossley, Merlin
Published in Nature genetics (01.04.2018)
Published in Nature genetics (01.04.2018)
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Targeted Disruption of the Basic Krüppel-Like Factor Gene (Klf3) Reveals a Role in Adipogenesis
Sue, Nancy, Jack, Briony H. A., Eaton, Sally A., Pearson, Richard C. M., Funnell, Alister P. W., Turner, Jeremy, Czolij, Robert, Denyer, Gareth, Bao, Shisan, Molero-Navajas, Juan Carlos, Perkins, Andrew, Fujiwara, Yuko, Orkin, Stuart H., Bell-Anderson, Kim, Crossley, Merlin
Published in Molecular and Cellular Biology (01.06.2008)
Published in Molecular and Cellular Biology (01.06.2008)
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Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing
Funnell, Alister P W, Mak, Ka Sin, Twine, Natalie A, Pelka, Gregory J, Norton, Laura J, Radziewic, Tania, Power, Melinda, Wilkins, Marc R, Bell-Anderson, Kim S, Fraser, Stuart T, Perkins, Andrew C, Tam, Patrick P, Pearson, Richard C M, Crossley, Merlin
Published in Molecular and Cellular Biology (01.08.2013)
Published in Molecular and Cellular Biology (01.08.2013)
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Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch
Norton, Laura J., Hallal, Samantha, Stout, Elizabeth S., Funnell, Alister P. W., Pearson, Richard C. M., Crossley, Merlin, Quinlan, Kate G. R.
Published in Scientific reports (09.06.2017)
Published in Scientific reports (09.06.2017)
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KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells
Norton, Laura J., Funnell, Alister P.W., Burdach, Jon, Wienert, Beeke, Kurita, Ryo, Nakamura, Yukio, Philipsen, Sjaak, Pearson, Richard C.M., Quinlan, Kate G.R., Crossley, Merlin
Published in Blood advances (25.04.2017)
Published in Blood advances (25.04.2017)
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The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo
Funnell, Alister P. W., Norton, Laura J., Mak, Ka Sin, Burdach, Jon, Artuz, Crisbel M., Twine, Natalie A., Wilkins, Marc R., Power, Carl A., Hung, Tzong-Tyng, Perdomo, José, Koh, Philip, Bell-Anderson, Kim S., Orkin, Stuart H., Fraser, Stuart T., Perkins, Andrew C., Pearson, Richard C. M., Crossley, Merlin
Published in Molecular and Cellular Biology (01.08.2012)
Published in Molecular and Cellular Biology (01.08.2012)
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Journal Article
Impaired B cell development in the absence of Krüppel-like factor 3
Vu, Thi Thanh, Gatto, Dominique, Turner, Vivian, Funnell, Alister P W, Mak, Ka Sin, Norton, Laura J, Kaplan, Warren, Cowley, Mark J, Agenès, Fabien, Kirberg, Jörg, Brink, Robert, Pearson, Richard C M, Crossley, Merlin
Published in The Journal of immunology (1950) (15.11.2011)
Published in The Journal of immunology (1950) (15.11.2011)
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Phosphorylation of Krüppel-like Factor 3 (KLF3/BKLF) and C-terminal Binding Protein 2 (CtBP2) by Homeodomain-interacting Protein Kinase 2 (HIPK2) Modulates KLF3 DNA Binding and Activity
Dewi, Vitri, Kwok, Alister, Lee, Stella, Lee, Ming Min, Tan, Yee Mun, Nicholas, Hannah R., Isono, Kyo-ichi, Wienert, Beeke, Mak, Ka Sin, Knights, Alexander J., Quinlan, Kate G.R., Cordwell, Stuart J., Funnell, Alister P.W., Pearson, Richard C.M., Crossley, Merlin
Published in The Journal of biological chemistry (27.03.2015)
Published in The Journal of biological chemistry (27.03.2015)
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Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor
Burdach, Jon, Funnell, Alister P W, Mak, Ka Sin, Artuz, Crisbel M, Wienert, Beeke, Lim, Wooi F, Tan, Lit Yeen, Pearson, Richard C M, Crossley, Merlin
Published in Nucleic acids research (01.01.2014)
Published in Nucleic acids research (01.01.2014)
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Journal Article
PU.1 and Haematopoietic Cell Fate: Dosage Matters
Mak, Ka Sin, Funnell, Alister P. W., Pearson, Richard C. M., Crossley, Merlin
Published in International Journal of Cell Biology (2011)
Published in International Journal of Cell Biology (2011)
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Preadolescent Disordered Eating Predicts Subsequent Eating Dysfunction
COMBS, Jessica L, PEARSON, Carolyn M, ZAPOLSKI, Tamika C. B, SMITH, Gregory T
Published in Journal of pediatric psychology (01.01.2013)
Published in Journal of pediatric psychology (01.01.2013)
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Journal Article
A CpG Mutational Hotspot in a ONECUT Binding Site Accounts for the Prevalent Variant of Hemophilia B Leyden
Funnell, Alister P.W., Wilson, Michael D., Ballester, Benoit, Mak, Ka Sin, Burdach, Jon, Magan, Natisha, Pearson, Richard C.M., Lemaigre, Frederic P., Stowell, Kathryn M., Odom, Duncan T., Flicek, Paul, Crossley, Merlin
Published in American journal of human genetics (07.03.2013)
Published in American journal of human genetics (07.03.2013)
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Journal Article
Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin
Wienert, Beeke, Funnell, Alister P. W., Norton, Laura J., Pearson, Richard C. M., Wilkinson-White, Lorna E., Lester, Krystal, Vadolas, Jim, Porteus, Matthew H., Matthews, Jacqueline M., Quinlan, Kate G. R., Crossley, Merlin
Published in Nature communications (14.05.2015)
Published in Nature communications (14.05.2015)
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