The Hsp90 molecular chaperone: an open and shut case for treatment
Pearl, Laurence H, Prodromou, Chrisostomos, Workman, Paul
Published in Biochemical journal (15.03.2008)
Published in Biochemical journal (15.03.2008)
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Therapeutic opportunities within the DNA damage response
Pearl, Laurence H., Schierz, Amanda C., Ward, Simon E., Al-Lazikani, Bissan, Pearl, Frances M. G.
Published in Nature reviews. Cancer (01.03.2015)
Published in Nature reviews. Cancer (01.03.2015)
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Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B
Tahtouh, Tania, Elkins, Jonathan M, Filippakopoulos, Panagis, Soundararajan, Meera, Burgy, Guillaume, Durieu, Emilie, Cochet, Claude, Schmid, Ralf S, Lo, Donald C, Delhommel, Florent, Oberholzer, Anselm E, Pearl, Laurence H, Carreaux, François, Bazureau, Jean-Pierre, Knapp, Stefan, Meijer, Laurent
Published in Journal of medicinal chemistry (08.11.2012)
Published in Journal of medicinal chemistry (08.11.2012)
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The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks
Ali, Ammar A E, Timinszky, Gyula, Arribas-Bosacoma, Raquel, Kozlowski, Marek, Hassa, Paul O, Hassler, Markus, Ladurner, Andreas G, Pearl, Laurence H, Oliver, Antony W
Published in Nature structural & molecular biology (01.07.2012)
Published in Nature structural & molecular biology (01.07.2012)
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Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity
Mollapour, Mehdi, Tsutsumi, Shinji, Truman, Andrew W., Xu, Wanping, Vaughan, Cara K., Beebe, Kristin, Konstantinova, Anna, Vourganti, Srinivas, Panaretou, Barry, Piper, Peter W., Trepel, Jane B., Prodromou, Chrisostomos, Pearl, Laurence H., Neckers, Len
Published in Molecular cell (18.03.2011)
Published in Molecular cell (18.03.2011)
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ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX
Baldock, Robert A., Day, Matthew, Wilkinson, Oliver J., Cloney, Ross, Jeggo, Penelope A., Oliver, Antony W., Watts, Felicity Z., Pearl, Laurence H.
Published in Cell reports (Cambridge) (15.12.2015)
Published in Cell reports (Cambridge) (15.12.2015)
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Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1
Pal, Mohinder, Morgan, Marc, Phelps, Sarah E.L., Roe, S. Mark, Parry-Morris, Sarah, Downs, Jessica A., Polier, Sigrun, Pearl, Laurence H., Prodromou, Chrisostomos
Published in Structure (London) (10.06.2014)
Published in Structure (London) (10.06.2014)
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Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1
Polo, Luis M., Xu, Yingqi, Hornyak, Peter, Garces, Fernando, Zeng, Zhihong, Hailstone, Richard, Matthews, Steve J., Caldecott, Keith W., Oliver, Antony W., Pearl, Laurence H.
Published in Cell reports (Cambridge) (15.01.2019)
Published in Cell reports (Cambridge) (15.01.2019)
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Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus
Rivera-Calzada, Angel, Arribas-Bosacoma, Raquel, Ruiz-Ramos, Alba, Escudero-Bravo, Paloma, Boskovic, Jasminka, Fernandez-Leiro, Rafael, Oliver, Antony W., Pearl, Laurence H., Llorca, Oscar
Published in Nature communications (18.11.2022)
Published in Nature communications (18.11.2022)
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RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex
Martino, Fabrizio, Pal, Mohinder, Muñoz-Hernández, Hugo, Rodríguez, Carlos F., Núñez-Ramírez, Rafael, Gil-Carton, David, Degliesposti, Gianluca, Skehel, J. Mark, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence H., Llorca, Oscar
Published in Nature communications (16.04.2018)
Published in Nature communications (16.04.2018)
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TopBP1 utilises a bipartite GINS binding mode to support genome replication
Day, Matthew, Tetik, Bilal, Parlak, Milena, Almeida-Hernández, Yasser, Räschle, Markus, Kaschani, Farnusch, Siegert, Heike, Marko, Anika, Sanchez-Garcia, Elsa, Kaiser, Markus, Barker, Isabel A., Pearl, Laurence H., Oliver, Antony W., Boos, Dominik
Published in Nature communications (27.02.2024)
Published in Nature communications (27.02.2024)
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The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins
Grundy, Gabrielle J., Rulten, Stuart L., Arribas-Bosacoma, Raquel, Davidson, Kathryn, Kozik, Zuzanna, Oliver, Antony W., Pearl, Laurence H., Caldecott, Keith W.
Published in Nature communications (11.04.2016)
Published in Nature communications (11.04.2016)
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Chaperoned Ubiquitylation—Crystal Structures of the CHIP U Box E3 Ubiquitin Ligase and a CHIP-Ubc13-Uev1a Complex
Zhang, Minghao, Windheim, Mark, Roe, S. Mark, Peggie, Mark, Cohen, Philip, Prodromou, Chrisostomos, Pearl, Laurence H.
Published in Molecular cell (23.11.2005)
Published in Molecular cell (23.11.2005)
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