Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by sortase A-mediated protein ligation
Madej, Mariusz P., Coia, Gregory, Williams, Charlotte C., Caine, Joanne M., Pearce, Lesley A., Attwood, Rebecca, Bartone, Nick A., Dolezal, Olan, Nisbet, Rebecca M., Nuttall, Stewart D., Adams, Timothy E.
Published in Biotechnology and bioengineering (01.06.2012)
Published in Biotechnology and bioengineering (01.06.2012)
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CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function
Bandala-Sanchez, Esther, Bediaga, Naiara G., Goddard-Borger, Ethan D., Ngui, Katrina, Naselli, Gaetano, Stone, Natalie L., Neale, Alana M., Pearce, Lesley A., Wardak, Ahmad, Czabotar, Peter, Haselhorst, Thomas, Maggioni, Andrea, Hartley-Tassell, Lauren A., Adams, Timothy E., Harrison, Leonard C.
Published in Proceedings of the National Academy of Sciences - PNAS (24.07.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (24.07.2018)
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Enzyme mediated incorporation of zirconium-89 or copper-64 into a fragment antibody for same day imaging of epidermal growth factor receptor
Rudd, Stacey E, Van Zuylekom, Jessica K, Raicevic, Anna, Pearce, Lesley A, Cullinane, Carleen, Williams, Charlotte C, Adams, Timothy E, Hicks, Rodney J, Donnelly, Paul S
Published in Chemical science (Cambridge) (07.07.2021)
Published in Chemical science (Cambridge) (07.07.2021)
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Dual Site-Specific Labeling of an Antibody Fragment through Sortase A and π‑Clamp Conjugation
Lee, Michael D, Tong, Wing Yin, Nebl, Thomas, Pearce, Lesley A, Pham, Tam M, Golbaz-Hagh, Arghavan, Puttick, Simon, Rose, Stephen, Adams, Timothy E, Williams, Charlotte C
Published in Bioconjugate chemistry (16.10.2019)
Published in Bioconjugate chemistry (16.10.2019)
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Preclinical Evaluation of a Fluorescent Probe Targeting Receptor CDCP1 for Identification of Ovarian Cancer
He, Yaowu, Khan, Tashbib, Kryza, Thomas, Jones, Martina L, Goh, Justin B, Lyons, Nicholas J, Pearce, Lesley A, Lee, Michael D, Gough, Madeline, Rogers, Rebecca, Davies, Claire M, Gilks, C. Blake, Hodgkinson, Thomas, Lourie, Rohan, Barry, Sinead C, Perrin, Lewis C, Williams, Charlotte C, Puttick, Simon, Adams, Timothy E, Munro, Trent P, Hooper, John D, Chetty, Naven
Published in Molecular pharmaceutics (06.09.2021)
Published in Molecular pharmaceutics (06.09.2021)
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CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy
Khan, Tashbib, Lyons, Nicholas J, Gough, Madeline, Kwah, Kayden K X, Cuda, Tahleesa J, Snell, Cameron E, Tse, Brian W, Sokolowski, Kamil A, Pearce, Lesley A, Adams, Timothy E, Rose, Stephen E, Puttick, Simon, Pajic, Marina, Adams, Mark N, He, Yaowu, Hooper, John D, Kryza, Thomas
Published in Theranostics (01.01.2022)
Published in Theranostics (01.01.2022)
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Biochemical Characterization of Individual Human Glycosylated pro-Insulin-like Growth Factor (IGF)-II and big-IGF-II Isoforms Associated with Cancer
Greenall, Sameer A., Bentley, John D., Pearce, Lesley A., Scoble, Judith A., Sparrow, Lindsay G., Bartone, Nicola A., Xiao, Xiaowen, Baxter, Robert C., Cosgrove, Leah J., Adams, Timothy E.
Published in The Journal of biological chemistry (04.01.2013)
Published in The Journal of biological chemistry (04.01.2013)
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Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-β peptide
Nisbet, Rebecca M., Nuttall, Stewart D., Robert, Remy, Caine, Joanne M., Dolezal, Olan, Hattarki, Meghan, Pearce, Lesley A., Davydova, Natalia, Masters, Colin L., Varghese, Jose N., Streltsov, Victor A.
Published in Proteins, structure, function, and bioinformatics (01.10.2013)
Published in Proteins, structure, function, and bioinformatics (01.10.2013)
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Structural characterization by transmission electron microscopy and immunoreactivity of recombinant Hendra virus nucleocapsid protein expressed and purified from Escherichia coli
Pearce, Lesley A., Yu, Meng, Waddington, Lynne J., Barr, Jennifer A., Scoble, Judith A., Crameri, Gary S., McKinstry, William J.
Published in Protein expression and purification (01.12.2015)
Published in Protein expression and purification (01.12.2015)
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Kinetic screening of antibody–Im7 conjugates by capture on a colicin E7 DNase domain using optical biosensors
Hosse, Ralf J., Tay, Leigh, Hattarki, Meghan K., Pontes-Braz, Luisa, Pearce, Lesley A., Nuttall, Stewart D., Dolezal, Olan
Published in Analytical biochemistry (15.02.2009)
Published in Analytical biochemistry (15.02.2009)
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ScFv multimers of the anti-neuraminidase antibody NC10: shortening of the linker in single-chain Fv fragment assembled in VL to VH orientation drives the formation of dimers, trimers, tetramers and higher molecular mass multimers
Dolezal, Olan, Pearce, Lesley A., Lawrence, Lynne J., McCoy, Airlie J., Hudson, Peter J., Kortt, Alexander A.
Published in Protein engineering, design and selection (01.08.2000)
Published in Protein engineering, design and selection (01.08.2000)
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Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-[beta] peptide
Nisbet, Rebecca M, Nuttall, Stewart D, Robert, Remy, Caine, Joanne M, Dolezal, Olan, Hattarki, Meghan, Pearce, Lesley A, Davydova, Natalia, Masters, Colin L, Varghese, Jose N, Streltsov, Victor A
Published in Proteins, structure, function, and bioinformatics (01.10.2013)
Published in Proteins, structure, function, and bioinformatics (01.10.2013)
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Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-β peptide: Aβ N-Terminal Structural Studies
Nisbet, Rebecca M., Nuttall, Stewart D., Robert, Remy, Caine, Joanne M., Dolezal, Olan, Hattarki, Meghan, Pearce, Lesley A., Davydova, Natalia, Masters, Colin L., Varghese, Jose N., Streltsov, Victor A.
Published in Proteins, structure, function, and bioinformatics (01.10.2013)
Published in Proteins, structure, function, and bioinformatics (01.10.2013)
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Single-chain Fv fragments of anti-neuraminidase antibody NC10 containing five- and ten-residue linkers form dimers and with zero-residue linker a trimer
Kortt, A A, Lah, M, Oddie, G W, Gruen, C L, Burns, J E, Pearce, L A, Atwell, J L, McCoy, A J, Howlett, G J, Metzger, D W, Webster, R G, Hudson, P J
Published in Protein engineering (01.04.1997)
Published in Protein engineering (01.04.1997)
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Expression inEscherichia coliof the PutativeN-Acetylneuraminate Lyase Gene (nanA) fromHaemophilus influenzae:Overproduction, Purification, and Crystallization
Lilley, Glenn G., Barbosa, João A.R.G., Pearce, Lesley A.
Published in Protein expression and purification (01.04.1998)
Published in Protein expression and purification (01.04.1998)
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