KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
Vaseva, Angelina V., Blake, Devon R., Gilbert, Thomas S.K., Ng, Serina, Hostetter, Galen, Azam, Salma H., Ozkan-Dagliyan, Irem, Gautam, Prson, Bryant, Kirsten L., Pearce, Kenneth H., Herring, Laura E., Han, Haiyong, Graves, Lee M., Witkiewicz, Agnieszka K., Knudsen, Erik S., Pecot, Chad V., Rashid, Naim, Houghton, Peter J., Wennerberg, Krister, Cox, Adrienne D., Der, Channing J.
Published in Cancer cell (12.11.2018)
Published in Cancer cell (12.11.2018)
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In silico fragment-based discovery of CIB1-directed anti-tumor agents by FRASE-bot
An, Yi, Lim, Jiwoong, Glavatskikh, Marta, Wang, Xiaowen, Norris-Drouin, Jacqueline, Hardy, P. Brian, Leisner, Tina M., Pearce, Kenneth H., Kireev, Dmitri
Published in Nature communications (02.07.2024)
Published in Nature communications (02.07.2024)
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PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling
Yang, Yang, Jayaprakash, Deepika, Jhujh, Satpal S, Reynolds, John J, Chen, Steve, Gao, Yanzhe, Anand, Jay Ramanlal, Mutter-Rottmayer, Elizabeth, Ariel, Pablo, An, Jing, Cheng, Xing, Pearce, Kenneth H, Blanchet, Sophie-Anne, Nandakumar, Nandana, Zhou, Pei, Fradet-Turcotte, Amélie, Stewart, Grant S, Vaziri, Cyrus
Published in Nucleic acids research (24.10.2024)
Published in Nucleic acids research (24.10.2024)
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Author Correction: A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis
Gao, Yanzhe, Mutter-Rottmayer, Elizabeth, Greenwalt, Alicia M., Goldfarb, Dennis, Yan, Feng, Yang, Yang, Martinez-Chacin, Raquel C., Pearce, Kenneth H., Tateishi, Satoshi, Major, Michael B., Vaziri, Cyrus
Published in Nature communications (14.11.2024)
Published in Nature communications (14.11.2024)
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A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis
Gao, Yanzhe, Mutter-Rottmayer, Elizabeth, Greenwalt, Alicia M., Goldfarb, Dennis, Yan, Feng, Yang, Yang, Martinez-Chacin, Raquel C., Pearce, Kenneth H., Tateishi, Satoshi, Major, Michael B., Vaziri, Cyrus
Published in Nature communications (05.07.2016)
Published in Nature communications (05.07.2016)
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Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7
Lamb, Kelsey N, Bsteh, Daniel, Dishman, Sarah N, Moussa, Hagar F, Fan, Huitao, Stuckey, Jacob I, Norris, Jacqueline L, Cholensky, Stephanie H, Li, Dongxu, Wang, Jingkui, Sagum, Cari, Stanton, Benjamin Z, Bedford, Mark T, Pearce, Kenneth H, Kenakin, Terry P, Kireev, Dmitri B, Wang, Gang Greg, James, Lindsey I, Bell, Oliver, Frye, Stephen V
Published in Cell chemical biology (17.10.2019)
Published in Cell chemical biology (17.10.2019)
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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM
Bashore, Frances M, Katis, Vittorio L, Du, Yuhong, Sikdar, Arunima, Wang, Dongxue, Bradshaw, William J, Rygiel, Karolina A, Leisner, Tina M, Chalk, Rod, Mishra, Swati, Williams, C Andrew, Gileadi, Opher, Brennan, Paul E, Wiley, Jesse C, Gockley, Jake, Cary, Gregory A, Carter, Gregory W, Young, Jessica E, Pearce, Kenneth H, Fu, Haian, Axtman, Alison D
Published in PloS one (15.02.2024)
Published in PloS one (15.02.2024)
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Structure–Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains
Stuckey, Jacob I, Simpson, Catherine, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Lee, Junghyun, Pasca, Ryan, Cheng, Nancy, Dickson, Bradley M, Pearce, Kenneth H, Frye, Stephen V, James, Lindsey I
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
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Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins
Rectenwald, Justin M, Guduru, Shiva Krishna Reddy, Dang, Zhao, Collins, Leonard B, Liao, Yi-En, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Kaufmann, Kyle W, Hammond, Scott M, Kireev, Dmitri B, Frye, Stephen V, Pearce, Kenneth H
Published in Molecules (Basel, Switzerland) (22.02.2020)
Published in Molecules (Basel, Switzerland) (22.02.2020)
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Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV‑2 and Potential Mechanisms
Puhl, Ana C, Fritch, Ethan J, Lane, Thomas R, Tse, Longping V, Yount, Boyd L, Sacramento, Carolina Q, Fintelman-Rodrigues, Natalia, Tavella, Tatyana Almeida, Maranhão Costa, Fabio Trindade, Weston, Stuart, Logue, James, Frieman, Matthew, Premkumar, Lakshmanane, Pearce, Kenneth H, Hurst, Brett L, Andrade, Carolina Horta, Levi, James A, Johnson, Nicole J, Kisthardt, Samantha C, Scholle, Frank, Souza, Thiago Moreno L, Moorman, Nathaniel John, Baric, Ralph S, Madrid, Peter B, Ekins, Sean
Published in ACS omega (23.03.2021)
Published in ACS omega (23.03.2021)
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Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition
Bledsoe, Randy K., Montana, Valerie G., Stanley, Thomas B., Delves, Chris J., Apolito, Christopher J., McKee, David D., Consler, Thomas G., Parks, Derek J., Stewart, Eugene L., Willson, Timothy M., Lambert, Millard H., Moore, John T., Pearce, Kenneth H., Xu, H.Eric
Published in Cell (12.07.2002)
Published in Cell (12.07.2002)
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Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors
Baughman, Brandi M, Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A, Jessen, Henning J, Pearce, Kenneth H, Frye, Stephen V, Shears, Stephen B
Published in PloS one (21.06.2017)
Published in PloS one (21.06.2017)
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A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors
Baughman, Brandi M, Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A, Jessen, Henning J, Pearce, Kenneth H, Frye, Stephen V, Shears, Stephen B
Published in PloS one (13.10.2016)
Published in PloS one (13.10.2016)
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Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library
Shell, Devan J., Rectenwald, Justin M., Buttery, Peter H., Johnson, Rebecca L., Foley, Caroline A., Guduru, Shiva K.R., Uguen, Mélanie, Rubiano, Juanita Sanchez, Zhang, Xindi, Li, Fengling, Norris-Drouin, Jacqueline L., Axtman, Matthew, Brian Hardy, P., Vedadi, Masoud, Frye, Stephen V., James, Lindsey I., Pearce, Kenneth H.
Published in SLAS discovery (01.12.2022)
Published in SLAS discovery (01.12.2022)
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Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology
Potjewyd, Frances M., Annor‐Gyamfi, Joel K., Aubé, Jeffrey, Chu, Shaoyou, Conlon, Ivie L., Frankowski, Kevin J., Guduru, Shiva K. R., Hardy, Brian P., Hopkins, Megan D., Kinoshita, Chizuru, Kireev, Dmitri B., Mason, Emily R., Moerk, Charles T., Nwogbo, Felix, Pearce, Kenneth H., Richardson, Timothy I., Rogers, David A., Soni, Disha M., Stashko, Michael, Wang, Xiaodong, Wells, Carrow, Willson, Timothy M., Frye, Stephen V., Young, Jessica E., Axtman, Alison D.
Published in Alzheimer's & dementia : translational research & clinical interventions (2022)
Published in Alzheimer's & dementia : translational research & clinical interventions (2022)
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Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins
Lamb, Kelsey N, Dishman, Sarah N, Waybright, Jarod M, Engelberg, Isabelle A, Rectenwald, Justin M, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Pearce, Kenneth H, James, Lindsey I, Frye, Stephen V
Published in ACS omega (11.01.2022)
Published in ACS omega (11.01.2022)
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AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery
Potjewyd, Frances M., Annor‐Gyamfi, Joel K., Aubé, Jeffrey, Chu, Shaoyou, Conlon, Ivie L., Frankowski, Kevin J., Guduru, Shiva K. R., Hardy, Brian P., Hopkins, Megan D., Kinoshita, Chizuru, Kireev, Dmitri B., Mason, Emily R., Moerk, Charles T., Nwogbo, Felix, Pearce, Kenneth H., Richardson, Timothy I., Rogers, David A., Soni, Disha M., Stashko, Michael, Wang, Xiaodong, Wells, Carrow, Willson, Timothy M., Frye, Stephen V., Young, Jessica E., Axtman, Alison D.
Published in Alzheimer's & dementia : translational research & clinical interventions (2022)
Published in Alzheimer's & dementia : translational research & clinical interventions (2022)
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