Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD)
Palmer, Nick, Peakman, Torren M., Norton, David, Rees, David C.
Published in Organic & biomolecular chemistry (07.02.2016)
Published in Organic & biomolecular chemistry (07.02.2016)
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Structure–Activity and Structure–Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1/NRF2) Protein–Protein Interaction
Heightman, Tom D, Callahan, James F, Chiarparin, Elisabetta, Coyle, Joseph E, Griffiths-Jones, Charlotte, Lakdawala, Ami S, McMenamin, Rachel, Mortenson, Paul N, Norton, David, Peakman, Torren M, Rich, Sharna J, Richardson, Caroline, Rumsey, William L, Sanchez, Yolanda, Saxty, Gordon, Willems, Henriëtte M. G, Wolfe, Lawrence, Woolford, Alison J.-A, Wu, Zining, Yan, Hongxing, Kerns, Jeffrey K, Davies, Thomas G
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2
Heightman, Tom D., Berdini, Valerio, Bevan, Luke, Buck, Ildiko M., Carr, Maria G., Courtin, Aurelie, Coyle, Joseph E., Day, James E. H., East, Charlotte, Fazal, Lynsey, Griffiths-Jones, Charlotte M., Howard, Steven, Kucia-Tran, Justyna, Martins, Vanessa, Muench, Sandra, Munck, Joanne M., Norton, David, O'Reilly, Marc, Palmer, Nicholas, Pathuri, Puja, Peakman, Torren M., Reader, Michael, Rees, David C., Rich, Sharna J., Shah, Alpesh, Wallis, Nicola G., Walton, Hugh, Wilsher, Nicola E., Woolford, Alison J-A, Cooke, Michael, Cousin, David, Onions, Stuart, Shannon, Jonathan, Watts, John, Murray, Christopher W.
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Journal Article
Isolation and Structural Proof of the Large Diamond Molecule, Cyclohexamantane (C26H30)
Dahl, Jeremy E. P., Moldowan, J. Michael, Peakman, Torren M., Clardy, Jon C., Lobkovsky, Emil, Olmstead, Marilyn M., May, Paul W., Davis, Tim J., Steeds, John W., Peters, Ken E., Pepper, Andy, Ekuan, Andy, Carlson, Robert M. K.
Published in Angewandte Chemie International Edition (09.05.2003)
Published in Angewandte Chemie International Edition (09.05.2003)
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Journal Article
Preparation of triazolobenzodiazepine derivatives as Vasopressin V1a antagonists
Beal, David M., Bryans, Justin S., Johnson, Patrick S., Newman, Julie, Pasquinet, Christelle, Peakman, Torren M., Ryckmans, Thomas, Underwood, Toby J., Wheeler, Simon
Published in Tetrahedron letters (09.11.2011)
Published in Tetrahedron letters (09.11.2011)
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Journal Article
The Molecular Fossil Record of Oleanane and Its Relation to Angiosperms
Moldowan, J. Michael, Dahl, Jeremy, Huizinga, Bradley J., Fago, Frederick J., Hickey, Leo J., Peakman, Torren M., Taylor, David Winship
Published in Science (American Association for the Advancement of Science) (05.08.1994)
Published in Science (American Association for the Advancement of Science) (05.08.1994)
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Journal Article
Cyclization of the Acyl Glucuronide Metabolite of a Neutral Endopeptidase Inhibitor to an Electrophilic Glutarimide: Synthesis, Reactivity, and Mechanistic Analysis
Meng, Xiaoli, Maggs, James L, Pryde, David C, Planken, Simon, Jenkins, Rosalind E, Peakman, Torren M, Beaumont, Kevin, Kohl, Christopher, Park, B. Kevin, Stachulski, Andrew V
Published in Journal of medicinal chemistry (29.11.2007)
Published in Journal of medicinal chemistry (29.11.2007)
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Journal Article
A highly selective method for 11β-OH protection of steroidal 11β, 17α-diols
Glossop, Paul A., Hoogenraad, Marcel, Peakman, Torren M., Roberts, Dannielle F.
Published in Steroids (01.05.2008)
Published in Steroids (01.05.2008)
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Journal Article
A highly selective method for 11 beta-OH protection of steroidal 11 beta, 17 alpha-diols
Glossop, Paul A., Hoogenraad, Marcel, Peakman, Torren M., Roberts, Dannielle F.
Published in Steroids (01.05.2008)
Published in Steroids (01.05.2008)
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Journal Article
Accuracy vs Time Dilemma on the Prediction of NMR Chemical Shifts: A Case Study (Chloropyrimidines)
Pérez, Manuel, Peakman, Torren M, Alex, Alexander, Higginson, Paul D, Mitchell, John C, Snowden, Martin J, Morao, Iñaki
Published in Journal of organic chemistry (14.04.2006)
Published in Journal of organic chemistry (14.04.2006)
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Journal Article
X‑ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor
St. Denis, Jeffrey D., Chessari, Gianni, Cleasby, Anne, Cons, Benjamin D., Cowan, Suzanna, Dalton, Samuel E., East, Charlotte, Murray, Christopher W., O’Reilly, Marc, Peakman, Torren, Rapti, Magdalini, Stow, Jessie L.
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Journal Article
A Fragment-Derived Clinical Candidate for Antagonism of X‑Linked and Cellular Inhibitor of Apoptosis Proteins: 1‑(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl‑1H,2H,3H‑pyrrolo[3,2‑b]pyridin-1-yl)-2-[(2R,5R)‑5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660)
Johnson, Christopher N., Ahn, Jong Sook, Buck, Ildiko M., Chiarparin, Elisabetta, Day, James E. H., Hopkins, Anna, Howard, Steven, Lewis, Edward J., Martins, Vanessa, Millemaggi, Alessia, Munck, Joanne M., Page, Lee W., Peakman, Torren, Reader, Michael, Rich, Sharna J., Saxty, Gordon, Smyth, Tomoko, Thompson, Neil T., Ward, George A., Williams, Pamela A., Wilsher, Nicola E., Chessari, Gianni
Published in Journal of medicinal chemistry (23.08.2018)
Published in Journal of medicinal chemistry (23.08.2018)
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Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X‑Linked Inhibitor of Apoptosis Protein (XIAP)
Tamanini, Emiliano, Buck, Ildiko M, Chessari, Gianni, Chiarparin, Elisabetta, Day, James E. H, Frederickson, Martyn, Griffiths-Jones, Charlotte M, Hearn, Keisha, Heightman, Tom D, Iqbal, Aman, Johnson, Christopher N, Lewis, Edward J, Martins, Vanessa, Peakman, Torren, Reader, Michael, Rich, Sharna J, Ward, George A, Williams, Pamela A, Wilsher, Nicola E
Published in Journal of medicinal chemistry (08.06.2017)
Published in Journal of medicinal chemistry (08.06.2017)
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Journal Article
Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase‑2 (SHP2)
Day, James E. H., Berdini, Valerio, Castro, Joan, Chessari, Gianni, Davies, Thomas G., Day, Philip J., St. Denis, Jeffrey D., Fujiwara, Hideto, Fukaya, Satoshi, Hamlett, Christopher C. F., Hearn, Keisha, Hiscock, Steven D., Holvey, Rhian S., Ito, Satoru, Kandola, Navrohit, Kodama, Yasuo, Liebeschuetz, John W., Martins, Vanessa, Matsuo, Kenichi, Mortenson, Paul N., Muench, Sandra, Nakatsuru, Yoko, Ochiiwa, Hiroaki, Palmer, Nicholas, Peakman, Torren, Price, Amanda, Reader, Michael, Rees, David C., Rich, Sharna J., Shah, Alpesh, Shibata, Yoshihiro, Smyth, Tomoko, Twigg, David G., Wallis, Nicola G., Williams, Glyn, Wilsher, Nicola E., Woodhead, Andrew, Shimamura, Tadashi, Johnson, Christopher N.
Published in Journal of medicinal chemistry (28.03.2024)
Published in Journal of medicinal chemistry (28.03.2024)
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Journal Article
Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β‑Glucocerebrosidase
Palmer, Nick, Agnew, Christopher, Benn, Caroline, Buffham, William J., Castro, Joan N., Chessari, Gianni, Clark, Mellissa, Cons, Benjamin D., Coyle, Joseph E., Dawson, Lee A., Hamlett, Christopher C. F., Hodson, Charlotte, Holding, Finn, Johnson, Christopher N., Liebeschuetz, John W., Mahajan, Pravin, McCarthy, James M., Murray, Christopher W., O’Reilly, Marc, Peakman, Torren, Price, Amanda, Rapti, Magdalini, Reeks, Judith, Schöpf, Patrick, St-Denis, Jeffrey D., Valenzano, Chiara, Wallis, Nicola G., Walser, Reto, Weir, Heather, Wilsher, Nicola E., Woodhead, Andrew, Bento, Carla F., Tisi, Dominic
Published in Journal of medicinal chemistry (11.07.2024)
Published in Journal of medicinal chemistry (11.07.2024)
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Journal Article
A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660)
Johnson, Christopher N, Ahn, Jong Sook, Buck, Ildiko M, Chiarparin, Elisabetta, Day, James E H, Hopkins, Anna, Howard, Steven, Lewis, Edward J, Martins, Vanessa, Millemaggi, Alessia, Munck, Joanne M, Page, Lee W, Peakman, Torren, Reader, Michael, Rich, Sharna J, Saxty, Gordon, Smyth, Tomoko, Thompson, Neil T, Ward, George A, Williams, Pamela A, Wilsher, Nicola E, Chessari, Gianni
Published in Journal of medicinal chemistry (23.08.2018)
Published in Journal of medicinal chemistry (23.08.2018)
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Journal Article