The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
Woodcock, Hannah V., Eley, Jessica D., Guillotin, Delphine, Platé, Manuela, Nanthakumar, Carmel B., Martufi, Matteo, Peace, Simon, Joberty, Gerard, Poeckel, Daniel, Good, Robert B., Taylor, Adam R., Zinn, Nico, Redding, Matthew, Forty, Ellen J., Hynds, Robert E., Swanton, Charles, Karsdal, Morten, Maher, Toby M., Fisher, Andrew, Bergamini, Giovanna, Marshall, Richard P., Blanchard, Andy D., Mercer, Paul F., Chambers, Rachel C.
Published in Nature communications (02.01.2019)
Published in Nature communications (02.01.2019)
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The developability of heteroaromatic and heteroaliphatic rings - do some have a better pedigree as potential drug molecules than others?
Ritchie, Timothy J, Macdonald, Simon J. F, Peace, Simon, Pickett, Stephen D, Luscombe, Christopher N
Published in MedChemComm (01.09.2012)
Published in MedChemComm (01.09.2012)
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Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
Woodcock, Hannah V., Eley, Jessica D., Guillotin, Delphine, Platé, Manuela, Nanthakumar, Carmel B., Martufi, Matteo, Peace, Simon, Joberty, Gerard, Poeckel, Daniel, Good, Robert B., Taylor, Adam R., Zinn, Nico, Redding, Matthew, Forty, Ellen J., Hynds, Robert E., Swanton, Charles, Karsdal, Morten, Maher, Toby M., Fisher, Andrew, Bergamini, Giovanna, Marshall, Richard P., Blanchard, Andy D., Mercer, Paul F., Chambers, Rachel C.
Published in Nature communications (11.09.2020)
Published in Nature communications (11.09.2020)
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A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1
Müller, Leonie, Burton, Amy K, Tayler, Chloe L, Rowedder, James E, Hutchinson, Jonathan P, Peace, Simon, Quayle, Julie M, Leveridge, Melanie V, Annan, Roland S, Trost, Matthias, Peltier-Heap, Rachel E, Dueñas, Maria Emilia
Published in SLAS discovery (01.01.2023)
Published in SLAS discovery (01.01.2023)
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The discovery of GSK221149A: A potent and selective oxytocin antagonist
Liddle, John, Allen, Michael J., Borthwick, Alan D., Brooks, David P., Davies, David E., Edwards, Richard M., Exall, Anne M., Hamlett, Chris, Irving, Wendy R., Mason, Andrew M., McCafferty, Gerald P., Nerozzi, Fabrizio, Peace, Simon, Philp, Joanne, Pollard, Derek, Pullen, Mark A., Shabbir, Shaila S., Sollis, Steve L., Westfall, Timothy D., Woollard, Pat M., Wu, Charlene, Hickey, Deirdre M.B.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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The Nitro-Mannich Reaction and Its Application to the Stereoselective Synthesis of 1,2-Diamines
Adams, Harry, Anderson, James C, Peace, Simon, Pennell, Andrew M. K
Published in Journal of organic chemistry (25.12.1998)
Published in Journal of organic chemistry (25.12.1998)
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Discovery of 3‑Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway
Hobbs, Heather, Bravi, Gianpaolo, Campbell, Ian, Convery, Maire, Davies, Hannah, Inglis, Graham, Pal, Sandeep, Peace, Simon, Redmond, Joanna, Summers, Declan
Published in Journal of medicinal chemistry (08.08.2019)
Published in Journal of medicinal chemistry (08.08.2019)
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Correction to Discovery of 3‑Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway
Hobbs, Heather, Bravi, Gianpaolo, Campbell, Ian, Convery, Maire, Davies, Hannah, Inglis, Graham, Pal, Sandeep, Peace, Simon, Redmond, Joanna, Summers, Declan
Published in Journal of medicinal chemistry (10.10.2019)
Published in Journal of medicinal chemistry (10.10.2019)
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Journal Article
Three Groups Good, Four Groups Bad? Atropisomerism in ortho-Substituted Diaryl Ethers
Betson, Mark S., Clayden, Jonathan, Worrall, Christopher P., Peace, Simon
Published in Angewandte Chemie (04.09.2006)
Published in Angewandte Chemie (04.09.2006)
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Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3‑Kinase δ through a Deconstruction and Regrowth Approach
Barton, Nick, Convery, Máire, Cooper, Anthony W. J, Down, Kenneth, Hamblin, J. Nicole, Inglis, Graham, Peace, Simon, Rowedder, James, Rowland, Paul, Taylor, Jonathan A, Wellaway, Natalie
Published in Journal of medicinal chemistry (27.12.2018)
Published in Journal of medicinal chemistry (27.12.2018)
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Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease
Amour, Augustin, Barton, Nick, Cooper, Anthony W. J, Inglis, Graham, Jamieson, Craig, Luscombe, Christopher N, Morrell, Josie, Peace, Simon, Perez, David, Rowland, Paul, Tame, Chris, Uddin, Sorif, Vitulli, Giovanni, Wellaway, Natalie
Published in Journal of medicinal chemistry (11.08.2016)
Published in Journal of medicinal chemistry (11.08.2016)
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Pyridyl-2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists: Synthesis, Pharmacokinetics, and In Vivo Potency
Borthwick, Alan D, Liddle, John, Davies, Dave E, Exall, Anne M, Hamlett, Christopher, Hickey, Deirdre M, Mason, Andrew M, Smith, Ian E. D, Nerozzi, Fabrizio, Peace, Simon, Pollard, Derek, Sollis, Steve L, Allen, Michael J, Woollard, Patrick M, Pullen, Mark A, Westfall, Timothy D, Stanislaus, Dinesh J
Published in Journal of medicinal chemistry (26.01.2012)
Published in Journal of medicinal chemistry (26.01.2012)
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Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease
Amour, Augustin, Barton, Nick, Cooper, Anthony W. J, Inglis, Graham, Jamieson, Craig, Luscombe, Christopher N, Morrell, Josie, Peace, Simon, Perez, David, Rowland, Paul, Tame, Christopher J, Uddin, Sorif, Vitulli, Giovanni, Wellaway, Natalie
Published in Journal of medicinal chemistry (27.10.2016)
Published in Journal of medicinal chemistry (27.10.2016)
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Journal Article
Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease
Amour, Augustin, Barton, Nick, Cooper, Anthony W. J, Inglis, Graham, Jamieson, Craig, Luscombe, Christopher N, Morrell, Josie, Peace, Simon, Perez, David, Rowland, Paul, Tame, Christopher J, Uddin, Sorif, Vitulli, Giovanni, Wellaway, Natalie
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Identification of a sulfonamide series of CCR2 antagonists
Peace, Simon, Philp, Joanne, Brooks, Carl, Piercy, Val, Moores, Kitty, Smethurst, Chris, Watson, Steve, Gaines, Simon, Zippoli, Mara, Mookherjee, Claudette, Ife, Robert
Published in Bioorganic & medicinal chemistry letters (01.07.2010)
Published in Bioorganic & medicinal chemistry letters (01.07.2010)
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Corrigendum to “In vivo activity of an azole series of CCR2 antagonists” [Bioorg. Med. Chem. Lett. 22 (2012) 7252–7255]
Smethurst, Chris A., Bevan, Nicola, Brooks, Carl, Emmons, Amanda, Gough, Peter J., Mookherjee, Claudette, Moores, Kitty, Peace, Simon, Philp, Joanne, Piercy, Val, Watson, Steve P., Zippoli, Mara
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
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