A Prostate-specific Antigen (PSA)-activated Vinblastine Prodrug Selectively Kills PSA-secreting Cells in Vivo
DeFeo-Jones, Deborah, Brady, Stephen F, Feng, Dong-Mei, Wong, Bradly K, Bolyar, Trina, Haskell, Kathleen, Kiefer, David M, Leander, Karen, McAvoy, Elizabeth, Lumma, Patricia, Pawluczyk, Joseph M, Wai, Jenny, Motzel, Sherri L, Keenan, Kevin, Van Zwieten, Matthew, Lin, Jiunn H, Garsky, Victor M, Freidinger, Roger, Oliff, Allen, Jones, Raymond E
Published in Molecular cancer therapeutics (01.05.2002)
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Published in Molecular cancer therapeutics (01.05.2002)
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Design and Synthesis of a Pro-Drug of Vinblastine Targeted at Treatment of Prostate Cancer with Enhanced Efficacy and Reduced Systemic Toxicity
Brady, Stephen F, Pawluczyk, Joseph M, Lumma, Patricia K, Feng, Dong-Mei, Wai, Jenny M, Jones, Raymond, DeFeo-Jones, Deborah, Wong, Bradley K, Miller-Stein, Cynthia, Lin, Jiunn H, Oliff, Allen, Freidinger, Roger M, Garsky, Victor M
Published in Journal of medicinal chemistry (10.10.2002)
Published in Journal of medicinal chemistry (10.10.2002)
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Development of Orally Active Oxytocin Antagonists: Studies on 1-(1-{4-[1-(2-Methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and Related Pyridines
Bell, Ian M, Erb, Jill M, Freidinger, Roger M, Gallicchio, Steven N, Guare, James P, Guidotti, Maribeth T, Halpin, Rita A, Hobbs, Doug W, Homnick, Carl F, Kuo, Michelle S, Lis, Edward V, Mathre, David J, Michelson, Stuart R, Pawluczyk, Joseph M, Pettibone, Douglas J, Reiss, Duane R, Vickers, Stanley, Williams, Peter D, Woyden, Carla J
Published in Journal of medicinal chemistry (04.06.1998)
Published in Journal of medicinal chemistry (04.06.1998)
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Microwave-initiated living free radical polymerization: optimization of the preparative scale synthesis of Rasta resins
Pawluczyk, Joseph M., McClain, Ray T., Denicola, Chris, Mulhearn, James J., Rudd, Deanne Jackson, Lindsley, Craig W.
Published in Tetrahedron letters (19.02.2007)
Published in Tetrahedron letters (19.02.2007)
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1-[1-[4-[(N-Acetyl-4-piperidinyl)oxy]-2- methoxybenzoyl]piperidin-4-yl]-4H-3,1- benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist
Williams, Peter D, Clineschmidt, Bradley V, Erb, Jill M, Freidinger, Roger M, Guidotti, Maribeth T, Lis, Edward V, Pawluczyk, Joseph M, Pettibone, Douglas J, Reiss, Duane R
Published in Journal of medicinal chemistry (01.11.1995)
Published in Journal of medicinal chemistry (01.11.1995)
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Nanomolar-affinity, non-peptide oxytocin receptor antagonists
Evans, Ben E, Lundell, George F, Gilbert, Kevin F, Bock, Mark G, Rittle, Kenneth E, Carroll, Leigh Anne, Williams, Peter D, Pawluczyk, Joseph M, Leighton, James L
Published in Journal of medicinal chemistry (01.12.1993)
Published in Journal of medicinal chemistry (01.12.1993)
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1-{1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4-yl}-4H-3,1-benzoxazin-2(1H)-one (L-371,257) : a new, orally bioavailable, non-peptide oxytocin antagonist
WILLIAMS, P. D, CLINESCHMIDT, B. V, WOYDEN, C. J, ERB, J. M, FREIDINGER, R. M, GUIDOTTI, M. T, LIS, E. V, PAWLUCZYK, J. M, PETTIBONE, D. J, REISS, D. R, VEBER, D. F
Published in Journal of medicinal chemistry (01.11.1995)
Published in Journal of medicinal chemistry (01.11.1995)
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1-(((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo[2.2.1]heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine (L-368,899): An Orally Bioavailable, Non-Peptide Oxytocin Antagonist with Potential Utility for Managing Preterm Labor
Williams, Peter D, Anderson, Paul S, Ball, Richard G, Bock, Mark G, Carroll, LeighAnne, Chiu, Shuet-Hing Lee, Clineschmidt, Bradley V, Culberson, J. Chris, Erb, Jill M
Published in Journal of medicinal chemistry (01.03.1994)
Published in Journal of medicinal chemistry (01.03.1994)
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Nonpeptide oxytocin antagonists: Analogs of L-371,257 with improved potency
Williams, Peter D., Bock, Mark G., Evans, Ben E., Freidinger, Roger M., Gallicchio, Steven N., Guidotti, Maribeth T., Jacobson, Marlene A., Kuo, Michelle S., Levy, Michelle R., Lis, Edward V., Michelson, Stuart R., Pawluczyk, Joseph M., Perlow, Debra S., Pettibone, Douglas J., Quigley, Amy G., Reiss, Duane R., Salvatore, Christopher, Stauffer, Kenneth J., Woyden, Carla J.
Published in Bioorganic & medicinal chemistry letters (03.05.1999)
Published in Bioorganic & medicinal chemistry letters (03.05.1999)
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Nonpeptide oxytocin antagonists: Potent, orally bioavailable analogs of L-371,257 containing A 1- R-(pyridyl)ethyl ether terminus
Kuo, Michelle S., Bock, Mark G., Freidinger, Roger M., Guidotti, Maribeth T., Lis, Edward V., Pawluczyk, Joseph M., Perlow, Debra S., Pettibone, Douglas J., Quigley, Amy G., Reiss, Duane R., Williams, Peter D., Woyden, Carla J.
Published in Bioorganic & medicinal chemistry letters (03.11.1998)
Published in Bioorganic & medicinal chemistry letters (03.11.1998)
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Conformationally constrained o-tolylpiperazine camphorsulfonamide oxytocin antagonists. Structural modifications that provide high receptor affinity and suggest a bioactive conformation
Williams, Peter D., Ball, Richard G., Clineschmidt, Bradley V., Culberson, J.Chris, Erb, Jill M., Freidinger, Roger M., Pawluczyk, Joseph M., Perlow, Debra S., Pettibone, Douglas J., Veber, Daniel F.
Published in Bioorganic & medicinal chemistry (01.09.1994)
Published in Bioorganic & medicinal chemistry (01.09.1994)
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Applications of Microwave-Assisted Organic Synthesis on the Multigram Scale
Wolkenberg, Scott E., Shipe, William D., Lindsley, Craig W., Guare, James P., Pawluczyk, Joseph M.
Published in ChemInform (29.08.2006)
Published in ChemInform (29.08.2006)
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