A phase I, first‐in‐human, randomized dose‐escalation study of anti‐activated factor XII monoclonal antibody garadacimab
McKenzie, Andrew, Roberts, Anthony, Malandkar, Sourabh, Feuersenger, Henrike, Panousis, Con, Pawaskar, Dipti
Published in Clinical and translational science (01.03.2022)
Published in Clinical and translational science (01.03.2022)
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Journal Article
Pharmacokinetic Profile of Subcutaneous C1-Esterase Inhibitor (C1-INH [SC]) in Adolescent and Adult Patients with Hereditary Angioedema (HAE)
Pawaskar, Dipti K., Jacobs, Iris, Pragst, Ingo, Feuersenger, Henrike
Published in Journal of allergy and clinical immunology (01.02.2018)
Published in Journal of allergy and clinical immunology (01.02.2018)
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Journal Article
Pharmacokinetic/pharmacodynamic modeling for dose selection for the first‐in‐human trial of the activated Factor XII inhibitor garadacimab (CSL312)
Pawaskar, Dipti, Chen, Xi, Glassman, Fiona, May, Frauke, Roberts, Anthony, Biondo, Mark, McKenzie, Andrew, Nolte, Marc W., Jusko, William J., Tortorici, Michael
Published in Clinical and translational science (01.03.2022)
Published in Clinical and translational science (01.03.2022)
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Journal Article
Subcutaneous (SC) vs Intravenous (IV) C1-esterase-inhibitor (C1-INH) Replacement Treatment For The Prevention Of Attacks Of Hereditary Angioedema (HAE): A Population-based Exposure-response Analysis
Zuraw, Bruce L., Cicardi, Marco, Craig, Timothy J., Longhurst, Hilary J., Lumry, William R., Bernstein, Jonathan A., Zhang, Ying, Pawaskar, Dipti K.
Published in Journal of allergy and clinical immunology (01.02.2018)
Published in Journal of allergy and clinical immunology (01.02.2018)
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Journal Article
Synergistic interactions between sorafenib and everolimus in pancreatic cancer xenografts in mice
Pawaskar, Dipti K., Straubinger, Robert M., Fetterly, Gerald J., Hylander, Bonnie H., Repasky, Elizabeth A., Ma, Wen W., Jusko, William J.
Published in Cancer chemotherapy and pharmacology (01.05.2013)
Published in Cancer chemotherapy and pharmacology (01.05.2013)
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Journal Article
Physiologically based pharmacokinetic models for everolimus and sorafenib in mice
Pawaskar, Dipti K., Straubinger, Robert M., Fetterly, Gerald J., Hylander, Bonnie H., Repasky, Elizabeth A., Ma, Wen W., Jusko, William J.
Published in Cancer chemotherapy and pharmacology (01.05.2013)
Published in Cancer chemotherapy and pharmacology (01.05.2013)
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Journal Article
Interactions of Everolimus and Sorafenib in Pancreatic Cancer Cells
Pawaskar, Dipti K., Straubinger, Robert M., Fetterly, Gerald J., Ma, Wen W., Jusko, William J.
Published in The AAPS journal (01.01.2013)
Published in The AAPS journal (01.01.2013)
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Journal Article
Interactions of Everolimus and Sorafenib in Whole Blood Lymphocyte Proliferation
Pawaskar, Dipti K., Straubinger, Robert M., Fetterly, Gerald J., Ma, Wen W., Jusko, William J.
Published in Pharmaceutical research (01.03.2013)
Published in Pharmaceutical research (01.03.2013)
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Journal Article
Prophylactic use of an anti-activated factor XII monoclonal antibody, garadacimab, for patients with C1-esterase inhibitor-deficient hereditary angioedema: a randomised, double-blind, placebo-controlled, phase 2 trial
Craig, Timothy, Magerl, Markus, Levy, Donald S, Reshef, Avner, Lumry, William R, Martinez-Saguer, Inmaculada, Jacobs, Joshua S, Yang, William H, Ritchie, Bruce, Aygören-Pürsün, Emel, Keith, Paul K, Busse, Paula, Feuersenger, Henrike, Pawaskar, Dipti, Jacobs, Iris, Pragst, Ingo, Doyle, Mittie K
Published in The Lancet (British edition) (05.03.2022)
Published in The Lancet (British edition) (05.03.2022)
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A Phase 1, Single-Center, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Intravenous and Subcutaneous Garadacimab (CSL312) in Healthy Subjects
McKenzie, Andrew, Roberts, Anthony, Malandkar, Sourabh, Feuersenger, Henrike, Panousis, Con, Pawaskar, Dipti
Published in Journal of allergy and clinical immunology (01.02.2021)
Published in Journal of allergy and clinical immunology (01.02.2021)
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Journal Article
EFFECTS OF REGN5381, A NATRIURETIC PEPTIDE RECEPTOR 1 AGONIST ANTIBODY, IN HYPERTENSIVE MOUSE MODELS AND MILDLY HYPERTENSIVE BUT OTHERWISE HEALTHY ADULTS IN A PHASE 1 FIRST-IN-HUMAN STUDY
Kithcart, Aaron P., Devalaraja-Narashimha, Kishor, Liu, Laura, Jin, Ximei, Torello, Justin, Zhang, Dongqin, Shekhar, Akshay, De Hoon, Jan, Botermans, Wouter, Herman, Gary, Cheng, Xiping, Pawaskar, Dipti, Gopal, Srihari, Dunn, Michael, Morton, Lori, Olenchock, Ben
Published in Journal of the American College of Cardiology (02.04.2024)
Published in Journal of the American College of Cardiology (02.04.2024)
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Journal Article
Population Pharmacokinetic/Pharmacodynamic Modelling Reveals A Positive Relationship Between Complement 4 Serum Antigen Concentrations And C1 Inhibitor Functional Activity Levels
Zuraw, Bruce L., Christiansen, Sandra C., Craig, Timothy, Longhurst, Hilary, Cicardi, Marco, Chiao, Joseph, Pragst, Ingo, Pawaskar, Dipti
Published in Journal of allergy and clinical immunology (01.02.2019)
Published in Journal of allergy and clinical immunology (01.02.2019)
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Journal Article
Subcutaneous C1-esterase inhibitor to prevent hereditary angioedema attacks: Safety findings from the COMPACT trial
Li, H Henry, Mycroft, Sarah, Christiansen, Sandra, Wood, Daniel N, Feuersenger, Henrike, Pawaskar, Dipti, Jacobs, Iris
Published in Allergy and asthma proceedings (14.09.2018)
Published in Allergy and asthma proceedings (14.09.2018)
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Journal Article
Long-Term Outcomes with Subcutaneous C1-Inhibitor Replacement Therapy for Prevention of Hereditary Angioedema Attacks
Craig, Timothy, Zuraw, Bruce, Longhurst, Hilary, Cicardi, Marco, Bork, Konrad, Grattan, Clive, Katelaris, Constance, Sussman, Gordon, Keith, Paul K, Yang, William, Hébert, Jacques, Hanzlikova, Jana, Staubach-Renz, Petra, Martinez-Saguer, Inmaculada, Magerl, Markus, Aygören-Pürsün, Emel, Farkas, Henriette, Reshef, Avner, Kivity, Shmuel, Neri, Sergio, Crisan, Ioana, Caballero, Teresa, Baeza, Maria L, Hernandez, Maria Dolores, Li, Henry, Lumry, William, Bernstein, Jonathan A, Hussain, Iftikar, Anderson, John, Schwartz, Lawrence B, Jacobs, Joshua, Manning, Michael, Levy, Donald, Riedl, Marc, Christiansen, Sandra, Feuersenger, Henrike, Pragst, Ingo, Mycroft, Sarah, Pawaskar, Dipti, Jacobs, Iris
Published in The journal of allergy and clinical immunology in practice (Cambridge, MA) (01.07.2019)
Published in The journal of allergy and clinical immunology in practice (Cambridge, MA) (01.07.2019)
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Journal Article
Population pharmacokinetics of subcutaneous C1‐inhibitor for prevention of attacks in patients with hereditary angioedema
Pawaskar, Dipti, Tortorici, Michael A., Zuraw, Bruce, Craig, Timothy, Cicardi, Marco, Longhurst, Hilary, Li, H. Henry, Lumry, William R., Martinez‐Saguer, Inmaculada, Jacobs, Joshua, Bernstein, Jonathan A., Riedl, Marc A., Katelaris, Constance H., Keith, Paul K., Feussner, Annette, Sidhu, Jagdev
Published in Clinical and experimental allergy (01.10.2018)
Published in Clinical and experimental allergy (01.10.2018)
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Journal Article
Exposure‐Response Model of Subcutaneous C1‐Inhibitor Concentrate to Estimate the Risk of Attacks in Patients With Hereditary Angioedema
Zhang, Ying, Tortorici, Michael A., Pawaskar, Dipti, Pragst, Ingo, Machnig, Thomas, Hutmacher, Matthew, Zuraw, Bruce, Cicardi, Marco, Craig, Timothy, Longhurst, Hilary, Sidhu, Jagdev
Published in CPT: pharmacometrics and systems pharmacology (01.03.2018)
Published in CPT: pharmacometrics and systems pharmacology (01.03.2018)
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Journal Article
Risk for Attacks in Hereditary Angioedema (HAE) Population Correlates with C1-inhibitor Functional Activity (C1-INHact)
Cicardi, Marco, Li, Huamin Henry, MD, PhD, FAAAAI, Chase, Chevy, MD, Anderson, John T., MD, Bernstein, Jonathan A., MD, FAAAAI, Farkas, Henriette, Zhang, Ying, PhD, Pawaskar, Dipti, Pragst, Ingo, PhD
Published in Journal of allergy and clinical immunology (01.02.2017)
Published in Journal of allergy and clinical immunology (01.02.2017)
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Journal Article
Placebo-Controlled Trials of C1-Inhibitor (C1-INH) Replacement Therapy for Routine Prevention of Attacks in Patients with Hereditary Angioedema (HAE)
Bernstein, Jonathan A., MD, FAAAAI, Li, Huamin Henry, MD, PhD, FAAAAI, Craig, Timothy J., DO, FAAAAI, Longhurst, Hilary J, Farkas, Henriette, Manning, Michael E., MD, FAAAAI, Machnig, Thomas, Lawo, John-Philip, Pawaskar, Dipti, Jacobs, Iris
Published in Journal of allergy and clinical immunology (01.02.2017)
Published in Journal of allergy and clinical immunology (01.02.2017)
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