Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
Bonuccelli, Gloria, Tsirigos, Aristotelis, Whitaker-Menezes, Diana, Pavlides, Stephanos, Pestell, Richard G., Chiavarina, Barbara, Frank, Philippe G., Flomenberg, Neal, Howell, Anthony, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Published in Cell cycle (Georgetown, Tex.) (01.09.2010)
Published in Cell cycle (Georgetown, Tex.) (01.09.2010)
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The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
Pavlides, Stephanos, Whitaker-Menezes, Diana, Castello-Cros, Remedios, Flomenberg, Neal, Witkiewicz, Agnieszka K., Frank, Philippe G., Casimiro, Mathew C., Wang, Chenguang, Fortina, Paolo, Addya, Sankar, Pestell, Richard G., Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Published in Cell cycle (Georgetown, Tex.) (01.12.2009)
Published in Cell cycle (Georgetown, Tex.) (01.12.2009)
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Journal Article
Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms
Sotgia, Federica, Martinez-Outschoorn, Ubaldo E, Howell, Anthony, Pestell, Richard G, Pavlides, Stephanos, Lisanti, Michael P
Published in Annual review of pathology (01.01.2012)
Published in Annual review of pathology (01.01.2012)
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Journal Article
Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: Implications for PET imaging of human tumors
Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Trimmer, Casey, Flomenberg, Neal, Wang, Chenguang, Pavlides, Stephanos, Pestell, Richard G., Howell, Anthony, Sotgia, Federica, Lisanti, Michael P
Published in Cell cycle (Georgetown, Tex.) (01.08.2011)
Published in Cell cycle (Georgetown, Tex.) (01.08.2011)
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Journal Article
Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: Achieving personalized medicine via Metabolo-Genomics
Martinez-Outschoorn, Ubaldo E., Prisco, Marco, Ertel, Adam, Tsirigos, Aristotelis, Lin, Zhao, Pavlides, Stephanos, Wang, Chengwang, Flomenberg, Neal, Knudsen, Erik S., Howell, Anthony, Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P
Published in Cell cycle (Georgetown, Tex.) (15.04.2011)
Published in Cell cycle (Georgetown, Tex.) (15.04.2011)
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Journal Article
Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts
Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Ertel, Adam, Flomenberg, Neal, Witkiewicz, Agnieszka K., Birbe, Ruth, Howell, Anthony, Pavlides, Stephanos, Gandara, Ricardo, Pestell, Richard G., Sotgia, Federica, Philp, Nancy J., Lisanti, Michael P
Published in Cell cycle (Georgetown, Tex.) (01.06.2011)
Published in Cell cycle (Georgetown, Tex.) (01.06.2011)
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Journal Article
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
Martinez-Outschoorn, Ubaldo E., Balliet, Renee M., Rivadeneira, Dayana, Chiavarina, Barbara, Pavlides, Stephanos, Wang, Chenguang, Whitaker-Menezes, Diana, Daumer, Kristin, Lin, Zhao, Witkiewicz, Agnieszka, Flomenberg, Neal, Howell, Anthony, Pestell, Richard, Knudsen, Erik, Sotgia, Federica, Lisanti, Michael P.
Published in Cell cycle (Georgetown, Tex.) (15.08.2010)
Published in Cell cycle (Georgetown, Tex.) (15.08.2010)
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Journal Article
Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: The seed and soil also needs "fertilizer"
Lisanti, Michael P, Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Pavlides, Stephanos, Whitaker-Menezes, Diana, Pestell, Richard G., Howell, Anthony, Sotgia, Federica
Published in Cell cycle (Georgetown, Tex.) (01.08.2011)
Published in Cell cycle (Georgetown, Tex.) (01.08.2011)
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Journal Article
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment
Martinez-Outschoorn, Ubaldo E., Trimmer, Casey, Lin, Zhao, Whitaker-Menezes, Diana, Chiavarina, Barbara, Zhou, Jie, Wang, Chenguang, Pavlides, Stephanos, Martinez-Cantarin, Maria P., Capozza, Franco, Witkiewicz, Agnieszka K., Flomenberg, Neal, Howell, Anthony, Pestell, Richard G., Caro, Jaime, Lisanti, Michael P., Sotgia, Federica
Published in Cell cycle (Georgetown, Tex.) (01.09.2010)
Published in Cell cycle (Georgetown, Tex.) (01.09.2010)
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Journal Article
Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue
Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E., Flomenberg, Neal, Birbe, Ruth, Witkiewicz, Agnieszka K., Howell, Anthony, Pavlides, Stephanos, Tsirigos, Aristotelis, Ertel, Adam, Pestell, Richard G., Broda, Paolo, Minetti, Carlo, Lisanti, Michael P., Sotgia, Federica
Published in Cell cycle (Georgetown, Tex.) (01.12.2011)
Published in Cell cycle (Georgetown, Tex.) (01.12.2011)
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Journal Article
Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment
Sotgia, Federica, Martinez-Outschoorn, Ubaldo E, Pavlides, Stephanos, Howell, Anthony, Pestell, Richard G, Lisanti, Michael P
Published in Breast cancer research : BCR (08.07.2011)
Published in Breast cancer research : BCR (08.07.2011)
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Journal Article
Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": A transcriptional informatics analysis with validation
Pavlides, Stephanos, Tsirigos, Aristotelis, Vera, Iset, Flomenberg, Neal, Frank, Philippe G., Casimiro, Mathew C., Wang, Chenguang, Fortina, Paolo, Addya, Sankar, Pestell, Richard G., Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Published in Cell cycle (Georgetown, Tex.) (01.06.2010)
Published in Cell cycle (Georgetown, Tex.) (01.06.2010)
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Journal Article
The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism
Pavlides, Stephanos, Tsirigos, Aristotelis, Migneco, Gemma, Whitaker-Menezes, Diana, Chiavarina, Barbara, Flomenberg, Neal, Frank, Philippe G., Casimiro, Mathew C., Wang, Chenguang, Pestell, Richard G., Martinez-Outschoorn, Ubaldo E., Howell, Anthony, Sotgia, Federica, Lisanti, Michael P.
Published in Cell cycle (Georgetown, Tex.) (01.09.2010)
Published in Cell cycle (Georgetown, Tex.) (01.09.2010)
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Journal Article
Caveolae and transcytosis in endothelial cells: role in atherosclerosis
Frank, Philippe G, Pavlides, Stephanos, Lisanti, Michael P
Published in Cell and tissue research (01.01.2009)
Published in Cell and tissue research (01.01.2009)
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Journal Article
Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors
Martinez-Outschoorn, Ubaldo E., Pavlides, Stephanos, Whitaker-Menezes, Diana, Daumer, Kristin M., Milliman, Janet N., Chiavarina, Barbara, Migneco, Gemma, Witkiewicz, Agnieszka K., Martinez-Cantarin, Maria P., Flomenberg, Neal, Howell, Anthony, Pestell, Richard G., Lisanti, Michael P., Sotgia, Federica
Published in Cell cycle (Georgetown, Tex.) (15.06.2010)
Published in Cell cycle (Georgetown, Tex.) (15.06.2010)
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Journal Article
HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis
Chiavarina, Barbara, Whitaker-Menezes, Diana, Migneco, Gemma, Martinez-Outschoorn, Ubaldo E., Pavlides, Stephanos, Howell, Anthony, Tanowitz, Herbert B., Casimiro, Mathew C., Wang, Chenguang, Pestell, Richard G., Grieshaber, Philip, Caro, Jaime, Sotgia, Federica, Lisanti, Michael P.
Published in Cell cycle (Georgetown, Tex.) (01.09.2010)
Published in Cell cycle (Georgetown, Tex.) (01.09.2010)
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Journal Article
Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells
Martinez-Outschoorn, Ubaldo E., Goldberg, Allison F., Lin, Zhao, Ko, Ying-Hui, Flomenberg, Neal, Wang, Chenguang, Pavlides, Stephanos, Pestell, Richard G., Howell, Anthony, Sotgia, Federica, Lisanti, Michael P.
Published in Cancer biology & therapy (15.11.2011)
Published in Cancer biology & therapy (15.11.2011)
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Journal Article
The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
Bonuccelli, Gloria, Whitaker-Menezes, Diana, Castello-Cros, Remedios, Pavlides, Stephanos, Pestell, Richard G., Fatatis, Alessandro, Witkiewicz, Agnieszka K., Vander Heiden, Matthew G., Migneco, Gemma, Chiavarina, Barbara, Frank, Philippe G., Capozza, Franco, Flomenberg, Neal, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Published in Cell cycle (Georgetown, Tex.) (15.05.2010)
Published in Cell cycle (Georgetown, Tex.) (15.05.2010)
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Journal Article
The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox
Martinez-Outschoorn, Ubaldo E., Whitaker-Menezes, Diana, Pavlides, Stephanos, Chiavarina, Barbara, Bonuccelli, Gloria, Trimmer, Casey, Tsirigos, Aristotelis, Migneco, Gemma, Witkiewicz, Agnieszka K., Balliet, Renee M., Mercier, Isabelle, Wang, Chengwang, Flomenberg, Neal, Howell, Anthony, Lin, Zhao, Caro, Jaime, Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P
Published in Cell cycle (Georgetown, Tex.) (01.11.2010)
Published in Cell cycle (Georgetown, Tex.) (01.11.2010)
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