Therapeutic base editing in the adult liver
Paulusma, Coen C., Bosma, Piter J.
Published in Nature reviews. Gastroenterology & hepatology (01.09.2021)
Published in Nature reviews. Gastroenterology & hepatology (01.09.2021)
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Journal Article
A biliary HCO3− umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes
Hohenester, Simon, Maillette de Buy Wenniger, Lucas, Paulusma, Coen C., van Vliet, Sandra J., Jefferson, Douglas M., Oude Elferink, Ronald P., Beuers, Ulrich
Published in Hepatology (Baltimore, Md.) (01.01.2012)
Published in Hepatology (Baltimore, Md.) (01.01.2012)
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Journal Article
Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype
Vaz, Frédéric M., Paulusma, Coen C., Huidekoper, Hidde, de Ru, Minke, Lim, Cynthia, Koster, Janet, Ho‐Mok, Kam, Bootsma, Albert H., Groen, Albert K., Schaap, Frank G., Oude Elferink, Ronald P. J., Waterham, Hans R., Wanders, Ronald J.A.
Published in Hepatology (Baltimore, Md.) (01.01.2015)
Published in Hepatology (Baltimore, Md.) (01.01.2015)
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Journal Article
CDC50A is required for aminophospholipid transport and cell fusion in mouse C2C12 myoblasts
Grifell-Junyent, Marta, Baum, Julia F, Välimets, Silja, Herrmann, Andreas, Paulusma, Coen C, López-Marqués, Rosa L, Günther Pomorski, Thomas
Published in Journal of cell science (01.03.2022)
Published in Journal of cell science (01.03.2022)
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Journal Article
Bile salt signaling and bile salt-based therapies in cardiometabolic disease
Groenen, Claire C J, Nguyen, Thuc-Anh, Paulusma, Coen C, van de Graaf, Stan F J
Published in Clinical science (1979) (10.01.2024)
Published in Clinical science (1979) (10.01.2024)
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Journal Article
Soluble Adenylyl Cyclase Regulates Bile Salt‐Induced Apoptosis in Human Cholangiocytes
Chang, Jung‐Chin, Go, Simei, de Waart, Dirk R., Munoz‐Garrido, Patricia, Beuers, Ulrich, Paulusma, Coen C., Oude Elferink, Ronald
Published in Hepatology (Baltimore, Md.) (01.08.2016)
Published in Hepatology (Baltimore, Md.) (01.08.2016)
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Journal Article
Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice
Aronson, Sem J., Bakker, Robert S., Shi, Xiaoxia, Duijst, Suzanne, ten Bloemendaal, Lysbeth, de Waart, Dirk R., Verheij, Joanne, Ronzitti, Giuseppe, Oude Elferink, Ronald P., Beuers, Ulrich, Paulusma, Coen C., Bosma, Piter J.
Published in Journal of hepatology (01.07.2019)
Published in Journal of hepatology (01.07.2019)
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Journal Article
The P4-ATPase ATP9A is a novel determinant of exosome release
Naik, Jyoti, Hau, Chi M, Ten Bloemendaal, Lysbeth, Mok, Kam S, Hajji, Najat, Wehman, Ann M, Meisner, Sander, Muncan, Vanesa, Paauw, Nanne J, de Vries, H E, Nieuwland, Rienk, Paulusma, Coen C, Bosma, Piter J
Published in PloS one (04.04.2019)
Published in PloS one (04.04.2019)
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Journal Article
P4 ATPases: flippases in health and disease
van der Mark, Vincent A, Elferink, Ronald P J Oude, Paulusma, Coen C
Published in International Journal of Molecular Sciences (11.04.2013)
Published in International Journal of Molecular Sciences (11.04.2013)
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Journal Article
Book Review
Vps33b is crucial for structural and functional hepatocyte polarity
Hanley, Joanna, Dhar, Dipok Kumar, Mazzacuva, Francesca, Fiadeiro, Rebeca, Burden, Jemima J, Lyne, Anne-Marie, Smith, Holly, Straatman-Iwanowska, Anna, Banushi, Blerida, Virasami, Alex, Mills, Kevin, Lemaigre, Frédéric P, Knisely, A.S, Howe, Steven, Sebire, Neil, Waddington, Simon N, Paulusma, Coen C, Clayton, Peter, Gissen, Paul
Published in Journal of hepatology (01.05.2017)
Published in Journal of hepatology (01.05.2017)
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Journal Article
Complementary Functions of the Flippase ATP8B1 and the Floppase ABCB4 in Maintaining Canalicular Membrane Integrity
Groen, Annemiek, Romero, Marta Rodriguez, Kunne, Cindy, Hoosdally, Sarah J, Dixon, Peter H, Wooding, Carol, Williamson, Catherine, Seppen, Jurgen, van den Oever, Karin, Mok, Kam S, Paulusma, Coen C, Linton, Kenneth J, Oude Elferink, Ronald P.J
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2011)
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2011)
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Journal Article
ATP8B1 Deficiency Results in Elevated Mitochondrial Phosphatidylethanolamine Levels and Increased Mitochondrial Oxidative Phosphorylation in Human Hepatoma Cells
Gómez-Mellado, Valentina E., Chang, Jung-Chin, Ho-Mok, Kam S., Bernardino Morcillo, Carmen, Kersten, Remco H. J., Oude Elferink, Ronald P. J., Verhoeven, Arthur J., Paulusma, Coen C.
Published in International journal of molecular sciences (15.10.2022)
Published in International journal of molecular sciences (15.10.2022)
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Journal Article
Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4
van der Mark, Vincent A., Ghiboub, Mohammed, Marsman, Casper, Zhao, Jing, van Dijk, Remco, Hiralall, Johan K., Ho-Mok, Kam S., Castricum, Zoë, de Jonge, Wouter J., Oude Elferink, Ronald P. J., Paulusma, Coen C.
Published in Cellular and molecular life sciences : CMLS (01.02.2017)
Published in Cellular and molecular life sciences : CMLS (01.02.2017)
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Journal Article
Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis
van der Woerd, Wendy L, Wichers, Catharina G.K, Vestergaard, Anna L, Andersen, Jens Peter, Paulusma, Coen C, Houwen, Roderick H.J, van de Graaf, Stan F.J
Published in Journal of hepatology (01.06.2016)
Published in Journal of hepatology (01.06.2016)
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Journal Article
Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis
Hohenester, Simon, Kanitz, Veronika, Kremer, Andreas E, Paulusma, Coen C, Wimmer, Ralf, Kuehn, Helen, Denk, Gerald, Horst, David, Elferink, Ronald Oude, Beuers, Ulrich
Published in Cells (Basel, Switzerland) (23.01.2020)
Published in Cells (Basel, Switzerland) (23.01.2020)
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Journal Article
ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes
de Waart, Dirk R., Naik, Jyoti, Utsunomiya, Karina S., Duijst, Suzanne, Ho‐Mok, Kam, Bolier, A. Ruth, Hiralall, Johan, Bull, Laura N., Bosma, Piter J., Oude Elferink, Ronald P.J., Paulusma, Coen C.
Published in Hepatology (Baltimore, Md.) (01.07.2016)
Published in Hepatology (Baltimore, Md.) (01.07.2016)
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Journal Article
Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport
Paulusma, Coen C., Groen, Annemiek, Kunne, Cindy, Ho‐Mok, Kam S., Spijkerboer, Astrid L., Rudi de Waart, D., Hoek, Frans J., Vreeling, Heleen, Hoeben, Kees A., van Marle, Jan, Pawlikowska, Ludmila, Bull, Laura N., Hofmann, Alan F., Knisely, A. S., Oude Elferink, Ronald P. J.
Published in Hepatology (Baltimore, Md.) (01.07.2006)
Published in Hepatology (Baltimore, Md.) (01.07.2006)
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Journal Article