Single-cell analysis tools for drug discovery and development
Heath, James R., Ribas, Antoni, Mischel, Paul S.
Published in Nature reviews. Drug discovery (01.03.2016)
Published in Nature reviews. Drug discovery (01.03.2016)
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Journal Article
Altered cellular metabolism in gliomas — an emerging landscape of actionable co-dependency targets
Bi, Junfeng, Chowdhry, Sudhir, Wu, Sihan, Zhang, Wenjing, Masui, Kenta, Mischel, Paul S.
Published in Nature reviews. Cancer (01.01.2020)
Published in Nature reviews. Cancer (01.01.2020)
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Journal Article
Glioblastoma: from molecular pathology to targeted treatment
Cloughesy, Timothy F, Cavenee, Webster K, Mischel, Paul S
Published in Annual review of pathology (01.01.2014)
Published in Annual review of pathology (01.01.2014)
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Journal Article
Exploring the landscape of focal amplifications in cancer using AmpliconArchitect
Deshpande, Viraj, Luebeck, Jens, Nguyen, Nam-Phuong D., Bakhtiari, Mehrdad, Turner, Kristen M., Schwab, Richard, Carter, Hannah, Mischel, Paul S., Bafna, Vineet
Published in Nature communications (23.01.2019)
Published in Nature communications (23.01.2019)
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Journal Article
LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin
Shackelford, David B., Abt, Evan, Gerken, Laurie, Vasquez, Debbie S., Seki, Atsuko, Leblanc, Mathias, Wei, Liu, Fishbein, Michael C., Czernin, Johannes, Mischel, Paul S., Shaw, Reuben J.
Published in Cancer cell (11.02.2013)
Published in Cancer cell (11.02.2013)
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Journal Article
An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers
Villa, Genaro R., Hulce, Jonathan J., Zanca, Ciro, Bi, Junfeng, Ikegami, Shiro, Cahill, Gabrielle L., Gu, Yuchao, Lum, Kenneth M., Masui, Kenta, Yang, Huijun, Rong, Xin, Hong, Cynthia, Turner, Kristen M., Liu, Feng, Hon, Gary C., Jenkins, David, Martini, Michael, Armando, Aaron M., Quehenberger, Oswald, Cloughesy, Timothy F., Furnari, Frank B., Cavenee, Webster K., Tontonoz, Peter, Gahman, Timothy C., Shiau, Andrew K., Cravatt, Benjamin F., Mischel, Paul S.
Published in Cancer cell (14.11.2016)
Published in Cancer cell (14.11.2016)
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Journal Article
mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc
Masui, Kenta, Tanaka, Kazuhiro, Akhavan, David, Babic, Ivan, Gini, Beatrice, Matsutani, Tomoo, Iwanami, Akio, Liu, Feng, Villa, Genaro R., Gu, Yuchao, Campos, Carl, Zhu, Shaojun, Yang, Huijun, Yong, William H., Cloughesy, Timothy F., Mellinghoff, Ingo K., Cavenee, Webster K., Shaw, Reuben J., Mischel, Paul S.
Published in Cell metabolism (05.11.2013)
Published in Cell metabolism (05.11.2013)
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Journal Article
The metabolomic landscape plays a critical role in glioma oncogenesis
Masui, Kenta, Cavenee, Webster K., Mischel, Paul S., Shibata, Noriyuki
Published in Cancer science (01.05.2022)
Published in Cancer science (01.05.2022)
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Journal Article
mTORC2 in the center of cancer metabolic reprogramming
Masui, Kenta, Cavenee, Webster K, Mischel, Paul S
Published in Trends in endocrinology and metabolism (01.07.2014)
Published in Trends in endocrinology and metabolism (01.07.2014)
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Journal Article
Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
Bi, Junfeng, Ichu, Taka-Aki, Zanca, Ciro, Yang, Huijun, Zhang, Wei, Gu, Yuchao, Chowdhry, Sudhir, Reed, Alex, Ikegami, Shiro, Turner, Kristen M., Zhang, Wenjing, Villa, Genaro R., Wu, Sihan, Quehenberger, Oswald, Yong, William H., Kornblum, Harley I., Rich, Jeremy N., Cloughesy, Timothy F., Cavenee, Webster K., Furnari, Frank B., Cravatt, Benjamin F., Mischel, Paul S.
Published in Cell metabolism (03.09.2019)
Published in Cell metabolism (03.09.2019)
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Journal Article
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
Gu, Yuchao, Albuquerque, Claudio P., Braas, Daniel, Zhang, Wei, Villa, Genaro R., Bi, Junfeng, Ikegami, Shiro, Masui, Kenta, Gini, Beatrice, Yang, Huijun, Gahman, Timothy C., Shiau, Andrew K., Cloughesy, Timothy F., Christofk, Heather R., Zhou, Huilin, Guan, Kun-Liang, Mischel, Paul S.
Published in Molecular cell (06.07.2017)
Published in Molecular cell (06.07.2017)
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Journal Article
Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
Tanaka, Kazuhiro, Sasayama, Takashi, Irino, Yasuhiro, Takata, Kumi, Nagashima, Hiroaki, Satoh, Naoko, Kyotani, Katsusuke, Mizowaki, Takashi, Imahori, Taichiro, Ejima, Yasuo, Masui, Kenta, Gini, Beatrice, Yang, Huijun, Hosoda, Kohkichi, Sasaki, Ryohei, Mischel, Paul S, Kohmura, Eiji
Published in The Journal of clinical investigation (01.04.2015)
Published in The Journal of clinical investigation (01.04.2015)
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Journal Article
Metabolic state of glioma stem cells and nontumorigenic cells
Vlashi, Erina, Lagadec, Chann, Vergnes, Laurent, Matsutani, Tomoo, Masui, Kenta, Poulou, Maria, Popescu, Ruxandra, Della Donna, Lorenza, Evers, Patrick, Dekmezian, Carmen, Reue, Karen, Christofk, Heather, Mischel, Paul S, Pajonk, Frank
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (20.09.2011)
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Journal Article
Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA
Nathanson, David A., Gini, Beatrice, Mottahedeh, Jack, Visnyei, Koppany, Koga, Tomoyuki, Gomez, German, Estin, Ascia, Hwang, Kiwook, Wang, Jun, Masui, Kenta, Paucar, Andres, Yang, Huijun, Ohashi, Minori, Zhu, Shaojun, Wykosky, Jill, Reed, Rachel, Nelson, Stanley F., Cloughesy, Timothy F., James, C. David, Rao, P. Nagesh, Kornblum, Harley I., Heath, James R., Cavenee, Webster K., Furnari, Frank B., Mischel, Paul S.
Published in Science (American Association for the Advancement of Science) (03.01.2014)
Published in Science (American Association for the Advancement of Science) (03.01.2014)
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Journal Article
Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells
Shi, Qihui, Qin, Lidong, Wei, Wei, Geng, Feng, Fan, Rong, Shik Shin, Young, Guo, Deliang, Hood, Leroy, Mischel, Paul S, Heath, James R
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2012)
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Journal Article
EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling
Liu, Feng, Hon, Gary C., Villa, Genaro R., Turner, Kristen M., Ikegami, Shiro, Yang, Huijun, Ye, Zhen, Li, Bin, Kuan, Samantha, Lee, Ah Young, Zanca, Ciro, Wei, Bowen, Lucey, Greg, Jenkins, David, Zhang, Wei, Barr, Cathy L., Furnari, Frank B., Cloughesy, Timothy F., Yong, William H., Gahman, Timothy C., Shiau, Andrew K., Cavenee, Webster K., Ren, Bing, Mischel, Paul S.
Published in Molecular cell (15.10.2015)
Published in Molecular cell (15.10.2015)
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Journal Article
Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells
Wang, Xiuxing, Yang, Kailin, Wu, Qiulian, Kim, Leo J Y, Morton, Andrew R, Gimple, Ryan C, Prager, Briana C, Shi, Yu, Zhou, Wenchao, Bhargava, Shruti, Zhu, Zhe, Jiang, Li, Tao, Weiwei, Qiu, Zhixin, Zhao, Linjie, Zhang, Guoxing, Li, Xiqing, Agnihotri, Sameer, Mischel, Paul S, Mack, Stephen C, Bao, Shideng, Rich, Jeremy N
Published in Science translational medicine (07.08.2019)
Published in Science translational medicine (07.08.2019)
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Journal Article
ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer
Nguyen, Nam-phuong D, Deshpande, Viraj, Luebeck, Jens, Mischel, Paul S, Bafna, Vineet
Published in Nucleic acids research (20.04.2018)
Published in Nucleic acids research (20.04.2018)
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Journal Article
mTOR complex 2 is an integrator of cancer metabolism and epigenetics
Masui, Kenta, Harachi, Mio, Cavenee, Webster K., Mischel, Paul S., Shibata, Noriyuki
Published in Cancer letters (28.05.2020)
Published in Cancer letters (28.05.2020)
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