In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models
Hughes, Paul E, Rex, Karen, Caenepeel, Sean, Yang, Yajing, Zhang, Yihong, Broome, Martin A, Kha, Hue T, Burgess, Teresa L, Amore, Benny, Kaplan-Lefko, Paula J, Moriguchi, Jodi, Werner, Jonathan, Damore, Michael A, Baker, Daniel, Choquette, Deborah M, Harmange, Jean-Christophe, Radinsky, Robert, Kendall, Richard, Dussault, Isabelle, Coxon, Angela
Published in Molecular cancer therapeutics (01.07.2016)
Published in Molecular cancer therapeutics (01.07.2016)
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Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics
Carter, Bing Z., Mak, Po Yee, Tao, Wenjing, Ayoub, Edward, Ostermann, Lauren B., Huang, Xuelin, Loghavi, Sanam, Boettcher, Steffen, Nishida, Yuki, Ruvolo, Vivian, Hughes, Paul E., Morrow, Phuong K., Haferlach, Torsten, Kornblau, Steven, Muftuoglu, Muharrem, Andreeff, Michael
Published in Blood cancer journal (New York) (24.04.2023)
Published in Blood cancer journal (New York) (24.04.2023)
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Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics
Carter, Bing Z., Mak, Po Yee, Tao, Wenjing, Ayoub, Edward, Ostermann, Lauren B., Huang, Xuelin, Loghavi, Sanam, Boettcher, Steffen, Nishida, Yuki, Ruvolo, Vivian, Hughes, Paul E., Morrow, Phuong K., Haferlach, Torsten, Kornblau, Steven, Muftuoglu, Muharrem, Andreeff, Michael
Published in Blood cancer journal (New York) (17.05.2023)
Published in Blood cancer journal (New York) (17.05.2023)
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Mixing Sows into Alternative Lactation Housing Affects Sow Aggression at Mixing, Future Reproduction and Piglet Injury, with Marked Differences between Multisuckle and Sow Separation Systems
Greenwood, Emma C, van Dissel, Jonathon, Rayner, Jessica, Hughes, Paul E, van Wettere, William H E J
Published in Animals (Basel) (05.09.2019)
Published in Animals (Basel) (05.09.2019)
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Journal Article
Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor
Hodous, Brian L, Geuns-Meyer, Stephanie D, Hughes, Paul E, Albrecht, Brian K, Bellon, Steve, Bready, James, Caenepeel, Sean, Cee, Victor J, Chaffee, Stuart C, Coxon, Angela, Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Hoffman, Doug, Johnson, Rebecca E, Kendall, Richard, Kim, Joseph L, Long, Alexander M, Morrison, Michael, Olivieri, Philip R, Patel, Vinod F, Polverino, Anthony, Rose, Paul, Tempest, Paul, Wang, Ling, Whittington, Douglas A, Zhao, Huilin
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer
Giffin, Michael J, Cooke, Keegan, Lobenhofer, Edward K, Estrada, Juan, Zhan, Jinghui, Deegen, Petra, Thomas, Melissa, Murawsky, Christopher M, Werner, Jonathan, Liu, Siyuan, Lee, Fei, Homann, Oliver, Friedrich, Matthias, Pearson, Joshua T, Raum, Tobias, Yang, Yajing, Caenepeel, Sean, Stevens, Jennitte, Beltran, Pedro J, Canon, Jude, Coxon, Angela, Bailis, Julie M, Hughes, Paul E
Published in Clinical cancer research (01.03.2021)
Published in Clinical cancer research (01.03.2021)
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Journal Article
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies
Caenepeel, Sean, Brown, Sean P, Belmontes, Brian, Moody, Gordon, Keegan, Kathleen S, Chui, Danny, Whittington, Douglas A, Huang, Xin, Poppe, Leszek, Cheng, Alan C, Cardozo, Mario, Houze, Jonathan, Li, Yunxiao, Lucas, Brian, Paras, Nick A, Wang, Xianghong, Taygerly, Joshua P, Vimolratana, Marc, Zancanella, Manuel, Zhu, Liusheng, Cajulis, Elaina, Osgood, Tao, Sun, Jan, Damon, Leah, Egan, Regina K, Greninger, Patricia, McClanaghan, Joseph D, Gong, Jianan, Moujalled, Donia, Pomilio, Giovanna, Beltran, Pedro, Benes, Cyril H, Roberts, Andrew W, Huang, David C, Wei, Andrew, Canon, Jude, Coxon, Angela, Hughes, Paul E
Published in Cancer discovery (01.12.2018)
Published in Cancer discovery (01.12.2018)
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Journal Article
Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway
Hughes, Paul E, Renshaw, Mark W, Pfaff, Martin, Forsyth, Jane, Keivens, Virginia M, Schwartz, Martin A, Ginsberg, Mark H
Published in Cell (21.02.1997)
Published in Cell (21.02.1997)
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Complementation of dominant suppression implicates CD98 in integrin activation
Ginsberg, Mark H, Fenczik, Csilla A, Sethi, Tariq, Ramos, Joe W, Hughes, Paul E
Published in Nature (London) (06.11.1997)
Published in Nature (London) (06.11.1997)
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Journal Article
Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors
Caenepeel, Sean, Renshaw-Gegg, Lisa, Baher, Angelo, Bush, Tammy L, Baron, Will, Juan, Todd, Manoukian, Raffi, Tasker, Andrew S, Polverino, Anthony, Hughes, Paul E
Published in Journal of experimental & clinical cancer research (15.07.2010)
Published in Journal of experimental & clinical cancer research (15.07.2010)
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Journal Article
Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition
Gliech, Colin R, Yeow, Zhong Y, Tapias-Gomez, Daniel, Yang, Yuchen, Huang, Zhaoyu, Tijhuis, Andréa E, Spierings, Diana CJ, Foijer, Floris, Chung, Grace, Tamayo, Nuria, Bahrami-Nejad, Zahra, Collins, Patrick, Nguyen, Thong T, Plata Stapper, Andres, Hughes, Paul E, Payton, Marc, Holland, Andrew J
Published in The EMBO journal (01.03.2024)
Published in The EMBO journal (01.03.2024)
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Journal Article
Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic-Resistant AML and AML Stem Cells
Carter, Bing Z, Mak, Po Yee, Tao, Wenjing, Zhang, Qi, Ruvolo, Vivian, Kuruvilla, Vinitha M, Wang, Xiangmeng, Mak, Duncan H, Battula, Venkata L, Konopleva, Marina, Jabbour, Elias J, Hughes, Paul E, Chen, Xiaoyue, Morrow, Phuong K, Andreeff, Michael
Published in Molecular cancer therapeutics (01.06.2022)
Published in Molecular cancer therapeutics (01.06.2022)
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Journal Article
Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS -Mutant Non-Small Cell Lung Cancer
Nangia, Varuna, Siddiqui, Faria M, Caenepeel, Sean, Timonina, Daria, Bilton, Samantha J, Phan, Nicole, Gomez-Caraballo, Maria, Archibald, Hannah L, Li, Chendi, Fraser, Cameron, Rigas, Diamanda, Vajda, Kristof, Ferris, Lorin A, Lanuti, Michael, Wright, Cameron D, Raskin, Kevin A, Cahill, Daniel P, Shin, John H, Keyes, Colleen, Sequist, Lecia V, Piotrowska, Zofia, Farago, Anna F, Azzoli, Christopher G, Gainor, Justin F, Sarosiek, Kristopher A, Brown, Sean P, Coxon, Angela, Benes, Cyril H, Hughes, Paul E, Hata, Aaron N
Published in Cancer discovery (01.12.2018)
Published in Cancer discovery (01.12.2018)
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Journal Article
Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors
Hodous, Brian L., Geuns-Meyer, Stephanie D., Hughes, Paul E., Albrecht, Brian K., Bellon, Steve, Caenepeel, Sean, Cee, Victor J., Chaffee, Stuart C., Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Johnson, Rebecca E., Kim, Joseph L., Long, Alexander M., Morrison, Michael, Olivieri, Philip R., Patel, Vinod F., Polverino, Anthony, Rose, Paul, Wang, Ling, Zhao, Huilin
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Journal Article
MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor
Caenepeel, Sean, Cooke, Keegan, Wadsworth, Sarah, Huang, Guo, Robert, Lidia, Moreno, Blanca Homet, Parisi, Giulia, Cajulis, Elaina, Kendall, Richard, Beltran, Pedro, Ribas, Antoni, Coxon, Angela, Hughes, Paul E
Published in Oncotarget (14.03.2017)
Published in Oncotarget (14.03.2017)
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Journal Article
Discovery and in Vivo Evaluation of Macrocyclic Mcl‑1 Inhibitors Featuring an α‑Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere
Rescourio, Gwenaella, Gonzalez, Ana Z, Jabri, Salman, Belmontes, Brian, Moody, Gordon, Whittington, Doug, Huang, Xin, Caenepeel, Sean, Cardozo, Mario, Cheng, Alan C, Chow, David, Dou, Hannah, Jones, Adrie, Kelly, Ron C, Li, Yihong, Lizarzaburu, Mike, Lo, Mei-Chu, Mallari, Rommel, Meleza, Cesar, Rew, Yosup, Simonovich, Scott, Sun, Daqing, Turcotte, Simon, Yan, Xuelei, Wong, Simon G, Yanez, Evelyn, Zancanella, Manuel, Houze, Jonathan, Medina, Julio C, Hughes, Paul E, Brown, Sean P
Published in Journal of medicinal chemistry (27.11.2019)
Published in Journal of medicinal chemistry (27.11.2019)
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Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic-ischemic brain injury in the infant rat
Wu, Dahao David, Lai, Maggie, Hughes, Paul E, Sirimanne, Ernest, Gluckman, Peter D, Williams, Chris E
Published in Brain research (24.07.1999)
Published in Brain research (24.07.1999)
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Journal Article
AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients With MTAP-Deleted Cancers
Belmontes, Brian, Slemmons, Katherine K, Su, Chun, Liu, Siyuan, Policheni, Antonia N, Moriguchi, Jodi, Tan, Hong, Xie, Fang, Aiello, Daniel Andrew, Yang, Yajing, Lazaro, Raul, Aeffner, Famke, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Vestergaard, Mikkel, Cowland, Sanne, Andersson, Jan, Sarvary, Ian, Chen, Qing, Sharma, Pooja, Lopez, Patricia, Tamayo, Nuria, Pettus, Liping H, Ghimire-Rijal, Sudipa, Mukund, Susmith, Allen, Jennifer R, DeVoss, Jason, Coxon, Angela, Rodon, Jordi, Ghiringhelli, Francois, Penel, Nicolas, Prenen, Hans, Glad, Sanne, Chuang, Chen-Hua, Keyvanjah, Kiana, Townsley, Danielle M, Butler, John R, Bourbeau, Matthew P, Caenepeel, Sean, Hughes, Paul E
Published in Cancer discovery (16.09.2024)
Published in Cancer discovery (16.09.2024)
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